马来酸替马洛尔与双氯芬酸钠口服抗炎模型的体外和体内对比研究

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-09-28 DOI:10.53879/id.60.09.13913

Namrata P. Nailwal, Gaurav M. Doshi

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引用次数: 0

摘要

本研究采用体外实验和大鼠体内模型对马来酸替马洛尔(一种非选择性β受体阻滞剂)进行了研究。在三种剂量水平(1.028 mg kg-1、5.14 mg kg-1和10.28 mg kg-1)下测试其抗炎活性。此外，肿瘤坏死因子-α (tNF-α)、白细胞介素-1 (IL- 1)和组织病理学检查也支持了这项研究。在1.028 mg kg -1、5.14 mg kg -1和10.28 mg kg -1时，该药表现出抗炎活性。血浆tNF-α和IL-1水平均受到抑制。组织病理学检查证实抗炎活性最高，为5.14 mg kg -1。因此，所进行的研究表明，口服马来酸噻洛尔确实具有抗炎作用。

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COMPARATIVE ANTI-INFLAMMATORY STUDIES ON TIMOLOL MALEATE AND DICLOFENAC SODIUM IN, IN VITRO AND IN VIVO MODELS BY ORAL ROUTES

The present study was conducted on timolol maleate (a non-selective beta-blocker) using in vitro assays and in vivo models of rats. It was tested for its anti-inflammatory activity at three dose levels (1.028 mg kg-1 , 5.14 mg kg -1 and 10.28 mg kg -1). Furthermore, the investigation was supported by the estimation of tumor necrosis factor-alpha (tNF-α), interleukin-1 (IL- 1) and histopathological examination. It was observed that at 1.028 mg kg -1, 5.14 mg kg -1 and 10.28 mg kg -1 the drug showed anti-inflammatory activities. moreover, plasma levels of tNF-α and IL-1 showed inhibition. Histopathological examination confirmed the highest anti-inflammatory activity at 5.14 mg kg -1. Thus, the conducted studies revealed that timolol maleate, when given orally does possesses an anti-inflammatory potential.

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量