{"title":"Sleep Disturbances in Survivors of Childhood Acute Lymphoblastic Leukemia: A Cross-Sectional Study.","authors":"Kanwaljeet Kaur Chopra, Aditya Kumar Gupta, Jagdish Prasad Meena, Biswaroop Chakrabarty, Rajesh Sagar, Ravindra Mohan Pandey, Rachna Seth","doi":"10.1007/s13312-025-00122-5","DOIUrl":"https://doi.org/10.1007/s13312-025-00122-5","url":null,"abstract":"<p><strong>Objectives: </strong>Survivors of childhood cancer are at risk of sleep disturbances, an often, neglected aspect of holistic health. This study was carried out to determine the prevalence of sleep disturbances in survivors of pediatric acute lymphoblastic leukemia (ALL) and to identify any risk factors for the same.</p><p><strong>Methods: </strong>Survivors of ALL aged 6-18 years, who had completed their treatment, at least two or more years ago, were enrolled. The Child Sleep Habits Questionnaire (CSHQ) was used to assess the sleep problems.</p><p><strong>Results: </strong>Out of 89 childhood survivors of ALL, 42.7% had sleep disturbances. Fears during treatment, painful memories during treatment, younger age at enrolment, and shorter interval from treatment completion were significantly more in patients having sleep problems.</p><p><strong>Conclusions: </strong>Approximately half of childhood ALL survivors had sleep problems. Fears during chemotherapy and shorter post-completion interval were significant risk factors for sleep problems in childhood cancer survivors.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychosocial Distress, Depression and Burden Among Primary Caregivers of Children With Steroid-Sensitive Nephrotic Syndrome.","authors":"Mritunjay Kumar, Rashmi Kumari, Rashmi Shukla, Namita Mishra, Amit Shukla, Bimlesh Prasad","doi":"10.1007/s13312-025-00132-3","DOIUrl":"https://doi.org/10.1007/s13312-025-00132-3","url":null,"abstract":"<p><strong>Objective: </strong>This study assessed the psychological distress, depression, and burden among primary caregivers of children with steroid-sensitive nephrotic syndrome (SSNS) and explored its association with disease severity and patient/caregiver demographics.</p><p><strong>Methods: </strong>Psychological assessment of primary caregivers of children aged 6 months to 15 years with SSNS was performed using General Health Questionnaire-12 for psychological distress, Beck Depression Inventory for depression, and Zarit Burden Interview-6 for caregiver burden.</p><p><strong>Results: </strong>Out of 72 eligible caregivers, 60 were included. Severe depression, severe psychological distress, and significant caregiver burden were observed in 38.3%, 30%, and 61.7% of primary caregivers, respectively. Steroid-dependent nephrotic syndrome (SDNS) and disease duration over 24 months increased severe psychological distress. Risk factors for caregiver depression included child < 7 years, female gender, frequently relapsing nephrotic syndrome (FRNS)/SDNS, steroid use > 6 months, > 4 relapses, and prior hospitalization. Caregiver burden was higher in younger age, FRNS/SDNS, hospitalization, and lower middle socio-economic status.</p><p><strong>Conclusion: </strong>Caregivers of children with SSNS experience significant psychological distress, depression, and financial burden.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-07-08DOI: 10.1007/s13312-025-00116-3
Shruti Pai, Sayeeda Arshiya Farheen, Sumithra Selvam, Ramya Padmanabha, B S Chandrakala, Rebecca Kuriyan
{"title":"Exclusive Breastfeeding and Body Composition in Indian Infants: A Prospective Study.","authors":"Shruti Pai, Sayeeda Arshiya Farheen, Sumithra Selvam, Ramya Padmanabha, B S Chandrakala, Rebecca Kuriyan","doi":"10.1007/s13312-025-00116-3","DOIUrl":"https://doi.org/10.1007/s13312-025-00116-3","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between exclusive breastfeeding (BF) and body composition at 3 and 6 months in infants residing in urban Southern India.</p><p><strong>Methods: </strong>Healthy term neonates (n = 135) were recruited at birth and followed up until 6 months. Information on maternal characteristics, sociodemographic factors, and BF were recorded. Anthropometry and body composition (air displacement plethysmography) were assessed. Independent t-test was used to compare variables between groups with or without exclusive BF. The association between exclusive BF and infant body composition at 3 and 6 months were examined using general linear models adjusted for covariates.</p><p><strong>Results: </strong>Exclusive BF rate at 3 and 6 months was 78.9% (90/114) and 22.1% (24/113), respectively. Infants who were exclusively breastfed (EBF) had higher adjusted odds of increased % fat mass (FM), [aOR (95%CI) 16.8 (1.53, 183.80), P = 0.021], FM(kg) [1.23 (1.02, 1.50), P = 0.029] and FM index [1.61 (0.99, 2.63), P = 0.057] and lower odds of % fat free mass (FFM) [0.06 (0.01, 0.67), P = 0.022] at 3 months compared to non-EBF infants. Similarly, EBF infants had higher odds of increased % FM [24.0 (1.69, 339.1), P = 0.019] and significantly lower FFM indices at 6 months.</p><p><strong>Conclusion: </strong>EBF Indian infants had higher FM and lower FFM compared to non-EBF infants in early infancy.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Implications of Musculoskeletal Manifestations in Acute Lymphoblastic Leukemia: A Decade's Experience from a Referral Center in Southern India.","authors":"Konsam Samuel Lyngdoh, Pandya Dhruti, Sidharth Totadri, Somdipa Pal, Jyothi Munireddy, Vandana Bharadwaj, Anand Prakash","doi":"10.1007/s13312-025-00064-y","DOIUrl":"10.1007/s13312-025-00064-y","url":null,"abstract":"<p><strong>Objective: </strong>Children with acute lymphoblastic leukemia (ALL) with musculoskeletal (MSK) manifestations may be misdiagnosed as juvenile idiopathic arthritis (JIA). The present study compared the baseline parameters and survival outcomes in patients with ALL with and without MSK symptoms.</p><p><strong>Methods: </strong>A retrospective chart review of children aged < 18 years diagnosed with ALL was performed. Based on contemporary parameters, the patients were stratified into standard-risk (SR), intermediate-risk (IR), and high-risk (HR) groups. Clinical and laboratory features and survival outcomes were compared between ALL patients with and without MSK symptoms.</p><p><strong>Results: </strong>Out of 255 participants, 67 (26%) had MSK manifestations; of these, 9 were pretreated for JIA with glucocorticoids/methotrexate. Patients with MSK manifestations had a longer median duration of symptoms before diagnosis (4 vs 2 weeks, P < 0.001), and a higher median platelet count (53 × 10<sup>9</sup>/L vs. 28 × 10<sup>9</sup>/L, P = 0.002). The 3-year event-free survival (EFS) for patients with MSK and without MSK manifestations were 84.4 ± 5.2% and 78.9 ± 3.4% (P = 0.900). All 9 pretreated patients received an IR/HR protocol (4 were SR if not for the pretreatment as JIA).</p><p><strong>Conclusion: </strong>Patients with ALL with MSK manifestations have more preserved blood counts and a longer duration of symptoms before diagnosis. Pretreatment of children with ALL misdiagnosed as JIA with glucocorticoids/methotrexate can delay the diagnosis, confound the risk stratification, and upstage the risk group requiring administration of more toxic chemotherapy than necessary otherwise.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"489-494"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-07-01Epub Date: 2025-05-22DOI: 10.1007/s13312-025-00095-5
Kanya Mukhopadhyay
{"title":"Nourishing the Future Generations: Role of Maternal Education, Empowerment and Autonomy.","authors":"Kanya Mukhopadhyay","doi":"10.1007/s13312-025-00095-5","DOIUrl":"10.1007/s13312-025-00095-5","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"547-548"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-07-01Epub Date: 2025-06-04DOI: 10.1007/s13312-025-00109-2
Ashima Mehta, Praveen Suman, Imran Noorani
{"title":"Accuracy of 'Communication and Symbolic Behaviour Scales Developmental Profile-Infant Toddler Checklist' for Screening Communication Delay in Children Aged 6-24 Months Referred to a Child Developmental Clinic.","authors":"Ashima Mehta, Praveen Suman, Imran Noorani","doi":"10.1007/s13312-025-00109-2","DOIUrl":"10.1007/s13312-025-00109-2","url":null,"abstract":"<p><strong>Objective: </strong>To assess the accuracy of the Communication and Symbolic Behaviour Scales Developmental Profile-Infant Toddler Checklist (CSBS-ITC) for screening communication delay in children aged 6-24 months.</p><p><strong>Method: </strong>This hospital-based observational cross-sectional study included 200 children aged 6-24 months of either sex attending the child development clinic. Participants were categorized into high- and low-risk groups based on perinatal and neurological risk factors. The CSBS-ITC was administered to parents, followed by a standardized developmental assessment using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CSBS-ITC were calculated.</p><p><strong>Results: </strong>Communication concerns were identified in 69% of children using the CSBS-ITC, and among these, 65% was confirmed to have language delays on the BSID-III assessment. CSBS-ITC demonstrated a high sensitivity (94%) and specificity (82%), with a positive predictive value of 87% and a negative predictive value of 80%.</p><p><strong>Conclusion: </strong>CSBS-ITC is a useful tool for screening communication delay in high-risk children aged 6-24 months, and the tool exhibits good screening accuracy.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"511-515"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indian pediatricsPub Date : 2025-07-01Epub Date: 2025-06-18DOI: 10.1007/s13312-025-00113-6
Rıza Taner Baran, Gamze Çelmeli, Ceyhun Tıkız, Arif Önder, Özge Gizli Çoban
{"title":"Gynecomastia in Adolescents: Impact on Mental Health and Body Image.","authors":"Rıza Taner Baran, Gamze Çelmeli, Ceyhun Tıkız, Arif Önder, Özge Gizli Çoban","doi":"10.1007/s13312-025-00113-6","DOIUrl":"10.1007/s13312-025-00113-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore depression, anxiety, and body image issues in adolescents with gynecomastia.</p><p><strong>Methods: </strong>Forty adolescents aged 12-18 years diagnosed with gynecomastia and 40 age-matched volunteer healthy adolescent boys were enrolled. Mental health issues were assessed using Beck Anxiety Inventory (BAI), Social Appearance Anxiety Scale (SAAS), the Children's Depression Inventory (CDI), Body Cathexis Scale (BCS), and the Brief Fear of Negative Evaluation Scale (BFNE).</p><p><strong>Results: </strong>The mean (SD) BFNE [29.82 (10.08) vs. 24.62 (9.96); P = 0.023] and the SAAS [42.27 (18.15) vs. 31.32 (14.71); P = 0.004] scales were significantly higher in the patient group compared to controls. A significant negative correlation was observed between age and SAAS (r = - 0.349), and age and BFNE (r = - 0.522). A significant positive correlation was seen between SAAS and the grade of gynecomastia (r = 0.479).</p><p><strong>Conclusion: </strong>Early psychological support is needed to reduce distress in adolescents with gynecomastia.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"521-524"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}