Indian pediatrics最新文献_第6页

Clinical Profile, Genotypes, and Outcomes in Children with Pyridoxine Dependent Epilepsy (PDE): A Single Center Experience from Southern India. 吡哆醇依赖性癫痫（PDE）儿童的临床特征、基因型和结局：来自印度南部的单中心经验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1007/s13312-025-00061-1

Vykuntaraju K Gowda, Prafful Gowda, Varunvenkat M Srinivasan, Udhav Kinhal, Hemadri Vegda, Viveka-Santhosh Reddy

{"title":"Clinical Profile, Genotypes, and Outcomes in Children with Pyridoxine Dependent Epilepsy (PDE): A Single Center Experience from Southern India.","authors":"Vykuntaraju K Gowda, Prafful Gowda, Varunvenkat M Srinivasan, Udhav Kinhal, Hemadri Vegda, Viveka-Santhosh Reddy","doi":"10.1007/s13312-025-00061-1","DOIUrl":"10.1007/s13312-025-00061-1","url":null,"abstract":"Objective: To describe the clinical, laboratory profile, and outcome of Indian children with pyridoxine-dependent epilepsy (PDE).Methods: Retrospective chart reviews of all children with a genetically confirmed diagnosis of PDE between April 2012 and March 2024 were included; clinical and laboratory data were analyzed.Results: Twenty-two children (13 boys) were diagnosed with PDE and all presented with seizures and encephalopathy. Oculogyric crisis was observed in majority (n = 20, 91%) cases. Variants were identified in ALDH7A1 (17), PLPBP (4), and PNPO (1) genes in the current cohort. One child expired within 24 h of initiation of pyridoxine. Another child had refractory seizures, two had epileptic spasms and seven had provoked seizures. Autistic features were noted in two and attention deficit hyperactivity disorder (ADHD) in 15 children.Conclusion: Seizures, encephalopathy, and oculogyric crisis help are clinical cues to aid in early diagnosis of PDE. PDE may be associated with comorbidities like autism and ADHD.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"366-371"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children. 口服硒辅助治疗儿童急性下呼吸道感染。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1007/s13312-025-00032-6

Akshita Soni, Sushil K Kabra

引用次数: 0

Neurostimulation in Childhood Epilepsy. 儿童癫痫的神经刺激。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1007/s13312-025-00063-z

Soumya Ghosh, Lakshmi Nagarajan

{"title":"Neurostimulation in Childhood Epilepsy.","authors":"Soumya Ghosh, Lakshmi Nagarajan","doi":"10.1007/s13312-025-00063-z","DOIUrl":"10.1007/s13312-025-00063-z","url":null,"abstract":"Epilepsy is a common and debilitating neurological disorder in children, and approximately a third of them have ongoing seizures despite adequate trial of antiseizure medications. Neurostimulation approaches may be an option for those with drug resistant epilepsy. Several invasive and non-invasive devices have been trialled and found to be effective in reducing seizure burden in drug resistant epilepsy. These techniques appear to be safe and well tolerated. We review the available evidence for the use of these devices, including vagus nerve stimulation, deep brain stimulation, responsive neurostimulation, chronic subthreshold cortical stimulation, transcranial magnetic stimulation and transcranial direct current stimulation. The results of trials are promising but there are fewer studies in children. Apart from vagus nerve stimulation, none of the other neurostimulation techniques are currently approved for use in children and their use is off-label or in clinical trials. Further well-designed trials are needed, especially in children, to identify the most effective neurostimulation options and optimal parameters for improvement of seizure burden and quality of life. Neurostimulation techniques are also being trialled for treatment of refractory status epilepticus, but lack of robust evidence (mainly case studies or case series reports) makes it difficult to predict therapeutic benefit at present.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"378-385"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Agminated Lentiginosis. 双侧毛囊角化症

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-04 DOI: 10.1007/s13312-025-00062-0

Ananya Arya, Gitesh Sawatkar, Priyanka Arke

引用次数: 0

Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial. 口服硒辅助治疗儿童急性下呼吸道感染：一项双盲随机对照试验。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1007/s13312-025-00028-2

Rubeena Jamir Shaikh, Trupti Amol Joshi, Smita Madhusudan Mundada, Shilpa Yashwant Pawar, Prabha Bhaskar Khaire More

{"title":"Oral Selenium as an Adjunct in the Treatment of Acute Lower Respiratory Tract Infections in Children: A Double-Blind Randomized Controlled Trial.","authors":"Rubeena Jamir Shaikh, Trupti Amol Joshi, Smita Madhusudan Mundada, Shilpa Yashwant Pawar, Prabha Bhaskar Khaire More","doi":"10.1007/s13312-025-00028-2","DOIUrl":"10.1007/s13312-025-00028-2","url":null,"abstract":"Objective: To evaluate the role of oral selenium in clinical recovery of acute lower respiratory tract infections (ALRTI) in under-five children.Methods: This double-blind, randomized controlled trial included children aged 6 months to 5 years hospitalised with ALRTI at a tertiary care hospital. Participants were randomized in 1:1 ratio to receive oral selenium (20-30 mcg/day) or placebo, once daily until discharge, along with standard treatment. The primary outcome was the time for clinical recovery. The secondary outcomes were the duration of hospital stay, modes of oxygen support required and side effects of selenium.Results: A total of 60 children were randomized to either groups. The median (IQR) time required for clinical recovery was 72 (54, 144) h in the selenium group and 96 (54, 120) h in the placebo group (P = 0.346). The median (IQR) duration of hospital stay was 6 (5, 7) days and 6 (6, 8) days in the selenium and placebo groups, respectively (P = 0.680). Mechanical ventilation was required in 10 (16.6%) and 21 (35%) children in the selenium and placebo groups, respectively (P = 0.020). No side effects were reported with the intervention.Conclusions: Oral selenium administered as an adjunct in a daily dose of 20-30 mcg orally for 5-7 days, does not reduce the time needed for clinical recovery or the duration of hospitalization but reduces the need for mechanical ventilation in under-five children with ALRTI.Trial registry: CTRI/2023/04/051842.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":"351-355"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Emergency Medicine. 儿科急诊医学。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 DOI: 10.1007/s13312-025-00086-6

Varun Anand

引用次数: 0

Hypoglycorrhachia: Unravelling the Pathogenetic Mechanisms. 低糖下丘脑：揭示发病机制。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1007/s13312-025-00057-x

Veena Kalra, Gouri Rao Passi

引用次数: 0

Effect of One Milligram Versus Two Milligram Intramuscular Vitamin K to Prevent Late-Onset Hemorrhagic Disease in Young Infants. 1毫克与2毫克肌注维生素K预防婴幼儿迟发性出血性疾病的效果

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1007/s13312-025-00067-9

Amala Srilatha Natarajan, C G Delhikumar

引用次数: 0

Advances in Neonatal Seizures (2024): An Update for Pediatricians. 新生儿癫痫的进展（2024）：儿科医生的最新进展。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.1007/s13312-025-00050-4

Aman Elwadhi, Hemasree Kandraju, Suvasini Sharma

{"title":"Advances in Neonatal Seizures (2024): An Update for Pediatricians.","authors":"Aman Elwadhi, Hemasree Kandraju, Suvasini Sharma","doi":"10.1007/s13312-025-00050-4","DOIUrl":"https://doi.org/10.1007/s13312-025-00050-4","url":null,"abstract":"Purpose: The diagnosis and management of seizures and epilepsy syndromes with onset in neonates has undergone several changes following the Internation League against Epilepsy (ILAE) guidelines. To update the Pediatricians regarding the recent advances, this update was planned.Methods: Recently published revised guidelines for neonatal seizures (up to 2024) by ILAE were reviewed and synthesized.Results: Video-EEG recording is considered gold standard for diagnosis, with less emphasis on clinical semiology. In resource limited settings, levels of diagnostic certainties may be used. One must be aware of the mandatory, alerts and exclusion criteria for various neonatal-onset epilepsy syndromes. Early neuroimaging facilitates diagnosis. Treatment primarily involves phenobarbitone (PHB) with other drugs to be used in certain special conditions, with universal early stoppage of drugs. Precision therapy is available for some metabolic and genetic etiologies.Conclusions: EEG monitoring in high-risk neonates is the standard of care. PHB still remains the first choice. Early cessation of anti-seizure medications in acute symptomatic seizures is the norm.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":"62 5","pages":"386-390"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalassemia: Looking Ahead. 地中海贫血：展望未来。

IF 1.7 4区医学

Indian pediatrics Pub Date : 2025-05-01 DOI: 10.1007/s13312-025-00082-w

Vasant Khalatkar

引用次数: 0