Hypertension in Pregnancy最新文献

{"title":"Neuroimaging characteristics and clinical outcomes of posterior reversible encephalopathy syndrome in preeclamptic and eclamptic patients.","authors":"Ahmet Beyazıt, İbrahim Barışcan Soydan, Kenan Serdar Dolapçıoğlu, Hanifi Bayaroğulları, Oya Soylu Karapınar, Arif Güngören","doi":"10.1080/10641955.2026.2636602","DOIUrl":"https://doi.org/10.1080/10641955.2026.2636602","url":null,"abstract":"<p><p>Posterior reversible encephalopathy syndrome (PRES) is a neurological complication linked to preeclampsia and eclampsia. This study compared the clinical and radiological features of PRES in patients with these conditions. This retrospective single-center cohort study from 2010 to 2024 included patients diagnosed with preeclampsia and eclampsia who underwent MRI due to neurological symptoms. Two radiologists, blinded to the clinical data, re-evaluated the MRIs twice. PRES cases were assessed based on the sites and patterns of involvement. Maternal and perinatal outcomes, along with laboratory characteristics, were reviewed through medical records. The study included 157 patients with preeclampsia and eclampsia who underwent MRI for neurological symptoms. PRES was diagnosed in 55 patients (35.0%), with a higher incidence of eclampsia (64.71%) compared to preeclampsia (20.75%). Patients with PRES were younger, had lower gravidity and parity, and were at an earlier gestational age than those with normal MRI findings. The parietal and occipital regions were the most affected in both preeclampsia and eclampsia patients with PRES. Parietal lobe and bilateral involvement were more common in the eclampsia group. Atypical involvement, including brainstem and cerebellar lesions, was observed in both groups. These findings suggest that eclampsia may represent a neurological manifestation of PRES.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2636602"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SII serves as an independent diagnostic indicator for GDM and is regulated by placental 5-HT/NF-κB signaling.","authors":"Weizhao Lin, Yujuan Tang, Jiahua Chen, Furong Liu, Shixin Chen, Qing Zhang, Xian Li, Pingping Song, Xuefeng Ma","doi":"10.1080/10641955.2026.2627865","DOIUrl":"https://doi.org/10.1080/10641955.2026.2627865","url":null,"abstract":"<p><p>Gestational diabetes mellitus (GDM) poses a significant threat to perinatal health. Diagnosis based solely on glycemic parameters shows limited accuracy. The Systemic Immune-Inflammation Index (SII), a quantitative marker of inflammation, may improve diagnostic precision. This study analyzed clinical data stratified by GDM and obesity status to evaluate the diagnostic utility of SII and its underlying mechanisms involving placental NF-κB and 5-hydroxytryptamine (5-HT) signaling. We observed elevated SII levels in GDM patients, which correlated positively with glucose levels and inflammatory indicators (white blood cell count, fasting blood glucose, postprandial blood glucose). Logistic regression and receiver operating characteristic analyses confirmed the diagnostic value of SII, which was further enhanced when combined with clinical covariates. Placental expression of tryptophan hydroxylase 1 (TPH1) and NF-κB was significantly increased in GDM and closely linked to SII levels. Dysregulation of placental 5-HT signaling, characterized by increased TPH1 and monoamine oxidase A (MAO-A) expression alongside reduced serotonin transporter (SERT), was associated with maternal overweight. Moreover, SII, BMI, TPH1, and NF-κB all correlated with insulin resistance (IR). These results support SII as a non-invasive diagnostic indicator for GDM and highlight the role of placental 5-HT/NF-κB signaling in its pathogenesis, providing insights for early diagnosis and targeted therapy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2627865"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of systemic inflammatory response index with severity of preeclampsia.","authors":"Lina Gao, Yan Dong, Xiaohui Liu, De Chen, Huixin Cheng, Jian Liu","doi":"10.1080/10641955.2026.2632210","DOIUrl":"https://doi.org/10.1080/10641955.2026.2632210","url":null,"abstract":"<p><strong>Objective: </strong>The systemic inflammatory response index (SIRI), a novel and integrated hematological index calculated as (neutrophil count × monocyte count)/lymphocyte count, has been recognized as a reliable marker of systemic inflammation. This article undertakes an analysis of clinical data from preeclampsia (PE) patients, aiming to comprehensively assess the relationship between SIRI, PE, and the severity of PE.</p><p><strong>Methods: </strong>A total of 783 pregnant women in their third trimester were divided into severe preeclampsia (SP) (<i>n</i> = 275), non-SP (<i>n</i> = 273), and control (<i>n</i> = 235) groups. Pearson correlation analysis was performed to investigate the relationship between SIRI and blood pressure. Receiver operating characteristic (ROC) curves were employed to evaluate the predictive ability of SIRI. Multivariate logistic regression analysis was used to assess the association between SIRI and the severity of PE.</p><p><strong>Results: </strong>There was a significant relationship between SIRI and systolic blood pressure (<i>r</i> = 0.488, <i>p</i> < 0.001) as well as diastolic blood pressure (<i>r</i> = 0.462, <i>p</i> < 0.001). ROC curve revealed that pregnant women with SIRI ≥ 1.84 × 10⁹/L were more likely to experience non-SP (AUC: 0.662; 95% CI: 0.615-0.710; <i>p</i> < 0.001), and those with SIRI ≥ 2.45 × 10⁹/L were prone to SP (AUC: 0.879; 95% CI: 0.850-0.910; <i>p</i> < 0.001). Multivariate logistic regression analysis demonstrated that SIRI served as an independent risk factor for both non-SP and SP (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>There is a strong correlation between SIRI and the severity of PE, and SIRI shows potential in predicting the severity of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2632210"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/10641955.2026.2651587","DOIUrl":"https://doi.org/10.1080/10641955.2026.2651587","url":null,"abstract":"","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2651587"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification risk factors for perinatal complications among pregnant women with pulmonary arterial hypertension.","authors":"Yanyu Wu, Yangjing Zhu, Gaiming Gao, Shunyuan Li, Yingle Chen, Liangcheng Zhang","doi":"10.1080/10641955.2026.2652977","DOIUrl":"https://doi.org/10.1080/10641955.2026.2652977","url":null,"abstract":"<p><strong>Background: </strong>The risk factors for perinatal complications in pregnant women with pulmonary arterial hypertension (PAH) remain controversial. This study aimed to explore the risk factors and constructed a prediction model for perinatal complications in pregnant women with PAH.</p><p><strong>Method: </strong>A total of 116 pregnant women with PAH were retrospectively recruited from the Union Hospital affiliated with the Fujian Medical University between January 2016 and December 2016. The risk factors for perinatal complications were identified by using logistic regression model, while the predictive value of identified factors was assessed using the area under a receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>Multivariate results indicated moderate PAH (OR: 15.38; 95% CI: 1.54-166.67; <i>P</i> = 0.020), and congenital heart disease (OR: 2.60; 95% CI: 1.25-5.41; <i>p</i> = 0.010) were associated with an increased risk of perinatal complications. A predictive model based on the aforementioned factors for perinatal complications in pregnant women with PAH was constructed, and the area under a ROC curve was 0.73 (95% CI: 0.60-0.86).</p><p><strong>Conclusion: </strong>Perinatal complications in pregnant women with PAH could be affected by the severity of PAH and congenital heart disease and that the predictive value of the constructed model was moderate.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2652977"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectrical impedance-derived extracellular fluid expansion and perinatal outcomes in preeclampsia.","authors":"Young Mi Jung, Hee Kyeong Lee, Min Jung Lee, Bo Young Choi, Hyeon Ji Kim, Kuyeong Han, Narin Kim, Seong Guk Kim, Jee Yoon Park","doi":"10.1080/10641955.2026.2665111","DOIUrl":"https://doi.org/10.1080/10641955.2026.2665111","url":null,"abstract":"<p><strong>Objective: </strong>To quantify extracellular fluid expansion in preeclampsia using bioelectrical impedance analysis (BIA) and to evaluate whether BIA-derived extracellular water (ECW) indices are associated with perinatal outcomes.</p><p><strong>Methods: </strong>In this prospective cohort study, 16 hospitalized women with high-risk pregnancies (7 with preeclampsia and 9 normotensive controls) underwent segmental BIA at a mean gestational age of 32 weeks. Total body water (TBW), intracellular water (ICW), ECW, and ECW/TBW were compared between groups. Fluid indices were additionally expressed as weight-adjusted and height-indexed measures. Associations between ECW/TBW and perinatal outcomes were reviewed and analyzed.</p><p><strong>Results: </strong>Compared with normotensive controls, women with preeclampsia had higher TBW, ICW, ECW, and ECW/TBW (all <i>p</i> < 0.05), with consistent segmental elevations most prominent in the lower extremities. Weight adjustment eliminated between-group differences in absolute fluid volumes, whereas height-indexing preserved significant elevations across compartments (all <i>p</i> ≤ 0.002). In the overall high-risk cohort, higher ECW/TBW was associated with earlier gestational age at delivery and lower 1-minute Apgar scores (both <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Preeclampsia is characterized by measurable extracellular fluid expansion on bedside BIA. Elevated ECW/TBW is associated with adverse perinatal outcomes among hospitalized high-risk pregnancies, supporting the potential clinical utility of non-invasive fluid assessment for risk stratification in hypertensive disorders of pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2665111"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of continuous analgesia during labor in pregnant women with hypertensive disorders: a comparative study on pain relief, anxiety, depression, and maternal-infant outcomes.","authors":"Tiantian Huang, Hongfang Liu, Jing Ren, Xiaoxia Gu","doi":"10.1080/10641955.2025.2583822","DOIUrl":"https://doi.org/10.1080/10641955.2025.2583822","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the effects of continuous analgesia versus standard pain management on pain intensity, psychological status (anxiety and depression), and maternal-infant outcomes in pregnant women with hypertensive disorders.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 124 pregnant women with hypertensive disorders admitted between December 2021 and December 2023. Participants were categorized into two groups based on the labor analgesia received: a non-continuous analgesia group (<i>n </i>= 51) and a continuous analgesia group (<i>n</i> = 73). Outcome measures included pain scores at different stages of dilation (4 cm and 8 cm) and anxiety/depression levels assessed pre-delivery, post-delivery, and 24 hours postpartum.</p><p><strong>Results: </strong>The continuous analgesia group demonstrated significantly lower pain scores at both 4 cm dilation (t = 8.888, <i>P</i> < 0.001) and 8 cm dilation (t = 9.604, <i>P</i> < 0.001) compared to the non-continuous group. Regarding psychological outcomes, the continuous analgesia group showed significantly lower anxiety levels pre-delivery (t = 2.606, <i>P</i> = 0.011), post-delivery (t = 2.343, <i>P</i> = 0.022), and 24 hours postpartum (t = 5.084, <i>P</i> < 0.001). Similarly, depression scores were significantly lower in the continuous analgesia group at all three time points: pre-delivery (t = 2.019, <i>P</i> = 0.046), post-delivery (t = 2.66, <i>P</i> = 0.009), and 24 hours postpartum (t = 4.103, <i>P</i> < 0.001). Correlation analysis revealed significant negative associations between continuous analgesia and maternal pain, anxiety, and depression (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Continuous analgesia during labor is associated with superior pain relief and a significant reduction in anxiety and depression levels for pregnant women with hypertensive disorders compared to standard pain management. These findings suggest that continuous analgesia may be a beneficial intervention for improving the maternal psychological experience in this high-risk population.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2583822"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation.","authors":"Shaoping Huang, Qing Su, Xuechun Li, Yang Zhang","doi":"10.1080/10641955.2025.2609374","DOIUrl":"https://doi.org/10.1080/10641955.2025.2609374","url":null,"abstract":"<p><strong>Background and objective: </strong>Trophoblast pyroptosis contributes to the pathogenesis of preeclampsia (PE). Succinylation is a posttranslational modification that is involved in the progression of various diseases. This study aimed to explore the role of the succinyltransferase KAT2A in PE by evaluating its impact on pyroptosis.</p><p><strong>Methods: </strong>Rats were injected with N-nitro-L-arginine methyl ester to generate a PE model, and blood pressure was detected. HTR-8/SVneo cells were treated with hypoxia and reoxygenation, and pyroptosis was evaluated by flow cytometry and western blotting. The mechanism was assessed using immunoprecipitation, cycloheximide chase experiment, and western blotting.</p><p><strong>Results: </strong>KAT2A was highly expressed in the placentas of PE rats. Knockdown of KAT2A inhibited pyroptosis of the HTR-8/SVneo cell model <i>in vitro</i> and ameliorated blood pressure and pyroptosis in the placenta <i>in vivo</i>. Additionally, KAT2A promoted the succinylation of NLRP3 at the lysine (K)21 site, and mutation of NLRP3 at this site reduced its stability. Moreover, overexpression of NLRP3 counteracted the inhibition of pyroptosis caused by KAT2A knockdown.</p><p><strong>Conclusion: </strong>Silencing of KAT2A inhibits trophoblast pyroptosis by downregulating NLRP3 expression, thereby alleviating PE. Mechanistically, KAT2A stabilizes NLRP3 by facilitating its succinylation at K21 site. These findings suggest that KAT2A may be a promising target for the treatment of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2609374"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for preeclampsia risk prediction in the first trimester: a nested case-control study.","authors":"Ru Feng, Jiajia Chen, Shuling Wang, Shu Li, Guijuan Zhang, Xiao Hao, Qing Zhang, Bing Wang, Linlin Hua","doi":"10.1080/10641955.2026.2616548","DOIUrl":"https://doi.org/10.1080/10641955.2026.2616548","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia (PE) is a serious and progressive multisystem disease that often results in negative outcomes for neonates. This study aimed to create a nomogram to identify high-risk women with PE in their first trimester.</p><p><strong>Methods: </strong>This study involved a nested case-control cohort including 47 PE patients and 122 controls from The Second Affiliated Hospital of Zhengzhou University from January 1, 2023, to May 31, 2024. We identified independent risk factors for PE via multivariate logistic regression and developed a nomogram model. Calibration curves were used to assess accuracy, and decision curve analysis (DCA) was used to evaluate clinical applicability.</p><p><strong>Results: </strong>Multivariate logistic regression revealed that pre-pregnancy body mass index (BMI), mean arterial pressure (MAP), and uric acid (UA) levels were positively correlated with PE, whereas placental growth factor (PLGF) was negatively correlated. The area under the curve (AUC) for the combined diagnostic value was 0.97 (95% CI: 0.96-0.99), suggesting satisfactory discrimination. DCA demonstrated that the predictive model provided high net benefits and significant clinical utility.</p><p><strong>Conclusions: </strong>The nomogram developed in this study, which includes pre-pregnancy BMI, PLGF, MAP, and UA for the prediction of PE risk, can assist clinicians in identifying high-risk individuals during the first trimester.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2616548"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental CD4⁺ T cells from women with gestational diabetes recapitulate disease features in a pregnant rat model, improved by metformin or mitotempo.","authors":"Danielle Frieson, Jean Vel, Tyler Johnson, Nathan Campbell, Baoying Zheng, Sheila Belk, Cameronne Dodd, Kenneth Butler, Babbette Lamarca, Evangeline Deer","doi":"10.1080/10641955.2026.2665113","DOIUrl":"https://doi.org/10.1080/10641955.2026.2665113","url":null,"abstract":"<p><strong>Objective: </strong>Gestational diabetes mellitus (GDM) refers to glucose intolerance, insulin sensitivity, and beta islet cell dysfunction during pregnancy. GDM pathogenesis is associated with hypertension, impaired placental and renal function, oxidative stress, and increased circulating CD4⁺ T cells. There are limited animal models to explore GDM pathology and treatment. This study sought to determine a role for GDM placental CD4⁺ T cells to parallel manifestations of the GDM phenotype in pregnant athymic nude rats.</p><p><strong>Methods: </strong>GDM placental CD4+ T cells (GDM T cells) were isolated upon delivery and injected into pregnant nude rats on gestational day (GD) 12. Mean arterial pressure and markers of renal injury, proteinuria, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin, were assessed on GD19. Glucose, insulin tolerance, and glucose tolerance tests were also performed. Renal and pancreatic tissues were stained using Periodic acid Schiff and hematoxylin and eosin, respectively. A one-way ANOVA was used for statistical analysis.</p><p><strong>Results: </strong>Adoptive transfer of GDMT cells increased blood pressure (120.8 ± 2.2 mmHg, <i>p</i> < 0.05) compared to controls (105.4 ± 2.8 mmHg) and normotensive Tcell recipients (96.3 ± 3.9 mmHg). Metformin or MitoTEMPO attenuated this response. GDM T cell recipients had elevated blood glucose (<i>p</i> < 0.05) and impaired glucose tolerance and insulin sensitivity, which improved with metformin or MitoTEMPO treatment. Renal injury was more severe in GDM T cell recipients, but attenuated with metformin or MitoTEMPO. Pancreatic morphology showed reduced beta islet numbers in GDM T cell recipients.</p><p><strong>Conclusion: </strong>GDM CD4⁺ T cells contribute to hypertension, glucose intolerance, and renal dysfunction, improved byMitoTEMPO. These findings supports optional therapeutics that support mitochondrial function during pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2665113"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}