Indian pediatrics最新文献_第7页

Feasibility and Safety of Percutaneous Device Closure of Patent Ductus Arteriosus in Preterm Neonates: Experience From a Single Center in Northern India. 经皮装置关闭早产儿动脉导管未闭的可行性和安全性：来自印度北部单一中心的经验。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-08 DOI: 10.1007/s13312-025-00157-8

Satya Prakash, Akash Singhal, Deepika Kainth, Lamk Kadiyani, Anu Thukral, M Jeeva Sankar, Saurabh Kumar Gupta, Sivasubramanian Ramakrishnan, Ramesh Agarwal, Ankit Verma

{"title":"Feasibility and Safety of Percutaneous Device Closure of Patent Ductus Arteriosus in Preterm Neonates: Experience From a Single Center in Northern India.","authors":"Satya Prakash, Akash Singhal, Deepika Kainth, Lamk Kadiyani, Anu Thukral, M Jeeva Sankar, Saurabh Kumar Gupta, Sivasubramanian Ramakrishnan, Ramesh Agarwal, Ankit Verma","doi":"10.1007/s13312-025-00157-8","DOIUrl":"https://doi.org/10.1007/s13312-025-00157-8","url":null,"abstract":"Objective: To report the feasibility and safety of percutaneous device closure of patent ductus arteriosus (PDA) in preterm neonates from a tertiary center in Northern India.Methods: A retrospective chart review of the clinical profile, nature of device used, and outcomes of inborn preterm neonates who underwent percutaneous device closure of PDA was conducted. The intervention was performed by experienced pediatric cardiologists using a transvenous approach under fluoroscopic guidance.Results: Ten neonates with median (Q1, Q3) gestation of 29 (27, 30) weeks underwent device (Piccolo device) closure at a median (Q1, Q3) age of 37 (27, 41) days. At the time of procedure, the median (Q1, Q3) weight of the infants was 1270 (1120, 1890) g and the median (Q1, Q3) PDA diameter was 3.0 (2.3, 3.0) mm. Successful PDA closure was achieved in nine neonates; six showed clinical improvement. No procedure-related death was observed.Conclusions: Percutaneous device closure of PDA in preterm neonates is safe and feasible.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility, Safety, and Effectiveness of Neonatal Air Transport in India: A Case Series. 可行性，安全性和有效性的新生儿航空运输在印度：一个案例系列。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-06 DOI: 10.1007/s13312-025-00146-x

Nalinikanta Panigrahy, Vijayanand Jamalpuri, V B Pratyush Modumudi, Nitasha Bagga, Dinesh Kumar Chirla

引用次数: 0

Effect of Intrapartum Antibiotic Exposure Time on Neonatal Sepsis: A Prospective Cohort Study. 产时抗生素暴露时间对新生儿败血症的影响：一项前瞻性队列研究。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-06 DOI: 10.1007/s13312-025-00133-2

Rishi Sharma, Sourabh Dutta, Vanita Suri, Pallab Ray, Mandula Phani Priya

{"title":"Effect of Intrapartum Antibiotic Exposure Time on Neonatal Sepsis: A Prospective Cohort Study.","authors":"Rishi Sharma, Sourabh Dutta, Vanita Suri, Pallab Ray, Mandula Phani Priya","doi":"10.1007/s13312-025-00133-2","DOIUrl":"https://doi.org/10.1007/s13312-025-00133-2","url":null,"abstract":"Objective: To examine the association between the duration of intrapartum antibiotic exposure (IAE) and the risk of culture-negative early-onset neonatal sepsis (EONS) and any late-onset neonatal sepsis (LONS) in the first week.Methods: Preterm neonates (≤ 34 weeks) were enrolled into: Group A (no IAE; n = 282), Group B (IAE < 24 h; n = 204) and Group C (IAE ≥ 24 h; n = 84). The risk factors for EONS and LONS were noted and all neonates were followed up for culture-negative EONS (primary outcome). Secondary outcomes included culture-positive EONS, culture-negative and culture-positive LONS, and multidrug-resistant sepsis. A univariable followed by multivariable analysis of risk factors to predict culture-negative EONS and LONS was performed. The cut-off (Youden's index) of IAE associated with various outcomes was determined.Results: From group A through C, gestation and birth weight declined, and the proportion at risk of EONS increased. Culture-negative EONS incidence increased (9.57% vs. 12.74% vs. 36.90%, respectively, Ptrends < 0.001), but its proportion among all EONS did not. Culture-positive LONS incidence declined (Ptrends = 0.038). The proportion of culture-negative LONS among all LONS increased (Ptrends = 0.024). Threshold values of 13.5 h and 4.5 h were associated with culture-negative EONS and culture-positive LONS in the first week, respectively. However, on adjusted analysis, IAE duration had no association with culture-negative EONS or LONS in the first week.Conclusions: Duration of IAE is not independently associated with increased incidence of culture-negative EONS or any LONS.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferior Vena Cava/Aorta Diameter Index for the Evaluation of Intravascular Volume Status in Children with Idiopathic Nephrotic Syndrome. 下腔静脉/主动脉直径指数评价儿童特发性肾病综合征血管内容量状况。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-06 DOI: 10.1007/s13312-025-00154-x

Anshuman Saha, A P Anila, K V Pavan, Arpana Iyengar, Anil Vasudevan

{"title":"Inferior Vena Cava/Aorta Diameter Index for the Evaluation of Intravascular Volume Status in Children with Idiopathic Nephrotic Syndrome.","authors":"Anshuman Saha, A P Anila, K V Pavan, Arpana Iyengar, Anil Vasudevan","doi":"10.1007/s13312-025-00154-x","DOIUrl":"https://doi.org/10.1007/s13312-025-00154-x","url":null,"abstract":"Objectives: To correlate the inferior vena cava/aorta diameter (IVC/Ao index) in children with nephrotic syndrome with clinical indicators of volume status, and to compare the IVC/Ao index between children in relapse and in remission.Methods: This prospective longitudinal study included children aged 2-18 years presenting with relapsed nephrotic syndrome. Low intravascular volume status was diagnosed if two of the three criteria (tachycardia, hypotension, prolonged capillary filling time) were present. Sonographic measurements of the IVC and aorta diameter were obtained by a single observer at recruitment and after achieving remission.Results: One hundred and three children (73 boys) with a median (Q1, Q3) age 72 (24, 216) months were recruited. 26 (25%) children had low intravascular volume at recruitment. The mean (SD) IVC/Ao index was lower in low volume status compared to normal volume status [0.74 (0.2) vs 0.83 (0.1); P = 0.090]. The correlation between IVC/Ao index and heart rate (r = -0.29, P = 0.003) and mean arterial pressure (r = 0.23, P = 0.018) was weak. IVC/Ao index was not an independent predictor of volume status (OR = 0.04, P = 0.331). The mean (SD) IVC/Ao index increased significantly from when in relapse to remission [0.94 (0.1) vs 1.05 (0.2), respectively; P = 0.001].Conclusions: The IVC/Ao index was lower in relapse than in remission, and did not predict low intravascular volume status independently.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Birth Defects Among Children Enrolled in Rashtriya Bal Swasthya Karyakram in Bihar. 在比哈尔邦的Rashtriya Bal Swasthya Karyakram注册的儿童中的出生缺陷。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-06 DOI: 10.1007/s13312-025-00160-z

Veena Kumari Singh, Haripriya Hari, Shria Datta, C M Singh, Anurag Deep

引用次数: 0

Circulating Intercellular Adhesion Molecule as a Novel Marker of Pulmonary Hypertension in Newborn. 循环细胞间粘附分子作为新生儿肺动脉高压的新标志物。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI: 10.1007/s13312-025-00037-1

Antoine Fakhry AbdelMassih, Sherif ElAnwary, Nourhan Taha, Noha Radwan, Mahmoud Othman AbouDeif

引用次数: 0

Invasive Ventilation Strategies in Neonates. 新生儿有创通气策略。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1007/s13312-025-00094-6

Jogender Kumar, Praveen Kumar, Vineet Bhandari

{"title":"Invasive Ventilation Strategies in Neonates.","authors":"Jogender Kumar, Praveen Kumar, Vineet Bhandari","doi":"10.1007/s13312-025-00094-6","DOIUrl":"10.1007/s13312-025-00094-6","url":null,"abstract":"We provide evidence-based recommendations and clinical guidance on strategies for invasive mechanical ventilation in neonates until successful extubation in the neonatal intensive care unit. A systematic search of the PubMed, Embase, and CENTRAL databases was performed to identify relevant published literature from the past five years. A critical review of the current literature was conducted to provide context-specific recommendations. We discuss the various modes of invasive mechanical ventilation in neonates, with specific recommendations for neonates with persistent pulmonary hypertension, congenital heart disease, congenital diaphragmatic hernia, pneumonia, meconium aspiration syndrome, air leak syndromes, evolving and established bronchopulmonary dysplasia, apnea, and very preterm infants with respiratory distress. Practical guidance for the initiation, titration, and weaning of volume-targeted ventilation is also provided. Synchronized patient-triggered modes (synchronized intermittent mandatory ventilation + pressure support ventilation/assist control ventilation) and volume-target/guarantee modes are the preferred modes of invasive mechanical ventilation in neonates with respiratory distress.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"608-618"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study. 月球iDXA用于评估印度儿童和青少年骨骼健康的参考数据：一项横断面研究

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-01 Epub Date: 2025-05-22 DOI: 10.1007/s13312-025-00091-9

Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar

{"title":"Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study.","authors":"Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar","doi":"10.1007/s13312-025-00091-9","DOIUrl":"10.1007/s13312-025-00091-9","url":null,"abstract":"Objective: Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.Methods: A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm2)], and bone mineral density [BMD (g/cm2)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm3)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.Results: Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.Conclusion: The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"578-585"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Antiretroviral Therapy and Vitamin E Supplementation on Total Antioxidant Capacity in Children Living with HIV. 抗逆转录病毒治疗和补充维生素E对艾滋病毒感染儿童总抗氧化能力的影响。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1007/s13312-025-00111-8

K Jai Kumar, Pooja Dewan, Rajarshi Kar, Edelbert Anthonio Almeida, Deepika Harit, Mrinalini Kotru, Mukesh Yadav

{"title":"Effect of Antiretroviral Therapy and Vitamin E Supplementation on Total Antioxidant Capacity in Children Living with HIV.","authors":"K Jai Kumar, Pooja Dewan, Rajarshi Kar, Edelbert Anthonio Almeida, Deepika Harit, Mrinalini Kotru, Mukesh Yadav","doi":"10.1007/s13312-025-00111-8","DOIUrl":"10.1007/s13312-025-00111-8","url":null,"abstract":"Objectives: To assess the total antioxidant capacity (TAC) in children living with HIV (CLHIV) and to evaluate the effect of antiretroviral therapy (ART) and vitamin E supplementation on TAC.Methods: The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.Results: A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. Three months of vitamin E supplementation, failed to produce a significant increase in TAC levels [10.4 (7.28, 14.92)] while the red cell indices and CD4 counts improved significantly with a marginal reduction in HIV viral load.Conclusion: Prolonged ART reduced antioxidant capacity. Three months of vitamin E supplementation produced marginal increase in TAC levels.Trial registry: CTRI/2022/12/047960 [Registered on: 08/12/2022] Trial Registered Prospectively.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"586-592"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of Musculoskeletal Anomalies in Indian Children with Down Syndrome. 印度唐氏综合症儿童肌肉骨骼异常的概况。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2025-08-01 Epub Date: 2025-04-07 DOI: 10.1007/s13312-025-00059-9

Deepshikha, Devendra Mishra, Sumit Sural, Seema Kapoor

{"title":"Profile of Musculoskeletal Anomalies in Indian Children with Down Syndrome.","authors":"Deepshikha, Devendra Mishra, Sumit Sural, Seema Kapoor","doi":"10.1007/s13312-025-00059-9","DOIUrl":"10.1007/s13312-025-00059-9","url":null,"abstract":"Objectives: This hospital-based study evaluated the magnitude and characteristics of musculoskeletal anomalies in children with Down syndrome.Methods: Children aged 3 months to 14 years, diagnosed to have Down syndrome by karyotyping, were evaluated for musculoskeletal anomalies. We excluded children diagnosed with another chronic condition affecting musculoskeletal health (e.g., cerebral palsy, muscular diseases); and those with any acute illness, which is likely to affect evaluation for musculoskeletal anomalies. A detailed history was taken, and clinical examination was performed by a pediatrician and an orthopedic surgeon. Detailed joint examination was done using pGALS (pediatric Gait Arms Legs and Spine), and Beighton Hypermobility Score was used to assess hypermobility in those aged 6 year or more. X-ray cervical spine (lateral view in neutral, flexion and extension) was done for all children to determine atlantoaxial instability. Additionally, in children with any suspected musculoskeletal anomaly on clinical examination, relevant radiological investigations were performed under the guidance of an orthopedic surgeon.Results: The median (IQR) age of the study population (n = 75) was 5 (2.5, 8) years with 56% boys. Musculoskeletal anomalies were identified in 86.6% (n = 65). Hypotonia and joint laxity (77.3% each) were common in the whole group; pes planus (82%) and orthopedic abnormalities (69.3%) were prevalent among ambulatory children. Occurrence of genu valgum was found to increase with increasing body mass index (P = 0.045).Conclusions: Musculoskeletal problems were common in children with Down syndrome, and this information may guide health professionals in early identification of musculoskeletal problems in children with Down syndrome.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"599-604"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0