TAVABOROLE氧化降解的导数紫外分光光度法测定

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-07-03 DOI:10.53879/id.60.06.13169

Mrinalini C. Damle, Mayuri H. Suryawanshi

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引用次数: 0

摘要

本研究的目的是利用一阶导数紫外分光光度法研究他瓦波罗在氧化条件下的降解行为。建立了一种简便、快速的分析方法，可作为他瓦波罗含量测定的质量控制工具。该方法是基于一段时间内的氧化研究。利用氧化降解研究得到的回收浓度的对数计算氧化降解反应的顺序。反应为一级动力学。根据ICH指南对方法进行了验证。在271 nm浓度范围5 ~ 25µg mL-1内呈线性响应。日内、日间精密度研究的相对标准偏差(RSD)为

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OXIDATIVE DEGRADATION OF TAVABOROLE: DETERMINATION BY DERIVATIVE UV SPECTROPHOTOMETRY

The aim of the present work was to investigate degradation behavior of tavaborole upon exposure to oxidative conditions using first order derivative UV spectrophotometric method. We have developed simple and fast analytical method that can be used as quality control tool for the determination of tavaborole. The method was based on oxidative studies over a period of time. The order of oxidative degradation reaction was calculated by using the log of recovered concentration obtained from the oxidative degradation study. The reaction was first order kinetics. The method was validated according to ICH guidelines. The linear response was found in the concentration range of 5-25 µg mL-1 at 271 nm. The % relative standard deviation (RSD) for precision studies of intraday and interday was

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

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