Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas.

IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI:10.1080/10641955.2025.2484019
Malika Leneuve-Dorilas, Fabrice Quet, Stéphanie Bernard, Lindsay Osei, Alphonse Louis, Marie-Noella Capé, Dominique Dotou, Anne-Christèle Dzierzek, Narcisse Elenga, Mathieu Nacher
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引用次数: 0

Abstract

Background: French Guiana is France's largest overseas territory, accounting for 1/6th of mainland France. French Guiana has the highest fertility rate in France and Latin America. However, infant mortality, especially neonatal mortality, remains 2.6 times higher than in mainland France. Preeclampsia was found to be the most important pregnancy-related condition contributing to preterm birth in the primary analysis of risk factors for preterm birth in French Guiana.

Methods: Therefore, by analyzing the Registre des Issues de Grossesse de Guyane (RIGI), we sought to better describe this condition and understand its risk factors in our area. A retrospective and comparative study was conducted using 2014-2020 data from the RIGI, which describes 53,522 viable births (≥22 weeks of amenorrhea) in all four perinatal facilities in French Guiana. The RIGI is performed by midwives after patients' delivery. It records data up to two hours postpartum.

Results: During the study 12.9% of children were born preterm at less than 37 WA (weeks of amenorrhea). 4.5% of the study population had preeclampsia, of which almost half, 49.5%, were expected to deliver prematurely. The Afro-Caribbean population has a higher risk of preeclampsia than the white population, more than double that of the caucasians. Despite adjustment for place of birth, there are spatial heterogeneities in preeclampsia, with an increased risk for residents of towns in western French Guiana.

Conclusion: In conclusion, preeclampsia is a major cause of preterm birth and morbidity in French Guiana. The great heterogeneity between populations and geographical areas requires specific blood tests such as angiogenic balance or still heavy metal assays.

法属圭亚那子痫前期危险因素:人口和地理区域之间的巨大异质性。
背景:法属圭亚那是法国最大的海外领土,占法国本土的六分之一。法属圭亚那是法国和拉丁美洲生育率最高的国家。然而,婴儿死亡率,特别是新生儿死亡率,仍然比法国大陆高2.6倍。在对法属圭亚那早产危险因素的初步分析中,发现先兆子痫是导致早产的最重要的妊娠相关疾病。方法:因此,通过分析《圭亚那问题登记册》(RIGI),我们试图更好地描述这种情况,并了解我们地区的危险因素。使用来自RIGI的2014-2020年数据进行了一项回顾性和比较研究,该研究描述了法属圭亚那所有四个围产设施中的53,522例活产(闭经≥22周)。RIGI由助产士在患者分娩后进行。它可以记录产后两小时的数据。结果:在研究期间,12.9%的儿童在37 WA(闭经周)以下早产。4.5%的研究人群患有先兆子痫,其中近一半(49.5%)预计会早产。非裔加勒比人患先兆子痫的风险比白人高,是白人的两倍多。尽管对出生地点进行了调整,但子痫前期存在空间异质性,法属圭亚那西部城镇居民的风险增加。结论:总之,子痫前期是法属圭亚那早产和发病率的主要原因。人口和地理区域之间的巨大异质性需要特定的血液检测,如血管生成平衡或重金属检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hypertension in Pregnancy
Hypertension in Pregnancy 医学-妇产科学
CiteScore
3.40
自引率
0.00%
发文量
21
审稿时长
6 months
期刊介绍: Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.
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