正常妊娠和子痫前期综合征外周血淋巴细胞总Th1/Th2细胞因子谱

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-02-01 Epub Date: 2021-11-23 DOI:10.1080/10641955.2021.2008424

Iara Dos Santos Fagundes, Eduardo Pletsch Brendler, Isadora Nunes Erthal, Raquel Jaqueline Eder Ribeiro, Rafaela Siviero Caron-Lienert, Denise Cantarelli Machado, Bartira Ercília Pinheiro da Costa, Carlos Eduardo Poli-de-Figueiredo

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引用次数: 3

摘要

评估子痫前期CD3+细胞(免疫活性T淋巴细胞)和外周血淋巴细胞，主要是CD4+ (T辅助细胞)和CD8+ (T细胞毒性细胞)亚群中Th1/Th2总细胞因子。流式细胞术检测外周血白细胞和淋巴细胞总数，细胞百分比:CD3+、INF-g+/CD3+、IL-4+/CD3+、IL-10+/CD3+、CD4+/CD8+。先兆子痫(n= 26)和正常妊娠(n= 25)参与者的年龄和胎龄相匹配。子痫前期CD4+淋巴细胞计数高于正常妊娠(43.6±5.8 vs 37.6±5.6%;P+细胞Th1/Th2移位未在子痫前期检测到，但可能存在于其他细胞类型，如CD4+和CD3 -淋巴细胞。

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Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome.

To evaluate total Th1/Th2 cytokines in CD3⁺ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3⁺, INF-g⁺/CD3⁺, IL-4⁺/CD3⁺, and IL-10⁺/CD3⁺, CD4⁺/CD8⁺ were determined by flow-cytometry. Preeclampsia (n= 26) and normal pregnancy (n= 25) participants were age and gestational age matched. CD4⁺ lymphocytes count was higher in preeclampsia, compared with normal pregnancy (43.6 ± 5.8 vs 37.6 ± 5.6%; P< 0.001). CD3⁺ cells Th1/Th2 shift was not detected in preeclampsia, yet may be present in other cell types, such as CD4⁺ and CD3 - lymphocytes.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.