循环细胞间粘附分子作为新生儿肺动脉高压的新标志物。

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-04-15 DOI:10.1007/s13312-025-00037-1

Antoine Fakhry AbdelMassih, Sherif ElAnwary, Nourhan Taha, Noha Radwan, Mahmoud Othman AbouDeif

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引用次数: 0

摘要

背景：细胞间aq1黏附分子（ICAMs）在剪切应力的作用下从内皮细胞释放。它们在持续性肺动脉高压（PPHN）中的作用尚未得到研究。方法：60例新生儿（30例PPHN， 30例对照组）进行血清ICAM检测和超声心动图检查。结果：PPHN患者左右心室功能明显下降。三尖瓣环状平面收缩偏移减少（病例8±1，对照组11±3.5）。ICAM升高的病例（332±96比208±36）。结论：ICAM是一种敏感的PPHN标志物。ICAM升高可能是由于内皮损伤或参与PPHN发病机制。需要进一步的研究来证实这些结果并探索这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Circulating Intercellular Adhesion Molecule as a Novel Marker of Pulmonary Hypertension in Newborn.

Background: IntercellularAQ1 adhesion molecules (ICAMs) are released from the endothelium in response to shear stress. Their role in persistent pulmonary hypertension (PPHN) remains un-investigated.

Methodology: Sixty neonates (30 PPHN, 30 controls) underwent serum ICAM testing and echocardiography.

Results: Right and left ventricular function was depressed in PPHN cases. Tricuspid annular plane systolic excursion was reduced (Cases 8±1 vs. Controls 11±3.5). ICAM was elevated in cases (332±96 vs. 208 ±36).

Conclusion: ICAM is a sensitive PPHN marker. Elevated ICAM may result from endothelial damage or contribute to PPHN pathogenesis. Further studies are needed to confirm these results and explore this relationship.

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.