Hypertension in Pregnancy最新文献

Identification of potential circadian rhythm-related hub genes and immune infiltration in preeclampsia through bioinformatics analysis. 通过生物信息学分析鉴定子痫前期潜在的昼夜节律相关中枢基因和免疫浸润。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-31 Epub Date: 2025-09-19 DOI: 10.1080/10641955.2025.2559734

Juan Tang, Qiuping Dong, Xiaowen Chen

{"title":"Identification of potential circadian rhythm-related hub genes and immune infiltration in preeclampsia through bioinformatics analysis.","authors":"Juan Tang, Qiuping Dong, Xiaowen Chen","doi":"10.1080/10641955.2025.2559734","DOIUrl":"https://doi.org/10.1080/10641955.2025.2559734","url":null,"abstract":"Objective: Preeclampsia (PE) is a severe pregnancy complication with unclear molecular mechanisms. Emerging evidence suggests that circadian rhythm disruption contributes to PE pathogenesis. The study aims to identify circadian rhythm-related genes in PE and explore their diagnostic value and immune characteristics.Methods: Four gene expression datasets (GSE75010, GSE60438, GSE186257, GSE14722) were downloaded from the GEO database. Modules correlated with PE were identified via weighted gene co-expression network analysis (WGCNA). Differential expression was assessed with the limma package in R, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were carried out using clusterProfiler. Diagnostic accuracy was evaluated using Receiver operating characteristic curves in training and validation sets. Immune infiltration was analyzed using CIBERSORT and Single Sample Gene Set Enrichment Analysis algorithms. PE patients were clustered into subtypes with ConsensusClusterPlus. ceRNA and Transcription Factor regulatory networks were constructed using miRTarBase, ENCODE, and NetworkAnalyst.Results: CRH and LEP were identified as circadian rhythm-related hub genes with strong diagnostic value. Molecular subtyping based on their expression revealed two PE subtypes with distinct immune infiltration patterns and biological functions. Regulatory network construction highlighted potential upstream mechanisms.Conclusion: This bioinformatics analysis provides preliminary evidence for CRH and LEP as potential circadian rhythm-related diagnostic biomarkers in PE. However, as the findings are derived from limited GEO datasets, they should be interpreted with caution, and large‑scale, multi‑center prospective studies measuring their expression in serum or placental tissues across diverse populations are required to confirm their clinical utility.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2559734"},"PeriodicalIF":2.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas. 法属圭亚那子痫前期危险因素：人口和地理区域之间的巨大异质性。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/10641955.2025.2484019

Malika Leneuve-Dorilas, Fabrice Quet, Stéphanie Bernard, Lindsay Osei, Alphonse Louis, Marie-Noella Capé, Dominique Dotou, Anne-Christèle Dzierzek, Narcisse Elenga, Mathieu Nacher

{"title":"Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas.","authors":"Malika Leneuve-Dorilas, Fabrice Quet, Stéphanie Bernard, Lindsay Osei, Alphonse Louis, Marie-Noella Capé, Dominique Dotou, Anne-Christèle Dzierzek, Narcisse Elenga, Mathieu Nacher","doi":"10.1080/10641955.2025.2484019","DOIUrl":"10.1080/10641955.2025.2484019","url":null,"abstract":"Background: French Guiana is France's largest overseas territory, accounting for 1/6th of mainland France. French Guiana has the highest fertility rate in France and Latin America. However, infant mortality, especially neonatal mortality, remains 2.6 times higher than in mainland France. Preeclampsia was found to be the most important pregnancy-related condition contributing to preterm birth in the primary analysis of risk factors for preterm birth in French Guiana.Methods: Therefore, by analyzing the Registre des Issues de Grossesse de Guyane (RIGI), we sought to better describe this condition and understand its risk factors in our area. A retrospective and comparative study was conducted using 2014-2020 data from the RIGI, which describes 53,522 viable births (≥22 weeks of amenorrhea) in all four perinatal facilities in French Guiana. The RIGI is performed by midwives after patients' delivery. It records data up to two hours postpartum.Results: During the study 12.9% of children were born preterm at less than 37 WA (weeks of amenorrhea). 4.5% of the study population had preeclampsia, of which almost half, 49.5%, were expected to deliver prematurely. The Afro-Caribbean population has a higher risk of preeclampsia than the white population, more than double that of the caucasians. Despite adjustment for place of birth, there are spatial heterogeneities in preeclampsia, with an increased risk for residents of towns in western French Guiana.Conclusion: In conclusion, preeclampsia is a major cause of preterm birth and morbidity in French Guiana. The great heterogeneity between populations and geographical areas requires specific blood tests such as angiogenic balance or still heavy metal assays.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2484019"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting oxidative stress in preeclampsia. 靶向氧化应激在子痫前期。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2024-12-27 DOI: 10.1080/10641955.2024.2445556

Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements

{"title":"Targeting oxidative stress in preeclampsia.","authors":"Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements","doi":"10.1080/10641955.2024.2445556","DOIUrl":"10.1080/10641955.2024.2445556","url":null,"abstract":"Preeclampsia is a complex condition characterized by elevated blood pressure and organ damage involving kidneys or liver, resulting in significant morbidity and mortality for both the mother and the fetus. Increasing evidence suggests that oxidative stress, often caused by mitochondrial dysfunction within fetal trophoblast cells may play a major role in the development and progression of preeclampsia. Oxidative stress occurs as a result of an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidant defenses, which can lead to placental cellular damage and endothelial cell dysfunction. Targeting oxidative stress appears to be a promising therapeutic approach that has the potential to improve both short- and long-term maternal and fetal outcomes, thus reducing the global burden of preeclampsia. The purpose of this review is to provide a comprehensive account of the mechanisms of oxidative stress in preeclampsia. Furthermore, it also examines potential interventions for reducing oxidative stress in preeclampsia, including natural antioxidant supplements, lifestyle modifications, mitochondrial targeting antioxidants, and pharmacological agents.A better understanding of the mechanism of action of proposed therapeutic strategies targeting oxidative stress is essential for the identification of companion biomarkers and personalized medicine approaches for the development of effective treatments of preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2445556"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of 24-hour urine protein levels for adverse maternal and perinatal outcomes in hypertensive pregnancies. 24小时尿蛋白水平对高血压妊娠孕产妇和围产期不良结局的预测价值。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-06-30 DOI: 10.1080/10641955.2025.2524327

Şebnem Karagün, Hamza Yıldız, Yusuf Dal, Sefanur Gamze Karaca, Ahmet Zeki Nessar, Mürşide Çevikoğlu Kıllı, Ayhan Coşkun

{"title":"Predictive value of 24-hour urine protein levels for adverse maternal and perinatal outcomes in hypertensive pregnancies.","authors":"Şebnem Karagün, Hamza Yıldız, Yusuf Dal, Sefanur Gamze Karaca, Ahmet Zeki Nessar, Mürşide Çevikoğlu Kıllı, Ayhan Coşkun","doi":"10.1080/10641955.2025.2524327","DOIUrl":"https://doi.org/10.1080/10641955.2025.2524327","url":null,"abstract":"Background: Proteinuria is a widely used biomarker for risk stratification in hypertensive pregnancies, with potential predictive value for adverse maternal and perinatal outcomes. This study evaluated the predictive value of 24-hour urine protein levels for adverse maternal and perinatal outcomes in hypertensive pregnancies.Methods: A retrospective cohort of 213 pregnant women with hypertension was categorized into four groups based on proteinuria severity: <300 mg (n = 147), 300-500 mg (n = 22), 500-2000 mg (n = 25), and > 2000 mg (n = 19).Methods: Higher proteinuria levels were significantly associated with increased rates of oligohydramnios (p = 0.001) and fetal growth restriction (FGR; p = 0.005), particularly in the > 2000 mg group (44.0% and 68.4%, respectively). Gestational age at delivery decreased with worsening proteinuria (p < 0.001), with the lowest mean age (32.84 ± 3.82 weeks) in the > 2000 mg group. Postpartum hospital stays were prolonged in chronic hypertension (p = 0.002) and severe proteinuria groups (p = 0.007). ROC analysis identified a 24-hour urine protein cutoff of 135 mg (AUC: 0.635, p = 0.001) for predicting fetal distress. The > 2000 mg group had universal magnesium sulfate use, earlier deliveries, and higher FGR rates. Chronic hypertension correlated with longer postpartum stays (p = 0.002) and higher postpartum renal disease (p = 0.040).Conclusion: These findings underscore proteinuria as a prognostic marker for adverse outcomes, supporting its role in risk stratification for hypertensive pregnancies. Future research should validate thresholds and explore targeted interventions.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2524327"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-28 DOI: 10.1080/10641955.2025.2532489

Mónica Chamillard, Virginia Díaz, Celina Gialdini, Julia Pasquale, Anayda Portela, Edgardo Abalos

{"title":"Similarities and differences in international clinical practice guidelines for preeclampsia diagnosis and diagnostics: a scoping review.","authors":"Mónica Chamillard, Virginia Díaz, Celina Gialdini, Julia Pasquale, Anayda Portela, Edgardo Abalos","doi":"10.1080/10641955.2025.2532489","DOIUrl":"10.1080/10641955.2025.2532489","url":null,"abstract":"Introduction: Preeclampsia is a leading cause of maternal and newborn deaths. Traditionally characterized by high-blood pressure and proteinuria, organ and placental dysfunction were later proposed in some clinical practice guidelines as additional components for its definition. Variability in diagnostic criteria across international guidelines could be a barrier to harmonized and equitable care in different settings.Methods: We reviewed current relevant clinical practice guidelines to identify similarities and differences in recommendations related to the definition and diagnosis of preeclampsia, and their supporting evidence. We also reviewed additional systematic reviews related to the diagnosis of preeclampsia. We searched different databases and websites of international and professional organizations for guidelines published or updated from 2014 to 2024. We searched databases to identify additional systematic reviews on preeclampsia diagnosis.Results: Fifteen guidelines from 11 organizations were identified with 11 systematic reviews supporting evidence on the diagnosis of preeclampsia. We found 21 additional systematic reviews, not included in these guidelines.Discusion: There is agreement for hypertension and proteinuria for the diagnosis of preeclampsia, without a uniform consensus on methods and devices for their assessment. Organ dysfunction is considered in eight guidelines and placental dysfunction in four, with some disagreements on their usefulness, and the methods and tools for their measurement. Few guidelines support their recommendations on preeclampsia diagnosis with systematic reviews.Conclusion: Consensus in preeclampsia definition is needed to guide not only clinical practice but also future research and policy, particularly in global health contexts.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2532489"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a lifestyle intervention for women with gestational diabetes mellitus based on the medical internet of things: a randomized controlled trial with mid-sample verification. 基于医疗物联网对妊娠期糖尿病妇女生活方式干预的评价：一项随机对照试验，中样本验证

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1080/10641955.2025.2552693

Jiying Wen, Liping Zhou, Haibin Hu, Dongmei Duan, Wenxia Zou, Yuheng Zhou, Xiaohong Lin, Yuntao Wu, Qimeng Zhao, Qingguo Zhao, Bing Li

{"title":"Evaluation of a lifestyle intervention for women with gestational diabetes mellitus based on the medical internet of things: a randomized controlled trial with mid-sample verification.","authors":"Jiying Wen, Liping Zhou, Haibin Hu, Dongmei Duan, Wenxia Zou, Yuheng Zhou, Xiaohong Lin, Yuntao Wu, Qimeng Zhao, Qingguo Zhao, Bing Li","doi":"10.1080/10641955.2025.2552693","DOIUrl":"10.1080/10641955.2025.2552693","url":null,"abstract":"Objective: To evaluate the effect of lifestyle intervention using a self-management model based on the medical Internet of Things (mIoT) for women with gestational diabetes mellitus (GDM).Methods: 240 eligible participants were initially enrolled, with 225 completing the trial (116 in the intervention group, 109 in the control group) due to 15 dropouts (4 in the intervention, 11 in the control) caused by delivery at non-study hospitals. The control group regularly received the lifestyle interventions. The intervention group received the same interventions based on mIoT. Data on glucose metabolism and lipid metabolism were collected at 4 weeks and 8 weeks after the intervention and pre-delivery at the admission. Maternal and infant outcomes were compared between the two groups.Results: After the intervention, the fast blood glucose (FBG) and weight gain in the intervention group were significantly decreased than those in the control group. The glucose-metabolism indexes and lipid metabolism indexes were significantly lower in the intervention group than the control group. The rates of preeclampsia, preterm birth, neonatal hypoglycemia, and fetal macrosomia were also significantly lower in the intervention group than those in the control group.Conclusion: The lifestyle intervention based on the medical Internet of things could improve the compliance and effectiveness of self-management in women with gestational diabetes mellitus, and it had a good clinical effect on their metabolic status in terms of blood glucose and lipids in late pregnancy and pregnancy outcomes.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2552693"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of behavioral phenotypes on response to a digital intervention to improve physical activity among postpartum individuals with hypertensive disorders of pregnancy. 行为表型对数字干预改善妊娠期高血压疾病患者身体活动的影响

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1080/10641955.2025.2556140

Hilary Bediako, Tang Li, Dazheng Zhang, Mary E Putt, Lisa Levine, Jinbo Chen, Jennifer Lewey

{"title":"Impact of behavioral phenotypes on response to a digital intervention to improve physical activity among postpartum individuals with hypertensive disorders of pregnancy.","authors":"Hilary Bediako, Tang Li, Dazheng Zhang, Mary E Putt, Lisa Levine, Jinbo Chen, Jennifer Lewey","doi":"10.1080/10641955.2025.2556140","DOIUrl":"https://doi.org/10.1080/10641955.2025.2556140","url":null,"abstract":"Importance: Hypertensive disorders of pregnancy (HDP) increase cardiovascular disease risk. Postpartum interventions can motivate lifestyle changes but are not universally effective.Objective: Our objective was to determine how behavioral phenotypes are associated with response to a digital health intervention designed to increase physical activity among 122 postpartum individuals with HDP.Design and methods: We conducted a secondary analysis of the STEP UP Mom trial, comparing a wearable step tracker with team-based gamification to a wearable step tracker alone over 12 weeks. Baseline behavioral characteristics were obtained using validated surveys. We applied the k-means clustering method to identify clusters.Main outcome and measure: Linear mixed-effects models were used to estimate mean step count difference between arms from baseline across follow-up within each cluster.Results: We identified two distinct, non-overlapping clusters. Cluster 1 had higher baseline steps and greater psychosocial distress, without significant difference in change in step count in the intervention arm compared to the control arm. Cluster 2 had lower baseline steps and less psychosocial distress and walked 1,335 significantly more steps per day in the intervention arm compared to the control arm. Sustained engagement with the study intervention did not differ between clusters.Conclusions and relevance: Behavioral phenotypes may help identify postpartum individuals who may benefit from tailored interventions in future studies to improve lifestyle changes.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2556140"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations of metabolic dysfunction-associated steatotic liver disease with gestational hypertension and preeclampsia: a two-sample Mendelian randomization study. 代谢功能障碍相关脂肪变性肝病与妊娠期高血压和子痫前期的因果关系：一项双样本孟德尔随机化研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2024-12-20 DOI: 10.1080/10641955.2024.2441862

Lu Zhang, Liang Fang, Jiahua Zou, Dong Zhou, Haonan Xie, Aihua Chen, Qingming Wu

{"title":"Causal associations of metabolic dysfunction-associated steatotic liver disease with gestational hypertension and preeclampsia: a two-sample Mendelian randomization study.","authors":"Lu Zhang, Liang Fang, Jiahua Zou, Dong Zhou, Haonan Xie, Aihua Chen, Qingming Wu","doi":"10.1080/10641955.2024.2441862","DOIUrl":"https://doi.org/10.1080/10641955.2024.2441862","url":null,"abstract":"Background: Hypertensive disorders of pregnancy (HDPs), which include gestational hypertension (GH) and preeclampsia (PE), are the primary causes of maternal morbidity and mortality worldwide. Recent studies have found a correlation between metabolic dysfunction-associated steatotic liver disease (MASLD) and HDPs, but the causality of this association remains to be identified. Therefore, this study aims to evaluate the causal relationship between MASLD and HDPs through Mendelian randomization (MR) analysis.Methods: The summary statistics from genome-wide association studies were employed to conduct a two-sample MR analysis. Five complementary MR methods, including inverse variance weighting (IVW), MR-Egger, weighted median, simple mode and weighted mode were performed to assess the causality of MASLD on GH and PE. Furthermore, we conducted various sensitivity analyses to ensure the stability and reliability of the results.Results: Genetically predicted MASLD significantly increased the risk of GH (IVW: OR = 1.138, 95% CI: 1.062-1.220, p < 0.001), while there was little evidence of a causal relationship between MASLD and PE (IVW: OR = 0.980, 95% CI: 0.910-1.056, p = 0.594). The sensitivity analyses indicated no presence of heterogeneity and horizontal pleiotropy.Conclusion: This MR study provided evidence supporting the causal effect of MASLD on GH. Our findings underscore the significance of providing more intensive prenatal care and early intervention for pregnant women with MASLD to prevent potential adverse obstetric outcomes.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2441862"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum. 妊娠期胎盘缺血可诱发产后高血压、脑炎症和氧化应激。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/10641955.2025.2454597

Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo, Natalia Wiemann, Ahfiya Howard, Mark Cunningham

{"title":"Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum.","authors":"Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo, Natalia Wiemann, Ahfiya Howard, Mark Cunningham","doi":"10.1080/10641955.2025.2454597","DOIUrl":"10.1080/10641955.2025.2454597","url":null,"abstract":"Background: Preeclampsia (PE) is characterized as de novo hypertension (HTN) with end-organ damage, especially in the brain. PE is hypothesized to be caused by placental ischemia. PE affects ~5-8% of USA pregnancies and increases the risk for HTN and cerebrovascular diseases (CVD) later in life. We hypothesize that blood pressure (BP), cerebral oxidative stress, and cerebral inflammation will increase in postpartum (PP) placental ischemic dams.Methods: Placental ischemia was induced in pregnant Sprague Dawley dams, utilizing reduced uterine perfusion pressure (RUPP) surgery. At 6 weeks PP (~3 human years), BP was measured via carotid catheterization, and cerebral oxidative stress and inflammation were assessed via ELISAs, biochemical assays, and Western blots.Results: BP, cerebral pro-inflammatory cytokines (TNF-α and IL-6), and GFAP (a marker of astrocyte activity) were increased in PP RUPP dams. Cerebral hydrogen peroxide (H2O2) was also increased in PP RUPP dams, and had a strong correlation with PP RUPP BP, proinflammatory cytokines (TNF- α and IL-6), and GFAP astrocyte activation.Conclusion: PP RUPP dams have increased BP, cerebral oxidative stress, and cerebral inflammation at 6 weeks postpartum. These changes in cerebral inflammation and oxidative stress may contribute to the pathology and development of HTN and CVDs in postpartum dams.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2454597"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated central blood pressure, NT-proBNP and hs-cTnI in women with maternal complications of hypertensive disorders of pregnancy. 妊娠期高血压疾病孕妇并发症的中心血压升高、NT-proBNP和hs-cTnI

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-01 DOI: 10.1080/10641955.2025.2524324

Xolani B Mbongozi, Stuart D R Galloway, Angus Hunter, Mirabel Nanjoh, Charles B Businge

{"title":"Elevated central blood pressure, NT-proBNP and hs-cTnI in women with maternal complications of hypertensive disorders of pregnancy.","authors":"Xolani B Mbongozi, Stuart D R Galloway, Angus Hunter, Mirabel Nanjoh, Charles B Businge","doi":"10.1080/10641955.2025.2524324","DOIUrl":"https://doi.org/10.1080/10641955.2025.2524324","url":null,"abstract":"Objective: The main objective of the study was to compare the levels of CBP and these cardiac biomarkers in women with maternal complications of hypertensive disorders of pregnancy (HDP).Methods: This was a cross-sectional study that enrolled 270 women with HDP and 270 normotensive pregnant controls. Data on basic characteristics and incidence of maternal complications were collected among the two groups. Additionally, information on cardiac biomarkers and CBP was gathered from the women with HDP, to compare the levels of these biomarkers with maternal complications experience by this group.Results: Non-hypertensive controls were significantly older than hypertensive cases and had a higher median gestational age at recruitment compared to hypertensive cases The median levels of CBP and cardiac biomarkers were significantly higher among hypertensive participants with maternal complications (n = 107/270) than those without complications (n = 163/270). Specifically, central systolic blood pressure (CSBP) was 133 (120-142) mmHg vs 128 (109-129) mmHg (p = 0.033) and central diastolic blood pressure (CDBP) was 75 (62-86) mmHg vs 69 (56-73) mmHg (p < 0.01), while NT-proBNP was 446 (145-1126) vs. 57 (21-167)) pg.ml-1; p < 0.0001, and hs-cTnI was 12 (7-35) ng.L-1 compared to 8 (3-8) ng.L-1; p < 0.0001, in cases v. controls, respectively.Conclusion: In conclusion, the study found that pregnant hypertensive women with maternal complications had significantly higher median values of CSBP and CDBP, NT-proBNP, and hs-cTnI in compared to those without complications. These findings suggest that measuring these vital signs and cardiac biomarkers in hypertensive pregnancies might be helpful for screening and monitoring maternal complications.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2524324"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0