Vasoactive Ventilation Renal Score as a Predictor of Outcomes in Children Admitted to PICU: An Observational Study.

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI:10.1007/s13312-025-00076-8

Shilpi Chauhan, Prerna Batra, Vikram Bhaskar, Piyush Gupta

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引用次数: 0

Abstract

Objectives: To determine the area under curve (AUC) for vasoactive ventilation renal score (VVRS) > 10 at 24-h of admission for predicting mortality in children aged 1-12 years admitted to pediatric intensive care unit (PICU). To also determine the AUC for VVRS > 10 at 48-h of admission for predicting mortality and to determine the AUC of VVRS > 10 at 24-h and 48-h of admission for predicting PICU stay > 3 days, hospital stay > 10 days and mechanical ventilation > 3 days.

Methods: This observational study included 310 children aged 1-12 years admitted in PICU. All required parameters were noted, and VVRS, ventilation index and change in creatinine at 24-h and 48-h of admission were recoded. Receiver operating characteristic curves were computed to determine the predictive role of VVRS > 10 at 24-h and 48-h for mortality, duration of PICU stay, hospital stay and mechanical ventilation.

Results: Seventy nine (25%) patients succumbed during the study. VVRS > 10 at 24-h and 48-h had a good predictive role for mortality with AUC of 0.873 (sensitivity 89.87%, specificity 69.70%) and 0.996 (sensitivity 96.20%, specificity 96.10%), respectively. Best cutoffs derived for VVRS (24-h), and VVRS (48-h) were > 2.5 and > 13.5. A higher AUC, sensitivity and specificity of VVRS at 48-h were observed for predicting prolonged PICU stay, duration of mechanical ventilation and hospital stay.

Conclusions: VVRS at 24-h and 48-h has a good predictive role for mortality in children admitted to PICU.

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血管活性通气肾脏评分作为PICU入院儿童预后的预测指标：一项观察性研究。

目的：探讨1-12岁儿童重症监护病房（PICU）入院24小时血管活动性通气肾评分（VVRS） bbb10的曲线下面积（AUC）预测死亡率的价值。测定VVRS > 10在入院48 h时的AUC，用于预测死亡率；测定VVRS > 10在入院24 h和48 h时的AUC，用于预测PICU住院时间> 3天、住院时间> 10天和机械通气时间> 3天。方法：本观察性研究纳入310例1-12岁PICU患儿。记录所有需要的参数，并记录入院24、48 h时VVRS、通气指数和肌酐变化。计算受试者工作特征曲线，确定24 h和48 h时VVRS bbb10对死亡率、PICU住院时间、住院时间和机械通气的预测作用。结果：79例（25%）患者在研究期间死亡。VVRS bbb10在24 h和48 h对死亡率有较好的预测作用，AUC分别为0.873（敏感性89.87%，特异性69.70%）和0.996（敏感性96.20%，特异性96.10%）。VVRS（24小时）和VVRS（48小时）的最佳截止值分别为> 2.5和> 13.5。在预测PICU时间延长、机械通气时间和住院时间方面，48 h VVRS的AUC、敏感性和特异性较高。结论：24h和48h VVRS对PICU患儿死亡率有较好的预测作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.