{"title":"Profile of Injuries Among Under-Five Children in Rural Areas of Khordha District, Odisha-A Community-Based Cross-Sectional Study.","authors":"Mythry Ravichandran, Arvind Kumar Singh, Prajna Paramita Giri, Priyamadhaba Behera, Binod Kumar Patro","doi":"10.1007/s13312-025-00036-2","DOIUrl":"10.1007/s13312-025-00036-2","url":null,"abstract":"<p><strong>Objectives: </strong>To estimate the prevalence, patterns, and risk factors for injury among under-five children.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted in the rural areas of Khordha district among 600 under-five children. A multistage sampling technique was used to assess the prevalence, patterns, and factors associated with injuries using a semi-structured questionnaire, followed by an environmental hazard assessment of the built environment of the selected participants.</p><p><strong>Results: </strong>Childhood injury prevalence was 44.6% (95% CI 40.6, 48.7). Falls were the commonest injuries; 87% falls occurred at home. Only 19% of the major injuries received formal healthcare. The child's age, parental awareness, and environmental hazard risk were associated with the occurrence of injuries.</p><p><strong>Conclusion: </strong>The built environment plays a significant role in childhood injuries in the rural areas of Odisha. Public health measures such as a safe built environment for households and neighborhoods should be promoted.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"356-360"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-04-15DOI: 10.1007/s13312-025-00037-1
Antoine Fakhry AbdelMassih, Sherif ElAnwary, Nourhan Taha, Noha Radwan, Mahmoud Othman AbouDeif
{"title":"Circulating Intercellular Adhesion Molecule as a Novel Marker of Pulmonary Hypertension in Newborn.","authors":"Antoine Fakhry AbdelMassih, Sherif ElAnwary, Nourhan Taha, Noha Radwan, Mahmoud Othman AbouDeif","doi":"10.1007/s13312-025-00037-1","DOIUrl":"https://doi.org/10.1007/s13312-025-00037-1","url":null,"abstract":"<p><strong>Background: </strong>IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.</p><p><strong>Methodology: </strong>Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.</p><p><strong>Results: </strong>Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).</p><p><strong>Conclusion: </strong>ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Profile of Musculoskeletal Anomalies in Indian Children with Down Syndrome.","authors":"Deepshikha, Devendra Mishra, Sumit Sural, Seema Kapoor","doi":"10.1007/s13312-025-00059-9","DOIUrl":"https://doi.org/10.1007/s13312-025-00059-9","url":null,"abstract":"<p><strong>Objectives: </strong>This hospital-based study evaluated the magnitude and characteristics of musculoskeletal anomalies in children with Down syndrome.</p><p><strong>Methods: </strong>Children aged 3 months to 14 years, diagnosed to have Down syndrome by karyotyping, were evaluated for musculoskeletal anomalies. We excluded children diagnosed with another chronic condition affecting musculoskeletal health (e.g., cerebral palsy, muscular diseases); and those with any acute illness, which is likely to affect evaluation for musculoskeletal anomalies. A detailed history was taken, and clinical examination was performed by a pediatrician and an orthopedic surgeon. Detailed joint examination was done using pGALS (pediatric Gait Arms Legs and Spine), and Beighton Hypermobility Score was used to assess hypermobility in those aged 6 year or more. X-ray cervical spine (lateral view in neutral, flexion and extension) was done for all children to determine atlantoaxial instability. Additionally, in children with any suspected musculoskeletal anomaly on clinical examination, relevant radiological investigations were performed under the guidance of an orthopedic surgeon.</p><p><strong>Results: </strong>The median (IQR) age of the study population (n = 75) was 5 (2.5, 8) years with 56% boys. Musculoskeletal anomalies were identified in 86.6% (n = 65). Hypotonia and joint laxity (77.3% each) were common in the whole group; pes planus (82%) and orthopedic abnormalities (69.3%) were prevalent among ambulatory children. Occurrence of genu valgum was found to increase with increasing body mass index (P = 0.045).</p><p><strong>Conclusions: </strong>Musculoskeletal problems were common in children with Down syndrome, and this information may guide health professionals in early identification of musculoskeletal problems in children with Down syndrome.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utility of Fecal Biomarkers to Predict Invasive Nature of Acute Infectious Diarrhea in Indian Children.","authors":"Prabhav Aggarwal, Raghvendra Singh, Masoom Nathani, Sonal Saxena, Oves Siddiqui","doi":"10.1007/s13312-025-00030-8","DOIUrl":"https://doi.org/10.1007/s13312-025-00030-8","url":null,"abstract":"<p><strong>Objective: </strong>To determine role of fecal calprotectin (FC) and fecal lactoferrin (FL) in diagnosis of invasive diarrhea.</p><p><strong>Methods: </strong>Stool samples from 75 children (≤ 12 years) with acute diarrhea were analysed using wet mount microscopy, culture, multiplex polymerase chain reaction, rapid tests for Rotavirus/ Adenovirus and quantitative ELISA for FC and FL.</p><p><strong>Results: </strong>The mean (SD) FC levels (μg/g) [774 (626.59) vs. 213 (251.48), P < 0.001] and FL levels (μg/g) [7.95 (4.72) vs. 4.22 (3.91), P = 0.004] were significantly higher in children with invasive diarrhea (n = 38) compared to those with non-invasive diarrhea (n = 37). Cut-off values of FC > 243 μg/g (sensitivity 81.57%, specificity 67.56%, AUC 0.813) and for FL > 6.02 μg/g (sensitivity 71.05%, specificity 81.08%, AUC 0.732) have diagnostic potential.</p><p><strong>Conclusions: </strong>FC and FL can aid diagnosis of acute invasive diarrhea.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-04-01Epub Date: 2025-03-28DOI: 10.1007/s13312-025-00054-0
Hongnan Ye
{"title":"Reforming Medical Education to Address the Challenge of Professional Identity for Medical Students.","authors":"Hongnan Ye","doi":"10.1007/s13312-025-00054-0","DOIUrl":"10.1007/s13312-025-00054-0","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"318-319"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-04-01DOI: 10.1007/s13312-025-00069-7
Joseph L Mathew
{"title":"Levofloxacin Preventive Therapy for Children Living with Adults with MDR-TB: Evidence-Based Medicine Viewpoint.","authors":"Joseph L Mathew","doi":"10.1007/s13312-025-00069-7","DOIUrl":"10.1007/s13312-025-00069-7","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"306-309"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simplifying Strategies to Enable Universal, Decentralized Cord Blood TSH Screening: Lessons from a Tertiary Care Center in North India.","authors":"Dhruv Singh Gaur, Varun Vij, Anju Virmani, Ganesh Jevalikar, Manish Malik","doi":"10.1007/s13312-025-00003-x","DOIUrl":"10.1007/s13312-025-00003-x","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the utility of cord blood thyroid stimulating hormone (CBTSH) for improving the universal newborn screening (UNBS) strategy, and to generate regional normative data.</p><p><strong>Methods: </strong>Data of UNBS using CBTSH and cord blood free thyroxine (CBfT4) over two years (01 April 2022 to 31 March 2024) in all inborn deliveries was analyzed using descriptive statistics.</p><p><strong>Results: </strong>Out of 2218 neonates delivered to 2094 mothers, data was available for 2116 newborns (54.4% males; 68.2% term gestation; 27%, 3.5%, and 0.9% late, early and extreme preemies, respectively; 61% appropriate-for-gestational age). The mean (SD) CBTSH was 7 (5.3) mIU/L (3rd-97th percentiles: 2.6-18.8 mIU/ml); higher in extreme preterms, extremely low birth weight (< 1000 g) and sick babies. Mean (SD) cord blood free thyroxine (CBfT4) was 0.99 (0.2) ng/dL (3rd-97th percentiles: 0.7-1.4 ng/dL), lower in extreme preterms. 58 newborns (recall rate 2.7%) had CBTSH > 20 mIU/L (all had normal CBfT4) and were recalled: 5 did not return, 52/53 were normal on retesting. Only 2/58 newborns had CBTSH > 40 mIU/L: one had confirmed CH. With CBTSH cutoff > 40 mIU/L, recall rate could have been reduced to 0.09%.</p><p><strong>Conclusion: </strong>We propose simplified screening strategies of \"retest and recall\", and using three CBTSH categories, i.e., (a) < 20 mIU/L: normal, discharge; (b) 20-40 mIU/L: test CBfT4, if < 0.7 ng/dL, do confirmatory venous TSH & fT4 at 72 h age (before discharge); (c) > 40 mIU/L: confirmatory venous TSH & fT4 at 72 h (before discharge): if venous TSH < 20 mIU/L: normal; TSH 20-40 mIU/L or fT4 < 0.7 ng/dL: recall and retest at 7-10 days age. If confirmatory venous TSH is high or fT4 is low, start replacement. This would improve decision-making and minimize burden of unnecessary recalls while ensuring early identification.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"276-282"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-04-01DOI: 10.1007/s13312-025-00070-0
Vasant Khalatkar
{"title":"Breaking the Chains of Childhood Obesity.","authors":"Vasant Khalatkar","doi":"10.1007/s13312-025-00070-0","DOIUrl":"10.1007/s13312-025-00070-0","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"259"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}