Indian pediatrics最新文献_第10页

Psychosocial Distress, Depression and Burden Among Primary Caregivers of Children With Steroid-Sensitive Nephrotic Syndrome. 类固醇敏感肾病综合征儿童主要照顾者的心理社会困扰、抑郁和负担

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-08 DOI: 10.1007/s13312-025-00132-3

Mritunjay Kumar, Rashmi Kumari, Rashmi Shukla, Namita Mishra, Amit Shukla, Bimlesh Prasad

{"title":"Psychosocial Distress, Depression and Burden Among Primary Caregivers of Children With Steroid-Sensitive Nephrotic Syndrome.","authors":"Mritunjay Kumar, Rashmi Kumari, Rashmi Shukla, Namita Mishra, Amit Shukla, Bimlesh Prasad","doi":"10.1007/s13312-025-00132-3","DOIUrl":"https://doi.org/10.1007/s13312-025-00132-3","url":null,"abstract":"Objective: This study assessed the psychological distress, depression, and burden among primary caregivers of children with steroid-sensitive nephrotic syndrome (SSNS) and explored its association with disease severity and patient/caregiver demographics.Methods: Psychological assessment of primary caregivers of children aged 6 months to 15 years with SSNS was performed using General Health Questionnaire-12 for psychological distress, Beck Depression Inventory for depression, and Zarit Burden Interview-6 for caregiver burden.Results: Out of 72 eligible caregivers, 60 were included. Severe depression, severe psychological distress, and significant caregiver burden were observed in 38.3%, 30%, and 61.7% of primary caregivers, respectively. Steroid-dependent nephrotic syndrome (SDNS) and disease duration over 24 months increased severe psychological distress. Risk factors for caregiver depression included child < 7 years, female gender, frequently relapsing nephrotic syndrome (FRNS)/SDNS, steroid use > 6 months, > 4 relapses, and prior hospitalization. Caregiver burden was higher in younger age, FRNS/SDNS, hospitalization, and lower middle socio-economic status.Conclusion: Caregivers of children with SSNS experience significant psychological distress, depression, and financial burden.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Implications of Musculoskeletal Manifestations in Acute Lymphoblastic Leukemia: A Decade's Experience from a Referral Center in Southern India. 急性淋巴细胞白血病的肌肉骨骼表现：印度南部转诊中心十年的经验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-07 DOI: 10.1007/s13312-025-00064-y

Konsam Samuel Lyngdoh, Pandya Dhruti, Sidharth Totadri, Somdipa Pal, Jyothi Munireddy, Vandana Bharadwaj, Anand Prakash

{"title":"The Implications of Musculoskeletal Manifestations in Acute Lymphoblastic Leukemia: A Decade's Experience from a Referral Center in Southern India.","authors":"Konsam Samuel Lyngdoh, Pandya Dhruti, Sidharth Totadri, Somdipa Pal, Jyothi Munireddy, Vandana Bharadwaj, Anand Prakash","doi":"10.1007/s13312-025-00064-y","DOIUrl":"10.1007/s13312-025-00064-y","url":null,"abstract":"Objective: Children with acute lymphoblastic leukemia (ALL) with musculoskeletal (MSK) manifestations may be misdiagnosed as juvenile idiopathic arthritis (JIA). The present study compared the baseline parameters and survival outcomes in patients with ALL with and without MSK symptoms.Methods: A retrospective chart review of children aged < 18 years diagnosed with ALL was performed. Based on contemporary parameters, the patients were stratified into standard-risk (SR), intermediate-risk (IR), and high-risk (HR) groups. Clinical and laboratory features and survival outcomes were compared between ALL patients with and without MSK symptoms.Results: Out of 255 participants, 67 (26%) had MSK manifestations; of these, 9 were pretreated for JIA with glucocorticoids/methotrexate. Patients with MSK manifestations had a longer median duration of symptoms before diagnosis (4 vs 2 weeks, P < 0.001), and a higher median platelet count (53 × 109/L vs. 28 × 109/L, P = 0.002). The 3-year event-free survival (EFS) for patients with MSK and without MSK manifestations were 84.4 ± 5.2% and 78.9 ± 3.4% (P = 0.900). All 9 pretreated patients received an IR/HR protocol (4 were SR if not for the pretreatment as JIA).Conclusion: Patients with ALL with MSK manifestations have more preserved blood counts and a longer duration of symptoms before diagnosis. Pretreatment of children with ALL misdiagnosed as JIA with glucocorticoids/methotrexate can delay the diagnosis, confound the risk stratification, and upstage the risk group requiring administration of more toxic chemotherapy than necessary otherwise.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"489-494"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory Metastatic Vulvar Crohn's Disease Mimicking Tuberculosis. 难治性转移性外阴克罗恩病模拟结核。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-04 DOI: 10.1007/s13312-025-00031-7

Vaibhav S Bellary, Jitendra S Oswal

引用次数: 0

Is Shorter (3-4 Days) Antibiotic Therapy Adequate Compared to Standard (5-7 Days) Duration in Neonates with Suspected (Culture Negative) Sepsis? No. 疑似（培养阴性）脓毒症新生儿的抗生素治疗时间较标准（5-7天）短（3-4天）是否足够？否。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-06-05 DOI: 10.1007/s13312-025-00102-9

Suksham Jain

引用次数: 0

Nourishing the Future Generations: Role of Maternal Education, Empowerment and Autonomy. 滋养后代：母亲教育、赋权和自主的作用。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-22 DOI: 10.1007/s13312-025-00095-5

Kanya Mukhopadhyay

引用次数: 0

Accuracy of 'Communication and Symbolic Behaviour Scales Developmental Profile-Infant Toddler Checklist' for Screening Communication Delay in Children Aged 6-24 Months Referred to a Child Developmental Clinic. “沟通与符号行为量表发展概况-婴幼儿量表”筛查6-24月龄儿童沟通迟缓的准确性

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-06-04 DOI: 10.1007/s13312-025-00109-2

Ashima Mehta, Praveen Suman, Imran Noorani

{"title":"Accuracy of 'Communication and Symbolic Behaviour Scales Developmental Profile-Infant Toddler Checklist' for Screening Communication Delay in Children Aged 6-24 Months Referred to a Child Developmental Clinic.","authors":"Ashima Mehta, Praveen Suman, Imran Noorani","doi":"10.1007/s13312-025-00109-2","DOIUrl":"10.1007/s13312-025-00109-2","url":null,"abstract":"Objective: To assess the accuracy of the Communication and Symbolic Behaviour Scales Developmental Profile-Infant Toddler Checklist (CSBS-ITC) for screening communication delay in children aged 6-24 months.Method: This hospital-based observational cross-sectional study included 200 children aged 6-24 months of either sex attending the child development clinic. Participants were categorized into high- and low-risk groups based on perinatal and neurological risk factors. The CSBS-ITC was administered to parents, followed by a standardized developmental assessment using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CSBS-ITC were calculated.Results: Communication concerns were identified in 69% of children using the CSBS-ITC, and among these, 65% was confirmed to have language delays on the BSID-III assessment. CSBS-ITC demonstrated a high sensitivity (94%) and specificity (82%), with a positive predictive value of 87% and a negative predictive value of 80%.Conclusion: CSBS-ITC is a useful tool for screening communication delay in high-risk children aged 6-24 months, and the tool exhibits good screening accuracy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"511-515"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gynecomastia in Adolescents: Impact on Mental Health and Body Image. 青少年男性乳房发育：对心理健康和身体形象的影响。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1007/s13312-025-00113-6

Rıza Taner Baran, Gamze Çelmeli, Ceyhun Tıkız, Arif Önder, Özge Gizli Çoban

引用次数: 0

Cannabidiol in Drug-Resistant Epilepsy (DRE) in Children: A Retrospective Study. 大麻二酚在儿童耐药癫痫（DRE）中的作用：回顾性研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI: 10.1007/s13312-025-00075-9

Vykuntaraju K Gowda, Halima Simin, Uddhava V Kinhal, G V Basavaraja, K S Sanjay

引用次数: 0

Risk Stratification-Based Therapy for Children with E-beta Thalassemia: A 20-Year Follow-Up Study. 儿童e - β地中海贫血的风险分层治疗：一项20年随访研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-05-26 DOI: 10.1007/s13312-025-00089-3

Kavitha Ganesan, Suresh Duraisamy, Anupama Nair, Vijayshree Muthukumar, Anurag Nalla Reddy, Minakshi Balwani, Nithya Seshadri, Ramya Uppuluri, Revathi Raj

{"title":"Risk Stratification-Based Therapy for Children with E-beta Thalassemia: A 20-Year Follow-Up Study.","authors":"Kavitha Ganesan, Suresh Duraisamy, Anupama Nair, Vijayshree Muthukumar, Anurag Nalla Reddy, Minakshi Balwani, Nithya Seshadri, Ramya Uppuluri, Revathi Raj","doi":"10.1007/s13312-025-00089-3","DOIUrl":"10.1007/s13312-025-00089-3","url":null,"abstract":"Objective: To present risk stratification-based follow-up of children with E-beta thalassemia.Methods: Children with E-beta thalassemia between August 2002 and August 2022 were classified as mild, moderate, or severe disease using Mahidol scoring. Children in the moderate group with < 20 or ≥ 20 nucleated red blood cells (nRBCs) per 100 white blood cells were clubbed with mild or severe phenotype, respectively. Children with mild/moderate severity received hydroxyurea (HU) and those with severe disease received regular transfusions.Results: Out of 104 children (median age of onset 3.5 years), 30 (29%), 46 (44%), and 28 (27%) were categorized as mild, moderate, and severe disease, at initial presentation. Based on nRBC count, 27 and 19 children in moderate category were recategorized as mild to moderate and moderate to severe. Fifty-six, 19, and 29 children received HU, transfusions with HU, and monthly transfusion and chelation, respectively. At a median follow-up of 8 years, 67/93 (72%) children classified as \"mild to moderate\" remained well on HU, and 26/93 (28%) children classified as \"moderate to severe\" remained on regular transfusions.Conclusion: Using nRBCs in addition to Mahidol scoring can serve as a useful tool to individualize therapy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"506-510"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukemia During Maintenance Chemotherapy and its Association with Severe Febrile Illness. 急性淋巴细胞白血病患儿维持化疗期间血清免疫球蛋白水平及其与重症温病的关系

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-15 DOI: 10.1007/s13312-025-00034-4

Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, Guruprasad Chellappan Sojamani, Shwetha Seetharam, Prasanth Varikkattu Rajendran, Jagathnath Krishna

{"title":"Serum Immunoglobulin Levels in Children with Acute Lymphoblastic Leukemia During Maintenance Chemotherapy and its Association with Severe Febrile Illness.","authors":"Maharshi Trivedi, Priyakumari Thankamony, Manjusha Nair, Binitha Rajeswari, Guruprasad Chellappan Sojamani, Shwetha Seetharam, Prasanth Varikkattu Rajendran, Jagathnath Krishna","doi":"10.1007/s13312-025-00034-4","DOIUrl":"10.1007/s13312-025-00034-4","url":null,"abstract":"Objective: To determine the proportion of children with acute lymphoblastic leukemia (ALL) with hypoglobulinemia during maintenance chemotherapy and to determine its association with severe febrile illnesses.Methods: Children with ALL receiving maintenance chemotherapy were prospectively recruited and serum immunoglobulin levels (IgG, IgM, IgA) were measured by turbidimetric method. Children were followed up for severe febrile illnesses for 6 months or till the completion of treatment.Results: We enrolled 199 children with mean (SD) age 82.03 (39.34) months; 58, 52, 47, and 42 children had received 0-6, 7-12, 13-18 and 19-24 months of maintenance chemotherapy, respectively. Hypo-IgG, hypo-IgA, and hypo-IgM were seen in 56.8%, 80.4%, and 86.4% of children. 91 (45.7%) children developed 147 episodes of severe febrile illness. Older age (> 5 years) was associated with decreased risk [odds ratio 95% CI] of hypo-IgG [0.540 (0.297, 0.982), P = 0.044], hypo-IgA [0.030 (0.011, 0.088), P = 0.001], and hypo-IgM [0.323 (0.117, 0.894), P = 0.030] and female gender had decreased risk of hypo-IgG (0.539 (0.305, 0.953), P = 0.033). Older age decreased the risk [0.585 (0.328, 1.041), P = 0.014] and girls were at increased risk [(1.118, 3.488), P = 0.019] of severe febrile illness. Hypoglobulinemia did not increase the risk of severe febrile illness.Conclusion: Hypoglobulinemia was not found to be an independent risk factor for severe febrile illnesses in children with ALL receiving maintenance chemotherapy.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"482-488"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0