胎盘转录组分析显示，HELLP综合征比先兆子痫表现出更大程度的胎盘代谢功能障碍。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-04-05 DOI:10.1080/10641955.2021.1908348

Lili Gong, Huanqiang Zhao, Yutong Cui, Xiaotian Li

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引用次数: 3

摘要

目的:HELLP综合征与先兆子痫之间的关系已被研究，但结论相互矛盾。本研究旨在通过分析胎盘转录组来探讨这两种疾病的发病机制。方法:采用R语言对从gene expression Omnibus数据库下载的基因表达谱进行分析。结果:共鉴定出HELLP综合征差异表达基因573个，子痫前期差异表达基因358个，其中HELLP综合征独有基因295个。一些代谢相关通路在HELLP综合征中独特富集。结论:HELLP综合征比先兆子痫表现出更大程度的胎盘代谢功能障碍，尽管这两种疾病可能有部分共同的发病机制。

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Transcriptome analysis of placentae reveals HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia.

Objective: The association between HELLP syndrome and preeclampsia has been investigated with conflicting conclusions. This study is to investigate the pathogenesis underlying these two diseases by analyzing placental transcriptome.Methods: The gene expression profile downloaded from Gene Expression Omnibus database was analyzed by R language.Results: A total of 573 differentially expressed genes in HELLP syndrome and 358 in preeclampsia were identified, among which 295 were unique to HELLP syndrome. Some metabolism-associated pathways were uniquely enriched in HELLP syndrome.Conclusions: HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia, although these two diseases might share partial pathogenesis.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.