Hypertension in Pregnancy最新文献

{"title":"Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats.","authors":"Ying Li, Yuanyuan Liu, Jinfeng Chen, Jian Hu","doi":"10.1080/10641955.2021.2013874","DOIUrl":"10.1080/10641955.2021.2013874","url":null,"abstract":"<p><strong>Objective: </strong>This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats.</p><p><strong>Methods: </strong>LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo.</p><p><strong>Results: </strong>Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats.</p><p><strong>Conclusions: </strong>Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"23-30"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39622391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconceptual leptin levels in gestational diabetes and hypertensive pregnancy.","authors":"Antti Peltokorpi,&nbsp;Lisinen Irina,&nbsp;Viikari Liisa,&nbsp;Kaaja Risto","doi":"10.1080/10641955.2022.2033763","DOIUrl":"https://doi.org/10.1080/10641955.2022.2033763","url":null,"abstract":"<p><p>Pregnancy - induced hypertension (PIH), preeclampsia (PE), and gestational diabetes (GDM) are common adverse outcomes in pregnancy.</p><p><strong>Objective: </strong>To find out whether preconceptual leptin levels differ in subsequent pregnancy between control vs. GDM and hypertensive pregnancy groups.</p><p><strong>Materials and methods: </strong>Data was from The Cardiovascular Risk in Young Finns Study and The Medical Birth Register of Finland. Of 293 subjects 71 developed GDM, 27 PIH/PE and 201 were controls.</p><p><strong>Results: </strong>Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).</p><p><strong>Conclusion: </strong>Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"70-77"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant status in hypertensive disorders of pregnancy.","authors":"Jasmina Ivanišević,&nbsp;Daniela Ardalić,&nbsp;Gorica Banjac,&nbsp;Jelena Janać,&nbsp;Petar Cabunac,&nbsp;Jelena Vekić,&nbsp;Aleksandra Zeljković,&nbsp;Vesna Spasojević-Kalimanovska,&nbsp;Nataša Karadžov Orlić,&nbsp;Vesna Mandić Marković,&nbsp;Željko Miković,&nbsp;Aleksandra Stefanović","doi":"10.1080/10641955.2021.2013875","DOIUrl":"https://doi.org/10.1080/10641955.2021.2013875","url":null,"abstract":"<p><strong>Objective: </strong>Pregnancy can be associated with maternal hypertension leading to possible complications in pregnancy outcome. Antioxidant status may be proned to changes during pregnancy with hypertension. The aim of our study was to estimate antioxidant status through high-risk pregnancies.</p><p><strong>Methods: </strong>Seventy-nine pregnant women with high-risk for preeclampsia development were included and 46 of them developed some hypertensive disorder in pregnancy. Superoxide-dismutase (SOD) and paraoxonase 1 (PON1) activities and relative proportion of PON1 activiity on different HDL subclasses were determined in 1^st, 2^nd, and 3^rd trimester and prior to delivery.</p><p><strong>Results: </strong>SOD activity was significantly lower in 2^nd and 3^rd trimesters when compared to 1^st trimester (P˂0.001) whereas PON1 activity was significantly higher in 3^rd than in 1^st trimester (P˂0.05) in group of hypertensive women. This group had significantly higher SOD and PON1 activities and relative proportion of PON1 on HDL_3c subclasses in the 1^st trimester, significantly increased PON1 in the 3^rd trimester and prior to delivery and significantly higher PON1 activity on HDL_3c subclasses (P˂0.05) than nonhypertensive group. In 1^st trimester and prior to delivery, total PON1 activity and relative proportion of PON1 on HDL_3c subclasses exhibited significant ability to mark out hypertension in pregnancy (P˂0.05).</p><p><strong>Conclusions: </strong>SOD activity decreased whereas total PON1 activity increased during pregnancy with hypertension. Pregnant women with hypertension had higher activities of PON1 and SOD and relative proportion of PON1 on HDL_3c subclasses than nonhypertensive ones. PON1 activity and relative proportion of PON1 on HDL_3c subclasses exhibited significant association with hypertension in pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"31-38"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39723415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined apocyanin and aspirin treatment activates the PI3K/Nrf2/HO-1 signaling pathway and ameliorates preeclampsia symptoms in rats.","authors":"Yaru Ju,&nbsp;Yan Feng,&nbsp;Xiaolin Hou,&nbsp;Lixia Wu,&nbsp;Huixia Yang,&nbsp;Hongjuan Zhang,&nbsp;Yan'Na Ma","doi":"10.1080/10641955.2021.2014518","DOIUrl":"https://doi.org/10.1080/10641955.2021.2014518","url":null,"abstract":"<p><strong>Objective: </strong>Pre-eclampsia (PE) is a pregnancy-associated disease characterized by placental dysfunction and increased oxidative stress. Apocyanin is a potent antioxidant and anti-inflammatory which has shown beneficial effects on PE pathogenesis. Aspirin is recognized as the recommendable drug in PE prevention and therapy. Therefore, we aimed to investigate the effects of combining apocyanin and aspirin to treat PE on rat models induced by N-nitro-L-arginine methyl ester (L-NAME) from gestational day (GD) 6 to 16 and elucidate the potential mechanisms.</p><p><strong>Methods: </strong>First, female pregnant rats were divided into five different groups: pregnant control, PE, PE + apocyanin, PE + aspirin, and PE + apocyanin + aspirin. Animals received apocyanin (16 mg/kg/day) orally or aspirin by gavage (1.5 mg/kg BM/day) from GD 4 to 16. Blood pressure and urine protein content were monitored every 4 days.</p><p><strong>Results: </strong>In the PE rat model, elevated systolic blood pressure and proteinuria were ameliorated by the combination of apocyanin and aspirin. Meanwhile, compared with single-dose apocyanin or aspirin, the combined treatment significantly corrected abnormal pregnancy outcomes, decreased sFlt-1 and PlGF, and alleviated oxidative stress both in blood and placental tissues. Moreover, the combined treatment upregulated PI3K, Akt, Nrf2, and HO-1 protein levels in the placental tissues from PE rats.</p><p><strong>Conclusion: </strong>Overall, our results suggested that combined treatment of apocyanin and aspirin ameliorates the PE symptoms compared with single-dose apocyanin or aspirin in a PE rat model. Also, we demonstrated that activating the PI3K/Nrf2/HO-1 pathway can be a valuable therapeutic target to improve the pregnancy outcomes of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"39-50"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39700158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome.","authors":"Iara Dos Santos Fagundes,&nbsp;Eduardo Pletsch Brendler,&nbsp;Isadora Nunes Erthal,&nbsp;Raquel Jaqueline Eder Ribeiro,&nbsp;Rafaela Siviero Caron-Lienert,&nbsp;Denise Cantarelli Machado,&nbsp;Bartira Ercília Pinheiro da Costa,&nbsp;Carlos Eduardo Poli-de-Figueiredo","doi":"10.1080/10641955.2021.2008424","DOIUrl":"https://doi.org/10.1080/10641955.2021.2008424","url":null,"abstract":"<p><p>To evaluate total Th1/Th2 cytokines in CD3⁺ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3⁺, INF-g⁺/CD3⁺, IL-4⁺/CD3⁺, and IL-10⁺/CD3⁺, CD4⁺/CD8⁺ were determined by flow-cytometry. Preeclampsia (<i>n</i>= 26) and normal pregnancy (<i>n</i>= 25) participants were age and gestational age matched. CD4⁺ lymphocytes count was higher in preeclampsia, compared with normal pregnancy (43.6 ± 5.8 vs 37.6 ± 5.6%; <i>P</i>< 0.001). CD3⁺ cells Th1/Th2 shift was not detected in preeclampsia, yet may be present in other cell types, such as CD4⁺ and CD3 - lymphocytes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"15-22"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39917586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA.","authors":"Phumelele Kikine,&nbsp;Yazira Pillay,&nbsp;Thajasvarie Naicker","doi":"10.1080/10641955.2021.2001819","DOIUrl":"https://doi.org/10.1080/10641955.2021.2001819","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.</p><p><strong>Methods: </strong>This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.</p><p><strong>Results: </strong>A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.</p><p><strong>Conclusion: </strong>Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"9-14"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39715670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Lu et al. regarding article, \"Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia\".","authors":"Zhuo Deng,&nbsp;Dan Lu","doi":"10.1080/10641955.2021.2024224","DOIUrl":"https://doi.org/10.1080/10641955.2021.2024224","url":null,"abstract":"We read with the great interest the article by Brownfoot et al., titled “Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia” (1). The authors deciphered the potential therapeutic value of combined someprazole and sulfasalazine additively in reducing the secretion of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) for the pathogenesis of preeclampsia (PE), which was identified as new candidate medication to treat or prevent PE. Previously, we have noticed that the impacts of PE on women are not limited to the pregnancy itself but rather extended to the long-term life (2). Studies have demonstrated consistently that post-PE women were at higher risk of developing cardiovascular disease later in life, such as ischemic heart disease, stroke and heart failure, and so on (3,4). Brown and Wu et al. have found that women with a history of PE had the increased incidence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) (5,6). In addition, it became more apparent that there was significant relation between insulin resistance and formerly PE (7). Notably, emerging evidence proving EGFR and sFlt-1 signaling pathways was associated with the long-term complications in PE became available (8). In light of the exciting clues, we wondered whether the available follow-up about long-term complication among women with PE and consequently the survival quality analysis would be included in evaluating the effectiveness of combining esomeprazole and sulfasalazine in extended studies for broadening our understanding of its effect. Hence, it was worth elucidating the long-term survival quality analysis, which might shed some light on the clinical value of combining esomeprazole and sulfasalazine and contribute to improve the prognosis of PE. Finally, we congratulate that the authors identified the combination of esomeprazole and sulfasalazine as the novel therapeutic strategies in PE and look forward to that our interest will stimulate intriguing findings carried out on the clinical use of esomeprazole and sulfasalazine.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"51-52"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39869971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of adverse outcomes in hypertensive disorders of pregnancy: a multicenter prospective cohort study.","authors":"Daniela N Vasquez,&nbsp;Andrea V Das Neves,&nbsp;Vanina M Aphalo,&nbsp;Laura Vidal,&nbsp;Miriam Moseinco,&nbsp;Jorge Lapadula,&nbsp;Analía Santa-Maria,&nbsp;Graciela Zakalik,&nbsp;Raúl A Gomez,&nbsp;Mónica Capalbo,&nbsp;Claudia Fernandez,&nbsp;Enrique Agüero-Villareal,&nbsp;Santiago Vommaro,&nbsp;Marcelo Moretti,&nbsp;Silvana B Soli,&nbsp;Florencia Ballestero,&nbsp;Juan P Sottile,&nbsp;Viviana Chapier,&nbsp;Carlos Lovesio,&nbsp;José Santos,&nbsp;Fernando Bertoletti,&nbsp;Fernando A Mos,&nbsp;Alejandro Risso-Vazquez,&nbsp;Mercedes Esteban-Chacon,&nbsp;Santiago Illutovich,&nbsp;Sebastián Chapela,&nbsp;Cecilia I Loudet,&nbsp;José L Scapellato,&nbsp;Alfredo D Intile,&nbsp;Elisa Estenssoro","doi":"10.1080/10641955.2021.1981373","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981373","url":null,"abstract":"<p><strong>Objectives: </strong>To explore variables associated with adverse maternal/fetal/neonatal outcomes among pregnant/postpartum patients admitted to ICU for hypertensive disorders of pregnancy (HDP).</p><p><strong>Methods: </strong>Multicenter, prospective, national cohort study.</p><p><strong>Results: </strong>Variables independently associated with maternal/fetal/neonatal mortality among 172 patients were as follows: Acute Physiology and Chronic Health Evaluation-II (APACHE-II)(OR1.20[1.06-1.35]), gestational age (OR0.698[0.59-0.82]) and aspartate aminotransferase (AST)(OR1.004[1.001-1.006]). Positive likelihood ratio for headache, epigastric pain, and visual disturbances to predict composite adverse outcomes were 1.23(1.16-1.30), 0.76(0.59-1.02), and 1.1(0.98-1.2), respectively.</p><p><strong>Conclusions: </strong>Maternal/fetal mortality due to HDP was independently associated with severity of illness on admission, gestational age, and elevated AST. Accuracy of clinical symptoms to predict composite adverse outcomes was low.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"279-287"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity.","authors":"Mitali Ray,&nbsp;Lacey W Heinsberg,&nbsp;Yvette P Conley,&nbsp;James M Roberts,&nbsp;Arun Jeyabalan,&nbsp;Carl A Hubel,&nbsp;Daniel E Weeks,&nbsp;Mandy J Schmella","doi":"10.1080/10641955.2021.1987453","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987453","url":null,"abstract":"<p><p><b>Objective:</b> Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity.<b>Methods:</b> WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race.<b>Results:</b> In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.<b>Conclusions:</b> These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"312-321"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740522/pdf/nihms-1751747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study.","authors":"Michael S Tanner,&nbsp;Deborah De Guingand,&nbsp;Maya Reddy,&nbsp;Saskia Rowson,&nbsp;Daniel L Rolnik,&nbsp;Fabricio Da Silva Costa,&nbsp;Mary-Ann Davey,&nbsp;Ben W Mol,&nbsp;Euan M Wallace,&nbsp;Kirsten R Palmer","doi":"10.1080/10641955.2021.1991371","DOIUrl":"https://doi.org/10.1080/10641955.2021.1991371","url":null,"abstract":"<p><p><b>Objective:</b>To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia.<b>Methods:</b> A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes.<b>Results:</b>We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications.<b>Conclusion:</b> Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"336-345"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}