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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES 2-(4-取代苄基)- 7-甲基- 2h -噻唑[3,2 - a]嘧啶-3,5-二酮的合成及生物活性
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.12341
Ankush Goyal, Baljeet S. Kaur, Amandeep Kaur, V. Gupta, M. Gupta
{"title":"SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-(4-SUBSTITUTED BENZYLIDENE)- 7-METHYL-2H-THIAZOLO[3, 2-A] PYRIMIDINE-3,5-DIONES","authors":"Ankush Goyal, Baljeet S. Kaur, Amandeep Kaur, V. Gupta, M. Gupta","doi":"10.53879/id.60.07.12341","DOIUrl":"https://doi.org/10.53879/id.60.07.12341","url":null,"abstract":"The organosulphur thiazolo-pyrimidines are fused heterocyclic compounds that can be anticipated as 7-thio counterparts of the genuine purine bases such as guanine and adenine. They have attained a growing significance in the domain of drug chemistry because of their diverse pharmacological activities. In the current study, 2-substituted benzylidene-7-methyl-2H-thiazolo [3,2-a] pyrimidine-3,5-dione derivatives were synthesised. The synthetic compounds were tested against the human myelomonocytic leukaemia cell line (U-937) for their ability to inhibit cancer cell growth as well as against Gram negative E. coli (MTCC 40) and Gram positive S. aureus (MTCC 87) for their ability to inhibit bacterial growth. The amine and halogen containing compounds exhibited the strongest anticancer and antibacterial effects among all the derivatives in series (7a-j). Compounds 7h, 7e, 7a, 7b, 7c, 7i, and 7j displayed improved activity in both assays compared to standard andriyamycin and ciprofloxacin, whereas 7d, 7f, and 7g were shown to be moderately active. Through the use of IR, NMR and mass spectrum analyses, the molecular structures of the synthesized compounds were determined.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44388304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AMELIORATIVE EFFECT OF AVENA SATIVA (OAT) IN DINITROBENZENE SULPHONIC ACID INDUCED INFLAMMATORY BOWEL DISEASE IN RATS 燕麦对二硝基苯磺酸诱导的大鼠炎症性肠病的改善作用
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13351
Bhagyabhumi P. Shah, Vismay N. Patel, Samir K. Shah
{"title":"AMELIORATIVE EFFECT OF AVENA SATIVA (OAT) IN DINITROBENZENE SULPHONIC ACID INDUCED INFLAMMATORY BOWEL DISEASE IN RATS","authors":"Bhagyabhumi P. Shah, Vismay N. Patel, Samir K. Shah","doi":"10.53879/id.60.07.13351","DOIUrl":"https://doi.org/10.53879/id.60.07.13351","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal tract disease. There is an upsurge of IBD cases worldwide and there is no gold standard therapy and the drugs used to treat IBD are having many major side effects. Thus, there is a need for a better treatment option. This study aimed to evaluate the prophylactic role of Avena sativa (oat) in 2, 4-dinitro benzene sulphonic acid (DNBS) (120 mg kg-1) induced IBD in rats. Animals were randomly allocated to five groups- negative control, model control receiving only DNBS, group receiving A. sativa extract (500 mg kg-1 and 1 g kg-1 p.o.) and the last group receiving sulphasalazine (100 mg kg-1, p.o.). Colitis-induced rats treated with A. sativa and sulphasalazine restored their body weight, stool consistency, and bleeding in stool and significantly improved several biochemical parameters such as colonic glutathione content, lactate dehydrogenase, myeloperoxidase and lipid peroxides levels as compared to the model control group. Findings suggest that A. sativa possesses antioxidant and anti-inflammatory activity and can be useful in treating IBD.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47215980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ORODISPERSIBLE FILM FABRICATION BY HOT MELT EXTRUSION FOR DENTAL PAIN AMELIORATION BY QUALITY BY DESIGN APPROACH 用热熔挤压法制备可分散膜，以设计方法改善牙齿疼痛的质量
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13501
Apoorva Phadke, P. Amin
{"title":"ORODISPERSIBLE FILM FABRICATION BY HOT MELT EXTRUSION FOR DENTAL PAIN AMELIORATION BY QUALITY BY DESIGN APPROACH","authors":"Apoorva Phadke, P. Amin","doi":"10.53879/id.60.07.13501","DOIUrl":"https://doi.org/10.53879/id.60.07.13501","url":null,"abstract":"Surgical dental procedures cause pain and inflammation leading to temporary restriction of the movement of the oral cavity. Consumption of analgesic medications in the form of tablets or dispersible tablets causes compliance issues due to the compromised movability of the mandibular joint. An Orally Disintegrating Film (ODF), due to its pliability and compact size, can be a patient compliant tool for management of postoperative dental pain over parenterally administered opioids, conventional as well as orodispersible tablets of steroids or NSAIDS. Due to the inadequacies involved in solvent-casting, an unmet need exists for a continuous, eco-friendly and patient compliant process of manufacturing. The present research work addresses the unmet need of a patient compliant delivery system containing ketorolac tromethamine by Hot Melt Extrusion. The ODF optimized by Quality by Design was found to be stable with excellent mechanical properties and provided superior release profile as compared to the equivalent marketed formulation.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47941299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHEMOMETRICS OPTIMIZED GREEN LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN COMBINED TABLET FORMULATION 化学计量学优化了同时测定复方普瑞巴林和依托昔布含量的绿色液相色谱法
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13380
S. Panda, Pratap C. Routa, R. Bera
{"title":"CHEMOMETRICS OPTIMIZED GREEN LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN COMBINED TABLET FORMULATION","authors":"S. Panda, Pratap C. Routa, R. Bera","doi":"10.53879/id.60.07.13380","DOIUrl":"https://doi.org/10.53879/id.60.07.13380","url":null,"abstract":"Pregabalin and etoricoxib have been recently approved as a potent fixed-dose combination to treat patients with neuropathic back pain effectively. The present investigation quantified both drugs by using a liquid chromatography method using principles of analytical quality-by-design. We assessed the risks, sorted critical method variables and studied their influence on critical analytical attributes using the BoxBehnken design. The optimal chromatographic solutions used acetonitrile: 10 mMol L-1 phosphate buffer of pH 3.51 (70:30 V/V) as the mobile phase. A C-18 column (250 mm × 4.6 mm, 5 µm) with mobile phase flow at 0.9 mL min-1 was used to achieve separation. The developed method's specificity, linearity, accuracy and precision were fair. Furthermore, the method was selective and recovered both analytes to their maximum extent. Additionally, the national environmental methods index approach revealed superior method greenness of the used method for routine quantification of pregabalin and etoricoxib from pharmaceutical samples.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46242161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IT IS TIME TO TAKE ADVANTAGE OF IN VITRO CELL BASED MODELS 现在是利用体外细胞模型的时候了
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.p0005
{"title":"IT IS TIME TO TAKE ADVANTAGE OF IN VITRO CELL BASED MODELS","authors":"","doi":"10.53879/id.60.07.p0005","DOIUrl":"https://doi.org/10.53879/id.60.07.p0005","url":null,"abstract":"Dear Reader, Preclinical tests are crucial for assessing the toxicity and safety of new drugs before moving on to evaluating their efficacy and immunogenicity. Animal models, as well as alternatives, have long been used to study human biology and pathology. However, animal experimentation has been restricted in recent years due to increasing complexities in animal usage and growing concerns about animal welfare groups. There have been ethical concerns raised about the unnecessary or excessive use of experimental animals. As a result, many jurisdictions, including the Indian government, the European Union (EU), the United States, Canada, and South Korea, have restricted usage of experimental animals. Another reason for the limitation of using animals in experiments is uncertainty of results. According to one study, 90% of experimental drugs fail clinical trials, implying that they do not accurately reflect human physiology. The Indian government recently amended the New Drugs and Clinical Trials 2023 (NDCT) Act aimed at fostering the replacement, reduction and refinement of animal testing and the use of non-animal and human-relevant methods to assess the safety and efficacy of new drugs.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42960166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUANTITATIVE ESTIMATION OF 6-GINGEROL, E-GUGGULSTERONE AND Z-GUGGULSTERONE IN A FIXED DOSE COMBINATION NANOEMULGEL BY RP-HPLC 反相高效液相色谱法定量测定固定剂量复合纳米凝胶中6-姜辣素、e -谷固酮和z -谷固酮的含量
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.13722
M. Momin, Vivek Basudkar, Sankalp Gharat, Anita Chando, T. Khan
{"title":"QUANTITATIVE ESTIMATION OF 6-GINGEROL, E-GUGGULSTERONE AND Z-GUGGULSTERONE IN A FIXED DOSE COMBINATION NANOEMULGEL BY RP-HPLC","authors":"M. Momin, Vivek Basudkar, Sankalp Gharat, Anita Chando, T. Khan","doi":"10.53879/id.60.07.13722","DOIUrl":"https://doi.org/10.53879/id.60.07.13722","url":null,"abstract":"Polyherbal formulations have proved to be efficacious for the therapeutic treatment of various diseases, However, the development of validated robust analytical methods for quantification is a major challenge. The aim of this project was to develop a simple analytical method for the quantification of 6-gingerol (6-GIN), E-guggulsterone (E-GGS) and Z-guggulsterone (Z-GGS) in nanoemulsion based gel using reverse phase high performance liquid chromatography (RP-HPLC). 6-GIN, E-GGS and Z-GGS were quantified using acetonitrile: water: methanol (70:20:10 V/V/V) as the mobile phase at 1.0 mL min-1 flow rate with photodiode array detection. The developed method was validated for linearity, accuracy, precision, specificity and robustness as per ICH Q2 (R1) guidelines. The drug content of the three actives in the developed nanoemulgel was found to be between 90% to 110% w/w. The developed analytical method is simple and can be used for quantification of 6-GIN, E-GGS and Z-GGS in fixed dose product containing these actives.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41696119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW 基孔肯雅热的流行病学、诊断和治疗综述
INDIAN DRUGS Pub Date : 2023-07-28 DOI: 10.53879/id.60.07.12845
D. Rani, M. Kaushik, Ranjit Singh
{"title":"EPIDEMIOLOGY, DIAGNOSIS AND TREATMENT OF CHIKUNGUNYA - A REVIEW","authors":"D. Rani, M. Kaushik, Ranjit Singh","doi":"10.53879/id.60.07.12845","DOIUrl":"https://doi.org/10.53879/id.60.07.12845","url":null,"abstract":"Chikungunya is a viral disease transmitted to humans by infected mosquitoes. Like most mosquito-borne infections, the virus can only be transmitted by blood-to-blood contact, through a mosquito bite or transfusion with infected blood. The disease is characterized by the common symptoms involving rashes, nausea and headache. In addition to this, it also causes intense joint pain and fever, which is known as arthralgia. It is widely spread in America, Africa and all over the world. The onset of chikungunya fever is more intense and the period of illness is shorter than that of dengue fever. Recently, chikungunya has become a serious public threat. The chikungunya symptoms are usually self-limiting and prophylactic treatment is currently unavailable to cure the disease, although various allopathic medicines, such as NSAID’s, analgesics, steroids, DMARDs and some anti-viral drugs claim to treat the disease. However, these medicines provide only symptomatic relief with serious side effects. Nowadays, researchers focus more towards an alternative treatment. The present review aims to highlight the epidemiology of chikungunya, treatment options available, and potential of alternative medicines for its treatment.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45442998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BIO-INSPIRED GREEN SYNTHESIS OF NICKEL NANOPARTICLES USING STERCULIA FOETIDA LEAF EXTRACT AND ITS APPLICATION FOR REMOVAL OF TRIVALENT CHROMIUM FROM AQUEOUS SOLUTION 用牛蒡叶提取物生物绿色合成纳米镍及其去除水溶液中三价铬的应用
INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.12743
U. Rani N., P. P, L. Tulasi S., T. Rao P.
{"title":"BIO-INSPIRED GREEN SYNTHESIS OF NICKEL NANOPARTICLES USING STERCULIA FOETIDA LEAF EXTRACT AND ITS APPLICATION FOR REMOVAL OF TRIVALENT CHROMIUM FROM AQUEOUS SOLUTION","authors":"U. Rani N., P. P, L. Tulasi S., T. Rao P.","doi":"10.53879/id.60.06.12743","DOIUrl":"https://doi.org/10.53879/id.60.06.12743","url":null,"abstract":"In the present work, a facile, eco-friendly, and cost-effective approach is described to remove Cr3+ toxic metal ions in an aqueous solution by nickel nanoparticles (NiNPs) synthesized via a green method utilizing Sterculia foetida leaf extract. The synthesized nickel nanoparticles were characterized by EDS (Energy- Dispersive X-Ray Spectroscopy), XRD (X-Ray diffraction), FT-IR (Fourier Transform Infrared Spectroscopy), and FE-SEM (Field Emission Scanning Electron Microscopy) spectroscopic methods. The spectroscopic signature studies revealed that the synthesized NiNPs are of spherical to irregular in shape with a mean particle size of 10±20 nm. The FT IR spectra confirmed the presence of OH, CC and CHO cross-linked stretching, CO and CCl stretching, representing the functional groups of polyphenols, flavonoids, and alkaloids type compounds in the synthesized nanoparticles. The EDS spectra confirmed the presence of nickel in the synthesized nanoparticles with a metal composition of 52.2%. In the XRD spectra, sharp diffraction peak two angles of green-produced NiNPs, which correspond to 111, 200 and 221 crystal planes, confirm the lattice structure of NiNPs. The synthesized NiNPs were used for the reduction of hexavalent chromium from aqueous solutions. The result revealed that immobilization of chromium heavy metals is an effect of initial concentration, ie. 100 µg mL-1 of Cr3+ concentration at 1 g L-1 of NiNPs adsorbent dosage within an average contact time of 1 h at 75 RPM. The present investigation revealed that these newly synthesized NiNPs might be potentially utilized for many environmental remediation applications.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46191974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENCAPSULATION OF THYME OIL INTO MICROSPONGES: PREPARATION, CHARACTERIZATION AND IN VITRO EVALUATION 百里香油微海绵包封:制备、表征及体外评价
INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13428
Shanti B. Mishra, Deeksha Singh, Amit K. Singh, Shradhanjali M Singh
{"title":"ENCAPSULATION OF THYME OIL INTO MICROSPONGES: PREPARATION, CHARACTERIZATION AND IN VITRO EVALUATION","authors":"Shanti B. Mishra, Deeksha Singh, Amit K. Singh, Shradhanjali M Singh","doi":"10.53879/id.60.06.13428","DOIUrl":"https://doi.org/10.53879/id.60.06.13428","url":null,"abstract":"Thyme essential oil (TEO) is a prominent essential oil reported to have diverse properties and biological activities including anti-inflammatory. This research aims to encapsulate TEO in prepared microsponges for the purpose of controlled drug delivery and reduce the frequency of drug administration by enhancing its bioavailability. For the preparation of TEO loaded microsponges, the quasi-emulsion diffusion technique was used by employing dichloromethane as solvent, polyvinyl alcohol as a stabilizer and ethyl cellulose as polymer. The formulation variables such as altering the concentration of PVA and EC were used for optimization and characterized by FTIR, SEM and evaluated for particle size, in vitro drug release and entrapment efficiency and further subjected for in vitro anti-inflammatory activity. results showed that all the dispersions were in the micro-size range with good entrapment efficiency and release profile. The percent inhibition of protein denaturation by TEO loaded microsponges was found within the significant range at various concentrations.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44374605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QUANTITATION OF GALLIC ACID IN ACACIA NILOTICA L. PODS BY HPTLC 高效液相色谱法测定白刺槐豆荚中没食子酸含量
INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13908
Kaksha Sankha, M. Momin, T. Khan
{"title":"QUANTITATION OF GALLIC ACID IN ACACIA NILOTICA L. PODS BY HPTLC","authors":"Kaksha Sankha, M. Momin, T. Khan","doi":"10.53879/id.60.06.13908","DOIUrl":"https://doi.org/10.53879/id.60.06.13908","url":null,"abstract":"The pods of Acacia nilotica L. are traditionally used for versatile medical applications and are rich in polyphenolics and flavonoids. The pods powder is available in the market either as branded or unbranded products and it is imperative that their quality be assessed by a valid analytical method. This method will help to ensure the quality of the pod powder and can be used as a standardization tool prior to incorporation in finished herbal products. We report here a simple, precise and reproducible analytical method for standardization of the pods and solvent extracts of A. nilotica by HPTLC using gallic acid as the reference standard. This method can be used as a quality control tool to assess the quality of these pods when used as raw materials as such or in formulations.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41603791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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