{"title":"Correlation Between Perfusion Index and Clinical Risk Index for Babies II Score in Preterm Sick Neonates: A Prospective Cohort Study.","authors":"Shambu S Angadi, Chaitra Angadi, H S Niranjan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the correlation between perfusion index (PI) and Clinical Risk Index for Babies (CRIB) II score in sick preterm neonates < 37-week gestation admitted to neonatal intensive care unit (NICU).</p><p><strong>Method: </strong>This observational study was conducted over period of 18 months in a tertiary care centre. All eligible preterm neonates admitted to NICU were examined. The PI and CRIB II score for each neonate were documented. The primary outcome of the study was correlation between PI and CRIB II scores at admission.</p><p><strong>Results: </strong>383 neonates were enrolled in the study. Mean gestation of neonates was 32 weeks. A strong correlation between PI and CRIB II scores at admission was noted (P = 0.01). We demonstrated a strong association between PI at admission and predischarge mortality of neonates with 92.9% sensitivity and 70% specificity. Lower PI was associated with need of inotropes and invasive ventilation and longer duration of hospital stay. Combined use of PI and CRIB II predicted mortality with 83.3% sensitivity and 80.5% specificity.</p><p><strong>Conclusion: </strong>The perfusion index is a potential bedside measure that correlated well with the CRIB II score, which is a validated tool to assess sick preterm neonates. Preductal PI at admission was associated with predischarge mortality, length of hospital stay, inotrope requirement and need for ventilator support in preterm neonates.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1097-1102"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alyaa Ahdy Abdelaziz, Ahmed Anwer Khattab, Mohammed Hossam Abdelmaksoud, Ramy Mohamed Ghazy, Ahmed Noaman
{"title":"Plasma Copeptin as a Prognostic Marker in Children with Heart Failure.","authors":"Alyaa Ahdy Abdelaziz, Ahmed Anwer Khattab, Mohammed Hossam Abdelmaksoud, Ramy Mohamed Ghazy, Ahmed Noaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role of plasma copeptin in predicting mortality in children with heart failure (HF) in addition to poor outcomes, including sepsis, multiorgan dysfunction syndrome, need for mechanical ventilation, and duration of stay in the pediatric intensive care unit.</p><p><strong>Methods: </strong>This diagnostic study included 76 children aged 1 month to 16 years who were hospitalized with congenital or acquired heart disease with HF, and an age- and gender-matched control group of 65 healthy children. Plasma copeptin level was evaluated within 24 hours of admission. Patient with HF were classified into quartiles according to copeptin levels.</p><p><strong>Results: </strong>The median plasma copeptin level (pmol/L) was significantly higher in children with HF compared to the healthy children (16.8 vs 8.0; P = 0.001). Patients were classified into quartiles according to their plasma copeptin level as follows; Q1, plasma copeptin level < 7.60 pmol/L; Q2, plasma copeptin level 7.60-10.75 pmol/L; Q3, plasma copeptin level 10.76-17.70 pmol/L; Q4, plasma copeptin level >17.70 pmol/L. The Pediatric Risk of Mortality III (PRISM III) score and inotropic scores were significantly different among the quartiles of copeptin levels in HF (P = 0.001 and 0.003, respectively). A higher proportion of patients who developed sepsis and MODS were in the fourth quartile (P = 0.001 and 0.022, respectively). All mechanically ventilated children were also in the fourth quartile. Plasma copeptin level of 35.5 pmol/L had a sensitivity of 72% and a specificity of 92.5% to predict mortality in children with HF (AUC = 0.72, P = 0.046).</p><p><strong>Conclusion: </strong>Plasma copeptin is a novel biomarker for the early prediction of mortality and poor outcomes in children with HF.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1103-1108"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142728181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strengthening the fight against CLABSI: Insights from comparative study of UVC vs PICC line.","authors":"Rohan Modi, Dipen Vasudev Patel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":"61 12","pages":"1149"},"PeriodicalIF":1.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Priyankar Pal, Jigna N Bathia, C Ravali Pratima Goud
{"title":"Is Severe Dengue a Cytokine Storm Syndrome?","authors":"Priyankar Pal, Jigna N Bathia, C Ravali Pratima Goud","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The immunopathogenesis of dengue severity remains an enigma. There is a growing body of evidence pointing towards a transient hyperinflammatory hypercytokinemic state responsible for the development of severe dengue including dengue hemorrhagic fever that coincides with the onset of thrombocytopenia, capillary leak, multiorgan dysfunction and hyperferritinemia. There are several reports of dengue associated hemophagocytic lymphohistiocytosis (HLH). However, the cytokine storm in dengue as well as in other infections may not conform to the classic HLH 2004 diagnostic criteria. Following the recent COVID-19 pandemic, there has been a paradigm shift in the understanding of infection-associated cytokine storms. There is a need to explore timely short-course immunotherapy for the management of selected patients with dengue spiraling into the critical phase.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1059-1064"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Update on the 2024 Guidelines by Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) on the Diagnosis and Management of Pediatric Acute Liver Failure.","authors":"Bikrant Bihari Lal, Seema Alam","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1054-1058"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Somashekhar M Nimbalkar, Purvi R Patel, Mayur K Shinde, Vikas Goyal
{"title":"Survey of Basic Neonatal Resuscitation Program (NRP) Participants in India.","authors":"Somashekhar M Nimbalkar, Purvi R Patel, Mayur K Shinde, Vikas Goyal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of the Basic Neonatal Resuscitation Program (NRP) course and to evaluate the perceived utility of the skills acquired during the course.</p><p><strong>Methods: </strong>This cross-sectional survey aimed to assess the perceptions of participants who attended the Basic NRP course, comprising online video modules and offline workshops, across India. Data were collected between October 2023 and November 2023 for the courses held from May 2022 to April 2023, using a semi-structured questionnaire distributed electronically or via telecommunication.</p><p><strong>Results: </strong>Out of 10,000 participants approached, 6,066 responded which included nurses (60.4%), pediatricians (20%), and medical officers (19.7%). Majority were females (76.4%), in private healthcare (62.1%), with the highest participation from West Bengal (14.72%) among the different states. Satisfaction with online videos was reported as very high by 48.5% and reasonable by 51.5% and one participant reported dissatisfaction. Compared to private healthcare settings, exposure to labor room experience was lesser in government facilities (48.8% vs. 42.5%, P < 0.001). The overall functional equipment was greater in government set-ups compared to private facilities (49.8% vs. 45.2%, P = 0.001).</p><p><strong>Conclusion: </strong>Participants reported improved neonatal resuscitation skills as well as opportunities and facilities to practice after Basic NRP course.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1029-1033"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Variant of 3M2 Syndrome in an Indian Patient: Expanding the Genotype.","authors":"Ankur Singh, Shikhar Garg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":"61 11","pages":"1069"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Triceps Skin Fold Measurement and Risk of Metabolic Syndrome in Overweight and Obese Adolescents.","authors":"Deepika Soundararajan, Premkumar Asokumar, Suresh Dhanam Venkatachalam, Mahesh Venkatesha, Santhanakrishnan Ramakrishnan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prevalence of childhood metabolic syndrome is rising with an increase in obesity. The current confirmatory diagnostic methods for metabolic syndrome are invasive. Triceps Skinfold Thickness (TSFT) measurement is a non-invasive alternative. This cross-sectional study evaluated the performance of TSFT for screening overweight and obese adolescents aged 10-16 years for metabolic syndrome. Out of 60 participants, 17 (28%) had metabolic syndrome. The mean (SD) TSFT measurements were significantly higher in adolescents with metabolic syndrome compared to those without metabolic syndrome [29.4 (6.0) vs. 24.3 (7.6); P = 0.018]. A cutoff of 26.7 mm for TSFT demonstrated 88% sensitivity and 72% specificity in predicting metabolic syndrome. TSFT was found as promising non-invasive screening tool for metabolic syndrome.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1047-1049"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Rare Cause of Iron Deficiency Anemia.","authors":"Sucheta Barnwal, Priyanka Aggarwal, Vineeta Gupta","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"1052-1053"},"PeriodicalIF":1.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}