K Jai Kumar, Pooja Dewan, Rajarshi Kar, Edelbert Anthonio Almeida, Deepika Harit, Mrinalini Kotru, Mukesh Yadav
{"title":"抗逆转录病毒治疗和补充维生素E对艾滋病毒感染儿童总抗氧化能力的影响。","authors":"K Jai Kumar, Pooja Dewan, Rajarshi Kar, Edelbert Anthonio Almeida, Deepika Harit, Mrinalini Kotru, Mukesh Yadav","doi":"10.1007/s13312-025-00111-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To assess the total antioxidant capacity (TAC) in children living with HIV (CLHIV) and to evaluate the effect of antiretroviral therapy (ART) and vitamin E supplementation on TAC.</p><p><strong>Methods: </strong>The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.</p><p><strong>Results: </strong>A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. Three months of vitamin E supplementation, failed to produce a significant increase in TAC levels [10.4 (7.28, 14.92)] while the red cell indices and CD4 counts improved significantly with a marginal reduction in HIV viral load.</p><p><strong>Conclusion: </strong>Prolonged ART reduced antioxidant capacity. Three months of vitamin E supplementation produced marginal increase in TAC levels.</p><p><strong>Trial registry: </strong>CTRI/2022/12/047960 [Registered on: 08/12/2022] Trial Registered Prospectively.</p>","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Antiretroviral Therapy and Vitamin E Supplementation on Total Antioxidant Capacity in Children Living with HIV.\",\"authors\":\"K Jai Kumar, Pooja Dewan, Rajarshi Kar, Edelbert Anthonio Almeida, Deepika Harit, Mrinalini Kotru, Mukesh Yadav\",\"doi\":\"10.1007/s13312-025-00111-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To assess the total antioxidant capacity (TAC) in children living with HIV (CLHIV) and to evaluate the effect of antiretroviral therapy (ART) and vitamin E supplementation on TAC.</p><p><strong>Methods: </strong>The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.</p><p><strong>Results: </strong>A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. 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Effect of Antiretroviral Therapy and Vitamin E Supplementation on Total Antioxidant Capacity in Children Living with HIV.
Objectives: To assess the total antioxidant capacity (TAC) in children living with HIV (CLHIV) and to evaluate the effect of antiretroviral therapy (ART) and vitamin E supplementation on TAC.
Methods: The study included CLHIV on ART ≥ 2 years, ART-naïve CLHIV and healthy controls. CLHIV on ART ≥ 2 years received vitamin E supplements in addition to combination ART for three months duration. TAC levels, α-tocopherol levels, hemogram, red blood cell indices, viral load and CD4 counts were estimated at baseline and after three months of ART.
Results: A total of 25 children were included per group. The median (IQR) TAC levels (mM Trolox Equiv) were significantly lower in CLHIV ART for ≥ 2 years [6.32 (8.7, 13.28)], compared to controls [11.89 (8.15, 14.38)] and ART-naïve CLHIV [12.69 (7.61, 16.78)]. TAC levels increased after 3 months of starting ART [15.57 (9.90, 17.49); P = 0.178]. α-tocopherol levels (µmol/L) were significantly different among the three groups, viz controls [72 (28.86, 80)], ART-naïve CLHIV [40.24 (30.36, 71.59)] and CLHIV on ART ≥ 2 years [16.77 (13.15, 20.21)]. Three months of vitamin E supplementation, failed to produce a significant increase in TAC levels [10.4 (7.28, 14.92)] while the red cell indices and CD4 counts improved significantly with a marginal reduction in HIV viral load.
Conclusion: Prolonged ART reduced antioxidant capacity. Three months of vitamin E supplementation produced marginal increase in TAC levels.
Trial registry: CTRI/2022/12/047960 [Registered on: 08/12/2022] Trial Registered Prospectively.
期刊介绍：
The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are:
-To publish original, relevant, well researched peer reviewed articles on issues related to child health.
-To provide continuing education to support informed clinical decisions and research.
-To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics.
-To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.
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