Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-08-24DOI: 10.1080/10641955.2021.1965621
Michael Baracy, Fareeza Afzal, Susanna M Szpunar, Makenzie Tremp, Karlee Grace, Marina Liovas, Muhammad Faisal Aslam
{"title":"Coronavirus disease 2019 (COVID-19) and the risk of hypertensive disorders of pregnancy: a retrospective cohort study.","authors":"Michael Baracy, Fareeza Afzal, Susanna M Szpunar, Makenzie Tremp, Karlee Grace, Marina Liovas, Muhammad Faisal Aslam","doi":"10.1080/10641955.2021.1965621","DOIUrl":"https://doi.org/10.1080/10641955.2021.1965621","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate of COVID-19 disease in pregnant women and its association with hypertensive disorders of pregnancy.<b>Design:</b> Retrospective Cohort Study<b>Setting:</b> Multicenter study from a large metropolitan hospital system<b>Methods:</b> Patients who tested positive for COVID-19 during their pregnancy and delivered were compared to the three subsequent deliveries of patients who tested negative (controls). We evaluated the impact of COVID-19 on the development of hypertensive disorders of pregnancy.<b>Results:</b> Compared with pregnancies negative for SARs-CoV-2 infection, maternal SARs-CoV-2 infection was associated with an increased risk for hypertensive disorders of pregnancy (OR 3.68, 95% CI 1.67 - 8.10).<b>Tweetable Abstract</b>Patients who test positive for COVID-19 during their pregnancy are at increased risk of developing a hypertensive disorder of pregnancy. Earlier SARs-CoV-2 infection results in an increased risk of developing a hypertensive disorder.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"226-235"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39341634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-06-18DOI: 10.1080/10641955.2021.1939712
Mehmet Akif Erdol, Atakan Tanacan, Hasan Eroglu, Nazan Vanli Tonyali, Mehmet Erdogan, Aykan Yucel, Nuray Yazihan, Dilek Sahin
{"title":"Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital.","authors":"Mehmet Akif Erdol, Atakan Tanacan, Hasan Eroglu, Nazan Vanli Tonyali, Mehmet Erdogan, Aykan Yucel, Nuray Yazihan, Dilek Sahin","doi":"10.1080/10641955.2021.1939712","DOIUrl":"https://doi.org/10.1080/10641955.2021.1939712","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT).<b>Method:</b> 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated.<b>Results:</b> NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04).<b>Conclusion:</b> NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"202-208"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1939712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39250913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia.","authors":"Fatemeh Mazlum, Behrouz Gharesi-Fard, Hossein Hadinedoushan, Yousef Bakhshizadeh Ghashti","doi":"10.1080/10641955.2021.1958836","DOIUrl":"https://doi.org/10.1080/10641955.2021.1958836","url":null,"abstract":"<p><strong>Objective: </strong>To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE).</p><p><strong>Methods: </strong>The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32.</p><p><strong>Results: </strong>Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients.</p><p><strong>Conclusion: </strong>Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"218-225"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1958836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39274408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-09-06DOI: 10.1080/10641955.2021.1974879
Stephen M Wagner, Han-Yang Chen, Megha Gupta, Matthew J Bicocca, Hector Mendez-Figueroa, Suneet P Chauhan
{"title":"Association between time of delivery and composite adverse outcomes in pregnancies complicated by hypertensive disorders.","authors":"Stephen M Wagner, Han-Yang Chen, Megha Gupta, Matthew J Bicocca, Hector Mendez-Figueroa, Suneet P Chauhan","doi":"10.1080/10641955.2021.1974879","DOIUrl":"https://doi.org/10.1080/10641955.2021.1974879","url":null,"abstract":"<p><strong>Introduction: </strong>A potential manner to lower the morbidity with the hypertensive disoreders of pregancy is to explore the time of day of delivery.</p><p><strong>Objective: </strong>To compare composite neonatal adverse outcomes among term women with hypertensive disorders.</p><p><strong>Methods: </strong>This population-based cohort study used the U.S. vital statistics dataset from 2013 to 2017. Time of delivery was categorized into three shifts. The primary outcome was composite neonatal adverse outcome..</p><p><strong>Results: </strong>Compared to neonates delivered at the first shift, the risk of composite neonatal adverse outcome was higher at the third shift (aRR = 1.19, 95% CI = 1.13-1.25).</p><p><strong>Conclusion: </strong>the risk of composite neonatal adverse outcome is higher if the delivery occurs at the third (23:00-7:00) shift.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"246-253"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-09-11DOI: 10.1080/10641955.2021.1975737
Rodney A McLaren, Melissa Magenta, Laura Gilroy, Maria Gabriela Duarte, Sujatha Narayanamoorthy, Jeremy Weedon, Howard Minkoff
{"title":"Predictors of readmission for postpartum preeclampsia.","authors":"Rodney A McLaren, Melissa Magenta, Laura Gilroy, Maria Gabriela Duarte, Sujatha Narayanamoorthy, Jeremy Weedon, Howard Minkoff","doi":"10.1080/10641955.2021.1975737","DOIUrl":"https://doi.org/10.1080/10641955.2021.1975737","url":null,"abstract":"<p><p><b>Objective</b>: To develop a predictive model for re-admission for postpartum preeclampsia (PPEC).<b>Methods</b>: A case-control study; cases were patients re-admitted for PPEC; controls were not re-admitted. Mixed linear modelling was used to develop a predictive model on the training set, then validated on the validation set.<b>Results</b>: Two-hundred-sixty-nine patients were readmitted, and matched to 538 controls. A risk calculator was developed and yielded a sensitivity and specificity for readmission of 80.9% and 53.5%, respectively.<b>Conclusion</b>: A predictive model using age, race, discharge blood pressures, and preeclampsia was able to predict re-admission for PPEC with a high level of sensitivity.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"254-260"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39408373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-05-06DOI: 10.1080/10641955.2021.1921793
Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan
{"title":"Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia.","authors":"Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan","doi":"10.1080/10641955.2021.1921793","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921793","url":null,"abstract":"ABSTRACT Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"186-192"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-05-12DOI: 10.1080/10641955.2021.1921791
Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Barbara Damnjanović Pažin, Srđan Stanimirović, Gorica Banjac, Aleksandra Stefanović, Vesna Spasojević-Kalimanovska, Amira Egić, Nina Rajović, Nataša Milić, Željko Miković
{"title":"Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study.","authors":"Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Barbara Damnjanović Pažin, Srđan Stanimirović, Gorica Banjac, Aleksandra Stefanović, Vesna Spasojević-Kalimanovska, Amira Egić, Nina Rajović, Nataša Milić, Željko Miković","doi":"10.1080/10641955.2021.1921791","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921791","url":null,"abstract":"<p><p><b>OBJECTIVE</b>: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia.<b>METHODS</b>: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester.<b>RESULTS</b>: A lower PAPP-A levels were found in the first trimester, while sFlt/PlGF was increased in the second and early third trimester in preeclampsia (p>0.05). FMF algorithm presented higher specificity (>70%), but had a drawback of lower sensitivity (35-77%).<b>CONCLUSION</b>: FMF algorithm had modest performance in the prediction of preeclampsia for high-risk pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"171-179"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-10-04DOI: 10.1080/10641955.2021.1981372
Yongping Wang, Zhihui Zhang
{"title":"Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis.","authors":"Yongping Wang, Zhihui Zhang","doi":"10.1080/10641955.2021.1981372","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981372","url":null,"abstract":"<p><strong>Purpose: </strong>This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE).</p><p><strong>Methods: </strong>The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR. The regulatory mechanism of SNHG7/miR-214-5p/TWIST1 axis on PE was determined using MTT, wound healing, transwell invasion, and western blot assays.</p><p><strong>Results: </strong>In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells.</p><p><strong>Conclusions: </strong>Up-regulated SNHG7 protects against PE through modulating the miR-214-5p/TWIST1 axi.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"261-270"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39483563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-08-31DOI: 10.1080/10641955.2021.1974031
Kun Dong, Ying Hou, Na Zhang, Bide Duan, Airong Ma, Zhiwei Zhang
{"title":"Down-regulated placental miR-21 contributes to preeclampsia through targeting RASA1.","authors":"Kun Dong, Ying Hou, Na Zhang, Bide Duan, Airong Ma, Zhiwei Zhang","doi":"10.1080/10641955.2021.1974031","DOIUrl":"https://doi.org/10.1080/10641955.2021.1974031","url":null,"abstract":"<p><p>Human placenta was obtained from early onset preeclampsia, late onset preeclampsia, and their gestational age-matched normal pregnancy. Using RT-qPCR, western blot, and immunohistochemistry, it was demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 were increased. Suppression of miR-21 in placental HTR-8/SVneo cells, remarkably upregulated RASA1, decreased proliferation, inhibited invasion, and promoted apoptosis of trophoblast cells, while overexpression of miR-21 alleviated these effects. Dual-luciferase reporter assays revealed RASA1 to be a direct target of miR-21 in trophoblast cells. miR-21 may serve key roles in the development of preeclampsia by targeting RASA1.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"236-245"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39372674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum survivin is decreased in women with preeclampsia.","authors":"Onur Güralp, Koray Gök, Nevin Tüten, Kübra Hamzaoglu, Melike Makul, Yahya Ozgun Oner, Huri Bulut, Meike Schild-Suhren, Eduard Malik, Abdullah Tüten","doi":"10.1080/10641955.2021.1917601","DOIUrl":"https://doi.org/10.1080/10641955.2021.1917601","url":null,"abstract":"<p><p><b>Objective</b>: To evaluate the serum survivin level in preeclampsia.<b>Methods</b>: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.<b>Results</b>: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure.<b>Conclusion</b>: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"144-151"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1917601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39000748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}