INDIAN DRUGS最新文献_第9页

A NOVEL VALIDATED STABILITY INDICATING METHOD FOR QUANTIFICATION OF EMPAGLIFLOZIN IN BULK AND MARKETED FORMULATION BY HPTLC APPLYING EXPERIMENTAL DESIGN APPROACH 采用实验设计方法，建立了一种高效液相色谱法定量恩格列净原料药和市售制剂的稳定性指示方法

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13038

Manojkumar K. Munde, Nilesh S. Kulkarni, A. K. Sen, Dhanya B. Sen

{"title":"A NOVEL VALIDATED STABILITY INDICATING METHOD FOR QUANTIFICATION OF EMPAGLIFLOZIN IN BULK AND MARKETED FORMULATION BY HPTLC APPLYING EXPERIMENTAL DESIGN APPROACH","authors":"Manojkumar K. Munde, Nilesh S. Kulkarni, A. K. Sen, Dhanya B. Sen","doi":"10.53879/id.60.06.13038","DOIUrl":"https://doi.org/10.53879/id.60.06.13038","url":null,"abstract":"For the purpose of analyzing empagliflozin, a stability indicating high performance thin layer chromatographic method was developed. This method was optimized using design of experiment. In order to optimize the process, independent variables such as the proportion of isopropyl alcohol in the mobile phase, the duration of time that the chamber was saturated and the distance of mobile phase travelled were considered. On an aluminum plate that had previously been coated with silica gel, development was carried out with the assistance of twin trough glass chambers in ascending lines. The findings from these studies led to the selection of a mobile phase that had a composition of ammonium acetate (2 %), triethylamine and isopropyl alcohol in the ratio of 4:1:5 (V/V/V), and this mobile phase was utilized in the process of method development using central composite design approach. The saturation time was established at 10 minutes, and the ultraviolet detection was performed at a wavelength of 237 nm. The value 0.82 was discovered to be the retention factor (Rf ) for empagliflozin. The method was linear, precise and accurate over the entire concentration range examined (100-600 ng band-1), along with correlation coefficient value of 0.992. The proposed method is quick and selective, and a straightforward method of sample preparation and analysis for empagliflozin in its bulk and commercially available dosage forms. The stability of the drug was tested under a variety of different stress conditions in accordance with ICH guidelines, and the results obtained from the force degradations indicate that the developed method is appropriate for stability studies.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48002190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOANALYTICAL METHOD VALIDATION: A COMPREHENSIVE ASSESSMENT OF VARIOUS REGULATORY GUIDELINES 生物分析方法验证：对各种监管指南的综合评估

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.12583

Anamika Singh, Tamanna Narsinghan

引用次数: 0

INVESTIGATION OF SUPERFLUITY POTENTIAL OF BCS-II DRUG BY USING SOLVENT SHIFT METHOD 溶剂移位法研究BCS-II药物的超流电位

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13252

Uditi Handa, Anuj Malik, Kumar Guarve

引用次数: 0

OXIDATIVE DEGRADATION OF TAVABOROLE: DETERMINATION BY DERIVATIVE UV SPECTROPHOTOMETRY TAVABOROLE氧化降解的导数紫外分光光度法测定

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13169

Mrinalini C. Damle, Mayuri H. Suryawanshi

引用次数: 0

FORMULATION AND DEVELOPMENT OF LONG-ACTING THERMOSENSITIVE AND MUCOADHESIVE VAGINAL GEL OF METRONIDAZOLE 长效温粘甲硝唑阴道凝胶的研制

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13069

Azima G. Munshi, M. Goyani, Meghraj V. Suryawanshi

引用次数: 0

PHYTOCHEMICAL SCREENING, ANTIBACTERIAL, ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITY OF ACMELLA OLERACEA FLOWERS 马齿苋花的植物化学筛选、抗菌、抗氧化和抗炎活性研究

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13657

N. Sanap, T. Khan

{"title":"PHYTOCHEMICAL SCREENING, ANTIBACTERIAL, ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITY OF ACMELLA OLERACEA FLOWERS","authors":"N. Sanap, T. Khan","doi":"10.53879/id.60.06.13657","DOIUrl":"https://doi.org/10.53879/id.60.06.13657","url":null,"abstract":"Acmella oleracea flowers are traditionally used to treat mouth ulcers in the rural areas of Nashik, Maharashtra, India. This research project is an effort to understand the scientific basis for the utility of A. oleracea flowers and validate it for potential antimicrobial, anti-inflammatory and antioxidant activity, some of the main causes of mouth ulcers. The aim of this project was to study the phytochemistry of the ethanol extract of A. oleracea flowers and evaluate antibacterial anti-inflammatory and antioxidant potential. The phytochemical screening ethanol extract indicates the presence of phenolics, flavonoids, glycosides, alkaloids and carbohydrates. The total phenolic and flavonoid content in the ethanol extract determined by Folin-Ciocalteu reagent and aluminum chloride method were found to be 29.992 mg GAE g-1 and 93.2 mg QE g-1, respectively. The antibacterial activity of the ethanol extract was evaluated against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus, using streptomycin as the reference standard. The best activity was observed against P. aeruginosa. The antioxidant activity of the was determined by 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide, nitric oxide scavenging and ferric reducing antioxidant power assays. The IC50 in the DPPH, hydrogen peroxide and nitric oxide scavenging assays were found to be 89.589 µg mL-1, 89.178 µg mL-1 and 50.86 µg mL-1 respectively. The anti-inflammatory activity was evaluated by in vitro albumin denaturation assay using naproxen as the reference standard. The ethanol extract demonstrated significant antibacterial, antiinflammatory and antioxidant activity, these combined effects could be responsible for its effectiveness in mouth ulcers and potentially justify the traditional use of A. oleracea flowers in mouth ulcers.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46173331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPPORTUNITIES FOR PHARMA INDUSTRY’S RESEARCH COLLABORATIONS WITH CSIR-CDRI 制药行业与CSIR-CDRI研究合作的机遇

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.p0005

引用次数: 0

ACECLOFENAC LOADED FILM FORMING GELS: IN VIVO STUDY 醋氯芬酸载膜凝胶的体内研究

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13865

H. Bajaj, M. Yadav, Seema B. Chauhan, Anjali Sharma, Navin C. Pant, Vinod Singh, Mamta F. Singh

{"title":"ACECLOFENAC LOADED FILM FORMING GELS: IN VIVO STUDY","authors":"H. Bajaj, M. Yadav, Seema B. Chauhan, Anjali Sharma, Navin C. Pant, Vinod Singh, Mamta F. Singh","doi":"10.53879/id.60.06.13865","DOIUrl":"https://doi.org/10.53879/id.60.06.13865","url":null,"abstract":"For arthritis, there is need of development of a drug delivery system which permits less frequent dosing by maintaining a close contact with the skin for prolonged time period, thereby improving the patient compliance, especially among elderly. Till date, film forming gels of aceclofenac for arthritis are not available in the market. It is a novel approach which can be used as an alternative to conventional topical and transdermal formulations to treat arthritis. Therefore, HPMC and Eudragit RL 100 based film forming gels of aceclofenac were prepared. On the basis of in vitro potential, the formulation was further selected and evaluated for their acute skin irritation studies and in vivo anti-arthritic activity using primary skin irritation (draize) test and Freund’s Complete Adjuvant (FCA) induced arthritis method. The tested formulations were devoid of any irritation potential and no edema formation was observed in any cases Irritation score (primary skin irritation index) for all the formulations was found to be zero, which indicates its safety and acceptability for transdermal administration. The in vivo study revealed that there was significant reduction in inflamed paw volume compared to the marketed formulation. The developed film forming gels could be a potential drug delivery platform for the management of arthritis.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49435851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A SENSITIVE, ECONOMICAL BIOANALYTICAL LC-MS/MS METHOD FOR SIMULTANEOUS ANALYSIS OF IRBESARTAN AND HYDROCHLOROTHIAZIDE 一种灵敏、经济的同时分析厄贝沙坦和氢氯噻嗪的lc-ms / ms方法

INDIAN DRUGS Pub Date : 2023-07-03 DOI: 10.53879/id.60.06.13200

Celina Nazareth, S. Pereira, R. Batheja

引用次数: 0

EFFECT OF PREPARATION TEMPERATURE ON ETHYLCELLULOSE MICROSPHERE PROPERTIES PREPARED BY OIL-IN-OIL EMULSION SOLVENT EVAPORATION PROCESS 制备温度对油包油乳液-溶剂蒸发法制备乙基纤维素微球性能的影响

INDIAN DRUGS Pub Date : 2023-05-28 DOI: 10.53879/id.60.05.12481

Prasanta K. Mohapatra, Sunit K. Sahoo

{"title":"EFFECT OF PREPARATION TEMPERATURE ON ETHYLCELLULOSE MICROSPHERE PROPERTIES PREPARED BY OIL-IN-OIL EMULSION SOLVENT EVAPORATION PROCESS","authors":"Prasanta K. Mohapatra, Sunit K. Sahoo","doi":"10.53879/id.60.05.12481","DOIUrl":"https://doi.org/10.53879/id.60.05.12481","url":null,"abstract":"The present study aims to formulate ethylcellulose microspheres using the oil-in-oil emulsion solvent evaporation method and judge the outcome of processing temperature on their features. The effects of the evaporation rate of the solvent on the particle properties and drug release characteristics of the microspheres were studied. Here, microspheres were prepared at different processing temperatues, viz., 10 0 C, 25 0 C, and 40 0 C, and their impact on the various characteristics of microspheres like surface topography, micrometrics, yield percent, encapsulation efficiency, in vitro dissolution, Fourier-transform infrared spectroscopy (FTIR) and release kinetics were elaborately studied. The FTIR study revealed that processing temperature did not affect drug-polymer compatibility. The study observed that the processing temperature had a great influence on the various characteristics of the prepared microsphere. It was observed from sieve analysis that the mean particle size of the microsphere increased with an increase in processing temperature, and the SEM study also corroborated the same result. SEM photographs showed processing at a higher temperature resulted in particles with a smooth surface, in contrast to a lower processing temperature that forms a bumpy surface. Furthermore, a higher temperature favoured formulation with a higher entrapment efficiency (94.42 ± 0.9 %) as compared to a lower temperature (85.2 ± 0.72 %). For a noteworthy timeframe, indinavir sulfate frames a solid solution in the ethylcellulose matrix and proceeds with the amorphous state. The results of an in vitro drug dissolution study showed that microspheres formulated at a higher temperature had a more sustaining effect as compared to those formulated at a lower temperature, which may have resulted due to their higher mean particle size. Using the Korsemeyer Peppas power law, it was found that the way drugs are released is controlled by diffusion.","PeriodicalId":13409,"journal":{"name":"INDIAN DRUGS","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49398176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0