Indian pediatrics最新文献

Mobile Direct Observed Therapy (MDOT) for Inhaler Therapy in Children With Newly Diagnosed Asthma: A Pilot Study. 移动直接观察疗法 (MDOT) 用于新诊断为哮喘的儿童的吸入器治疗：试点研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-10

Amit Pathania, Kana Ram Jat, Meenakshi Pathania, Rakesh Lodha, Sushil K Kabra

{"title":"Mobile Direct Observed Therapy (MDOT) for Inhaler Therapy in Children With Newly Diagnosed Asthma: A Pilot Study.","authors":"Amit Pathania, Kana Ram Jat, Meenakshi Pathania, Rakesh Lodha, Sushil K Kabra","doi":"","DOIUrl":"","url":null,"abstract":"Objective: We aimed to assess the acceptability of Mobile Direct Observed Therapy (MDOT) amongst the parents/caregivers of children with asthma.Methods: This open-label pilot randomized controlled trial enrolled newly diagnosed children aged 5-15 years with asthma, who were followed up telephonically for six weeks. Parents of children in the intervention arm were requested to record a video of the metered dose inhaler with spacer (MDI-S) technique of their child on a mobile phone and share it through WhatsApp with investigator who then provided corrective measures as required by a text/video message. The children in the control arm continued follow-up telephonically without exchange of any videos for six weeks. The primary outcome measures were the acceptability of MDOT and the effect of such interaction on the correctness of the MDI-S technique. Secondary outcome measures were the level of asthma control as per GINA guidelines and the caregivers' perception and feedback about MDOT.Results: A total of 30 children were enrolled, 15 in each arm. Thirteen (86%) parents uploaded good-quality videos. The average number of incorrect steps decreased from 2.64 in the first video to 0.18 after the fourth video and nil after the fifth video in the MDOT group. At six weeks of follow-up, the average number of incorrect steps was significantly lower in the MDOT group compared to the control group (0 vs 2.9; P < 0.001). The proportion of children having controlled asthma was better in the MDOT group compared to controls (85% vs 70%) (P = 0.39). All parents liked MDOT.Conclusion: MDOT was well accepted by caregivers of children with asthma and was helpful in improving the MDI-S technique.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1109-1113"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Molecular Profile of Duchenne Muscular Dystrophy (DMD): Case-Record Analysis From Uttar Pradesh, India. 杜氏肌肉萎缩症 (DMD) 的临床和分子特征：印度北方邦的病例记录分析。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-24

Ankur Singh, Minketan Sidar, Akhtar Ali, Abhishek Abhinay, Rajniti Prasad, Om Prakash Mishra

{"title":"Clinical and Molecular Profile of Duchenne Muscular Dystrophy (DMD): Case-Record Analysis From Uttar Pradesh, India.","authors":"Ankur Singh, Minketan Sidar, Akhtar Ali, Abhishek Abhinay, Rajniti Prasad, Om Prakash Mishra","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To assess the clinical and molecular profile of patients with Duchenne Muscular Dystrophy (DMD) presenting to a tertiary center in Eastern Region of Uttar Pradesh, India.Methods: In this retrospective study, case records of all patients diagnosed as DMD were analyzed to ascertain the clinical phenotype and molecular profile. Multiplex polymerase chain reaction (mPCR) technique, Multiplex Ligation Dependent Probe Amplification (MLPA) and Next Generation Sequencing (NGS) were used for establishing the molecular diagnosis. Leiden Open Variation Database (LOVD) frame checker online tool was used to predict clinical severity of the cases.Results: Records of 112 children with DMD were analyzed. The median (IQR) age of onset and clinical presentation of disease was 60 (12, 132) months and 90 (33, 156) months, respectively. The most common clinical presentations were difficulty in standing from sitting position (n = 107), difficulty in climbing stairs (n = 106), and difficulty in walking (n = 99). Bilateral calf muscle hypertrophy and a positive Gower's sign was seen in 110 and 108 patients at presentation. The median (IQR) creatinine phosphokinase (CPK) levels at diagnosis were 6296.5 (4320, 7432.5) U/L. The genetic variation in 111 patients were reported as deletion (n = 105), duplication (n = 3), and point variation (n = 3). 22 patients could benefit from the available exon skipping therapy. Exondys (exon 51 skipping) could be used in 14 patients.Conclusion: Deletions were recorded in a much higher proportion of patients compared to previous studies from India. There were 22 patients who could have been benefitted by the available exon skipping therapy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1119-1122"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mumps Epidemic in Navi Mumbai in 2023-24: Lessons for the Health Management System. 2023-24 年纳维孟买流行性腮腺炎：健康管理系统的经验教训。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-24

Dhanya Dharmapalan, Jeetendra Gavhane, Asmita Patil, Satish Shahane, Suhas Warad, Yashank Yewale, Praveen Mody, Vijay Yewale, T Jacob John

{"title":"Mumps Epidemic in Navi Mumbai in 2023-24: Lessons for the Health Management System.","authors":"Dhanya Dharmapalan, Jeetendra Gavhane, Asmita Patil, Satish Shahane, Suhas Warad, Yashank Yewale, Praveen Mody, Vijay Yewale, T Jacob John","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the morbidity due to the mumps epidemic in Navi Mumbai region of Maharashtra during 2023-24 and identify the preventive strategies.Methods: An outbreak investigation was carried by pediatricians in Navi Mumbai, Maharashtra, India, between December 2023 and February 2024. A clinical case of mumps was defined as any person with acute onset of unilateral or bilateral, tender, swelling of the parotid or other salivary gland(s), lasting at least two days.Results: 217 documented cases of mumps were investigated. Among them 197 (90.78%) had never received mumps vaccine, and 20 had received Measles-Mumps-Rubella vaccine (MMR) in the private sector. 185 children had been immunized with Measles-Rubella Vaccine (MR) in the National Immunization programme. The opportunity to vaccinate with the additional component of mumps had been missed during immunization with MR vaccine.Conclusion: This outbreak investigation highlights the need to establish a Public Health Division in the Government for monitoring all contagious diseases in the community and the timely detection and control of all outbreaks.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1123-1126"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appropriate Methodology for Studies on Normative Data: Correspondence: Author's Reply.

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15

Anup Thakur, Anita Singh

引用次数: 0

Auxological Dynamics of Cephalic Index in Indian Children with Down Syndrome: A Longitudinal Study. 印度唐氏综合症儿童头围指数的辅助动态变化：纵向研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-10

Harvinder Kaur, Anil Kumar Bhalla, Rupinder Kaur, Inusha Panigrahi, Neha Sudhera

引用次数: 0

Strengthening the fight against CLABSI: Insights from comparative study of UVC vs PICC line: Author's Reply.

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15

Srinivas Murki

引用次数: 0

Genetic Profile of Beta-Thalassemia and Sickle Cell Disease in Eastern Uttar Pradesh. 印度北方邦东部 Beta-Thalassemia 和镰状细胞病的遗传概况。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-10

Priyanka Aggarwal, Akhtar Ali, Vineeta Gupta

引用次数: 0

POCUS in Critically-ill Children with Acute Kidney Injury. 急性肾损伤重症儿童的 POCUS。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-11-26

Sidharth Sethi, Jieji Hu, Rupesh Raina

引用次数: 0

Sensing the Simmering Inflammation: Clues for Diagnosis of Underlying Rheumatic Disorder. 感知酝酿中的炎症：诊断潜在风湿病的线索

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-10

Chandrika S Bhat, Athimalaipet V Ramanan, Narendra Kumar Bagri

引用次数: 0

Autonomic Disturbances in Children with Nutcracker Syndrome: A Case Control Study. 胡桃钳综合征患儿的自主神经紊乱：病例对照研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2024-12-15 Epub Date: 2024-09-10

Yasemin Nuran Dönmez, Adem Yasin Koksoy, Derya Bako, Dilek Giray, Serdar Epcacan

{"title":"Autonomic Disturbances in Children with Nutcracker Syndrome: A Case Control Study.","authors":"Yasemin Nuran Dönmez, Adem Yasin Koksoy, Derya Bako, Dilek Giray, Serdar Epcacan","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To describe the autonomic nervous system abnormalities including frequency of orthostatic symptoms, orthostatic response to the active standing test and analysis of heart rate variability (HRV) parameters in children with Nutcracker syndrome (NCS).Methods: A case-control study was conducted between May and November 2023. We included children with NCS and healthy age- and sex-matched healthy controls. Children were evaluated for autonomic system disturbances by history for orthostatic symptoms, performance in an active standing test, 24-hour holter monitoring to determine the heart rate variability (HRV), maximum and minimum heart rates, and the average heart rate and urine analysis for orthostatic proteinuria and hematuria.Results: 45 children with NCS and 47 age-matched healthy controls were included. Orthostatic symptoms were observed in 55.5% of the NCS patients, with dizziness being the predominant complaint (37%), followed by fatigue (20%), palpitations (13%), headache (11%), vision disturbances (11%), syncope (6%), chest discomfort (4%), and diaphoresis (2%). In the 24-h holter monitoring of 24 patients, a decrease in the standard deviation of the NN intervals (SDNN), root mean square of successive R-wave peak to R-wave peak (RR) interval differences (rMSSD) was observed. SDNN was significantly lower in NCS compared to the control group; 135.5 (42.3) vs 155.9 (35.2), P = 0.039. rMSDD was also significantly lower in the NCS compared to control group; 46.2 (19.7) vs 61.3 (26.6), P = 0.020. The mean (SD) maximum heart rate was higher in NCS compared to control group; 172.3 (28.4) vs 159.4 (14.6), P = 0.015.Conclusion: Autonomic nervous system dysfunction and orthostatic disturbances may be seen in children with NCS.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1114-1118"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0