药物-环糊精配合物:现状与最新进展

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-10-28 DOI:10.53879/id.60.10.12952

Vikas S. Panwar, Lokesh Adhikari, Mona Semalty, Ajay Semalty

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引用次数: 0

摘要

环糊精是一种水溶性低聚糖，是由环糊精葡萄糖基转移酶(CGTase)作用于含有淀粉的培养基而形成的。环糊精被证明是制药工业中具有成本效益的突破，它与聚合物和药物一起配制，以提高原料药的安全性、生物利用度和溶解度。本文综述了环糊精在给药领域的研究现状及进展。综述了环糊精用于改善水溶性差产品的溶解度和溶出性能的研究进展，重点介绍了环糊精的理化性质、实用方法、毒性、与环糊精的相容性及其应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS

Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to improve the safety, bioavailability, and solubility of APIs. This review describes the current status and advancement of cyclodextrin research in drug delivery. The use of cyclodextrins to improve the solubility and dissolution properties of poor water-soluble products has been reviewed exhaustively with a specific focus on their physicochemical property, practical methods, toxicity, the drug-cyclodextrin compatibility and its applications.

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量