{"title":"Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia.","authors":"Fatemeh Mazlum, Behrouz Gharesi-Fard, Hossein Hadinedoushan, Yousef Bakhshizadeh Ghashti","doi":"10.1080/10641955.2021.1958836","DOIUrl":"https://doi.org/10.1080/10641955.2021.1958836","url":null,"abstract":"<p><strong>Objective: </strong>To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE).</p><p><strong>Methods: </strong>The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32.</p><p><strong>Results: </strong>Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients.</p><p><strong>Conclusion: </strong>Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"218-225"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1958836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39274408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-09-06DOI: 10.1080/10641955.2021.1974879
Stephen M Wagner, Han-Yang Chen, Megha Gupta, Matthew J Bicocca, Hector Mendez-Figueroa, Suneet P Chauhan
{"title":"Association between time of delivery and composite adverse outcomes in pregnancies complicated by hypertensive disorders.","authors":"Stephen M Wagner, Han-Yang Chen, Megha Gupta, Matthew J Bicocca, Hector Mendez-Figueroa, Suneet P Chauhan","doi":"10.1080/10641955.2021.1974879","DOIUrl":"https://doi.org/10.1080/10641955.2021.1974879","url":null,"abstract":"<p><strong>Introduction: </strong>A potential manner to lower the morbidity with the hypertensive disoreders of pregancy is to explore the time of day of delivery.</p><p><strong>Objective: </strong>To compare composite neonatal adverse outcomes among term women with hypertensive disorders.</p><p><strong>Methods: </strong>This population-based cohort study used the U.S. vital statistics dataset from 2013 to 2017. Time of delivery was categorized into three shifts. The primary outcome was composite neonatal adverse outcome..</p><p><strong>Results: </strong>Compared to neonates delivered at the first shift, the risk of composite neonatal adverse outcome was higher at the third shift (aRR = 1.19, 95% CI = 1.13-1.25).</p><p><strong>Conclusion: </strong>the risk of composite neonatal adverse outcome is higher if the delivery occurs at the third (23:00-7:00) shift.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"246-253"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-09-11DOI: 10.1080/10641955.2021.1975737
Rodney A McLaren, Melissa Magenta, Laura Gilroy, Maria Gabriela Duarte, Sujatha Narayanamoorthy, Jeremy Weedon, Howard Minkoff
{"title":"Predictors of readmission for postpartum preeclampsia.","authors":"Rodney A McLaren, Melissa Magenta, Laura Gilroy, Maria Gabriela Duarte, Sujatha Narayanamoorthy, Jeremy Weedon, Howard Minkoff","doi":"10.1080/10641955.2021.1975737","DOIUrl":"https://doi.org/10.1080/10641955.2021.1975737","url":null,"abstract":"<p><p><b>Objective</b>: To develop a predictive model for re-admission for postpartum preeclampsia (PPEC).<b>Methods</b>: A case-control study; cases were patients re-admitted for PPEC; controls were not re-admitted. Mixed linear modelling was used to develop a predictive model on the training set, then validated on the validation set.<b>Results</b>: Two-hundred-sixty-nine patients were readmitted, and matched to 538 controls. A risk calculator was developed and yielded a sensitivity and specificity for readmission of 80.9% and 53.5%, respectively.<b>Conclusion</b>: A predictive model using age, race, discharge blood pressures, and preeclampsia was able to predict re-admission for PPEC with a high level of sensitivity.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"254-260"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39408373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-05-06DOI: 10.1080/10641955.2021.1921793
Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan
{"title":"Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia.","authors":"Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan","doi":"10.1080/10641955.2021.1921793","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921793","url":null,"abstract":"ABSTRACT Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"186-192"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-05-12DOI: 10.1080/10641955.2021.1921791
Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Barbara Damnjanović Pažin, Srđan Stanimirović, Gorica Banjac, Aleksandra Stefanović, Vesna Spasojević-Kalimanovska, Amira Egić, Nina Rajović, Nataša Milić, Željko Miković
{"title":"Use of FMF algorithm for prediction of preeclampsia in high risk pregnancies: a single center longitudinal study.","authors":"Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Barbara Damnjanović Pažin, Srđan Stanimirović, Gorica Banjac, Aleksandra Stefanović, Vesna Spasojević-Kalimanovska, Amira Egić, Nina Rajović, Nataša Milić, Željko Miković","doi":"10.1080/10641955.2021.1921791","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921791","url":null,"abstract":"<p><p><b>OBJECTIVE</b>: This study aimed to assess the accuracy of The Fetal Medicine Foundation (FMF) screening algorithm for the prediction of preeclampsia.<b>METHODS</b>: Out of 138 women with high-risk pregnancies prospectively followed, 30 developed preeclampsia. The clinical examination and biochemical measurements were performed at first, second, early and late third trimester.<b>RESULTS</b>: A lower PAPP-A levels were found in the first trimester, while sFlt/PlGF was increased in the second and early third trimester in preeclampsia (p>0.05). FMF algorithm presented higher specificity (>70%), but had a drawback of lower sensitivity (35-77%).<b>CONCLUSION</b>: FMF algorithm had modest performance in the prediction of preeclampsia for high-risk pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"171-179"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-10-04DOI: 10.1080/10641955.2021.1981372
Yongping Wang, Zhihui Zhang
{"title":"Increased expression of lncRNA SNHG7 promotes the cell viability, migration, and invasion in pre-eclampsia via modulating the miR-214-5p/TWIST1 axis.","authors":"Yongping Wang, Zhihui Zhang","doi":"10.1080/10641955.2021.1981372","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981372","url":null,"abstract":"<p><strong>Purpose: </strong>This study is aimed to elucidate the molecular mechanism of lncRNA SNHG7 on pre-eclampsia (PE).</p><p><strong>Methods: </strong>The expression of SNHG7, miR-214-5p and TWIST1 in PE placental tissues was detected by qRT-PCR. The regulatory mechanism of SNHG7/miR-214-5p/TWIST1 axis on PE was determined using MTT, wound healing, transwell invasion, and western blot assays.</p><p><strong>Results: </strong>In PE pregnancies, SNHG7 and TWIST1 were decreased, while miR-214-5p was increased.The elevated miR-214-5p and decreased TWIST1 partly eliminated the promoting effects of SNHG7 up-regulation on the viability and metastasis of JEG-3 cells.</p><p><strong>Conclusions: </strong>Up-regulated SNHG7 protects against PE through modulating the miR-214-5p/TWIST1 axi.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"261-270"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39483563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-08-01Epub Date: 2021-08-31DOI: 10.1080/10641955.2021.1974031
Kun Dong, Ying Hou, Na Zhang, Bide Duan, Airong Ma, Zhiwei Zhang
{"title":"Down-regulated placental miR-21 contributes to preeclampsia through targeting RASA1.","authors":"Kun Dong, Ying Hou, Na Zhang, Bide Duan, Airong Ma, Zhiwei Zhang","doi":"10.1080/10641955.2021.1974031","DOIUrl":"https://doi.org/10.1080/10641955.2021.1974031","url":null,"abstract":"<p><p>Human placenta was obtained from early onset preeclampsia, late onset preeclampsia, and their gestational age-matched normal pregnancy. Using RT-qPCR, western blot, and immunohistochemistry, it was demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 were increased. Suppression of miR-21 in placental HTR-8/SVneo cells, remarkably upregulated RASA1, decreased proliferation, inhibited invasion, and promoted apoptosis of trophoblast cells, while overexpression of miR-21 alleviated these effects. Dual-luciferase reporter assays revealed RASA1 to be a direct target of miR-21 in trophoblast cells. miR-21 may serve key roles in the development of preeclampsia by targeting RASA1.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"236-245"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39372674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum survivin is decreased in women with preeclampsia.","authors":"Onur Güralp, Koray Gök, Nevin Tüten, Kübra Hamzaoglu, Melike Makul, Yahya Ozgun Oner, Huri Bulut, Meike Schild-Suhren, Eduard Malik, Abdullah Tüten","doi":"10.1080/10641955.2021.1917601","DOIUrl":"https://doi.org/10.1080/10641955.2021.1917601","url":null,"abstract":"<p><p><b>Objective</b>: To evaluate the serum survivin level in preeclampsia.<b>Methods</b>: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.<b>Results</b>: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure.<b>Conclusion</b>: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"144-151"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1917601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39000748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Household food insecurity associations with pregnancy hypertension, diabetes mellitus and infant birth anthropometric measures: a cross-sectional study of Iranian mothers.","authors":"Elham Hojaji, Mobina Aghajani, Rosa Zavoshy, Mostafa Noroozi, Hassan Jahanihashemi, Neda Ezzeddin","doi":"10.1080/10641955.2021.1874010","DOIUrl":"https://doi.org/10.1080/10641955.2021.1874010","url":null,"abstract":"<p><p><b>Objective</b>: The purpose of this study was to determine the associations between food insecurity on pregnancy and its outcomes.<b>Materials and methods</b>: This cross-sectional study was carried out on 700 Iranian mothers. Household socioeconomic status, prenatal information and household food security status <b>were assessed using questionnaires. Data analysis was applied by SPSS version 22.</b><b>Results</b>: The results of the study showed a significant association between food insecurity with gestational diabetes mellitus. The results also showed a significant association between birth weight, and height with pregnancy-induced hypertension.<b>Conclusion</b>: food insecure women should be recognized, and receive appropriate training and assistance.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"109-117"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1874010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38764948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension in PregnancyPub Date : 2021-05-01Epub Date: 2021-02-14DOI: 10.1080/10641955.2021.1884258
Virgínia Juliani Gomes, Priscila Rezeck Nunes, Sarah McCann Haworth, Valéria Cristina Sandrim, José Carlos Peraçoli, Maria Terezinha S Peraçoli, Mattias Carlström
{"title":"Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells.","authors":"Virgínia Juliani Gomes, Priscila Rezeck Nunes, Sarah McCann Haworth, Valéria Cristina Sandrim, José Carlos Peraçoli, Maria Terezinha S Peraçoli, Mattias Carlström","doi":"10.1080/10641955.2021.1884258","DOIUrl":"https://doi.org/10.1080/10641955.2021.1884258","url":null,"abstract":"<p><p><b>Objective:</b> To investigate whether the supernatant from monocytes of preeclamptic and normotensive pregnant women, cultured in vitro with silibinin, can modulate oxidative stress in HUVEC.<b>Methods</b>: Concentrations of IL-1β, IL-10, and TNF-α in monocyte culture supernatants were determined by ELISA. HUVEC and their supernatant cultures were employed for determination of NO, nitrite and nitrate, lipid peroxidation, and hemeoxygenase-1 (HO-1).<b>Results</b>: HUVEC treatment with supernatant of preeclamptic monocytes cultured with silibinin produced increased levels of nitrite, reduced lipid peroxidation, and increased HO-1.<b>Conclusion</b>: Supernatant of monocytes from preeclamptic women induce oxidative stress in HUVEC which can be reduced by silibinin treatment.<b>Abbreviations:</b> DAF-FM<sup>TM</sup>, Diaminofluorescein-FM; EDTA, Ethylenediaminetetraacetic acid; HO-1, heme oxygenase-1; HPLC, high-performance liquid chromatography; HUVEC, human umbilical vein endothelial cell; MDA, malondialdehyde; NO, nitric oxide; NT, normotensive; PE, preeclampsia; ROS, reactive oxygen species; Sb, silibinin.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"124-132"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1884258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25368548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}