INDIAN DRUGS最新文献_第7页

CUSTARD APPLE PEELS CONTAINING SAPONIN: ISOLATION AND FORMULATION OF HERBAL SHAMPOO 含皂苷的蛋奶沙司苹果皮的分离及草药洗发水的研制

INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13219

S. Nangare, Dipesh P. Gosavi, Jidnyasa Pantwalawalkar, V. Chatap

引用次数: 0

EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF OSELTAMIVIR PHOSPHATE, FAMCICLOVIR AND ACYCLOVIR IN PURE AND DOSAGE FORMS 提取分光光度法测定磷酸奥司他韦、福昔洛韦和阿昔洛韦纯和剂型的含量

INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.12879

Nandeesha Itigimatha, B. Yallur, M. D. Hadagali

{"title":"EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF OSELTAMIVIR PHOSPHATE, FAMCICLOVIR AND ACYCLOVIR IN PURE AND DOSAGE FORMS","authors":"Nandeesha Itigimatha, B. Yallur, M. D. Hadagali","doi":"10.53879/id.60.08.12879","DOIUrl":"https://doi.org/10.53879/id.60.08.12879","url":null,"abstract":"For the determination of oseltamivir phosphate (OSP), acyclovir (ACL), and famciclovir (FMV) medicines in pure form and their formulations, quick, accurate, and simple spectrophotometric procedures have been established. The procedures were relied on the formation of ion-pair complexes between the drugs and anionic dyes (OSP with bromothymol blue (BTB), ACL with methyl red (MTR) and FMV with methyl orange (MTO)) in an acidic medium, separately. The yellow OSP-bromothymol blue complex, orange ACL-methyl red complex and orange-yellow FMV-methyl orange complex formed were quantitatively extracted with chloroform and their absorbance measured at 416, 416 and 488 nm wavelengths, respectively. The limits of detection and quantification were found to be 0.5, 1.5, 1.0 µg mL-1 and 1.7, 5.0 and 3.3 µg mL-1 for the OSP, ACL and FMV, respectively. The linearity was established from 1-5, 2-12 and 5-14 µg mL-1 for OSP, ACL and FMV, respectively. R2 (regression coefficient) values were above 0.996 for all the three drugs. Recovery (accuracy) results were found within 98.0 % to 102 %. The developed methods comply with the ICH guidelines. The developed methods were successfully used to measure OSP, ACL and FMV in both their pure and in formulation forms.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43469880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF FAVIPIRAVIR 法匹拉韦的紫外光谱测定方法的建立与验证

INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13094

Rupali P. Patil, S. Firke, Md. Mojeeb G. Khan, Mohan Ganpat Kalaskar, A. Shirkhedkar

引用次数: 0

FORMULATION AND EVALUATION OF THERMO-RESPONSIVE OCULAR IN SITU GEL OF CIPROFLOXACIN AND OLOPATADINE HCL 盐酸环丙沙星奥洛他定热反应性眼原位凝胶的研制与评价

INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13772

D. A. Shaikh, Munira M. Momin

引用次数: 0

STATISTICAL OPTIMIZATION AND ASSESSMENT OF DIVALPROEX SODIUM EXTENDED RELEASE TABLET 双丙戊酸钠缓释片的统计优化与评价

INDIAN DRUGS Pub Date : 2023-08-28 DOI: 10.53879/id.60.08.13485

R. Gunda, N. S. K. Jujjuru, Vijayalakshmi A., Prathap M., Koteswararao G. S. N

{"title":"STATISTICAL OPTIMIZATION AND ASSESSMENT OF DIVALPROEX SODIUM EXTENDED RELEASE TABLET","authors":"R. Gunda, N. S. K. Jujjuru, Vijayalakshmi A., Prathap M., Koteswararao G. S. N","doi":"10.53879/id.60.08.13485","DOIUrl":"https://doi.org/10.53879/id.60.08.13485","url":null,"abstract":"The purpose of the current experimental research was to optimize the quantities of macromolecules such as Eudragit L/100-55 and HPMC-K-100M for the development of extended release tablets of divalproex sodium, an anti-convulsant or epileptic agent used in the effective management of bipolar disorders, mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of Eudragit L/100-55 and HPMC-K-100M in variable compositions and variable amounts as per 32 factorial design technique. Tablets were prepared by direct compression technique. Quantities of polymers required for exhibiting extended release of active agent from the tablet were chosen as independent variables, in similar manner time required for drug release was chosen as dependent variable (t10%, t50%, t75%, t90%). Nine formulations were created in accordance with the plan, formulated, and tested for quality control criteria. It is obvious from the data that all formulations exceed the compendial restrictions. Kinetic parameters were established, and the data from the dissolution investigation suited kinetic models very well. For the responses, polynomial equations were created and validated. The optimum formulation of SOD5, which contains 31.25 mg of Eudragit L/100-55 & 31.25 mg of HPMCK-100M, exhibits resemblance to the commercial product of f2=85.91 and f1=2.25 (DIVALEX). SOD5 is made in a zero-order fashion, and the mechanism of drug release was found to be non - Fickian in nature (n = 0.645)","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47709695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APPLICATION OF VEGETABLE OILS AS NATURAL, GREEN AND SUSTAINABLE SOLVENTS FOR EXTRACTION OF PLANT MATERIALS: STUDY OF PHYTOCHEMICAL CHARACTERIZATION AND CHEMICAL PROFILING OF VARIOUS OLEO-EXTRACTS OF GLYCYRRHIZA GLABRA 植物油作为天然、绿色、可持续溶剂在植物材料提取中的应用:甘草各种油提取物的植物化学特性及化学分析研究

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13371

M. Sahoo, R. Varier, A. Kumari R., B. Sundari H., M. H., Bala Guru H., R. K

{"title":"APPLICATION OF VEGETABLE OILS AS NATURAL, GREEN AND SUSTAINABLE SOLVENTS FOR EXTRACTION OF PLANT MATERIALS: STUDY OF PHYTOCHEMICAL CHARACTERIZATION AND CHEMICAL PROFILING OF VARIOUS OLEO-EXTRACTS OF GLYCYRRHIZA GLABRA","authors":"M. Sahoo, R. Varier, A. Kumari R., B. Sundari H., M. H., Bala Guru H., R. K","doi":"10.53879/id.60.07.13371","DOIUrl":"https://doi.org/10.53879/id.60.07.13371","url":null,"abstract":"In the last decade there is a growing interest in application of green and more friendly environment solvents in both industrial and academia sectors due to various environmental concerns. Vegetable oils has been used as effective natural non-toxic and environment-friendly solvents for extraction of various classes of phytochemical constituents from different herbs. In the present study, various edible vegetable oils like palm oil, rice bran oil, sesame oil and sunflower oil were used for preparation of oleoextract of a medicinal plant Glycyrrhiza glabra, commonly known as Licorice. The resulting extracts were analyzed by HPTLC. Determination of Total Phenolic Contents (TPC) and Total Flavonoid Contents (TFC) was carried out by UV-Vis spectrophotometry method for standardization of the oleo-extracts of the herb. The HPTLC fingerprint showed presence of licorice components and phenolics and flavonoids in various oleo-extracts of the herb. So the oils exhibited satisfactory solvent effects with capability of extracting various phytochemicals from licorice and can be a used as a greener, safer and alternative approach to petrochemical solvents for herbal drug extraction and enrichment of phytoconstituents.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48708135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOASSAY GUIDED HEPATOPROTECTIVE ACTIVITY OF POLYGONATUM CIRRHIFOLIUM AGAINST ISONIAZID AND RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS 生物测定指导黄精对异烟肼和利福平肝毒性的保护作用

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13557

P. Grover, R. Ghai, K. Nagarajan, Vinay V. Kumar, R. Goel, Charanpreet Kaur, Reenu Chauhan

{"title":"BIOASSAY GUIDED HEPATOPROTECTIVE ACTIVITY OF POLYGONATUM CIRRHIFOLIUM AGAINST ISONIAZID AND RIFAMPICIN INDUCED HEPATOTOXICITY IN RATS","authors":"P. Grover, R. Ghai, K. Nagarajan, Vinay V. Kumar, R. Goel, Charanpreet Kaur, Reenu Chauhan","doi":"10.53879/id.60.07.13557","DOIUrl":"https://doi.org/10.53879/id.60.07.13557","url":null,"abstract":"The present investigation was performed to examine the hepatoprotective effect of the aqueous ethanolic extract of Polygonatum cirrhifolium in antitubercular drug-induced liver damage. P. cirrhifolium rhizomes were crushed, dissolved in various solvents (in order of polarity), and then tested for phytochemicals. Based on their findings, mass extraction utilizing the ethanol-water mixture (50: 50) was carried out using the Soxhlet method. The doses for animal research were established through acute toxicity tests. The hepatoprotective potential of aqueous ethanolic extract (50:50) of rhizomes was determined in Wistar rats at doses of 200 mg kg-1 and 400 mg kg-1 p.o. per day. Blood samples were examined for the biochemical markers SGOT, SGPT, ALP, total bilirubin, and albumin. Histopathology of the liver was also conducted followed by in vitro anti-oxidant studies. Simultaneously, the extract was subjected to LCMS characterization. P. cirrhifolium extract at both the doses 200 mg kg-1 and 400 mg kg-1 has shown significant hepatoprotective activity against hepatotoxicity induced by INH+ RIF in a dose-dependent manner, as depicted by the significant changes in the values of blood biomarkers and in vitro anti-oxidant studies. Histopathological studies showed that the treatment with 200 mg kg-1 and 400 mg kg-1 of P. cirrhifolium exhibited regeneration of liver architecture and portal system by reducing the haemorrhage and inflammatory infiltrate. LC-MS characterization showed serpentine, 5-hydroxy methylfurfural and cephalotaxine as active constituents. It can be inferred that hydroethanolic extract of P. cirrhifolium protects the liver from anti-TB induced toxicity and this protection could be due to the active phytoconstituents.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43783066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS 斑马鱼幼虫模型替代大鼠非膨出囊模型进行BCSⅲ类药物渗透评价的可行性

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13976

P. Devarajan, Bhagyashri K Joshi

{"title":"FEASIBILITY OF ZEBRAFISH LARVA MODEL AS A VIABLE SUBSTITUTE TO RAT NON-EVERTED SAC MODEL FOR PERMEATION EVALUATION OF BCS III DRUGS","authors":"P. Devarajan, Bhagyashri K Joshi","doi":"10.53879/id.60.07.13976","DOIUrl":"https://doi.org/10.53879/id.60.07.13976","url":null,"abstract":"The oral route is the most convenient route of drug administration. Many drugs exhibit poor oral bioavailability. BCS III drugs exhibit high solubility and present a massive challenge due to poor permeability. Different permeation enhancers viz., nonionic Cremophor® RH 40, Tween® 80 and Lutrol® F68, anionic docusate sodium with sodium cholate, and anionic polymer sodium carboxymethyl cellulose were evaluated using rat non-everted sac method and zebrafish larva model. Maximum permeation enhancement was seen with docusate sodium for both drugs. The permeation enhancement ratio for netilmicin sulphate was 4.07±0.657, while for deferoxamine mesylate it was 1.482±0.378. Cremophor® RH 40 enabled augmented flux of netilmicin sulphate, and Tween® 80 showed enhanced permeation of deferoxamine mesylate. An excellent correlation was observed between apparent permeability and flux with drug absorbed per zebrafish larva (µg) (R2 = 0.938) for netilmicin sulphate and for deferoxamine mesylate (R2 = 0.9397). An important outcome of the study is the demonstration of the feasibility of the zebrafish larvae model as a viable substitute to the non-everted sac method, which could also enable screening of potential permeation enhancers for the development of orally bioavailable formulations of BCS III.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46839942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY 紫外-可见光谱法同时测定原料药和制剂中普瑞巴林和依托里昔的方法开发与验证

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13016

Akhil M. B., S. V. Kutty, Y. Haribabu, N. K.

引用次数: 0

FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF ELLAGIC ACID PHYTO-VESICULAR SYSTEM FOR BIOAVAILABILITY ENHANCEMENT 提高生物利用度鞣花酸-植物-免疫系统的制备、优化及表征

INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13552

Varsha Rawat, Vishal Jain

引用次数: 0