Inferior Vena Cava/Aorta Diameter Index for the Evaluation of Intravascular Volume Status in Children with Idiopathic Nephrotic Syndrome.

IF 1.5 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-08-06 DOI:10.1007/s13312-025-00154-x

Anshuman Saha, A P Anila, K V Pavan, Arpana Iyengar, Anil Vasudevan

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引用次数: 0

Abstract

Objectives: To correlate the inferior vena cava/aorta diameter (IVC/Ao index) in children with nephrotic syndrome with clinical indicators of volume status, and to compare the IVC/Ao index between children in relapse and in remission.

Methods: This prospective longitudinal study included children aged 2-18 years presenting with relapsed nephrotic syndrome. Low intravascular volume status was diagnosed if two of the three criteria (tachycardia, hypotension, prolonged capillary filling time) were present. Sonographic measurements of the IVC and aorta diameter were obtained by a single observer at recruitment and after achieving remission.

Results: One hundred and three children (73 boys) with a median (Q1, Q3) age 72 (24, 216) months were recruited. 26 (25%) children had low intravascular volume at recruitment. The mean (SD) IVC/Ao index was lower in low volume status compared to normal volume status [0.74 (0.2) vs 0.83 (0.1); P = 0.090]. The correlation between IVC/Ao index and heart rate (r = -0.29, P = 0.003) and mean arterial pressure (r = 0.23, P = 0.018) was weak. IVC/Ao index was not an independent predictor of volume status (OR = 0.04, P = 0.331). The mean (SD) IVC/Ao index increased significantly from when in relapse to remission [0.94 (0.1) vs 1.05 (0.2), respectively; P = 0.001].

Conclusions: The IVC/Ao index was lower in relapse than in remission, and did not predict low intravascular volume status independently.

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下腔静脉/主动脉直径指数评价儿童特发性肾病综合征血管内容量状况。

目的：探讨肾病综合征患儿下腔静脉/主动脉直径（IVC/Ao指数）与容积状态临床指标的相关性，比较复发期和缓解期患儿的IVC/Ao指数。方法：这项前瞻性纵向研究纳入了2-18岁的复发性肾病综合征患儿。如果三个标准（心动过速，低血压，毛细血管充盈时间延长）中的两个存在，则诊断为血管内容量低。超声测量下腔静脉和主动脉直径由一个单一的观察者在恢复和达到缓解后获得。结果：招募了103名儿童（73名男孩），中位年龄（Q1, Q3）为72（24,216）个月。26例（25%）患儿入组时血管内容积低。与正常容积状态相比，低容积状态的平均（SD） IVC/Ao指数较低[0.74 (0.2)vs 0.83 (0.1)]；p = 0.090]。IVC/Ao指数与心率（r = -0.29, P = 0.003）、平均动脉压（r = 0.23, P = 0.018）相关性较弱。IVC/Ao指数不是容积状态的独立预测因子（OR = 0.04, P = 0.331）。平均（SD） IVC/Ao指数从复发到缓解显著增加[分别为0.94（0.1）比1.05 (0.2)；p = 0.001]。结论：IVC/Ao指数在复发时低于缓解时，并且不能独立预测低血管内容积状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.