In vivo最新文献

{"title":"Modified Advanced Lung Cancer Inflammation Index Is an Independent Prognostic Factor for Gastric Cancer Patients Who Receive Curative Treatment.","authors":"Toru Aoyama, Itaru Hashimoto, Yukio Maezawa, Ryuki Esashi, Sosuke Yamamoto, Kiyoko Shimada, Keisuke Kazama, Ayako Tamagawa, Mie Tanabe, Keisuke Komori, Natsumi Kamiya, Naoko Okuda, Koji Numata, Mamoru Uchiyama, Aya Saito, Norio Yukawa","doi":"10.21873/invivo.13952","DOIUrl":"https://doi.org/10.21873/invivo.13952","url":null,"abstract":"<p><strong>Background/aim: </strong>Body composition changes and nutritional status affect the oncological outcomes in various malignancies. Modified advanced lung cancer inflammation index (mALI) evaluates both body composition changes and nutritional status. Herein, we aimed to examine the potential of mALI as a biomarker for gastric cancer (GC).</p><p><strong>Patients and methods: </strong>The medical records of 327 consecutive patients with gastric cancer who underwent curative resection at Yokohama City University from 2015 to 2022 were retrospectively reviewed. mALI was defined follows: Appendicular skeletal muscle index×Serum albumin/Neutrophil-to-lymphocyte ratio. The clinical impact of the mALI on the short- and long-term oncological outcomes was evaluated using Kaplan-Meier curves and Cox's proportional hazards models.</p><p><strong>Results: </strong>The 327 patients were classified into the mALI-low (n=121) and mALI-high (n=206) groups, respectively. The 1-, 3-, and 5-year overall survival (OS) rates were 94.0%, 71.4%, and 59.2%, respectively, in the mALI-low group, and 95.5%, 85.0%, and 79.9%, in the mALI-high group. In the multivariable analysis for OS, the mALI was identified as an independent prognostic factor [hazard ratio (HR)=1.794; 95% confidence interval (CI)=1.155-2.786, <i>p</i>=0.009]. The 1-, 3-, and 5-year recurrence-free survival (RFS) rates were 79.6%, 66.0%, and 54.3%, respectively, in the mALI-low group, and 90.7%, 79.1%, and 75.5% in the mALI-high group. The multivariable analysis of RFS, identified the mALI as an independent prognostic factor (HR=1.654; 95% CI=1.105-2.477, <i>p</i>=0.015). In addition, the mALI status affected short-term oncological outcomes, including the occurrence of postoperative surgical complications and the introduction of postoperative adjuvant chemotherapy.</p><p><strong>Conclusion: </strong>The mALI was an independent prognostic factor for OS and RFS in patients with GC. Our results suggest that the mALI is a promising biomarker for GC and a useful tool for the treatment and management of GC.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1524-1532"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Sandblasting Parameters on the Properties of Additively Manufactured and Machined Titanium Surfaces.","authors":"Osman Akbas, Leif Reck, Anne Jahn, Jörg Hermsdorf, Meike Stiesch, Andreas Greuling","doi":"10.21873/invivo.13979","DOIUrl":"https://doi.org/10.21873/invivo.13979","url":null,"abstract":"<p><strong>Background/aim: </strong>In dentistry, the surfaces of titanium implants are often sandblasted and acid-etched in order to support successful osseointegration. The aim of this study was to investigate the impact of various sandblasting parameters on the surface roughness, contact angle and surface energy of additively manufactured (TiAl6V4) and machined commercially pure titanium (cpTi) surfaces.</p><p><strong>Materials and methods: </strong>A total of 56 disc-shaped samples were produced using either laser powder bed fusion (TiAl6V4) or using precision cutting (cpTi). The samples were then sandblasted with different angles, distances, and pressures using an automated sandblasting machine. Afterwards, surface roughness and contact angle for water and diiodomethane were measured, and scanning electron microscopy images were taken.</p><p><strong>Results: </strong>The results showed that the initially rough TiAl6V4 samples became smoother after sandblasting, while the smooth cpTi surfaces became rougher. Sandblasting pressure had the most significant influence on surface roughness. The surface energy of sandblasted TiAl6V4 samples showed no significant change compared to the as-built state (26.6±1.3 to 26.3±1.8 mJ/m²). In contrast, cpTi samples showed a reduction in surface energy after sandblasting (32.3±1.6 to 26.8±1.2 mJ/m²). Scanning electron microscopy revealed irregular surfaces with grooves and ridges for both types of samples. The roughness of TiAl6V4 decreased at higher sandblasting pressures, whereas cpTi surfaces became rougher.</p><p><strong>Conclusion: </strong>Surface roughness after sandblasting is strongly influenced by the initial surface, which differs in additively manufactured TiAl6V4 samples compared to machined cpTi surfaces.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1767-1785"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase II Trial of Capecitabine Plus Bevacizumab for Elderly Patients With Metastatic Colorectal Cancer: OGSG 1102.","authors":"Toshifumi Yamaguchi, Motoki Yoshida, Koichi Taira, Shinya Tokunaga, Takeshi Kato, Masato Nakamura, Naotoshi Sugimoto, Soichi Fumita, Masayoshi Yasui, Yasuhiro Miyake, Hisato Kawakami, Yukinori Kurokawa, Toshio Shimokawa, Taroh Satoh","doi":"10.21873/invivo.13950","DOIUrl":"https://doi.org/10.21873/invivo.13950","url":null,"abstract":"<p><strong>Background/aim: </strong>The combination of capecitabine and bevacizumab is a standard first-line chemotherapy regimen for vulnerable patients with unresectable colorectal cancer. However, the safety and efficacy of this regimen in Japanese patients have not been sufficiently investigated.</p><p><strong>Patients and methods: </strong>This phase II study included patients aged ≥76 years or those aged 65-75 years who were unsuitable for intensive chemotherapy. Capecitabine at 2000 mg/m²/day (days 1-14) plus bevacizumab at 7.5 mg/kg (day 1) were administered every 3 weeks. The primary endpoint was progression-free survival. Secondary endpoints included overall survival, response rate, disease control rate, and toxicities.</p><p><strong>Results: </strong>Thirty-six patients were enrolled between July 2011 and July 2014, of whom 33 were included in the analysis. The median patient age was 78 years (range=67-86 years). A total of 28 patients had a performance status of 0 or 1, and five of 2. The median progression-free and overall survival were 10.3 (95% confidence interval=9.2-15.4) and 27.9 (95% confidence interval=24.2-50.1) months, respectively. The response and disease control rates were 30.3% and 91.0%, respectively. The major grade 3 or 4 toxicities were hypertension (n=12, 36%) and hand-foot syndrome (n=4, 12%). One patient experienced a grade 4 gastrointestinal perforation.</p><p><strong>Conclusion: </strong>The combination of capecitabine and bevacizumab demonstrated favorable efficacy and tolerability in Japanese patients with metastatic colorectal cancer who were unsuitable for intensive chemotherapy.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1505-1513"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface.","authors":"Mike Barbeck","doi":"10.21873/invivo.13976","DOIUrl":"https://doi.org/10.21873/invivo.13976","url":null,"abstract":"","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1739"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Cellular Behavior by Surface Design of Titanium-based Biomaterials.","authors":"Tonya Andreeva, Osman Akbas, Anne Jahn, Andreas Greuling, Andreas Winkel, Meike Stiesch, Rumen Krastev","doi":"10.21873/invivo.13980","DOIUrl":"https://doi.org/10.21873/invivo.13980","url":null,"abstract":"<p><strong>Background/aim: </strong>Titanium alloys, especially Ti₆Al₄V, are widely used in orthopedic and dental implants. Additive manufacturing has emerged as an innovative fabrication technique for titanium implants, gradually replacing traditional machining methods. A notable feature of additively manufactured medical devices is their considerable surface heterogeneity and roughness. Coating these materials to achieve physical and chemical uniformity is essential for enhancing biocompatibility. This study evaluates the combined effect of surface roughness (ranging from sub-micrometer to micrometer scale) and three nanometer-thick polyelectrolyte multilayer coatings on protein adsorption, as well as the adhesion and proliferation of normal human osteoblasts.</p><p><strong>Materials and methods: </strong>The adhesion of human osteoblasts to various substrates (either uncoated or coated) was quantified using a lactate dehydrogenase assay and scanning electron microscopy. The surface density of adsorbed human serum albumin was analyzed by the Bradford assay.</p><p><strong>Results: </strong>Application of polyelectrolyte multilayer coatings significantly increased the hydrophilicity of titanium substrates without altering their sub-micrometer and micrometer roughness or topography. The coatings rich in reactive amino groups were found to enhance the adsorption of human serum albumin and promote the adhesion of osteoblasts.</p><p><strong>Conclusion: </strong>The chemical composition of the surface, particularly the presence of free primary amino groups, significantly affects cellular behavior in machined, sand-blasted, and additively manufactured titanium materials, while the impact of surface roughness appears secondary. No correlation was observed between surface hydrophilicity and protein adsorption or cell attachment.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1786-1798"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of Invariant Natural Killer T Cells Enhances Ischemia-Reperfusion Injury in Steatotic Mouse Livers.","authors":"Y U Kuroda, Yoshiya Ito, Nobuyuki Nishizawa, Mina Tanabe, Takuya Goto, Atsushi Yamashita, Kanako Hosono, Masashi Satoh, Yusuke Kumamoto, Naoki Hiki, Hideki Amano","doi":"10.21873/invivo.13939","DOIUrl":"https://doi.org/10.21873/invivo.13939","url":null,"abstract":"<p><strong>Background/aim: </strong>Hepatic steatosis is a significant independent risk factor for liver surgery because of its vulnerability to ischemia-reperfusion (IR) injury. Invariant natural killer T (iNKT) cells contribute to IR injury in healthy liver. We previously reported that activated iNKT cells mitigate liver IR injury and facilitate liver repair by interacting with macrophages. This study aimed to assess the role of activated iNKT cells in IR injury in steatotic livers.</p><p><strong>Materials and methods: </strong>Male C57/BL6 mice were fed a normal diet (ND) or high-fat diet (HFD) for 12 weeks before liver IR. iNKT cells were activated by intraperitoneal injection of α-galactosylceramide (α-GC) into HFD-fed mice. This study assessed liver injury, cytokine levels, and immune cell accumulation.</p><p><strong>Results: </strong>HFD-fed mice exhibited increased levels of liver injury, pro-inflammatory mediators, and macrophages compared to those of ND-fed mice. Administration of α-GC to HFD-fed mice enhanced liver IR injury that was associated with increased numbers of iNKT cells and pro-inflammatory macrophages compared with those in the vehicle-treated group. Additionally, liver repair was delayed in α-GC-treated HFD-fed mice, as demonstrated by the increased necrotic area and decreased proliferating cell nuclear antigen expression. This was accompanied by reduced levels of anti-inflammatory mediators and reparative macrophages. Pro-inflammatory cytokine levels were increased in activated hepatic iNKT cells co-cultured with macrophages isolated from HFD-fed mice.</p><p><strong>Conclusion: </strong>The activation of hepatic iNKT cells aggravates steatotic liver IR injury by upregulating pro-inflammatory mediators and macrophages, while suppressing anti-inflammatory mediators and reparative macrophages.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1355-1369"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Hydrogen Capsule Therapy for Primary Biliary Cholangitis With Elevated IgG4: A Case Report on Immune Marker Normalization.","authors":"Yun-Ting Lin, Jeng-Wei Lu, Jung-Chun Lin, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Hsiao-Chen Liu, Kuang-Yih Wang, Feng-Cheng Liu","doi":"10.21873/invivo.13968","DOIUrl":"https://doi.org/10.21873/invivo.13968","url":null,"abstract":"<p><strong>Background/aim: </strong>Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by bile duct destruction, cholestasis, and inflammation, often leading to fibrosis and cirrhosis. While ursodeoxycholic acid (UDCA) is the standard treatment, some patients exhibit suboptimal responses, necessitating adjunctive therapies. Molecular hydrogen (H₂), known for its antioxidant and anti-inflammatory properties, has shown potential in mitigating oxidative stress and immune dysregulation in autoimmune liver diseases. This case report evaluates the therapeutic efficacy of H₂ capsules in managing PBC with elevated liver enzymes and immune dysregulation.</p><p><strong>Case report: </strong>A 44-year-old male with PBC, splenomegaly, and elevated IgG4 levels presented with acute cholestatic hepatitis. Laboratory tests revealed significantly elevated aspartate transaminase (AST) (279 U/l) and alanine aminotransferase (ALT) (183 U/l). Despite UDCA therapy, liver enzymes remained persistently high. On August 30, 2024, molecular hydrogen capsule therapy was introduced as adjunctive treatment. Over four months, AST and ALT levels declined to 95 U/l and 70 U/l, respectively, without adverse effects. Immune markers (KLRG-1, PD-1, and Tim3), previously reduced during PBC flares, normalized post-treatment. Imaging confirmed stable fibrosis, and IgG4 levels decreased, suggesting reduced autoimmune activity. The patient also reported improvements in fatigue and pruritus, enhancing overall quality of life.</p><p><strong>Conclusion: </strong>Molecular hydrogen capsules therapy may serve as a safe and effective adjunctive treatment for PBC, contributing to improved liver enzyme levels, immune regulation, and patient well-being. Further studies are warranted to validate these findings and establish standardized treatment protocols in autoimmune liver diseases.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1669-1675"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colposcopic Alterations Are More Frequent in Smokers and Appear at a Younger Age.","authors":"Diego Erasun Mora, Ana Vázquez Del Campo, Alazne DE Castro Momioto, Alberto Muñoz Solano, Jose Schneider","doi":"10.21873/invivo.13946","DOIUrl":"https://doi.org/10.21873/invivo.13946","url":null,"abstract":"<p><strong>Background/aim: </strong>Tobacco use is a recognized cofactor risk for cervical cancer induced by high-risk Human Papilloma Virus (HR-HPV). This study aimed to evaluate the specific influence of tobacco use on colposcopic examination results in women infected by HR-HPV.</p><p><strong>Patients and methods: </strong>HR-HPV-positive women undergoing a loop electrosurgical excision procedure (LLETZ) after colposcopic examination were considered for this study. A total of 819 patients from a regional screening program were included, of whom 320 were smokers and 499 non-smokers.</p><p><strong>Results: </strong>Smokers were significantly younger (41.1 <i>vs.</i> 43.8, <i>p</i><0.01), more frequently exhibited grade II colposcopic changes (63.9% <i>vs.</i> 53.3%, <i>p</i><0.05), had worse histopathological outcomes (CIN2+: 75.7% <i>vs.</i> 67.9%, <i>p</i><0.05; CIN3+: 51.4% <i>vs.</i> 44.0%, <i>p</i><0.05), and higher rates of affected surgical margins, with borderline significance (22.6% <i>vs.</i> 17.8%, <i>p</i>=0.055). While no significant differences in viral clearance were observed at six months, smokers showed a trend toward worse outcomes at two years (<i>p</i>=0.07).</p><p><strong>Conclusion: </strong>Smoking in any amount is associated with worse colposcopic and histopathological findings, and this occurs at younger ages.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1453-1457"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Yield of Whole-body Computed Tomography in Dogs and Cats in the Oncology Setting.","authors":"Maria DE Almeida, Hugo Gregório, André Pereira, Felisbina L Queiroga","doi":"10.21873/invivo.13933","DOIUrl":"https://doi.org/10.21873/invivo.13933","url":null,"abstract":"<p><strong>Background/aim: </strong>Clinical staging has become essential in veterinary oncology. It is crucial for creating effective treatment plans and predicting outcomes. Whole-body computed tomography (WBCT) can serve as a comprehensive staging examination, offering a detailed view of a patient's internal anatomy. This retrospective study aimed to assess the diagnostic yield of WBCT in diagnosing cancer in dogs and cats.</p><p><strong>Patients and methods: </strong>We reviewed medical records of cats and dogs that underwent a WBCT scan between January 2016 and May 2023. Only cases with a confirmed cytological or histological diagnosis of the primary tumor and complete medical records were considered. We collected data on histological diagnoses and diagnostic methods used.</p><p><strong>Results: </strong>Our study included 57 animals that underwent WBCT for cancer-related reasons. Metastases were detected in 14 dogs, with four showing metastases in multiple locations, five in the lungs, three in the lymph nodes, one in the skeleton, and one in the liver, yielding a diagnostic rate of 31.8%. In cats, metastases were detected in six cases (five in the lungs and one in the lymph nodes), with a diagnostic yield of 46.2%. WBCT identified metastasis in over 35% of cases, including those outside the thoracic and abdominal cavities, indicating potentially greater accuracy than radiography and ultrasound.</p><p><strong>Conclusion: </strong>WBCT is an effective and safe method for tumor staging and oncological diagnosis in dogs and cats.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1293-1302"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Anemia Is an Independent Prognostic Factor for Esophageal Cancer Patients Who Receive Curative Treatment.","authors":"Kiyoko Shimada, Toru Aoyama, Itaru Hashimoto, Yukio Maezawa, Ryuki Esashi, Momoko Fukuda, Mihwa Ju, Sosuke Yamamoto, Keisuke Kazama, Natsumi Kamiya, Naoko Okuda, Ayako Tamagawa, Koji Numata, Mamoru Uchiyama, Aya Saito, Norio Yukawa","doi":"10.21873/invivo.13969","DOIUrl":"https://doi.org/10.21873/invivo.13969","url":null,"abstract":"<p><strong>Background/aim: </strong>We retrospectively evaluated the clinical impact of anemia during the perioperative period on both short- and long-term oncological outcomes in patients with resectable esophageal cancer who received curative treatment.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed the medical records and collected data from consecutive patients with esophageal cancer who underwent curative resection at Yokohama City University from 2005 to 2022.</p><p><strong>Results: </strong>A total of 198 patients were included in this study. According to previous studies and the 3- and 5- year overall survival rates, a hemoglobin level of 11 g/dl was selected as the optimal cutoff value in the present study; preoperative hemoglobin of <11 g/dl and >11 g/dl were observed in 34 patients (Hb-low group) and 164 patients (Hb-high group), respectively. The 3- and 5-year OS rates were 39.1% and 34.8%, respectively, in the Hb-low group and 70.3% and 62.1% in the Hb-high group. There were significant differences between the two groups (<i>p</i>=0.003). Univariate and multivariate analyses demonstrated that the preoperative Hb level was as an independent prognostic factor for OS [hazard ratio (HR)=1.809; 95% confidence interval (CI)=1.073-3.050, <i>p</i>=0.026]. Moreover, the 3- and 5-year recurrence-free survival (RFS) rates were 16.6% and 16.6%, respectively, in the Hb-low group and 51.8% and 45.1% in the Hb-high group (<i>p</i><0.001). In the multivariate analysis, the preoperative Hb status was also selected as an independent prognostic factor for RFS (HR=1.977; 95%CI=1.240-3.151 <i>p</i>=0.004).</p><p><strong>Conclusion: </strong>Preoperative anemia is an independent prognostic factor in patients with esophageal cancer. Our results suggest its potential significance in the treatment and management of these patients.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1676-1684"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}