含氨硫脲鼻内微乳剂的研制与评价

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-09-28 DOI:10.53879/id.60.09.13783

Sachin N. Kothawade, Vishal V. Pande

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引用次数: 0

摘要

目前正在研究使用微乳液作为一种递送系统来改善整个鼻黏膜的吸收。加入黏附聚合物有助于延长在粘膜上的滞留时间。目前研究的主要目标是创造一种纳米配方的氨硫pride，旨在增加药物的渗透性，并通过生物相容性脂质含量保护它，避免首过代谢和外排机制，并选择给药途径，将氨硫pride输送到大脑或中枢神经系统，以增加氨硫pride在精神分裂症靶向部位的生物利用度。为了计算透光率、释放曲线以及脑和血浆中氨硫pride的水平，选择、开发和验证了适当的分析方法。结果表明，黏合剂能延长微乳的停留时间，达到了目标作用位点

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FORMULATION AND EVALUATION OF AMISULPRIDE LOADED INTRANASAL MICROEMULSION

The use of microemulsion as a delivery system for improving take-up across the nasal mucosa is cur-rently being studied. A mucoadhesive polymer is added to help extend the retention time on the mucosa.The primary goal of the current research was to create a nano-formulation of amisulpride with the intention of increasing the drug’s permeability and protecting it with a biocompatible lipid content, avoiding first-pass metabolism and efflux mechanisms, and selecting the route of administration to deliver amisulpride to the brain or CNS to increase the bioavailability of amisulpride at the targeted site of Schizophrenia. For calculating the percentage of transmittance, the release profile, and the levels of amisulpride in the brain and plasma, appropriate analytical methods were chosen, developed and validated. The results revealed that the residence time of me (microemulsion) was enhanced by the mucoadhesive agent and that a targeted site of action was achieved

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

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