HYDROXYPROPYL CELLULOSE-CARBOPOL AND HYDROXYPROPYL CELLULOSE -NOVEON COMPOSITE MOUTH DISSOLVING FILMS OF AMBROXOL HYDROCHLORIDE

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-08-28 DOI:10.53879/id.60.08.13041

A. Gangurde, Suhas. K. Khairnar, Vinod A. Bairag

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Abstract

Ambroxol hydrochloride is a choice of drug in acute and chronic lung infections. In the COVID-19 situation, ambroxol played a crucial role in treating bronchitis and potentiating, the effect of antibiotics in lung infections. In the present study, a patient-friendly drug delivery system of ambroxol hydrochloride was prepared by solvent casting method to produce better mechanical strength in the film. To impart better mechanical strength without affecting disintegration and dissolution, composite films of hydroxypropyl cellulose - Carbopol-981NF and hydroxypropyl cellulose – Noveon-AA1 were developed and evaluated. Nine formulations were prepared using varying levels of film formers. The evaluated film formulations were in folding endurance range 32±2.00 to 92±8.05, tensile strength range 27.51±1.22 to 130.32± 0.98 g cm-2, % elongation range 14.12±0.32 to 26.54±0.08 and disintegration time range 54±1.42 to 114±1.52 seconds, and more than 90% drug dissolution occurred within 5 min. All the prepared formulations showed compatibility between ambroxol hydrochloride and ingredients of film.

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羟丙基纤维素-卡波姆和羟丙基纤维素-NOVEON复合盐酸氨溴索口腔溶解膜

盐酸氨溴索是治疗急性和慢性肺部感染的首选药物。在新冠肺炎的情况下，氨溴索在治疗支气管炎和增强抗生素对肺部感染的作用方面发挥了至关重要的作用。在本研究中，通过溶剂浇铸法制备了一种对患者友好的盐酸氨溴索给药系统，以在薄膜中产生更好的机械强度。为了在不影响崩解和溶解的情况下赋予更好的机械强度，开发并评估了羟丙基纤维素-卡波-981NF和羟丙基纤维素-Noven-AA1的复合膜。使用不同水平的成膜剂制备了九种制剂。评价的薄膜制剂的耐折性范围为32±2.00至92±8.05，拉伸强度范围为27.51±1.22至130.32±0.98 g cm-2，%伸长率范围为14.12±0.32至26.54±0.08，崩解时间范围为54±1.42至114±1.52秒，且90%以上的药物溶解发生在5分钟内。所有制备的制剂都显示出盐酸氨溴索与薄膜成分之间的相容性。

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量