FCGR2A Gene Polymorphism Association in Children with Multisystem Inflammatory Syndrome.

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI:10.1007/s13312-025-00047-z

Esra Yeşiltepe, Derya Duman, Necdet Kuyucu, Sevcan Tuğ Bozdoğan, Lara Çıtırık, Edanur Yeşil, Derya Karpuz

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引用次数: 0

Abstract

Objective: Fc gamma receptor IIa (FCGR2A) gene polymorphism is associated with increased susceptibility to autoimmune and infectious diseases. The aim of the present study was to evaluate the association of FCGR2A rs1801274 polymorphism with the development and severity of multisystem inflammatory syndrome in children (MIS-C).

Methods: This case-control study was conducted in a single center with MIS-C patients and healthy children. Clinical and cardiac imaging data of the participants was collected. The association between the clinical severity of the disease and FCGR2A rs1801274 polymorphism were investigated.

Results: There was no significant association between FCGR2A rs1801274 polymorphism and cardiovascular complications in MIS-C patients. However, those with homozygous FCGR2A rs1801274 gene polymorphism developed severe cardiac dysfunction and required immunomodulatory agents other than intravenous immunoglobulin. The mean age of the patients with severe MIS-C was significantly higher than those with mild MIS-C, and systolic dysfunction was significant.

Conclusions: Further multicenter studies in different ethnic groups are needed to evaluate the association between differences in the FCGR2A rs1801274 gene and severity of MIS-C and/or other inflammatory diseases.

Trial registry: Mersin University Clinical Trial Registry, Decision number 2022/280 dated April 20, 2022.

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FCGR2A基因多态性与儿童多系统炎症综合征的关系

目的：Fc γ受体IIa （FCGR2A）基因多态性与自身免疫性疾病和感染性疾病易感性增加相关。本研究的目的是评估FCGR2A rs1801274多态性与儿童多系统炎症综合征（MIS-C）的发展和严重程度的关系。方法：本病例-对照研究在单中心进行，患者为misc患者和健康儿童。收集参与者的临床和心脏影像资料。研究临床疾病严重程度与FCGR2A rs1801274多态性的关系。结果：misc患者FCGR2A rs1801274多态性与心血管并发症无显著相关性。然而，纯合子FCGR2A rs1801274基因多态性的患者发生严重的心功能障碍，需要静脉注射免疫球蛋白以外的免疫调节剂。重度MIS-C患者的平均年龄明显高于轻度MIS-C患者，且收缩功能障碍明显。结论：需要进一步在不同种族的多中心研究来评估FCGR2A rs1801274基因差异与MIS-C和/或其他炎症性疾病严重程度之间的关系。试验注册：Mersin University临床试验注册，2022年4月20日决定号2022/280。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.