溶剂移位法研究BCS-II药物的超流电位

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-07-03 DOI:10.53879/id.60.06.13252

Uditi Handa, Anuj Malik, Kumar Guarve

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引用次数: 0

摘要

本研究的目的是通过溶剂位移法研究BCS-II药物(右美沙芬HBr)的超电位，评价聚合物增益因子对超电位的影响，以提高口服缓释药物的生物利用度。在生物相关介质中使用不同的缓释聚合物(HPMC - 15cps、黄原胶、CMC钠)来维持过流电位。结果表明，与不含聚合物相比，所有聚合物均显著提高了右美沙芬HBr的溶解度1.07-2.49倍。HPMC和黄原胶在0.1% w/V时均表现出良好的沉淀抑制作用，在SIFsp中为10.2 ~ 22.1倍，在PBS (pH 7.4)中为6.04 ~ 6.75倍。对这些结果的解释表明，HPMC (15cps)对降落伞概念和黄原胶对滑翔机概念的作用。因此，通过在非配方药物中选择优良聚合物来开发多余配方来维持多余电位。

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INVESTIGATION OF SUPERFLUITY POTENTIAL OF BCS-II DRUG BY USING SOLVENT SHIFT METHOD

This research work’s motive was to investigate the superfluity potential of the BCS-II drug (Dextromethorphan HBr) by solvent shift method to evaluate the impact of polymer gain factor on superfluity potential for the enhancement of bioavailability of orally prolonged release. To maintain the superfluity potential, different drug-release retarding polymers were used (HPMC 15cps, xanthan gum, sodium CMC) in a bio-relevant medium. The outcomes of this, reveal that all polymers remarkably enhanced the solubility of dextromethorphan HBr 1.07-2.49 fold when compared to those without polymer. HPMC and xanthan gum both at 0.1 % w/V showed excellent precipitation inhibitor's role at about 10.2-22.1 factor in SIFsp and 6.04-6.75 factor in PBS (pH 7.4). Elucidation of these results, show that HPMC (15cps) works on the parachute concept and Xanthan Gum on the glider concept. Hence, the superfluity potential is maintained by the selection of excellent polymers in non-formulated drugs to develop the superfluity formulation.

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

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