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Hypertension in Pregnancy最新文献

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Prehypertension in early pregnancy is a risk factor for hypertensive disorders during pregnancy: A historical cohort study in Japan. 妊娠早期高血压前期是妊娠期高血压疾病的危险因素:日本的一项历史队列研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-26 DOI: 10.1080/10641955.2020.1864637
Takeshi Nagao, Keisuke Saito, Michiko Yamanaka
{"title":"Prehypertension in early pregnancy is a risk factor for hypertensive disorders during pregnancy: A historical cohort study in Japan.","authors":"Takeshi Nagao,&nbsp;Keisuke Saito,&nbsp;Michiko Yamanaka","doi":"10.1080/10641955.2020.1864637","DOIUrl":"https://doi.org/10.1080/10641955.2020.1864637","url":null,"abstract":"<p><p><b>Objective</b>: We evaluated the association between pre-hypertension (120-139 or 80-89 mmHg) in early pregnancy, hypertensive disorders of pregnancy (HDP), and perinatal adverse outcomes. <b>Methods</b>: We included 14,066 pregnant women, treated between 2003 and 2019 in Japan. Based on a blood pressure chart review recorded before 20 weeks of gestation, we stratified participants into the prehypertension (n = 3,806) and normotensive (n = 10,260) groups. <b>Results</b>: Prehypertension, an independent risk factor for HDP in the multivariate analysis (<i>P</i>< 0.001), was significantly associated with preterm and small-for-gestational age infants. <b>Conclusion</b>: Prehypertension potentially confers a risk for adverse perinatal outcomes in apparently normal pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"51-55"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1864637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38745481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia. 可溶性Flt1水平与有或无严重子痫前期黑人妇女的心功能障碍有关。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-20 DOI: 10.1080/10641955.2020.1861462
Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D Sammel, Michal A Elovitz, Bonnie Ky
{"title":"Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia.","authors":"Lisa Levine,&nbsp;Zolt Arany,&nbsp;Adina Kern-Goldberger,&nbsp;Nathanael Koelper,&nbsp;Jennifer Lewey,&nbsp;Mary D Sammel,&nbsp;Michal A Elovitz,&nbsp;Bonnie Ky","doi":"10.1080/10641955.2020.1861462","DOIUrl":"https://doi.org/10.1080/10641955.2020.1861462","url":null,"abstract":"<p><p><b>Background</b>: We evaluate soluble fms-like tyrosine kinase-1 (sFlt-1) levels and cardiac function during pregnancy and postpartum among Black women with and without preeclampsia. <b>Study design</b>: Prospective longitudinal cohort study from 2015 to 2017 of Black women with preterm severe preeclampsia and normotensive pregnant controls.We obtained echocardiograms and sFlt-1 levels during pregnancy and postpartum. <b>Results</b>: 93 Black women were included (43 cases, 50 controls). Higher sFlt1 levels were correlated with worse longitudinal strain, diastolic dysfunction, decreased ventricular-arterial coupling, and increased chamber and arterial elastance at the time of preeclampsia diagnosis and postpartum. <b>Conclusions</b>: Higher sFlt1 levels are associated with cardiovascular dysfunction during pregnancy and postpartum.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"44-49"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1861462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38738601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Role of maternal nutrition and oxidative stress in placental telomere attrition in women with preeclampsia. 母体营养和氧化应激在子痫前期妇女胎盘端粒磨损中的作用。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-07 DOI: 10.1080/10641955.2020.1869248
Aditi A Godhamgaonkar, Deepali P Sundrani, Sadhana R Joshi
{"title":"Role of maternal nutrition and oxidative stress in placental telomere attrition in women with preeclampsia.","authors":"Aditi A Godhamgaonkar,&nbsp;Deepali P Sundrani,&nbsp;Sadhana R Joshi","doi":"10.1080/10641955.2020.1869248","DOIUrl":"https://doi.org/10.1080/10641955.2020.1869248","url":null,"abstract":"<p><p><b>Background:</b>Maternal nutrition influences the growth and development of the fetus and influences pregnancy outcome. We have earlier demonstrated altered maternal nutrition and increased oxidative stress in women with preeclampsia. Oxidative stress is known to be associated with reduced telomere length and short telomere aggregates. Increased telomere attrition leads to increased cellular senescence and tissue ageing. <b>Methods:</b>The present review focuses on the role of maternal nutrition and oxidative stress in telomere attrition in preeclampsia. <b>Results and Conclusion:</b>Future studies need to examine the association between maternal nutritional status in early pregnancy, oxidative stress and telomere attrition in preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"63-74"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1869248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38789864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy. 基于单倍型的肌球蛋白磷酸酶靶亚基1 (PPP1R12A)基因与妊娠高血压疾病的病例对照研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-18 DOI: 10.1080/10641955.2021.1872613
Ai Kono, Kaori Shinya, Tomohiro Nakayama, Elisa Shikata, Tatsuo Yamamoto, Kei Kawana
{"title":"Haplotype-based, case-control study of myosin phosphatase target subunit 1 (<i>PPP1R12A)</i> gene and hypertensive disorders of pregnancy.","authors":"Ai Kono,&nbsp;Kaori Shinya,&nbsp;Tomohiro Nakayama,&nbsp;Elisa Shikata,&nbsp;Tatsuo Yamamoto,&nbsp;Kei Kawana","doi":"10.1080/10641955.2021.1872613","DOIUrl":"https://doi.org/10.1080/10641955.2021.1872613","url":null,"abstract":"<p><p><b>Objective</b>: Hypertensive disorders of pregnancy (HDP) are thought to be a multifactorial genetic disease. Myosin light chain phosphorylation, which is involved in the regulation of vascular smooth muscle contraction and relaxation and thus contributes to the maintenance of blood pressure, is related to HDP. The official symbol of the gene for the production of MYPT1 protein is <i>PPP1R12A</i> gene. Thus, we investigated the possibility that the <i>PPP1R12A</i> gene is related to HDP. <b>Methods</b>: Subjects were 194 pregnant women with HDP and a control group of 262 pregnant women from those women examined. Four SNVs (rs7296839, rs11114256, rs2596793, and rs2694657) were selected from the <i>PPP1R12A</i> gene region. The HDP group was divided according to disease type, and each group was analyzed in comparison with the control group. <b>Results</b>: In the association analysis using the <i>PPP1R12A</i> gene, there were significant differences between the control group and the superimposed preeclampsia (SPE) group for rs11114256 in allele frequency distribution (P = 0.017) and genome frequency distribution in the dominant model (P = 0.014), and for rs2694657 genotype distribution frequency in the recessive model (P = 0.018). In the association analysis using haplotypes, there was a significant difference for G-A-A-G (rs7296839-rs11114256-rs2596793-rs2694657). In an analysis of haplotype-based case-control study, there was a significant difference for G-A-A-G between the control group (0.00%) and the HDP group (2.46%) (P = 0.038). Furthermore, the G-T-A-G haplotype was significantly higher in SPE group than in control group (P = 0.011). <b>Conclusions</b>: The implication is that the <i>PPP1R12A</i> gene may be a disease-susceptibility gene for SPE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"88-96"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1872613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38834188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects of slow and deep breathing on reducing obstetric intervention in women with pregnancy-induced hypertension: a feasibility study protocol. 慢速深呼吸对减少妊娠高血压妇女产科干预的影响：可行性研究方案。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-19 DOI: 10.1080/10641955.2020.1869250
M Felton, V A Hundley, S Grigsby, A K McConnell
{"title":"Effects of slow and deep breathing on reducing obstetric intervention in women with pregnancy-induced hypertension: a feasibility study protocol.","authors":"M Felton, V A Hundley, S Grigsby, A K McConnell","doi":"10.1080/10641955.2020.1869250","DOIUrl":"10.1080/10641955.2020.1869250","url":null,"abstract":"<p><p><b>Objective</b>: To evaluate whether a slow and deep breathing (SDB) intervention is acceptable to pregnant women. <b>Methods</b>: The trial aims to recruit 67 pregnant women who have developed pregnancy-induced hypertension (clinicaltrials.gov: NCT04059822). SDB will be undertaken daily for 10 min using a video aid and women will self-monitor blood pressure (BP) daily. At 36-weeks gestation women will complete an online questionnaire. Adherence, recruitment rates, and acceptance of the intervention will be evaluated. <b>Conclusion</b>: The findings from this trial will evaluate if women accept SDB as a treatment method. Initial analysis will evaluate if BP and/or obstetric interventions reduce following SDB intervention.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"81-87"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38754218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patients' perspective on aspirin during pregnancy: a survey. 孕妇对阿司匹林的看法:一项调查。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-06-20 DOI: 10.1080/10641955.2020.1777299
Jeske M Bij de Weg, Carolien N H Abheiden, Marjon A de Boer, Conni de Groot, Johanna I P de Vries
{"title":"Patients' perspective on aspirin during pregnancy: a survey.","authors":"Jeske M Bij de Weg,&nbsp;Carolien N H Abheiden,&nbsp;Marjon A de Boer,&nbsp;Conni de Groot,&nbsp;Johanna I P de Vries","doi":"10.1080/10641955.2020.1777299","DOIUrl":"https://doi.org/10.1080/10641955.2020.1777299","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate patients' knowledge and counseling perspective on aspirin reducing the risk of hypertensive disorders of pregnancy (HDP).</p><p><strong>Methods: </strong>A quantitative survey was performed including women who are members of the patient orgasnization Dutch HELLP Foundation due to a history of HDP.</p><p><strong>Results: </strong>Awareness of the risk-reducing effect of aspirin on HDP was present in 51.9% of the 189 women. The majority was informed by their gynecologist (89.8%) and preferred to be informed by a gynecologist (79.4%), at the postpartum checkup (42.3%) or in the consecutive pregnancy (30.7%), both orally and written (62.4%).</p><p><strong>Conclusion: </strong>Half of the women with a history of HDP were aware of the risk-reducing effect of aspirin in a consecutive pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"371-378"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1777299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38068940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial. 甲基多巴与拉贝洛尔或不用药治疗妊娠期轻度和中度慢性高血压：一项随机临床试验。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-07-22 DOI: 10.1080/10641955.2020.1791902
Mohamed Rezk, Mohamed Emarh, Alaa Masood, Ragab Dawood, Elsayed El-Shamy, Awni Gamal, Hassan Badr
{"title":"Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial.","authors":"Mohamed Rezk,&nbsp;Mohamed Emarh,&nbsp;Alaa Masood,&nbsp;Ragab Dawood,&nbsp;Elsayed El-Shamy,&nbsp;Awni Gamal,&nbsp;Hassan Badr","doi":"10.1080/10641955.2020.1791902","DOIUrl":"10.1080/10641955.2020.1791902","url":null,"abstract":"<p><strong>Objective: </strong>to assess the maternal and fetal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or labetalol) therapy compared to no medication.</p><p><strong>Methods: </strong>This multicenter randomized clinical study was conducted at Menoufia University hospital, Shibin El-kom Teaching hospital at Menoufia governorate, Egypt.486 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 164), labetalol group (n = 160), and control or no medication group (n = 162) who were followed from the beginning of pregnancy till the end of puerperium to record maternal and fetal outcome.</p><p><strong>Results: </strong>There was a highly significant difference between treatment groups (methyldopa and labetalol) and control group regarding the development of maternal severe hypertension, development of preeclampsia, renal impairment, presence of ECG changes, placental abruption, and repeated admission to hospital for blood pressure control (p < 0.001) with higher occurrence in the control (no treatment) group. Neonates in the labetalol group were more prone for the development of small for gestational age (SGA), neonatal hypotension, neonatal hyperbilirubinemia, and admission to NICU than their counterparts in the methyldopa and control groups (p < 0.001). The rate of prematurity was significantly higher in the control group than the treatment groups (p < 0.05).</p><p><strong>Conclusion: </strong>Treatment of mild to moderate chronic hypertension during pregnancy is beneficial in decreasing both maternal and fetal morbidity. The use of labetalol was associated with higher rates of SGA, neonatal hypotension, and neonatal hyperbilirubinemia compared to methyldopa or no medication.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"39 4","pages":"393-398"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1791902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The relationship between circadian blood pressure variability and maternal/perinatal outcomes in women with preeclampsia with severe features. 重度子痫前期妇女昼夜血压变化与孕产妇/围产期结局之间的关系。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-08-03 DOI: 10.1080/10641955.2020.1797777
Liuying Zhong, Wenfeng Deng, Weihan Zheng, Shuting Yu, Xiaosi Huang, Yaohong Wen, Philip C N Chiu, Cheuk-Lun Lee
{"title":"The relationship between circadian blood pressure variability and maternal/perinatal outcomes in women with preeclampsia with severe features.","authors":"Liuying Zhong, Wenfeng Deng, Weihan Zheng, Shuting Yu, Xiaosi Huang, Yaohong Wen, Philip C N Chiu, Cheuk-Lun Lee","doi":"10.1080/10641955.2020.1797777","DOIUrl":"10.1080/10641955.2020.1797777","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether circadian blood pressure (BP) variation of women with preeclampsia (PE) with severe features was associated with adverse maternal/perinatal outcomes.</p><p><strong>Methods: </strong>173 women with PE with severe features were recruitedand categorized into three groups: dipper, non-dipper and reverse dipper type BP group.. Maternal and perinatal outcomes were compared among groups.</p><p><strong>Results: </strong>There were significant differences in gestational ages, premature delivery, retinopathy, HELLP syndrome, mean birth weight, rate of low birth weight infants and fetal growth restriction.</p><p><strong>Conclusion: </strong>Aberrant circadian pattern of BP in women with PE with severe features was associated with several adverse maternal/perinatal outcomes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"405-410"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38229782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats. 褪黑素调节去松果体RUPP大鼠胎心氧化应激和细胞凋亡。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-08-14 DOI: 10.1080/10641955.2020.1802595
Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Mehmet Akif Ovali, Orkut Güçlü, Ufuk Demir, Ayten Doğan, Metehan Uzun
{"title":"Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats.","authors":"Oğuzhan Doğanlar,&nbsp;Zeynep Banu Doğanlar,&nbsp;Mehmet Akif Ovali,&nbsp;Orkut Güçlü,&nbsp;Ufuk Demir,&nbsp;Ayten Doğan,&nbsp;Metehan Uzun","doi":"10.1080/10641955.2020.1802595","DOIUrl":"https://doi.org/10.1080/10641955.2020.1802595","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats.</p><p><strong>Methods: </strong>The fetal heart samples were obtained from melatonin administrated RUPP rats.</p><p><strong>Results: </strong>Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels.</p><p><strong>Conclusion: </strong>Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"429-443"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1802595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia. 肿瘤坏死因子α (TNF-α)阻断改善自然杀伤细胞(NK)活化、高血压和线粒体氧化应激在子痫前期临床前大鼠模型。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-07-10 DOI: 10.1080/10641955.2020.1793999
Mark W Cunningham, Aswathi Jayaram, Evangeline Deer, Lorena M Amaral, Venkata Ramana Vaka, Tarek Ibrahim, Denise C Cornelius, Babbette LaMarca
{"title":"Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.","authors":"Mark W Cunningham,&nbsp;Aswathi Jayaram,&nbsp;Evangeline Deer,&nbsp;Lorena M Amaral,&nbsp;Venkata Ramana Vaka,&nbsp;Tarek Ibrahim,&nbsp;Denise C Cornelius,&nbsp;Babbette LaMarca","doi":"10.1080/10641955.2020.1793999","DOIUrl":"https://doi.org/10.1080/10641955.2020.1793999","url":null,"abstract":"<p><p>The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS).  Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats.</p><p><strong>Methods: </strong>On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19.</p><p><strong>Results: </strong>MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN.</p><p><strong>Conclusion: </strong>TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"399-404"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1793999","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38143543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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