Indian pediatrics最新文献_第2页

Cannabidiol in Drug-Resistant Epilepsy (DRE) in Children: A Retrospective Study. 大麻二酚在儿童耐药癫痫（DRE）中的作用：回顾性研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI: 10.1007/s13312-025-00075-9

Vykuntaraju K Gowda, Halima Simin, Uddhava V Kinhal, G V Basavaraja, K S Sanjay

引用次数: 0

Risk Stratification-Based Therapy for Children with E-beta Thalassemia: A 20-Year Follow-Up Study. 儿童e - β地中海贫血的风险分层治疗：一项20年随访研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-26 DOI: 10.1007/s13312-025-00089-3

Kavitha Ganesan, Suresh Duraisamy, Anupama Nair, Vijayshree Muthukumar, Anurag Nalla Reddy, Minakshi Balwani, Nithya Seshadri, Ramya Uppuluri, Revathi Raj

{"title":"Risk Stratification-Based Therapy for Children with E-beta Thalassemia: A 20-Year Follow-Up Study.","authors":"Kavitha Ganesan, Suresh Duraisamy, Anupama Nair, Vijayshree Muthukumar, Anurag Nalla Reddy, Minakshi Balwani, Nithya Seshadri, Ramya Uppuluri, Revathi Raj","doi":"10.1007/s13312-025-00089-3","DOIUrl":"10.1007/s13312-025-00089-3","url":null,"abstract":"Objective: To present risk stratification-based follow-up of children with E-beta thalassemia.Methods: Children with E-beta thalassemia between August 2002 and August 2022 were classified as mild, moderate, or severe disease using Mahidol scoring. Children in the moderate group with < 20 or ≥ 20 nucleated red blood cells (nRBCs) per 100 white blood cells were clubbed with mild or severe phenotype, respectively. Children with mild/moderate severity received hydroxyurea (HU) and those with severe disease received regular transfusions.Results: Out of 104 children (median age of onset 3.5 years), 30 (29%), 46 (44%), and 28 (27%) were categorized as mild, moderate, and severe disease, at initial presentation. Based on nRBC count, 27 and 19 children in moderate category were recategorized as mild to moderate and moderate to severe. Fifty-six, 19, and 29 children received HU, transfusions with HU, and monthly transfusion and chelation, respectively. At a median follow-up of 8 years, 67/93 (72%) children classified as \"mild to moderate\" remained well on HU, and 26/93 (28%) children classified as \"moderate to severe\" remained on regular transfusions.Conclusion: Using nRBCs in addition to Mahidol scoring can serve as a useful tool to individualize therapy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"506-510"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukemia During Maintenance Chemotherapy and its Association with Severe Febrile Illness. 急性淋巴细胞白血病患儿维持化疗期间血清免疫球蛋白水平及其与重症温病的关系

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1007/s13312-025-00034-4

Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, Guruprasad Chellappan Sojamani, Shwetha Seetharam, Prasanth Varikkattu Rajendran, Jagathnath Krishna

{"title":"Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukemia During Maintenance Chemotherapy and its Association with Severe Febrile Illness.","authors":"Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, Guruprasad Chellappan Sojamani, Shwetha Seetharam, Prasanth Varikkattu Rajendran, Jagathnath Krishna","doi":"10.1007/s13312-025-00034-4","DOIUrl":"10.1007/s13312-025-00034-4","url":null,"abstract":"Objective: To determine the proportion of children with acute lymphoblastic leukemia (ALL) with hypoglobulinemia during maintenance chemotherapy and to determine its association with severe febrile illnesses.Methods: Children with ALL receiving maintenance chemotherapy were prospectively recruited and serum immunoglobulin levels (IgG, IgM, IgA) were measured by turbidimetric method. Children were followed up for severe febrile illnesses for 6 months or till the completion of treatment.Results: We enrolled 199 children with mean (SD) age 82.03 (39.34) months; 58, 52, 47, and 42 children had received 0-6, 7-12, 13-18 and 19-24 months of maintenance chemotherapy, respectively. Hypo-IgG, hypo-IgA, and hypo-IgM were seen in 56.8%, 80.4%, and 86.4% of children. 91 (45.7%) children developed 147 episodes of severe febrile illness. Older age (> 5 years) was associated with decreased risk [odds ratio 95% CI] of hypo-IgG [0.540 (0.297, 0.982), P = 0.044], hypo-IgA [0.030 (0.011, 0.088), P = 0.001], and hypo-IgM [0.323 (0.117, 0.894), P = 0.030] and female gender had decreased risk of hypo-IgG (0.539 (0.305, 0.953), P = 0.033). Older age decreased the risk [0.585 (0.328, 1.041), P = 0.014] and girls were at increased risk [(1.118, 3.488), P = 0.019] of severe febrile illness. Hypoglobulinemia did not increase the risk of severe febrile illness.Conclusion: Hypoglobulinemia was not found to be an independent risk factor for severe febrile illnesses in children with ALL receiving maintenance chemotherapy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"482-488"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence of Children to the Indian Academy of Pediatrics (IAP) Guidelines on Permissible Daily Screen Exposure-A Hospital-Based Cross-Sectional Study from Southern India. 儿童对印度儿科学会（IAP）每日可允许屏幕暴露指南的依从性——一项来自印度南部医院的横断面研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-27 DOI: 10.1007/s13312-025-00097-3

Siva Sai Sushumna Veluguri, Diptirekha Satapathy, Thirunavukkarasu Arun Babu, Vinothkumar Kalidoss

引用次数: 0

Is Shorter (3-4 Days) Antibiotic Therapy Adequate Compared to Standard (5-7 Days) Duration in Neonates with Suspected (Culture Negative) Sepsis? Yes. 疑似（培养阴性）脓毒症新生儿的抗生素治疗时间较标准（5-7天）短（3-4天）是否足够？是。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-06-02 DOI: 10.1007/s13312-025-00103-8

Shiv Sajan Saini

引用次数: 0

Vasoactive Ventilation Renal Score as a Predictor of Outcomes in Children Admitted to PICU: An Observational Study. 血管活性通气肾脏评分作为PICU入院儿童预后的预测指标：一项观察性研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI: 10.1007/s13312-025-00076-8

Shilpi Chauhan, Prerna Batra, Vikram Bhaskar, Piyush Gupta

{"title":"Vasoactive Ventilation Renal Score as a Predictor of Outcomes in Children Admitted to PICU: An Observational Study.","authors":"Shilpi Chauhan, Prerna Batra, Vikram Bhaskar, Piyush Gupta","doi":"10.1007/s13312-025-00076-8","DOIUrl":"10.1007/s13312-025-00076-8","url":null,"abstract":"Objectives: To determine the area under curve (AUC) for vasoactive ventilation renal score (VVRS) > 10 at 24-h of admission for predicting mortality in children aged 1-12 years admitted to pediatric intensive care unit (PICU). To also determine the AUC for VVRS > 10 at 48-h of admission for predicting mortality and to determine the AUC of VVRS > 10 at 24-h and 48-h of admission for predicting PICU stay > 3 days, hospital stay > 10 days and mechanical ventilation > 3 days.Methods: This observational study included 310 children aged 1-12 years admitted in PICU. All required parameters were noted, and VVRS, ventilation index and change in creatinine at 24-h and 48-h of admission were recoded. Receiver operating characteristic curves were computed to determine the predictive role of VVRS > 10 at 24-h and 48-h for mortality, duration of PICU stay, hospital stay and mechanical ventilation.Results: Seventy nine (25%) patients succumbed during the study. VVRS > 10 at 24-h and 48-h had a good predictive role for mortality with AUC of 0.873 (sensitivity 89.87%, specificity 69.70%) and 0.996 (sensitivity 96.20%, specificity 96.10%), respectively. Best cutoffs derived for VVRS (24-h), and VVRS (48-h) were > 2.5 and > 13.5. A higher AUC, sensitivity and specificity of VVRS at 48-h were observed for predicting prolonged PICU stay, duration of mechanical ventilation and hospital stay.Conclusions: VVRS at 24-h and 48-h has a good predictive role for mortality in children admitted to PICU.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"495-500"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary Hypogammaglobulinemia: An Under-Recognized Clinical Entity in Children. 继发性低γ球蛋白血症：儿童中未被充分认识的临床实体。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1007/s13312-025-00084-8

Pandiarajan Vignesh, Surjit Singh

引用次数: 0

Infantile Epileptic Spasms Syndrome Due to Neonatal Hypoglycemic Brain Injury: A Retrospective Audit. 新生儿低血糖性脑损伤引起的婴儿癫痫痉挛综合征：回顾性审计。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-09 DOI: 10.1007/s13312-025-00038-0

Shreya Gupta, Gouri Rao Passi

引用次数: 0

Resuscitation Following Drowning: Key Updates for Improved Outcomes from the American Heart Association (AHA) and the American Academy of Pediatrics (AAP) Guidelines. 溺水后复苏：美国心脏协会（AHA）和美国儿科学会（AAP）指南中改善预后的关键更新。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1007/s13312-025-00085-7

Saroj Kumar Tripathy, Abhishek Kumar, Sarthak Das

引用次数: 0

An Update of the KDIGO Chronic Kidney Disease Guidelines 2024: Takeaway for Pediatricians. 2024年KDIGO慢性肾病指南的更新：儿科医生的外卖

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-26 DOI: 10.1007/s13312-025-00101-w

Akanksha Mahajan, Mukta Mantan

引用次数: 0