INDIAN DRUGS最新文献_第6页

FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS 斑马鱼幼虫模型替代大鼠非膨出囊模型进行BCSⅲ类药物渗透评价的可行性

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13976

P. Devarajan, Bhagyashri K Joshi

{"title":"FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS","authors":"P. Devarajan, Bhagyashri K Joshi","doi":"10.53879/id.60.07.13976","DOIUrl":"https://doi.org/10.53879/id.60.07.13976","url":null,"abstract":"The oral route is the most convenient route of drug administration. Many drugs exhibit poor oral bioavailability. BCS III drugs exhibit high solubility and present a massive challenge due to poor permeability. Different permeation enhancers viz., nonionic Cremophor® RH 40, Tween® 80 and Lutrol® F68, anionic docusate sodium with sodium cholate, and anionic polymer sodium carboxymethyl cellulose were evaluated using rat non-everted sac method and zebrafish larva model. Maximum permeation enhancement was seen with docusate sodium for both drugs. The permeation enhancement ratio for netilmicin sulphate was 4.07±0.657, while for deferoxamine mesylate it was 1.482±0.378. Cremophor® RH 40 enabled augmented flux of netilmicin sulphate, and Tween® 80 showed enhanced permeation of deferoxamine mesylate. An excellent correlation was observed between apparent permeability and flux with drug absorbed per zebrafish larva (µg) (R2 = 0.938) for netilmicin sulphate and for deferoxamine mesylate (R2 = 0.9397). An important outcome of the study is the demonstration of the feasibility of the zebrafish larvae model as a viable substitute to the non-everted sac method, which could also enable screening of potential permeation enhancers for the development of orally bioavailable formulations of BCS III.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46839942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY 紫外-可见光谱法同时测定原料药和制剂中普瑞巴林和依托里昔的方法开发与验证

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13016

Akhil M. B., S. V. Kutty, Y. Haribabu, N. K.

引用次数: 0

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES 2-(4-取代苄基)- 7-甲基- 2h -噻唑[3,2 - a]嘧啶-3,5-二酮的合成及生物活性

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.12341

Ankush Goyal, Baljeet S. Kaur, Amandeep Kaur, V. Gupta, M. Gupta

{"title":"SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES","authors":"Ankush Goyal, Baljeet S. Kaur, Amandeep Kaur, V. Gupta, M. Gupta","doi":"10.53879/id.60.07.12341","DOIUrl":"https://doi.org/10.53879/id.60.07.12341","url":null,"abstract":"The organosulphur thiazolo-pyrimidines are fused heterocyclic compounds that can be anticipated as 7-thio counterparts of the genuine purine bases such as guanine and adenine. They have attained a growing significance in the domain of drug chemistry because of their diverse pharmacological activities. In the current study, 2-substituted benzylidene-7-methyl-2H-thiazolo [3,2-a] pyrimidine-3,5-dione derivatives were synthesised. The synthetic compounds were tested against the human myelomonocytic leukaemia cell line (U-937) for their ability to inhibit cancer cell growth as well as against Gram negative E. coli (MTCC 40) and Gram positive S. aureus (MTCC 87) for their ability to inhibit bacterial growth. The amine and halogen containing compounds exhibited the strongest anticancer and antibacterial effects among all the derivatives in series (7a-j). Compounds 7h, 7e, 7a, 7b, 7c, 7i, and 7j displayed improved activity in both assays compared to standard andriyamycin and ciprofloxacin, whereas 7d, 7f, and 7g were shown to be moderately active. Through the use of IR, NMR and mass spectrum analyses, the molecular structures of the synthesized compounds were determined.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44388304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMELIORATIVE EFFECT OF AVENA SATIVA (OAT) IN DINITROBENZENE SULPHONIC ACID INDUCED INFLAMMATORY BOWEL DISEASE IN RATS 燕麦对二硝基苯磺酸诱导的大鼠炎症性肠病的改善作用

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13351

Bhagyabhumi P. Shah, Vismay N. Patel, Samir K. Shah

引用次数: 0

QUANTITATIVE ESTIMATION OF 6-GINGEROL, E-GUGGULSTERONE AND Z-GUGGULSTERONE IN A FIXED DOSE COMBINATION NANOEMULGEL BY RP-HPLC 反相高效液相色谱法定量测定固定剂量复合纳米凝胶中6-姜辣素、e -谷固酮和z -谷固酮的含量

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13722

M. Momin, Vivek Basudkar, Sankalp Gharat, Anita Chando, T. Khan

引用次数: 0

EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW 基孔肯雅热的流行病学、诊断和治疗综述

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.12845

D. Rani, M. Kaushik, Ranjit Singh

{"title":"EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW","authors":"D. Rani, M. Kaushik, Ranjit Singh","doi":"10.53879/id.60.07.12845","DOIUrl":"https://doi.org/10.53879/id.60.07.12845","url":null,"abstract":"Chikungunya is a viral disease transmitted to humans by infected mosquitoes. Like most mosquito-borne infections, the virus can only be transmitted by blood-to-blood contact, through a mosquito bite or transfusion with infected blood. The disease is characterized by the common symptoms involving rashes, nausea and headache. In addition to this, it also causes intense joint pain and fever, which is known as arthralgia. It is widely spread in America, Africa and all over the world. The onset of chikungunya fever is more intense and the period of illness is shorter than that of dengue fever. Recently, chikungunya has become a serious public threat. The chikungunya symptoms are usually self-limiting and prophylactic treatment is currently unavailable to cure the disease, although various allopathic medicines, such as NSAID’s, analgesics, steroids, DMARDs and some anti-viral drugs claim to treat the disease. However, these medicines provide only symptomatic relief with serious side effects. Nowadays, researchers focus more towards an alternative treatment. The present review aims to highlight the epidemiology of chikungunya, treatment options available, and potential of alternative medicines for its treatment.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45442998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIO-INSPIRED GREEN SYNTHESIS OF NICKEL NANOPARTICLES USING STERCULIA FOETIDA LEAF EXTRACT AND ITS APPLICATION FOR REMOVAL OF TRIVALENT CHROMIUM FROM AQUEOUS SOLUTION 用牛蒡叶提取物生物绿色合成纳米镍及其去除水溶液中三价铬的应用

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.12743

U. Rani N., P. P, L. Tulasi S., T. Rao P.

{"title":"BIO-INSPIRED GREEN SYNTHESIS OF NICKEL NANOPARTICLES USING STERCULIA FOETIDA LEAF EXTRACT AND ITS APPLICATION FOR REMOVAL OF TRIVALENT CHROMIUM FROM AQUEOUS SOLUTION","authors":"U. Rani N., P. P, L. Tulasi S., T. Rao P.","doi":"10.53879/id.60.06.12743","DOIUrl":"https://doi.org/10.53879/id.60.06.12743","url":null,"abstract":"In the present work, a facile, eco-friendly, and cost-effective approach is described to remove Cr3+ toxic metal ions in an aqueous solution by nickel nanoparticles (NiNPs) synthesized via a green method utilizing Sterculia foetida leaf extract. The synthesized nickel nanoparticles were characterized by EDS (Energy- Dispersive X-Ray Spectroscopy), XRD (X-Ray diffraction), FT-IR (Fourier Transform Infrared Spectroscopy), and FE-SEM (Field Emission Scanning Electron Microscopy) spectroscopic methods. The spectroscopic signature studies revealed that the synthesized NiNPs are of spherical to irregular in shape with a mean particle size of 10±20 nm. The FT IR spectra confirmed the presence of OH, CC and CHO cross-linked stretching, CO and CCl stretching, representing the functional groups of polyphenols, flavonoids, and alkaloids type compounds in the synthesized nanoparticles. The EDS spectra confirmed the presence of nickel in the synthesized nanoparticles with a metal composition of 52.2%. In the XRD spectra, sharp diffraction peak two angles of green-produced NiNPs, which correspond to 111, 200 and 221 crystal planes, confirm the lattice structure of NiNPs. The synthesized NiNPs were used for the reduction of hexavalent chromium from aqueous solutions. The result revealed that immobilization of chromium heavy metals is an effect of initial concentration, ie. 100 µg mL-1 of Cr3+ concentration at 1 g L-1 of NiNPs adsorbent dosage within an average contact time of 1 h at 75 RPM. The present investigation revealed that these newly synthesized NiNPs might be potentially utilized for many environmental remediation applications.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46191974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENCAPSULATION OF THYME OIL INTO MICROSPONGES: PREPARATION, CHARACTERIZATION AND IN VITRO EVALUATION 百里香油微海绵包封:制备、表征及体外评价

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13428

Shanti B. Mishra, Deeksha Singh, Amit K. Singh, Shradhanjali M Singh

引用次数: 0

QUANTITATION OF GALLIC ACID IN ACACIA NILOTICA L. PODS BY HPTLC 高效液相色谱法测定白刺槐豆荚中没食子酸含量

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13908

Kaksha Sankha, M. Momin, T. Khan

引用次数: 0

BIOANALYTICAL METHOD VALIDATION: A COMPREHENSIVE ASSESSMENT OF VARIOUS REGULATORY GUIDELINES 生物分析方法验证：对各种监管指南的综合评估

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.12583

Anamika Singh, Tamanna Narsinghan

引用次数: 0