发布求助
文献互助 智能选刊 最新文献

INDIAN DRUGS最新文献

筛选
英文 中文
LOW CALORIE ARTIFICIAL SWEETENERS AS AN ALTERNATIVE IN PHARMACEUTICAL DOSAGE FORM DESIGN 低热量人工甜味剂作为药物剂型设计的替代品
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.12662
Pravin Gupta, Manish Kumar
{"title":"LOW CALORIE ARTIFICIAL SWEETENERS AS AN ALTERNATIVE IN PHARMACEUTICAL DOSAGE FORM DESIGN","authors":"Pravin Gupta, Manish Kumar","doi":"10.53879/id.60.09.12662","DOIUrl":"https://doi.org/10.53879/id.60.09.12662","url":null,"abstract":"Tremendous research is going on in the field of preparing low calorie diet for diabetes, obesity, hyper-tension, and heart disease, providing potential area for growth to the food and pharmaceutical industry. Dosage forms prepared for diabetic patients lack sucrose as breakdowns into glucose and fructose which starts from the mouth itself and majority of it is digested in the small intestine. As soon as it is digested, it gives rise to blood glucose level. In order to control such glucose spikes in blood, their diet is immediately shifted toward low calorie food and medications with low glycemic index. Artificial intense sweeteners e.g. acesulfame potassium, sucralose, xylitol etc. in moderate amount, intensity of sweet-ness and physical characteristics were proved safe by USFDA. this review covers a brief description, stability conditions and pharmacokinetic analysis of artificial sugars.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEVELOPMENT, VALIDATION AND COMPARISON OF RP-HPLC AND UV METHODS USING STATISTICAL ANALYSIS ONE WAY ANOVA TEST FOR REPAGLINIDE IN FORMULATION 瑞格列奈处方中反相高效液相色谱法和紫外法的建立、验证和比较
INDIAN DRUGS Pub Date : 2023-09-28 DOI: 10.53879/id.60.09.13574
Meghna P. Patel, Kushani N. Desai, Monika Sangani
{"title":"DEVELOPMENT, VALIDATION AND COMPARISON OF RP-HPLC AND UV METHODS USING STATISTICAL ANALYSIS ONE WAY ANOVA TEST FOR REPAGLINIDE IN FORMULATION","authors":"Meghna P. Patel, Kushani N. Desai, Monika Sangani","doi":"10.53879/id.60.09.13574","DOIUrl":"https://doi.org/10.53879/id.60.09.13574","url":null,"abstract":"In the present study, analytical UV and Rp-HpLC methods for repaglinide were developed for tablet formulation. UV method shows linearity in the range of 10-30 μg mL-1 with a relative coefficient of 0.9999. Linearity is shown in HpLC method in the range of 10- 30 μg mL-1 with a relative coefficient of 0.9985. each method was validated for different validation parameters like specificity, repeatability, accuracy, precision, linearity, robustness, limit of detection and limit of quantification. the results were obtained as per ICH guidelines. The developed UV and HpLC methods were compared with some available methods by statistical analysis one way ANOVA (Analysis of Variance) test, and it was found to be statistically significant","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTRACTION, IDENTIFICATION AND ESTIMATION OF CAFFEINE IN GREEN AND BLACK TEA SAMPLES BY A SIMPLE UV-VISIBLE SPECTROSCOPIC METHOD 用紫外可见光谱法提取、鉴定和测定绿茶和红茶样品中的咖啡因
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13070
Ravali Mudigiri, Archana Jorige
{"title":"EXTRACTION, IDENTIFICATION AND ESTIMATION OF CAFFEINE IN GREEN AND BLACK TEA SAMPLES BY A SIMPLE UV-VISIBLE SPECTROSCOPIC METHOD","authors":"Ravali Mudigiri, Archana Jorige","doi":"10.53879/id.60.08.13070","DOIUrl":"https://doi.org/10.53879/id.60.08.13070","url":null,"abstract":"Caffeine is a widely consumed psychoactive compound present in coffee, tea, soft drinks, energy drinks, and chocolates. It is a diuretic and a central nervous system (CNS) stimulant. Apart from stimulating the CNS, it exerts beneficial effects in combination with other substances like L-theanine and catechins. Caffeine was extracted from green tea and black tea samples using various solvents. The maximum yield of caffeine was obtained from dichloromethane extracts. The extracted caffeine was identified by TLC and FTIR. A simple UV spectroscopic method was developed and validated for the estimation of caffeine in green tea and black tea. The wavelength maximum of caffeine was obtained at 272 nm in distilled water. The Beer-Lambert law was obeyed in the concentration range of 0.5 to 35 µg mL-1 for caffeine. The linearity, accuracy, precision, robustness, and ruggedness, limit of detection and limit of quantification of this method are within the limits of ICH guidelines. This method was found to be precise as % RSD was less than two. The LOD and LOQ values were 0.03 µg mL-1 and 0.091 µg mL-1,respectively. The percentage purity of caffeine from green tea and black tea samples was found to be 98.32% and 99.42 %. Thus, the proposed method was found to be rapid, specific, precise and accurate for the routine analysis of caffeine in green and black tea samples.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49223193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
L-ASPARAGINASE ENZYME PRODUCTION FROM MARINE FUNGUS BEAUVERIA BASSIANA – STATISTICAL OPTIMIZATION 海洋真菌白僵菌产L-天冬酰胺酶的统计优化
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13301
Venkata Kamala, Kumari Paravastu, G. G. Sankar
{"title":"L-ASPARAGINASE ENZYME PRODUCTION FROM MARINE FUNGUS BEAUVERIA BASSIANA – STATISTICAL OPTIMIZATION","authors":"Venkata Kamala, Kumari Paravastu, G. G. Sankar","doi":"10.53879/id.60.08.13301","DOIUrl":"https://doi.org/10.53879/id.60.08.13301","url":null,"abstract":"Statistical optimization was done to enhance the production of L-asparaginase by submerged fermentation from the marine fungus Beauveria bassiana, which was isolated from sediments and corals of sea. Optimization of different process parameters for the production of L-asparaginase and validation using response surface methodology involving central composite design (CCD) was performed with four variables, carbon source, nitrogen source which are essentially important for the growth of the microorganism and other conditions like pH and inoculum level, which include dextrose at 0.43% w/V, L-asparagine 1.1%w/V, pH 7.5 and an inoculum level of 10.2% w/V, respectively. Extracellular production of L-asparaginase by B. bassiana and its potential for L-asparaginase production is reported in the present study.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42639489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OPPORTUNITY TO INNOVATE FOR INFANTS 为婴儿提供创新机会
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.p0005
{"title":"OPPORTUNITY TO INNOVATE FOR INFANTS","authors":"","doi":"10.53879/id.60.08.p0005","DOIUrl":"https://doi.org/10.53879/id.60.08.p0005","url":null,"abstract":"Dear Reader, Lactose intolerance is well-known for decades. Difficulty to metabolize lactose due to a genetic disorder, though exists in a large population, has not been taken too seriously. Reason being, it’s not a fatal disorder and the intolerance leads to some amount of bloating, indigestion, maybe a bit of acidity, and distaste to drink milk. However, as science and technology progressed, one of the numerous causes for fatalities of newly born infants and children have come to the forefront. Though rare, genetic (inherited) disorders in which the body cannot turn food into energy and metabolize, have been detected. These are referred as inborn errors of metabolism (IEM). Such disorders are usually caused by defects in specific proteins (enzymes) that help breakdown (metabolize) parts of food. Examples include organic acidurias, fatty acid oxidation defect, urea cycle disorder, mitochondrial disease, galactosemia, maple sugar urine disease (maple sugar disorder), fructose intolerance, phenyl ketone urea amongst others","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43678141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN SILICO STUDIES OF SOME NEWLY DESIGNED BENZIMIDAZOLETHIAZOLIDINONE BASED ANTAGONISTS OF HUMAN ESTROGEN RECEPTOR 一些新设计的苯并咪唑-噻唑烷酮类人体雌激素受体拮抗剂的计算机研究
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.14087
Jyoti Monga, Niladry S. Ghosh, S. Mujwar, Isha Rani
{"title":"IN SILICO STUDIES OF SOME NEWLY DESIGNED BENZIMIDAZOLETHIAZOLIDINONE BASED ANTAGONISTS OF HUMAN ESTROGEN RECEPTOR","authors":"Jyoti Monga, Niladry S. Ghosh, S. Mujwar, Isha Rani","doi":"10.53879/id.60.08.14087","DOIUrl":"https://doi.org/10.53879/id.60.08.14087","url":null,"abstract":"Breast cancer is globally associated with majority of the women. Indeed, high estrogen levels are the most common subtype of breast cancer. Three different classes of estrogen receptor antagonists are frequently used to treat such kinds of breast cancers. Each of these interacts directly with the initiation and activation of the estrogen signalling pathway. However, new medicines must be developed because resistance limits the therapeutic effectiveness. In silico studies for drug discovery have become popular in recent years due to their low cost and quick execution. To develop novel therapeutics for breast cancer, three different series of benzimidazole compounds targeting the estrogen receptor were docked. Among these three series, benzimidazole fused with pyrazole showed significant results and the leading compound was 32 based on docking results. The docking data was further validated by executing molecular dynamics (MD) simulations for the stability of designed leads within the macromolecular cavity in relation to time. Therefore, it is proposed that the pyrazole fused benzimidazole nucleus can be a promising pharmacophore for developing novel anticancer therapeutics for breast cancer.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47650080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CONCISE OUTLINE ON INNOVATIVE PERMEATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY APPROACH 简要概述了创新的透皮给药方法的渗透促进剂
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.12392
Parmita Phaugat, Manish Dhall, Suchitra Nishal
{"title":"A CONCISE OUTLINE ON INNOVATIVE PERMEATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY APPROACH","authors":"Parmita Phaugat, Manish Dhall, Suchitra Nishal","doi":"10.53879/id.60.08.12392","DOIUrl":"https://doi.org/10.53879/id.60.08.12392","url":null,"abstract":"The transdermal drug administration system represents a potent substitute for administering medications orally and is also designed to offer a substitute for hypodermic injections. Presently, three generations of penetration enhancer to permeate through skin are available 1st Generation embraces chemical approaches and pertain to augment the efficacy of the drug transferred across the integral skin, 2nd generation encompasses physical permeation technologies and 3rd generation consists of microneedle and needleless penetration enhancers. There is renewed interest in transdermal drug delivery. This review focuses on some existing novel approaches and the additive upshot of techniques for increasing the permeation of drugs via skin penetration. By using the right methods, drug carriers, or certain chemical agents, it is important to cause the stratum corneum to change physically or biomolecularly.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46691854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ANTICANCER ACTIVITY OF VITAMIN D3–TAMOXIFEN COMBINATION MICROEMULSION ON MCF-7 BREAST CELL LINE AND ITS SYNERGISTIC EFFECT 维生素d3 -他莫昔芬联合微乳对McF-7乳腺细胞株的抗癌活性及其协同作用
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.14101
Krantisagar S. More, B. Dalal, Aruna Shankarkumar, P. Devarajan
{"title":"ANTICANCER ACTIVITY OF VITAMIN D3–TAMOXIFEN COMBINATION MICROEMULSION ON MCF-7 BREAST CELL LINE AND ITS SYNERGISTIC EFFECT","authors":"Krantisagar S. More, B. Dalal, Aruna Shankarkumar, P. Devarajan","doi":"10.53879/id.60.08.14101","DOIUrl":"https://doi.org/10.53879/id.60.08.14101","url":null,"abstract":"This study investigates the anticancer activity of a combination microemulsion of vitamin D3 and tamoxifen (TMX-VD3 ME) for a synergistic effect on the MCF-7 breast cancer cell line. The combination microemulsion was prepared by dissolving the drugs in oil, mixing the oil with a surfactant, cosurfactant, and water. ME (VD3 1.5 mg mL-1, TMX 10 mg mL-1) was optimized for stability, globule size, and PDI. MTT assay was used to evaluate the cytotoxicity of the microemulsion. The results demonstrated a concentration-dependent increase in cell uptake with a decrease in cell viability. Flow cytometry revealed enhanced apoptosis and cell cycle arrest in G0/G1 phase and 3.45-fold enhanced efficacy in the migration assay. Additionally, the combination TMX-VD3 ME microemulsion exhibited enhanced anticancer efficacy compared to individual treatments of vitamin D3 ME or tamoxifen ME alone, indicating a synergistic effect. The zebrafish model revealed synergistic antiangiogenic activity of the vitamin D3 ME formulations.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44309028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
FORCED DEGRADATION STUDIES FOR ETHAMBUTOL BY RP-HPLC 反相高效液相色谱法研究乙胺丁醇的强制降解
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13714
V. Bhusari, Utkarsh S. Bhosale, Nikita K. Jagtap, M. Ghante
{"title":"FORCED DEGRADATION STUDIES FOR ETHAMBUTOL BY RP-HPLC","authors":"V. Bhusari, Utkarsh S. Bhosale, Nikita K. Jagtap, M. Ghante","doi":"10.53879/id.60.08.13714","DOIUrl":"https://doi.org/10.53879/id.60.08.13714","url":null,"abstract":"Literature survey of ethambutol reveals no stability indicating analytical method being reported for estimation, either in bulk or in a pharmaceutical dosage form. Therefore, a stability indicating analytical method needed to be developed and validated. In the current research, a RP-HPLC method was developed to separate ethambutol from its degradation products. Ethambutol is exposed to stressors like hydrolysis, oxidation, neutral (water), and photolysis decomposition, and the degradation products were separated using an ODS Hypersil C-18 column. Buffer: acetonitrile was used as mobile phase at a flow rate of 0.5 mg mL-1. Ethambutol showed a retention time of 6.1 min. Validation study was performed as per guidelines prescribed by ICH Q2(R1). Pharmaceutical industries can use the developed method to perform routine drug analysis on pharmaceutical dosage forms.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41866462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HYDROXYPROPYL CELLULOSE-CARBOPOL AND HYDROXYPROPYL CELLULOSE -NOVEON COMPOSITE MOUTH DISSOLVING FILMS OF AMBROXOL HYDROCHLORIDE 羟丙基纤维素-卡波姆和羟丙基纤维素-NOVEON复合盐酸氨溴索口腔溶解膜
INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13041
A. Gangurde, Suhas. K. Khairnar, Vinod A. Bairag
{"title":"HYDROXYPROPYL CELLULOSE-CARBOPOL AND HYDROXYPROPYL CELLULOSE -NOVEON COMPOSITE MOUTH DISSOLVING FILMS OF AMBROXOL HYDROCHLORIDE","authors":"A. Gangurde, Suhas. K. Khairnar, Vinod A. Bairag","doi":"10.53879/id.60.08.13041","DOIUrl":"https://doi.org/10.53879/id.60.08.13041","url":null,"abstract":"Ambroxol hydrochloride is a choice of drug in acute and chronic lung infections. In the COVID-19 situation, ambroxol played a crucial role in treating bronchitis and potentiating, the effect of antibiotics in lung infections. In the present study, a patient-friendly drug delivery system of ambroxol hydrochloride was prepared by solvent casting method to produce better mechanical strength in the film. To impart better mechanical strength without affecting disintegration and dissolution, composite films of hydroxypropyl cellulose - Carbopol-981NF and hydroxypropyl cellulose – Noveon-AA1 were developed and evaluated. Nine formulations were prepared using varying levels of film formers. The evaluated film formulations were in folding endurance range 32±2.00 to 92±8.05, tensile strength range 27.51±1.22 to 130.32± 0.98 g cm-2, % elongation range 14.12±0.32 to 26.54±0.08 and disintegration time range 54±1.42 to 114±1.52 seconds, and more than 90% drug dissolution occurred within 5 min. All the prepared formulations showed compatibility between ambroxol hydrochloride and ingredients of film.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42734538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信