Hypertension in PregnancyPub Date : 2021-02-01Epub Date: 2021-01-19DOI: 10.1080/10641955.2020.1869250
M Felton, V A Hundley, S Grigsby, A K McConnell
{"title":"Effects of slow and deep breathing on reducing obstetric intervention in women with pregnancy-induced hypertension: a feasibility study protocol.","authors":"M Felton, V A Hundley, S Grigsby, A K McConnell","doi":"10.1080/10641955.2020.1869250","DOIUrl":"10.1080/10641955.2020.1869250","url":null,"abstract":"<p><p><b>Objective</b>: To evaluate whether a slow and deep breathing (SDB) intervention is acceptable to pregnant women. <b>Methods</b>: The trial aims to recruit 67 pregnant women who have developed pregnancy-induced hypertension (clinicaltrials.gov: NCT04059822). SDB will be undertaken daily for 10 min using a video aid and women will self-monitor blood pressure (BP) daily. At 36-weeks gestation women will complete an online questionnaire. Adherence, recruitment rates, and acceptance of the intervention will be evaluated. <b>Conclusion</b>: The findings from this trial will evaluate if women accept SDB as a treatment method. Initial analysis will evaluate if BP and/or obstetric interventions reduce following SDB intervention.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"81-87"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38754218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-06-20DOI: 10.1080/10641955.2020.1777299
Jeske M Bij de Weg, Carolien N H Abheiden, Marjon A de Boer, Conni de Groot, Johanna I P de Vries
{"title":"Patients' perspective on aspirin during pregnancy: a survey.","authors":"Jeske M Bij de Weg, Carolien N H Abheiden, Marjon A de Boer, Conni de Groot, Johanna I P de Vries","doi":"10.1080/10641955.2020.1777299","DOIUrl":"https://doi.org/10.1080/10641955.2020.1777299","url":null,"abstract":"<p><strong>Objective: </strong>To elucidate patients' knowledge and counseling perspective on aspirin reducing the risk of hypertensive disorders of pregnancy (HDP).</p><p><strong>Methods: </strong>A quantitative survey was performed including women who are members of the patient orgasnization Dutch HELLP Foundation due to a history of HDP.</p><p><strong>Results: </strong>Awareness of the risk-reducing effect of aspirin on HDP was present in 51.9% of the 189 women. The majority was informed by their gynecologist (89.8%) and preferred to be informed by a gynecologist (79.4%), at the postpartum checkup (42.3%) or in the consecutive pregnancy (30.7%), both orally and written (62.4%).</p><p><strong>Conclusion: </strong>Half of the women with a history of HDP were aware of the risk-reducing effect of aspirin in a consecutive pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"371-378"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1777299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38068940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial.","authors":"Mohamed Rezk, Mohamed Emarh, Alaa Masood, Ragab Dawood, Elsayed El-Shamy, Awni Gamal, Hassan Badr","doi":"10.1080/10641955.2020.1791902","DOIUrl":"10.1080/10641955.2020.1791902","url":null,"abstract":"<p><strong>Objective: </strong>to assess the maternal and fetal outcome in women with mild to moderate chronic hypertension on antihypertensive drug (methyldopa or labetalol) therapy compared to no medication.</p><p><strong>Methods: </strong>This multicenter randomized clinical study was conducted at Menoufia University hospital, Shibin El-kom Teaching hospital at Menoufia governorate, Egypt.486 pregnant women with mild to moderate chronic hypertension were randomized into three groups; methyldopa group (n = 164), labetalol group (n = 160), and control or no medication group (n = 162) who were followed from the beginning of pregnancy till the end of puerperium to record maternal and fetal outcome.</p><p><strong>Results: </strong>There was a highly significant difference between treatment groups (methyldopa and labetalol) and control group regarding the development of maternal severe hypertension, development of preeclampsia, renal impairment, presence of ECG changes, placental abruption, and repeated admission to hospital for blood pressure control (p < 0.001) with higher occurrence in the control (no treatment) group. Neonates in the labetalol group were more prone for the development of small for gestational age (SGA), neonatal hypotension, neonatal hyperbilirubinemia, and admission to NICU than their counterparts in the methyldopa and control groups (p < 0.001). The rate of prematurity was significantly higher in the control group than the treatment groups (p < 0.05).</p><p><strong>Conclusion: </strong>Treatment of mild to moderate chronic hypertension during pregnancy is beneficial in decreasing both maternal and fetal morbidity. The use of labetalol was associated with higher rates of SGA, neonatal hypotension, and neonatal hyperbilirubinemia compared to methyldopa or no medication.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"39 4","pages":"393-398"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1791902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10588181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-08-03DOI: 10.1080/10641955.2020.1797777
Liuying Zhong, Wenfeng Deng, Weihan Zheng, Shuting Yu, Xiaosi Huang, Yaohong Wen, Philip C N Chiu, Cheuk-Lun Lee
{"title":"The relationship between circadian blood pressure variability and maternal/perinatal outcomes in women with preeclampsia with severe features.","authors":"Liuying Zhong, Wenfeng Deng, Weihan Zheng, Shuting Yu, Xiaosi Huang, Yaohong Wen, Philip C N Chiu, Cheuk-Lun Lee","doi":"10.1080/10641955.2020.1797777","DOIUrl":"10.1080/10641955.2020.1797777","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether circadian blood pressure (BP) variation of women with preeclampsia (PE) with severe features was associated with adverse maternal/perinatal outcomes.</p><p><strong>Methods: </strong>173 women with PE with severe features were recruitedand categorized into three groups: dipper, non-dipper and reverse dipper type BP group.. Maternal and perinatal outcomes were compared among groups.</p><p><strong>Results: </strong>There were significant differences in gestational ages, premature delivery, retinopathy, HELLP syndrome, mean birth weight, rate of low birth weight infants and fetal growth restriction.</p><p><strong>Conclusion: </strong>Aberrant circadian pattern of BP in women with PE with severe features was associated with several adverse maternal/perinatal outcomes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"405-410"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38229782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-08-14DOI: 10.1080/10641955.2020.1802595
Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Mehmet Akif Ovali, Orkut Güçlü, Ufuk Demir, Ayten Doğan, Metehan Uzun
{"title":"Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats.","authors":"Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Mehmet Akif Ovali, Orkut Güçlü, Ufuk Demir, Ayten Doğan, Metehan Uzun","doi":"10.1080/10641955.2020.1802595","DOIUrl":"https://doi.org/10.1080/10641955.2020.1802595","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats.</p><p><strong>Methods: </strong>The fetal heart samples were obtained from melatonin administrated RUPP rats.</p><p><strong>Results: </strong>Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels.</p><p><strong>Conclusion: </strong>Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"429-443"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1802595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38269730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-07-10DOI: 10.1080/10641955.2020.1793999
Mark W Cunningham, Aswathi Jayaram, Evangeline Deer, Lorena M Amaral, Venkata Ramana Vaka, Tarek Ibrahim, Denise C Cornelius, Babbette LaMarca
{"title":"Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.","authors":"Mark W Cunningham, Aswathi Jayaram, Evangeline Deer, Lorena M Amaral, Venkata Ramana Vaka, Tarek Ibrahim, Denise C Cornelius, Babbette LaMarca","doi":"10.1080/10641955.2020.1793999","DOIUrl":"https://doi.org/10.1080/10641955.2020.1793999","url":null,"abstract":"<p><p>The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats.</p><p><strong>Methods: </strong>On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19.</p><p><strong>Results: </strong>MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN.</p><p><strong>Conclusion: </strong>TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"399-404"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1793999","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38143543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum apelin and galectin-3 in preeclampsia in Iraq.","authors":"Aamal Sattar Taha, Zohreh Zahraei, Hussein Kadhem Al-Hakeim","doi":"10.1080/10641955.2020.1777300","DOIUrl":"https://doi.org/10.1080/10641955.2020.1777300","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE).</p><p><strong>Methods: </strong>Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant.</p><p><strong>Results: </strong>The PE group had significantly lower apelin and higher galectin-3 levels than the control group. PE group exhibited dyslipidemia and had higher β-cell functions than the controls. Galectin-3 level correlates with insulin, glucose, and IR. High galectin-3 also is correlated positively with dyslipidemia.</p><p><strong>Conclusion: </strong>In PE, there is a possible contribution of galectin-3 to the harmful effects of IR and dyslipidemia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"379-386"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1777300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38044513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-08-03DOI: 10.1080/10641955.2020.1801717
Virginia Dines, Matthew D'Costa, Mary Fidler, Andrea Kattah
{"title":"The role of kidney biopsy in diagnosis of preeclampsia in kidney transplant patients.","authors":"Virginia Dines, Matthew D'Costa, Mary Fidler, Andrea Kattah","doi":"10.1080/10641955.2020.1801717","DOIUrl":"https://doi.org/10.1080/10641955.2020.1801717","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this report is to review two patients who developed proteinuria in pregnancy after kidney transplant in order to highlight the importance of maintaining a broad differential and the diagnostic utility of kidney biopsy in this clinical scenario.</p><p><strong>Methods: </strong>Two cases of women with kidney transplants who presented with proteinuria in pregnancy are described and the literature is reviewed.</p><p><strong>Results: </strong>In both cases, a kidney biopsy allowed for prompt diagnosis and treatment.</p><p><strong>Conclusion: </strong>Kidney biopsy should be considered an important diagnostic tool in this clinical scenario.</p><p><strong>Abbreviations: </strong>ACE: angiotensin-converting enzyme; ESKD: end-stage kidney disease; FSGS: focal segmental glomerulosclerosis; RAAS: renin aldosterone angiotensin system.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"418-422"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1801717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38230225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-10-23DOI: 10.1080/10641955.2020.1833914
Zhenya Fang, Anna Li, Yaqiong Sun, Xietong Wang, Meihua Zhang
{"title":"Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles.","authors":"Zhenya Fang, Anna Li, Yaqiong Sun, Xietong Wang, Meihua Zhang","doi":"10.1080/10641955.2020.1833914","DOIUrl":"https://doi.org/10.1080/10641955.2020.1833914","url":null,"abstract":"<p><p><b>Objective:</b> To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia. <b>Methods:</b> EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure and proteinuria were measured. The blood pressure and proteinuria increased in each of PE groups, and were improved by EPCs which was strengthened by PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure. <b>Conclusion:</b> Transplantation of EPCs treated with PMPs improved blood pressure and proteinuria more effectively.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"461-470"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1833914","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38622471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2020-11-01Epub Date: 2020-09-27DOI: 10.1080/10641955.2020.1818090
Anouk Bokslag, Anne B Fons, Laurien J Zeverijn, Pim W Teunissen, Christianne J M de Groot
{"title":"Maternal recall of a history of early-onset preeclampsia, late-onset preeclampsia, or gestational hypertension: a validation study.","authors":"Anouk Bokslag, Anne B Fons, Laurien J Zeverijn, Pim W Teunissen, Christianne J M de Groot","doi":"10.1080/10641955.2020.1818090","DOIUrl":"https://doi.org/10.1080/10641955.2020.1818090","url":null,"abstract":"<p><p><b>Objective:</b> This study assessed women's ability to recall different types of hypertensive disorders of pregnancy because of its disproportionate cardiovascular risk later in life. <b>Methods:</b> Participants were 5-10 years post-partum with a history of early-onset-, late-onset preeclampsia, or gestational hypertension. Recall was assessed by questionnaire and compared to medical records. <b>Results:</b> Questionnaire-based recall of early-onset preeclampsia had high sensitivity and specificity, late-onset preeclampsia poor sensitivity and high specificity and gestational hypertension had very poor sensitivity and high specificity. <b>Conclusion:</b> Early-onset preeclampsia can accurately be assessed using a simple questionnaire. Recall of late-onset preeclampsia and gestational hypertension was not accurate.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":" ","pages":"444-450"},"PeriodicalIF":1.5,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1818090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38426384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}