紫外-可见光谱法同时测定原料药和制剂中普瑞巴林和依托里昔的方法开发与验证

Q4 Pharmacology, Toxicology and Pharmaceutics

INDIAN DRUGS Pub Date : 2023-07-28 DOI:10.53879/id.60.07.13016

Akhil M. B., S. V. Kutty, Y. Haribabu, N. K.

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引用次数: 0

摘要

采用双点标准化方法，建立了一种简便、准确、准确、经济的同时测定复方制剂中普瑞巴林和依托里昔的方法。以甲醇为溶剂，加入溴甲酚绿显色剂。溴甲酚绿只与普瑞巴林反应形成绿色离子对复合物。普瑞巴林和依托里昔b的最大吸收波长分别为618nm和235nm。发现该方法对普瑞巴林的线性范围为6-22µg mL-1，对依托里昔的线性范围是4.8-17.6µg mL-1。进行了验证参数，发现该方法是线性的、准确的、精确的、坚固的和稳健的。

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METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF PREGABALIN AND ETORICOXIB IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-VISIBLE SPECTROSCOPY

A simple, accurate, precise and economical method has been developed for the simultaneous estimation of pregabalin and etoricoxib in combined dosage form by using double point standardization method. Methanol is used as the solvent and chromogenic agent added was bromocresol green. Bromocresol green is only reactive with pregabalin form a green colour ion pair complex. l max of pregabalin and etoricoxib was at 618 nm and 235 nm, respectively. The method was found to be linear in the range of 6-22 µg mL-1 for pregabalin and 4.8-17.6 µg mL-1 for etoricoxib. Validation parameters was performed and method was found to be linear, accurate, precise, rugged and robust.

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来源期刊

INDIAN DRUGS Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.30

自引率

0.00%

发文量