Indian pediatrics最新文献_第6页

Skin Damage Risk and its Severity Caused by Pulse Oximetery Saturation Probe Attachment in Preterm Neonates: A Prospective Observational Study from Western India. 脉搏血氧饱和度探头附着引起的早产儿皮肤损伤风险及其严重程度：一项来自印度西部的前瞻性观察研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-26 DOI: 10.1007/s13312-025-00100-x

Aditya Hemendra Bhatt, Dipen Vasudev Patel, Reshma Kushal Pujara, Mayur Kiran Shinde, Somashekhar Marutirao Nimbalkar

引用次数: 0

Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study. 月球iDXA用于评估印度儿童和青少年骨骼健康的参考数据：一项横断面研究

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-22 DOI: 10.1007/s13312-025-00091-9

Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar

{"title":"Reference Data for Lunar iDXA for the Assessment of Bone Health in Indian Children and Youth: A Cross-Sectional Study.","authors":"Anuradha Khadilkar, Chirantap Oza, Neha Sanwalka, Neha Kajale, Vivek Patwardhan, Dipali Ladkat, Alex Ireland, Raja Padidela, Vaman Khadilkar","doi":"10.1007/s13312-025-00091-9","DOIUrl":"10.1007/s13312-025-00091-9","url":null,"abstract":"Objective: Dual energy x-ray absorptiometry (DXA) is the commonest bone densitometry technique in children. As no pediatric reference database for Indian children using a narrow fan beam densitometer is available, the aim of the study was to provide sex- and age-specific reference percentile curves for the assessment of bone health using the Lunar iDXA in 1-19-year-old Indian children.Methods: A cross-sectional study was carried out between November 2017 and July 2022 involving 1247 (607 girls) healthy children from Pune, India. The bone mineral content [BMC (g)], bone area [BA (cm2)], and bone mineral density [BMD (g/cm2)] were measured using the GE-Lunar iDXA narrow-angle fan beam scanner. Reference percentile curves were generated for total body BMC (TBBMC), total body BA (TBBA), lumbar spine bone mineral apparent density [BMAD (g/cm3)], and left femoral neck BMAD. Additionally, we provided percentile curves for TBBA relative to height, TBBMC relative to TBBA, lean body mass (LBM) relative to height, and TBBMC relative to LBM.Results: Mean (SD) bone parameters were expressed by age groups for boys and girls separately. The average annual age-related increase in TBBMD, lumbar spine BMD, and femoral neck BMD was 6.3, 7.2, and 4.5%, respectively, across different age groups. The median TBBA and TBBMC for height were higher in boys than girls by 14.7 and 24.9%, respectively. Similarly, the median TBBMC for LBM was 36.8% higher in boys as compared to girls.Conclusion: The study reports reference curves for DXA parameters (narrow fan beam) for Indian children and youth.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle Medicine and the Role of the Pediatrician. 生活方式医学和儿科医生的角色。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-12 DOI: 10.1007/s13312-025-00066-w

Mahima Gulati, Suneela Garg

引用次数: 0

Clinical Spectrum of Ocular Manifestations of Mumps in Children: A Cross-Sectional Study. 儿童流行性腮腺炎眼部表现的临床谱：一项横断面研究。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-05 DOI: 10.1007/s13312-025-00079-5

Sheetal Madalagi, Kalyani Malasane, Deepti Joshi, R Krishnaprasad

{"title":"Clinical Spectrum of Ocular Manifestations of Mumps in Children: A Cross-Sectional Study.","authors":"Sheetal Madalagi, Kalyani Malasane, Deepti Joshi, R Krishnaprasad","doi":"10.1007/s13312-025-00079-5","DOIUrl":"https://doi.org/10.1007/s13312-025-00079-5","url":null,"abstract":"Objective: This study aimed to describe the ophthalmological and neuro-ophthalmological manifestations of mumps in children.Methods: This cross-sectional study included 41 children aged < 18 years who were clinically diagnosed with mumps by a pediatrician and referred to a tertiary eye hospital. Comprehensive ophthalmic evaluation included visual acuity testing, slit-lamp biomicroscopy, fundus examination, ocular movement assessment, and squint measurement.Results: The mean time from onset of parotitis to ocular symptoms was 7 days. Out of 41 children, 15 (36.85%) had follicular conjunctivitis. Other ophthalmic findings included acute non-granulomatous uveitis (17.07%), acute acquired esotropia (17.07%), optic neuritis (9.75%), sixth nerve palsy (9.75%), encephalitis (4.87%), dacryoadenitis (2.43%), myasthenia gravis (2.43%), and accommodative insufficiency (2.43%).Conclusion: Apart from causing systemic involvement, mumps causes varied ocular manifestations which highlight the importance of a unified role of pediatricians and ophthalmologists in managing children with mumps.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome. FCGR2A基因多态性与儿童多系统炎症综合征的关系

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1007/s13312-025-00047-z

Esra Yeşiltepe, Derya Duman, Necdet Kuyucu, Sevcan Tuğ Bozdoğan, Lara Çıtırık, Edanur Yeşil, Derya Karpuz

{"title":"FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome.","authors":"Esra Yeşiltepe, Derya Duman, Necdet Kuyucu, Sevcan Tuğ Bozdoğan, Lara Çıtırık, Edanur Yeşil, Derya Karpuz","doi":"10.1007/s13312-025-00047-z","DOIUrl":"https://doi.org/10.1007/s13312-025-00047-z","url":null,"abstract":"Objective: Fc gamma receptor IIa (FCGR2A) gene polymorphism is associated with increased susceptibility to autoimmune and infectious diseases. The aim of the present study was to evaluate the association of FCGR2A rs1801274 polymorphism with the development and severity of multisystem inflammatory syndrome in children (MIS-C).Methods: This case-control study was conducted in a single center with MIS-C patients and healthy children. Clinical and cardiac imaging data of the participants was collected. The association between the clinical severity of the disease and FCGR2A rs1801274 polymorphism were investigated.Results: There was no significant association between FCGR2A rs1801274 polymorphism and cardiovascular complications in MIS-C patients. However, those with homozygous FCGR2A rs1801274 gene polymorphism developed severe cardiac dysfunction and required immunomodulatory agents other than intravenous immunoglobulin. The mean age of the patients with severe MIS-C was significantly higher than those with mild MIS-C, and systolic dysfunction was significant.Conclusions: Further multicenter studies in different ethnic groups are needed to evaluate the association between differences in the FCGR2A rs1801274 gene and severity of MIS-C and/or other inflammatory diseases.Trial registry: Mersin University Clinical Trial Registry, Decision number 2022/280 dated April 20, 2022.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":"62 5","pages":"372-377"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Profile, Genotypes, and Outcomes in Children with Pyridoxine Dependent Epilepsy (PDE): A Single Center Experience from Southern India. 吡哆醇依赖性癫痫（PDE）儿童的临床特征、基因型和结局：来自印度南部的单中心经验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1007/s13312-025-00061-1

Vykuntaraju K Gowda, Prafful Gowda, Varunvenkat M Srinivasan, Udhav Kinhal, Hemadri Vegda, Viveka-Santhosh Reddy

{"title":"Clinical Profile, Genotypes, and Outcomes in Children with Pyridoxine Dependent Epilepsy (PDE): A Single Center Experience from Southern India.","authors":"Vykuntaraju K Gowda, Prafful Gowda, Varunvenkat M Srinivasan, Udhav Kinhal, Hemadri Vegda, Viveka-Santhosh Reddy","doi":"10.1007/s13312-025-00061-1","DOIUrl":"10.1007/s13312-025-00061-1","url":null,"abstract":"Objective: To describe the clinical, laboratory profile, and outcome of Indian children with pyridoxine-dependent epilepsy (PDE).Methods: Retrospective chart reviews of all children with a genetically confirmed diagnosis of PDE between April 2012 and March 2024 were included; clinical and laboratory data were analyzed.Results: Twenty-two children (13 boys) were diagnosed with PDE and all presented with seizures and encephalopathy. Oculogyric crisis was observed in majority (n = 20, 91%) cases. Variants were identified in ALDH7A1 (17), PLPBP (4), and PNPO (1) genes in the current cohort. One child expired within 24 h of initiation of pyridoxine. Another child had refractory seizures, two had epileptic spasms and seven had provoked seizures. Autistic features were noted in two and attention deficit hyperactivity disorder (ADHD) in 15 children.Conclusion: Seizures, encephalopathy, and oculogyric crisis help are clinical cues to aid in early diagnosis of PDE. PDE may be associated with comorbidities like autism and ADHD.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"366-371"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children. 口服硒辅助治疗儿童急性下呼吸道感染。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1007/s13312-025-00032-6

Akshita Soni, Sushil K Kabra

引用次数: 0

Neurostimulation in Childhood Epilepsy. 儿童癫痫的神经刺激。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1007/s13312-025-00063-z

Soumya Ghosh, Lakshmi Nagarajan

{"title":"Neurostimulation in Childhood Epilepsy.","authors":"Soumya Ghosh, Lakshmi Nagarajan","doi":"10.1007/s13312-025-00063-z","DOIUrl":"10.1007/s13312-025-00063-z","url":null,"abstract":"Epilepsy is a common and debilitating neurological disorder in children, and approximately a third of them have ongoing seizures despite adequate trial of antiseizure medications. Neurostimulation approaches may be an option for those with drug resistant epilepsy. Several invasive and non-invasive devices have been trialled and found to be effective in reducing seizure burden in drug resistant epilepsy. These techniques appear to be safe and well tolerated. We review the available evidence for the use of these devices, including vagus nerve stimulation, deep brain stimulation, responsive neurostimulation, chronic subthreshold cortical stimulation, transcranial magnetic stimulation and transcranial direct current stimulation. The results of trials are promising but there are fewer studies in children. Apart from vagus nerve stimulation, none of the other neurostimulation techniques are currently approved for use in children and their use is off-label or in clinical trials. Further well-designed trials are needed, especially in children, to identify the most effective neurostimulation options and optimal parameters for improvement of seizure burden and quality of life. Neurostimulation techniques are also being trialled for treatment of refractory status epilepticus, but lack of robust evidence (mainly case studies or case series reports) makes it difficult to predict therapeutic benefit at present.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"378-385"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Agminated Lentiginosis. 双侧毛囊角化症

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.1007/s13312-025-00062-0

Ananya Arya, Gitesh Sawatkar, Priyanka Arke

引用次数: 0

Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial. 口服硒辅助治疗儿童急性下呼吸道感染：一项双盲随机对照试验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1007/s13312-025-00028-2

Rubeena Jamir Shaikh, Trupti Amol Joshi, Smita Madhusudan Mundada, Shilpa Yashwant Pawar, Prabha Bhaskar Khaire More

{"title":"Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial.","authors":"Rubeena Jamir Shaikh, Trupti Amol Joshi, Smita Madhusudan Mundada, Shilpa Yashwant Pawar, Prabha Bhaskar Khaire More","doi":"10.1007/s13312-025-00028-2","DOIUrl":"10.1007/s13312-025-00028-2","url":null,"abstract":"Objective: To evaluate the role of oral selenium in clinical recovery of acute lower respiratory tract infections (ALRTI) in under-five children.Methods: This double-blind, randomized controlled trial included children aged 6 months to 5 years hospitalised with ALRTI at a tertiary care hospital. Participants were randomized in 1:1 ratio to receive oral selenium (20-30 mcg/day) or placebo, once daily until discharge, along with standard treatment. The primary outcome was the time for clinical recovery. The secondary outcomes were the duration of hospital stay, modes of oxygen support required and side effects of selenium.Results: A total of 60 children were randomized to either groups. The median (IQR) time required for clinical recovery was 72 (54, 144) h in the selenium group and 96 (54, 120) h in the placebo group (P = 0.346). The median (IQR) duration of hospital stay was 6 (5, 7) days and 6 (6, 8) days in the selenium and placebo groups, respectively (P = 0.680). Mechanical ventilation was required in 10 (16.6%) and 21 (35%) children in the selenium and placebo groups, respectively (P = 0.020). No side effects were reported with the intervention.Conclusions: Oral selenium administered as an adjunct in a daily dose of 20-30 mcg orally for 5-7 days, does not reduce the time needed for clinical recovery or the duration of hospitalization but reduces the need for mechanical ventilation in under-five children with ALRTI.Trial registry: CTRI/2023/04/051842.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"351-355"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0