Indian pediatrics最新文献_第8页

Mitochondrial Dysfunction, Oxidative Stress and Premature Aging in Children With Nutritional Rickets. 营养性佝偻病儿童的线粒体功能障碍、氧化应激和早衰。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-06-07

Raaj Lakshmi, - Aaradhana, Mohit Mehndiratta, Dheeraj Shah, Piyush Gupta

{"title":"Mitochondrial Dysfunction, Oxidative Stress and Premature Aging in Children With Nutritional Rickets.","authors":"Raaj Lakshmi, - Aaradhana, Mohit Mehndiratta, Dheeraj Shah, Piyush Gupta","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To assess the mitochondrial dysfunction, oxidative stress and premature aging in children with nutritional rickets.Methods: This cross-sectional study enrolled children aged 6 months - 5 years with nutritional rickets attending a tertiary care hospital between January 2021 and August 2022. Mitochondrial dysfunction, oxidative stress and premature aging were assessed by measuring the mitochondrial DNA (mtDNA) content, total antioxidant status (TAOS) and telomere length (TL) in 40 children with nutritional rickets and 40 age- and sex- matched healthy children without rickets (controls).Results: The median (IQR) mtDNA content was significantly higher in children with rickets as compared to controls [152.27 (111.83, 218.66) vs 93.7 (72.5, 134.14); P < 0.001], implying mitochondrial dysfunction attributed to increased mitochondrial biogenesis in children with rickets. The median (IQR) TAOS ( mM Trolox equiv.) was significantly lower in children with rickets than controls [4.54 (3.93, 5.73) vs 7.86 (5.09, 9.58); P < 0.001)]. The median (IQR) TL in cases was significantly longer in children with rickets compared to controls [417.31 (111.83,218.66) vs 93.7 (72.5,134.14); P < 0.001] implying that children with rickets do not have premature aging.Conclusions: Children with rickets have high oxidative stress and mitochondrial dysfunction but no evidence of premature aging.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"750-755"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Supplementation in Children with Attention Deficit Hyperactivity Disorder: A Single Centre Study. 注意缺陷多动障碍儿童的铁质补充：单中心研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-07-12

Varun Kumar, Monica Juneja, Smita Kaushik, Arpita Gupta

{"title":"Iron Supplementation in Children with Attention Deficit Hyperactivity Disorder: A Single Centre Study.","authors":"Varun Kumar, Monica Juneja, Smita Kaushik, Arpita Gupta","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To assess the effect of iron supplementation on symptoms in children with attention deficit hyperactivity disease (ADHD).Methods: A prospective single arm intervention study was conducted on children aged 4-12 years, newly diagnosed with ADHD, attending the child development clinic in a tertiary centre in Northern India. A baseline hemogram and serum ferritin levels were assessed in all children. ADHD symptom severity was assessed with age-appropriate neuropsychometric questionnaires, and objective tests of attention at baseline and after six weeks of oral iron therapy.Results: Out of 32 participants, 23 were found to be ferritin sufficient (serum ferritin > 30 ng/mL) at enrolment. There was no difference in the median scores of neuropsychometric tests at the baseline of ferritin sufficient and ferritin deficient children. A statistically significant change in median scores of inattention and hyperactivity subscale on Conner's Rating Scale (P = 0.036) as well as significant improvement on tests of attention; Children's Color Trails Test (CCTT) (P = 0.006) were observed after six weeks of iron therapy in all children.Conclusion: The study showed promising results of iron supplementation in the treatment of ADHD symptoms in children. Keywords: ADHD, Anemia, Inattention, Serum ferritin.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"745-749"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HSPDA Treatment - Does the Outcome Reflect Reality?: Author's Reply. HSPDA 治疗--结果是否反映了现实？作者的回复。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15

Deepika Kainth, Ramesh Agarwal

引用次数: 0

Basal and FSH-stimulated Inhibin B in Precocious Puberty. 性早熟的基础和 FSH 刺激抑制素 B

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-05-25

Shakun Chaudhary, Rama Walia, Anil Bhansali, Devi Dayal, Naresh Sachdeva, Tulika Singh, Sanjay Kumar Bhadada

{"title":"Basal and FSH-stimulated Inhibin B in Precocious Puberty.","authors":"Shakun Chaudhary, Rama Walia, Anil Bhansali, Devi Dayal, Naresh Sachdeva, Tulika Singh, Sanjay Kumar Bhadada","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP).Methods: This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (n = 10), healthy girls with normal pubertal development (pubertal control) (n = 8) and healthy prepubertal girls (prepubertal control) (n = 7). Girls with early puberty were classified as premature thelarche or GDPP based on GnRH agonist stimulation test.Results: Median (IQR) basal inhibin B levels (pg/mL) in premature thelarche was 5.42 (2.91, 30.58) and FSH-stimulated inhibin B was 236.72 (111.53, 4431.73) (P = 0.043). Median (IQR) basal inhibin B in GDPP was 64.11 (24.96, 792.45) pg/mL and FSH-stimulated inhibin B was 833.66 (500.11-1266.18) pg/mL (P = 0.043). Basal inhibin B was discriminatory between GDPP and premature thelarche (P = 0.032). Median (IQR) basal inhibin B in prepubertal and pubertal controls was 20.36 (9.61, 29.12) and 75.48 (58.55, 165.55) pg/mL, respectively.Conclusion: Basal inhibin B is useful in differentiation of premature thelarche from GDPP while the role of FSH-stimulated inhibin B needs to be further explored in large sample size.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"756-759"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extended Pulse Oximetry Screening in Healthy Neonates. 健康新生儿的扩展脉搏氧饱和度筛查。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-06-07

Supreet Khurana, Suksham Jain, Deepak Chawla, Jeet Ram Kashyap

引用次数: 0

Incontinentia Pigmenti. Incontinentia Pigmenti.

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-07-12

Tiasa Pal, Sonia Agrawal, Chander Grover

引用次数: 0

HSPDA Treatment - Does the Outcome Reflect Reality? HSPDA 治疗--结果是否反映现实？

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15

Aditya Bhatt, Somashekhar Nimbalkar

引用次数: 0

Profile of Chronic Non-Epilepsy Drug Use in Children with Epilepsy: Single Centre Experience. 癫痫儿童长期服用非癫痫药物的概况：单中心经验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-07-12

Mehul Suthar, Devendra Mishra, Monica Juneja, Bhupinder Singh Kalra, Yajika Arya

引用次数: 0

Peer-Assisted Learning Versus Faculty-Led Teaching of Interviewing Skills: A Comparative Study. 同伴辅助学习与教师指导面试技巧教学的比较研究：比较研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-04-05

Sameerah Abdulrahman, Nazdar Ezzaddin Alkhateeb, Samir Mahmood Othman

{"title":"Peer-Assisted Learning Versus Faculty-Led Teaching of Interviewing Skills: A Comparative Study.","authors":"Sameerah Abdulrahman, Nazdar Ezzaddin Alkhateeb, Samir Mahmood Othman","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To assess the impact of peer-assisted learning (PAL) on students' proficiency in patient interviewing skills and to explore medical students' perception on peer tutors in educational setting.Methods: A cross-sectional observational study was performed in the College of Medicine, Hawler Medical University, Erbil, Iraq, between September 2021 and November 2021. The participants included second year medical students who were attending the Integrated Basic Sciences (IBS) module. The peer tutors were chosen from a group of sixth year medical students who had completed an intensive 18-hour communication skills course. The summative video assessment marks of study participants and their perceptions on the process were compared between the faculty-led group and the peer-assisted learning (PAL) group.Results: Peer-assisted learning group (n = 83) had significantly higher mean (SD) scores compared to those in the faculty-led group (n = 92), [74.6 (8.1) vs 70.4 (7.1), P < 0.001]. Encouraging feedback was received from students regarding the PAL sessions with the most positive feedback regarding the ease in asking questions.Conclusion: Peer-assisted learning improved students' performance in patient interviewing skills and fostered positive perceptions of the learning experience.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"735-739"},"PeriodicalIF":1.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflection: A Tool for Learning and Assessment in Competency-Based Curriculum. 反思：能力本位课程中的学习和评估工具。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-08-15 Epub Date: 2024-06-20

Nilima Shah, Piyush Gupta, Tejinder Singh

引用次数: 0