Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar
{"title":"月球iDXA用于评估印度儿童和青少年骨骼健康的参考数据：一项横断面研究","authors":"Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar","doi":"10.1007/s13312-025-00091-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.</p><p><strong>Methods: </strong>A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm<sup>2</sup>)], and bone mineral density [BMD (g/cm<sup>2</sup>)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm<sup>3</sup>)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.</p><p><strong>Results: </strong>Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.</p><p><strong>Conclusion: </strong>The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study.\",\"authors\":\"Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar\",\"doi\":\"10.1007/s13312-025-00091-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.</p><p><strong>Methods: </strong>A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm<sup>2</sup>)], and bone mineral density [BMD (g/cm<sup>2</sup>)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm<sup>3</sup>)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.</p><p><strong>Results: </strong>Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.</p><p><strong>Conclusion: </strong>The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.</p>\",\"PeriodicalId\":13291,\"journal\":{\"name\":\"Indian pediatrics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13312-025-00091-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13312-025-00091-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study.
Objective: Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.
Methods: A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm2)], and bone mineral density [BMD (g/cm2)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm3)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.
Results: Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.
Conclusion: The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.
期刊介绍：
The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are:
-To publish original, relevant, well researched peer reviewed articles on issues related to child health.
-To provide continuing education to support informed clinical decisions and research.
-To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics.
-To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.
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