Indian pediatrics最新文献_第8页

Recurrent Acute Flaccid Paralysis in a Child Linked to CD59 Variant. 与CD59变异相关的儿童复发性急性弛缓性麻痹

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-06-01 DOI: 10.1007/s13312-026-00369-6

Venkataraman Viswanathan, Baalakumar Nirmalkumar, Karnati Guna Madhuri

引用次数: 0

Senior-Løken Syndrome Type 4 Masquerading as Inherited Bone Marrow Failure Syndrome. 老年lø ken综合征4型伪装成遗传性骨髓衰竭综合征。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-06-10 DOI: 10.1007/s13312-026-00379-4

Chandradeep Srivastava, Priyanka Aggarwal, Vineeta Gupta

引用次数: 0

Evaluation of HLA-DQ Genetic Risk Classes in Pediatric Cases for Celiac Disease: Role of HLA-DQ2 and DQ8 Haplotypes. 评估儿童乳糜泻病例HLA-DQ遗传风险等级：HLA-DQ2和DQ8单倍型的作用

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI: 10.1007/s13312-026-00302-x

Hatice Yilmaz Dagli, Reha Artan, Aygen Yılmaz

{"title":"Evaluation of HLA-DQ Genetic Risk Classes in Pediatric Cases for Celiac Disease: Role of HLA-DQ2 and DQ8 Haplotypes.","authors":"Hatice Yilmaz Dagli, Reha Artan, Aygen Yılmaz","doi":"10.1007/s13312-026-00302-x","DOIUrl":"10.1007/s13312-026-00302-x","url":null,"abstract":"Objectives: To determine the human leukocyte antigen (HLA)-DQ genotype pattern in children with celiac disease (CD).Methods: We retrospectively reviewed 490 patients aged 2-18 years who presented to our clinic between 2014 and 2024 with suspected CD and underwent HLA-DQ tissue typing.Results: Out of 490 patients, 220 were diagnosed as CD and 270 as controls. Analysis of CD samples for HLA types revealed that 140 (63.6%) were only HLA-DQ2 positive, 25 (11.3%) were only HLA-DQ8 positive, and 35 (15.9%) were both HLA-DQ2 and HLA-DQ8 positive. However, 20 (9%) of our patients were neither HLA-DQ2 nor HLA-DQ8 positive. In the control group, 102 patients were HLA-DQ2 positive and 66 were HLA-DQ8 positive Being homozygous for HLA-DQ2 increased the risk for CD by 16.49 times, and being homozygous for HLA-DQ8 increased the risk for CD by 4.39 times.Conclusions: HLA-DQ2/8 genotypes are strongly associated with pediatric patients with CD in Turkey. These genotypes and their combinations do not alter clinical presentation. HLA-DQ2/8 strongly contributes to the development of CD.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"547-551"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Extubation Failure Prevention Trial Using Nebulised Epinephrine (NEPTUNE): A Randomized Controlled Trial. 雾化肾上腺素（NEPTUNE）预防新生儿拔管失败试验：一项随机对照试验。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI: 10.1007/s13312-026-00306-7

Arunima Bhardwaj, Ashish Jain, Nidhi Jain, Shoham Majumder

{"title":"Neonatal Extubation Failure Prevention Trial Using Nebulised Epinephrine (NEPTUNE): A Randomized Controlled Trial.","authors":"Arunima Bhardwaj, Ashish Jain, Nidhi Jain, Shoham Majumder","doi":"10.1007/s13312-026-00306-7","DOIUrl":"10.1007/s13312-026-00306-7","url":null,"abstract":"Objective: To evaluate whether epinephrine nebulization, when used in addition to standard care, reduces extubation failure (EF) in term and preterm neonates.Methods: A parallel, randomized controlled superiority trial was conducted in a tertiary-care neonatal intensive care unit (NICU) between May 2023 and July 2024. Due to the nature of the intervention, blinding was not feasible. A total of 158 ventilated neonates (ventilation duration: 48 h to 2 weeks) were enrolled at the point of planned extubation and randomized to either the standard care group (SG) or the epinephrine nebulization group (EG). The primary outcome was extubation failure, defined as the need for reintubation within 48 h. Secondary outcomes included reintubation beyond 48 h, time to reintubation, serial Silverman-Anderson scores post-extubation, incidence of laryngeal edema, duration of non-invasive respiratory support, post-extubation and total hospital stay, mortality, and adverse effects.Results: The incidence of EF within 48 h was not significantly different in the EG and SG groups (14.8% vs 24.7%; P = 0.119) by intention-to-treat analysis. Per-protocol analysis showed EF of 9.2% in EG vs 24.7% in SG (P = 0.020). The post-extubation Silverman-Anderson scores showed no significant differences at immediate, 4, 8, or 12-h assessments; however, at 24 h, the EG demonstrated significantly lower scores suggestive of lesser respiratory distress compared with the SG [2.13 (1.06) vs 2.62 (1.40); P = 0.030]. Rates of laryngeal edema, adverse events including tachycardia, hypertension, peripheral vasoconstriction, ventilator-associated pneumonia, and antibiotic requirement did not differ significantly between groups.Conclusion: Epinephrine nebulization administered after extubation did not reduce the incidence of extubation failure in ventilated neonates.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"541-546"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and Independent Risk Factors of Central Venous Catheter-Related Thrombosis in Critically Ill Children: A Prospective Study in Vietnam. 越南危重儿童中心静脉导管相关血栓形成的发生率和独立危险因素：一项前瞻性研究

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-08-01 Epub Date: 2026-05-19 DOI: 10.1007/s13312-026-00363-y

Duc Van Mai, Phi Duong Nguyen, Thy Vu Phuong Le, An Thi Thanh Dao

{"title":"Incidence and Independent Risk Factors of Central Venous Catheter-Related Thrombosis in Critically Ill Children: A Prospective Study in Vietnam.","authors":"Duc Van Mai, Phi Duong Nguyen, Thy Vu Phuong Le, An Thi Thanh Dao","doi":"10.1007/s13312-026-00363-y","DOIUrl":"10.1007/s13312-026-00363-y","url":null,"abstract":"Objective: To determine the incidence and identify independent risk factors of central venous catheter (CVC)-related thrombosis in critically ill children admitted to a pediatric intensive care unit in a middle-income country, and to contribute context-specific prospective data relevant to clinical practice.Methods: In this prospective observational study, catheterization episodes in children undergoing central venous catheter (CVC) placement were systematically screened with Doppler ultrasonography within 24-48h after insertion and weekly thereafter. Clinical and catheter-related variables were analyzed using multivariable generalized estimating equation models with a logit link to identify independent predictors of catheter-associated thrombosis.Results: A total of 129 catheters, including 105 infusion catheters and 24 hemodialysis catheters, corresponding to 111 catheterization episodes were evaluated in 103 children. Thrombotic events related to CVCs occurred in 22 of 111 catheterization episodes (19.8%). In the overall cohort, multivariate generalized estimating equation analysis identified a history of thrombosis as an independent predictor of CVC-related thrombosis. In the infusion catheter subgroup, femoral vein CVC placement and catheter dwell time > 7 days were additional independent risk factors.Conclusions: Approximately one in five catheterization episodes in critically ill children was associated with thrombosis. History of thrombosis was an independent predictor overall; femoral vein CVC placement and CVC dwell time > 7 days were significant in the infusion catheter subgroup. These findings emphasize the need for risk-adapted ultrasound surveillance and careful catheter management in high-acuity, resource-limited pediatric intensive care settings.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"558-564"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tele-training Versus In-Person Training in Early Intervention for Parents of Children with Cerebral Palsy: A Pilot Randomized Controlled Trial. 远程培训与现场培训对脑瘫患儿家长早期干预的影响：一项随机对照试验。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-07-30 DOI: 10.1007/s13312-026-00404-6

Marina H L Laskor, Achuthan Sridharan, Velappan Dhanalakshmi, Arunachalam Jeyasankari, Nivedita Mondal

引用次数: 0

Clinical Profile and Induction Protocol of Video Electroencephalography in Children with Functional Neurological Symptom Disorder. 儿童功能性神经症状障碍的视频脑电图临床特征及诱导方案。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-07-24 DOI: 10.1007/s13312-026-00401-9

Vishnupriya Veeraraghavan, Diksha Sharma, Subhamoni Kaman, Akhila Das, Murchana Khound, Jaya Shankar Kaushik

{"title":"Clinical Profile and Induction Protocol of Video Electroencephalography in Children with Functional Neurological Symptom Disorder.","authors":"Vishnupriya Veeraraghavan, Diksha Sharma, Subhamoni Kaman, Akhila Das, Murchana Khound, Jaya Shankar Kaushik","doi":"10.1007/s13312-026-00401-9","DOIUrl":"https://doi.org/10.1007/s13312-026-00401-9","url":null,"abstract":"Objectives: To describe the clinical features and a structure, non-invasive induction protocol performed during video electroencephalography (V-EEG) of children with functional neurological symptom disorder (FNSD).Methods: This observational study conducted over 1 year (November 2024-November 2025) enrolled children aged 6-14 years with clinically suspected FNSD. The children underwent V-EEG followed by a stepwise, non-invasive induction protocol. The study assessed the success of event induction, distress during induction, time taken to induce events, and dissociative symptoms using the Childhood Dissociative Checklist (CDC).Results: A total of 58 children (39 girls) with FNSD were included. Motor symptoms were the most common presentation (n = 20, 34.5%). Twenty-nine out of 35 children who underwent the induction protocol showed reproducible events during testing. Verbal suggestion focused on psychosocial stressors was the most effective technique in 22 (62.9%) children. CDC scores and distress scores were comparable across the different induction techniques (verbal suggestion, temporal compression, and moist swab application). No adverse effects related to the induction procedure were reported.Conclusions: The non-invasive induction protocol used along with V-EEG was safe and useful supportive tool for diagnosing FNSD in children.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Laboratory Features of Pediatric Agammaglobulinemia: A Comparative Analysis of Classical, Common Variable Immunodeficiency, and Syndromic Forms. 儿童无球蛋白血症的临床和实验室特征：经典、常见的可变免疫缺陷和综合征形式的比较分析。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-07-23 DOI: 10.1007/s13312-026-00405-5

Tugce Akkus, Mehmet Ali Karaselek, Sukru Nail Guner, Sevgi Keles, Ismail Reisli

{"title":"Clinical and Laboratory Features of Pediatric Agammaglobulinemia: A Comparative Analysis of Classical, Common Variable Immunodeficiency, and Syndromic Forms.","authors":"Tugce Akkus, Mehmet Ali Karaselek, Sukru Nail Guner, Sevgi Keles, Ismail Reisli","doi":"10.1007/s13312-026-00405-5","DOIUrl":"https://doi.org/10.1007/s13312-026-00405-5","url":null,"abstract":"Objective: To compare the clinical, laboratory, and treatment characteristics of classical, common variable immunodeficiency (CVID)-related, and syndromic agammaglobulinemia in children with profound hypogammaglobulinemia.Methods: We retrospectively reviewed 25 children with profound hypogammaglobulinemia evaluated between 2005 and 2023. Patients were classified as classical (G1), CVID-related (G2a), or syndromic (G2b) agammaglobulinemia, and their clinical presentation, laboratory findings, and treatment outcomes were compared.Results: Of the 25 children, 20 (80%) were boys. Classical agammaglobulinemia was diagnosed at a younger age and was associated with a longer duration of immunoglobulin replacement therapy. A family history of unexplained deaths was more frequent in non-classical forms. Syndromic agammaglobulinemia was characterized by growth failure and lower platelet counts.Conclusion: Agammaglobulinemia comprises clinically distinct classical, CVID-related, and syndromic forms. Recognition of phenotypic clues, including family history, growth failure, and thrombocytopenia, may facilitate earlier diagnosis, timely referral, and initiation of immunoglobulin replacement therapy, thereby reducing infection-related morbidity.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotypic and Phenotypic Profile of Hereditary Spastic Paraplegia in Children: A Single-Centre Study from Northern India. 儿童遗传性痉挛性截瘫的基因型和表型：一项来自印度北部的单中心研究。

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-07-23 DOI: 10.1007/s13312-026-00403-7

Niladri Das, Arya Shambhavi, Haseena Sait, Amita Moirangthem, Deepti Saxena, Shubha R Phadke

{"title":"Genotypic and Phenotypic Profile of Hereditary Spastic Paraplegia in Children: A Single-Centre Study from Northern India.","authors":"Niladri Das, Arya Shambhavi, Haseena Sait, Amita Moirangthem, Deepti Saxena, Shubha R Phadke","doi":"10.1007/s13312-026-00403-7","DOIUrl":"https://doi.org/10.1007/s13312-026-00403-7","url":null,"abstract":"Objective: To characterize the genotypic and phenotypic spectrum of children with genetically confirmed hereditary spastic paraplegia (HSP) at a tertiary care center in Northern India.Methods: This prospective case series included patients with genetically confirmed (whole exome sequencing or clinical exome sequencing) HSP attending the Medical Genetics Clinic of a tertiary care center in Northern India between 2018 and 2023. Neurological and radiological assessments were also conducted.Results: A total of 21 patients from 16 families were included. The median (q1, q3) age of onset of symptoms was 5 (1.5, 8.5) years, and the median (q1, q3) age of diagnosis was 8 (5, 13.5) years. The most common features at diagnosis were toe walking with progressive spasticity of lower limbs. Genetic testing identified 18 variants across eight different genes, including six pathogenic variants, 10 likely pathogenic variants, and two variants of uncertain significance (VUS). Thirteen families had autosomal recessive (AR) HSP, two had autosomal dominant (AD) HSP, and one had X-linked HSP. The most frequently identified subtype was SPG35 (spastic paraplegia type 35), observed in six families, followed by SPG11 in three families and SPG52 in two families. There was one family each with SPG18B, SPG15, CSPSD (cataracts, spastic paraplegia, and speech delay), SPG4, and SPG2.Conclusions: Hereditary spastic paraplegia exhibits genotypic and phenotypic heterogeneity with a predominance of AR inheritance. Five novel variants and some recurrent variants, suggesting potential founder effects, were noted. HSP should be suspected in cases with slowly progressive spasticity in lower limbs, even without a family history, which may mimic cerebral palsy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Cardiac Function Among Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA) Preterm (28-34 Weeks) Neonates During the First 72 Hours of Life: A Prospective Study. 小胎龄（SGA）和适宜胎龄（AGA）早产儿（28-34周）出生后72小时心功能的比较：一项前瞻性研究

IF 1.5 4区医学

Indian pediatrics Pub Date : 2026-07-16 DOI: 10.1007/s13312-026-00400-w

Priyanka Gupta, Sai Kiran Deshabhotla, Venkateshwarlu Vardhelli, Sadhana Narala, Sruthi Nair, Prasen Reddy Tamatam, Tejo Pratap Oleti

{"title":"Comparison of Cardiac Function Among Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA) Preterm (28-34 Weeks) Neonates During the First 72 Hours of Life: A Prospective Study.","authors":"Priyanka Gupta, Sai Kiran Deshabhotla, Venkateshwarlu Vardhelli, Sadhana Narala, Sruthi Nair, Prasen Reddy Tamatam, Tejo Pratap Oleti","doi":"10.1007/s13312-026-00400-w","DOIUrl":"https://doi.org/10.1007/s13312-026-00400-w","url":null,"abstract":"Objective: Small for gestational age (SGA) neonates are known to have altered cardiovascular adaptation; however, data on cardiac function during the early transitional period in preterm neonates remain limited. This study aimed to compare cardiac function during the first 72 h of life between preterm SGA and appropriate for gestational age (AGA) neonates.Methods: In this prospective study done at an Indian tertiary care neonatal centre, cardiac function by echocardiography was compared at three predefined time points during the first 72 h of life between hemodynamically stable preterm (28 0/6-34 6/7) SGA and AGA neonates.Results: A total of 57 SGA and 91 AGA neonates were studied. On descriptive analysis, systolic and diastolic filling parameters were comparable between SGA and AGA neonates across time points. On repeated measures analysis adjusted for gestational age, sex, maternal factors, and antenatal doppler findings, there was no significant group difference in the left ventricular output (primary outcome variable). Among the secondary outcome variables, ejection fraction and isovolumic relaxation time showed significant differences on initial analysis; however, these did not remain significant after Bonferroni correction for multiple comparisons. Perfusion index demonstrated a significant time effect that persisted after Bonferroni correction, indicating dynamic changes during the early transitional period.Conclusion: Hemodynamically stable SGA and AGA neonates had comparable left ventricular output and other systolic and diastolic functional parameters, except for a time-related change in perfusion index, likely reflecting physiological transition.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0