Hypertension in Pregnancy最新文献

{"title":"Maternal hypertensive disorders in East Asia, 1990-2023: incidence, deaths, DALYs and maternal mortality in women aged 20-54 years using GBD 2023.","authors":"Xianting Yong, Haonan Shi, Yue Meng, Rong Li, Yanlin Wang, Liping Wang","doi":"10.1080/10641955.2026.2668801","DOIUrl":"10.1080/10641955.2026.2668801","url":null,"abstract":"<p><strong>Objective: </strong>Hypertensive disorders of pregnancy (HDP) are a major cause of illness and death and it can be prevented.</p><p><strong>Methods: </strong>We analysed Global Burden of Disease (GBD) 2023 estimates for maternal hypertensive disorders (ICD-10 O10-O16) in six locations (China, Japan, Democratic People's Republic of Korea [DPRK], Republic of Korea, Mongolia, and Taiwan [Province of China]) from 1990-2023 among women aged 20-54 years, reporting counts and age-standardised rates (per 100 000 population) for incidence, deaths and disability-adjusted life years (DALYs), and the maternal mortality ratio (MMR; per 100 000 live births), with 95% uncertainty intervals (UIs).</p><p><strong>Results: </strong>In 2023, incident HDP cases were highest in China (654 396; 95% UI 446 312-949 988), while the age-standardised incidence rate peaked in Mongolia (419.03; 388.67-450.37). Mortality and disability burden were greatest in DPRK (age-standardised death rate 0.393; 0.184-0.749; DALY rate 25.73; 12.92-48.12; MMR 31.61; 13.23-60.86), followed by Mongolia, and lowest in Japan and the Republic of Korea. Across 1990-2023, rates declined markedly in all locations; for example, China's age-standardised death rate fell from 1.15 (0.82-1.57) to 0.03 (0.02-0.05) and its DALY rate from 80.08 (58.66-106.68) to 4.73 (3.04-6.87).</p><p><strong>Conclusion: </strong>With the increasing proportion of advanced maternal age, we must optimize antenatal risk stratification, adopt context-appropriate prevention and treatment, strengthen emergency obstetric care, and establish systematic postpartum cardiovascular follow-up to reduce HDP incidence.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2668801"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectrical impedance-derived extracellular fluid expansion and perinatal outcomes in preeclampsia.","authors":"Young Mi Jung, Hee Kyeong Lee, Min Jung Lee, Bo Young Choi, Hyeon Ji Kim, Kuyeong Han, Narin Kim, Seong Guk Kim, Jee Yoon Park","doi":"10.1080/10641955.2026.2665111","DOIUrl":"10.1080/10641955.2026.2665111","url":null,"abstract":"<p><strong>Objective: </strong>To quantify extracellular fluid expansion in preeclampsia using bioelectrical impedance analysis (BIA) and to evaluate whether BIA-derived extracellular water (ECW) indices are associated with perinatal outcomes.</p><p><strong>Methods: </strong>In this prospective cohort study, 16 hospitalized women with high-risk pregnancies (7 with preeclampsia and 9 normotensive controls) underwent segmental BIA at a mean gestational age of 32 weeks. Total body water (TBW), intracellular water (ICW), ECW, and ECW/TBW were compared between groups. Fluid indices were additionally expressed as weight-adjusted and height-indexed measures. Associations between ECW/TBW and perinatal outcomes were reviewed and analyzed.</p><p><strong>Results: </strong>Compared with normotensive controls, women with preeclampsia had higher TBW, ICW, ECW, and ECW/TBW (all <i>p</i> < 0.05), with consistent segmental elevations most prominent in the lower extremities. Weight adjustment eliminated between-group differences in absolute fluid volumes, whereas height-indexing preserved significant elevations across compartments (all <i>p</i> ≤ 0.002). In the overall high-risk cohort, higher ECW/TBW was associated with earlier gestational age at delivery and lower 1-minute Apgar scores (both <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Preeclampsia is characterized by measurable extracellular fluid expansion on bedside BIA. Elevated ECW/TBW is associated with adverse perinatal outcomes among hospitalized high-risk pregnancies, supporting the potential clinical utility of non-invasive fluid assessment for risk stratification in hypertensive disorders of pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2665111"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification risk factors for perinatal complications among pregnant women with pulmonary arterial hypertension.","authors":"Yanyu Wu, Yangjing Zhu, Gaiming Gao, Shunyuan Li, Yingle Chen, Liangcheng Zhang","doi":"10.1080/10641955.2026.2652977","DOIUrl":"10.1080/10641955.2026.2652977","url":null,"abstract":"<p><strong>Background: </strong>The risk factors for perinatal complications in pregnant women with pulmonary arterial hypertension (PAH) remain controversial. This study aimed to explore the risk factors and constructed a prediction model for perinatal complications in pregnant women with PAH.</p><p><strong>Method: </strong>A total of 116 pregnant women with PAH were retrospectively recruited from the Union Hospital affiliated with the Fujian Medical University between January 2016 and December 2016. The risk factors for perinatal complications were identified by using logistic regression model, while the predictive value of identified factors was assessed using the area under a receiver operating characteristic (ROC) curve.</p><p><strong>Results: </strong>Multivariate results indicated moderate PAH (OR: 15.38; 95% CI: 1.54-166.67; <i>P</i> = 0.020), and congenital heart disease (OR: 2.60; 95% CI: 1.25-5.41; <i>p</i> = 0.010) were associated with an increased risk of perinatal complications. A predictive model based on the aforementioned factors for perinatal complications in pregnant women with PAH was constructed, and the area under a ROC curve was 0.73 (95% CI: 0.60-0.86).</p><p><strong>Conclusion: </strong>Perinatal complications in pregnant women with PAH could be affected by the severity of PAH and congenital heart disease and that the predictive value of the constructed model was moderate.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2652977"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular hypertrophy as a predictor of adverse maternal and neonatal outcomes in chronic hypertension in pregnancy: a multicenter study.","authors":"Bei Zhang, Guilong Pan, Wei Wang, Kai Zhang, Xiao Song, Wei Tian, Ran Chu, Shuyi Li, Hui An, Shuo Zhang","doi":"10.1080/10641955.2026.2719498","DOIUrl":"10.1080/10641955.2026.2719498","url":null,"abstract":"<p><strong>Objective: </strong>The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study included pregnant women with CHTN from four tertiary hospitals in China. Baseline characteristics were compared using the Kruskal-Wallis and Chi-squared tests with Bonferroni correction. Logistic regression (LR) identified risk factors for adverse outcomes. Four machine learning (ML) algorithms were validated, nomograms were developed for model visualization, and SHapley Additive exPlanations (SHAP) determined variable importance.</p><p><strong>Results: </strong>Among 500 women, 117 (23.4%) had normal geometry, 118 (23.6%) concentric remodeling, 88 (17.6%) eccentric hypertrophy, and 177 (35.4%) concentric hypertrophy. Adverse maternal and fetal outcomes occurred in 126 (25.2%) and 359 (71.8%) women, respectively. LVH was independently associated with adverse maternal outcomes (OR 2.16, 95% CI 1.13-4.13) and fetal outcomes (OR 2.42, 95% CI 1.31-4.45). Additional maternal predictors included NYHA class III-IV, pre-eclampsia, oligohydramnios, elevated alanine aminotransferase and lactate dehydrogenase, hypoalbuminemia, greater bleeding loss, and blood transfusion. Fetal predictors included increased posterior wall thickness, oligohydramnios, abnormal umbilical artery flow, elevated alanine aminotransferase and blood urea nitrogen, low total protein, and proteinuria. ML models showed AUCs of 0.70-0.87 for maternal and 0.80-0.88 for fetal outcomes; SHAP identified LVH as an important contributor in both models.</p><p><strong>Conclusion: </strong>Early-pregnancy LVH was associated with higher risks of adverse maternal and fetal outcomes in women with CHTN. These models may support individualized risk stratification but require prospective external validation before clinical implementation.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2719498"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive disorders of pregnancy: epidemiology, pathophysiology, therapeutic strategies, and maternal-offspring outcomes.","authors":"Chengcheng Mu, Shouzhu Xu, Bing Xu, Dongdong Wu, Xinrui Chang, Donglin Yang, Ting Ye, Jing Zhao, Xiaohang Yang","doi":"10.1080/10641955.2026.2742300","DOIUrl":"https://doi.org/10.1080/10641955.2026.2742300","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy (HDP) encompass chronic hypertension, gestational hypertension, preeclampsia, and preeclampsia superimposed on chronic hypertension, affecting about 5% to 10% of pregnancies worldwide and remaining a major cause of maternal and perinatal morbidity and mortality. Their burden is increasing with rising obesity, advanced maternal age, evolving diagnostic criteria, and marked socioeconomic and racial-ethnic disparities. This review summarises current evidence on the epidemiology, pathophysiology, biomarkers, clinical management, and long-term outcomes of HDP, highlighting recent advances and unresolved questions. Mechanistically, HDP is characterised by systemic endothelial dysfunction and angiogenic imbalance, particularly involving soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng), together with immune maladaptation, oxidative stress, and genetic and environmental contributors such as endocrine-disrupting chemicals (EDCs) and sleep-disordered breathing (SDB). The sFlt-1/PlGF ratio is among the most validated tools for short-term risk assessment in suspected preeclampsia, while retinal microvascular imaging may provide a non-invasive marker of systemic microvascular dysfunction. Clinically, trial evidence supports treating mild chronic hypertension to below 140/90 mmHg to reduce adverse outcomes without compromising foetal growth. Long-term maternal cardiovascular and metabolic risks vary according to HDP phenotype, severity, gestational age at onset, and associated preterm delivery or foetal growth restriction, whereas offspring neurodevelopmental associations are largely observational and may be influenced by prematurity and shared familial or socioeconomic factors. Experimental strategies supported primarily by preclinical or early translational evidence include PPARγ agonists, placenta-targeted nanomedicine, and transcutaneous auricular vagus nerve stimulation. Machine learning combined with longitudinal multi-omics data may support precision risk stratification and individualised management.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2742300"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of continuous analgesia during labor in pregnant women with hypertensive disorders: a comparative study on pain relief, anxiety, depression, and maternal-infant outcomes.","authors":"Tiantian Huang, Hongfang Liu, Jing Ren, Xiaoxia Gu","doi":"10.1080/10641955.2025.2583822","DOIUrl":"10.1080/10641955.2025.2583822","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the effects of continuous analgesia versus standard pain management on pain intensity, psychological status (anxiety and depression), and maternal-infant outcomes in pregnant women with hypertensive disorders.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 124 pregnant women with hypertensive disorders admitted between December 2021 and December 2023. Participants were categorized into two groups based on the labor analgesia received: a non-continuous analgesia group (<i>n </i>= 51) and a continuous analgesia group (<i>n</i> = 73). Outcome measures included pain scores at different stages of dilation (4 cm and 8 cm) and anxiety/depression levels assessed pre-delivery, post-delivery, and 24 hours postpartum.</p><p><strong>Results: </strong>The continuous analgesia group demonstrated significantly lower pain scores at both 4 cm dilation (t = 8.888, <i>P</i> < 0.001) and 8 cm dilation (t = 9.604, <i>P</i> < 0.001) compared to the non-continuous group. Regarding psychological outcomes, the continuous analgesia group showed significantly lower anxiety levels pre-delivery (t = 2.606, <i>P</i> = 0.011), post-delivery (t = 2.343, <i>P</i> = 0.022), and 24 hours postpartum (t = 5.084, <i>P</i> < 0.001). Similarly, depression scores were significantly lower in the continuous analgesia group at all three time points: pre-delivery (t = 2.019, <i>P</i> = 0.046), post-delivery (t = 2.66, <i>P</i> = 0.009), and 24 hours postpartum (t = 4.103, <i>P</i> < 0.001). Correlation analysis revealed significant negative associations between continuous analgesia and maternal pain, anxiety, and depression (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Continuous analgesia during labor is associated with superior pain relief and a significant reduction in anxiety and depression levels for pregnant women with hypertensive disorders compared to standard pain management. These findings suggest that continuous analgesia may be a beneficial intervention for improving the maternal psychological experience in this high-risk population.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2583822"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards an understanding of COVID-19-associated preeclampsia.","authors":"A Medel-Martinez, A Cebollada-Solanas, M Strunk, M Fabre, V M Fernández-Soria, R Ramos-Ruiz, C Paules, D Oros, J Schoorlemmer","doi":"10.1080/10641955.2026.2707092","DOIUrl":"https://doi.org/10.1080/10641955.2026.2707092","url":null,"abstract":"<p><strong>Introduction: </strong>SARS-CoV-2 infection during pregnancy has been associated with higher rates of preeclampsia (PE). While placental abnormalities resembling PE have been reported in COVID-19 pregnancies, the molecular mechanisms underlying the association remain unclear.</p><p><strong>Methods: </strong>We conducted bulk RNA sequencing on placental tissues from four pregnancy groups: uneventful prepandemic (preCOVID-19), prepandemic PE (preCOVID-19 PE), COVID-19 without PE (COVID no PE), and COVID-19 complicated by PE or other hypertensive disorders (COVID PE). Differential expression was analyzed using Deseq2 likelihood ratio test (LRT), and gene set enrichment analysis identified dysregulated pathways.</p><p><strong>Results: </strong>Clustering of LRT-significant differentially expressed genes (DEGs) identified a set of 16 genes (defined by the false discovery rate adjusted <i>p</i>-value < 0.05) across the four pregnancy groups, showing stepwise expression changes-lowest in preCOVID-19 uneventful, followed by those in COVID-19 without PE, then preCOVID-19 PE, and highest in COVID PE. This cluster included genes associated with placental dysfunction, such as <i>LAMA5</i> and <i>BTNL9</i>. While morphogenesis-related pathways were enriched across all pathological groups, immune activation pathways were predominantly enriched in COVID PE, moderately in preCOVID-19 PE, and absent in COVID no PE.</p><p><strong>Discussion: </strong>Our findings identify a COVID-19-associated placental signature that mirrors PE features and shows a progressive expression pattern defining a continuum of placental stress, with maternal SARS-CoV-2 infection potentially exacerbating underlying dysfunction.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2707092"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation.","authors":"Shaoping Huang, Qing Su, Xuechun Li, Yang Zhang","doi":"10.1080/10641955.2025.2609374","DOIUrl":"https://doi.org/10.1080/10641955.2025.2609374","url":null,"abstract":"<p><strong>Background and objective: </strong>Trophoblast pyroptosis contributes to the pathogenesis of preeclampsia (PE). Succinylation is a posttranslational modification that is involved in the progression of various diseases. This study aimed to explore the role of the succinyltransferase KAT2A in PE by evaluating its impact on pyroptosis.</p><p><strong>Methods: </strong>Rats were injected with N-nitro-L-arginine methyl ester to generate a PE model, and blood pressure was detected. HTR-8/SVneo cells were treated with hypoxia and reoxygenation, and pyroptosis was evaluated by flow cytometry and western blotting. The mechanism was assessed using immunoprecipitation, cycloheximide chase experiment, and western blotting.</p><p><strong>Results: </strong>KAT2A was highly expressed in the placentas of PE rats. Knockdown of KAT2A inhibited pyroptosis of the HTR-8/SVneo cell model <i>in vitro</i> and ameliorated blood pressure and pyroptosis in the placenta <i>in vivo</i>. Additionally, KAT2A promoted the succinylation of NLRP3 at the lysine (K)21 site, and mutation of NLRP3 at this site reduced its stability. Moreover, overexpression of NLRP3 counteracted the inhibition of pyroptosis caused by KAT2A knockdown.</p><p><strong>Conclusion: </strong>Silencing of KAT2A inhibits trophoblast pyroptosis by downregulating NLRP3 expression, thereby alleviating PE. Mechanistically, KAT2A stabilizes NLRP3 by facilitating its succinylation at K21 site. These findings suggest that KAT2A may be a promising target for the treatment of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2609374"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental CD4⁺ T cells from women with gestational diabetes recapitulate disease features in a pregnant rat model, improved by metformin or mitotempo.","authors":"Danielle Frieson, Jean Vel, Tyler Johnson, Nathan Campbell, Baoying Zheng, Sheila Belk, Cameronne Dodd, Kenneth Butler, Babbette Lamarca, Evangeline Deer","doi":"10.1080/10641955.2026.2665113","DOIUrl":"10.1080/10641955.2026.2665113","url":null,"abstract":"<p><strong>Objective: </strong>Gestational diabetes mellitus (GDM) refers to glucose intolerance, insulin sensitivity, and beta islet cell dysfunction during pregnancy. GDM pathogenesis is associated with hypertension, impaired placental and renal function, oxidative stress, and increased circulating CD4⁺ T cells. There are limited animal models to explore GDM pathology and treatment. This study sought to determine a role for GDM placental CD4⁺ T cells to parallel manifestations of the GDM phenotype in pregnant athymic nude rats.</p><p><strong>Methods: </strong>GDM placental CD4+ T cells (GDM T cells) were isolated upon delivery and injected into pregnant nude rats on gestational day (GD) 12. Mean arterial pressure and markers of renal injury, proteinuria, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin, were assessed on GD19. Glucose, insulin tolerance, and glucose tolerance tests were also performed. Renal and pancreatic tissues were stained using Periodic acid Schiff and hematoxylin and eosin, respectively. A one-way ANOVA was used for statistical analysis.</p><p><strong>Results: </strong>Adoptive transfer of GDMT cells increased blood pressure (120.8 ± 2.2 mmHg, <i>p</i> < 0.05) compared to controls (105.4 ± 2.8 mmHg) and normotensive Tcell recipients (96.3 ± 3.9 mmHg). Metformin or MitoTEMPO attenuated this response. GDM T cell recipients had elevated blood glucose (<i>p</i> < 0.05) and impaired glucose tolerance and insulin sensitivity, which improved with metformin or MitoTEMPO treatment. Renal injury was more severe in GDM T cell recipients, but attenuated with metformin or MitoTEMPO. Pancreatic morphology showed reduced beta islet numbers in GDM T cell recipients.</p><p><strong>Conclusion: </strong>GDM CD4⁺ T cells contribute to hypertension, glucose intolerance, and renal dysfunction, improved byMitoTEMPO. These findings supports optional therapeutics that support mitochondrial function during pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2665113"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram for preeclampsia risk prediction in the first trimester: a nested case-control study.","authors":"Ru Feng, Jiajia Chen, Shuling Wang, Shu Li, Guijuan Zhang, Xiao Hao, Qing Zhang, Bing Wang, Linlin Hua","doi":"10.1080/10641955.2026.2616548","DOIUrl":"10.1080/10641955.2026.2616548","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia (PE) is a serious and progressive multisystem disease that often results in negative outcomes for neonates. This study aimed to create a nomogram to identify high-risk women with PE in their first trimester.</p><p><strong>Methods: </strong>This study involved a nested case-control cohort including 47 PE patients and 122 controls from The Second Affiliated Hospital of Zhengzhou University from January 1, 2023, to May 31, 2024. We identified independent risk factors for PE via multivariate logistic regression and developed a nomogram model. Calibration curves were used to assess accuracy, and decision curve analysis (DCA) was used to evaluate clinical applicability.</p><p><strong>Results: </strong>Multivariate logistic regression revealed that pre-pregnancy body mass index (BMI), mean arterial pressure (MAP), and uric acid (UA) levels were positively correlated with PE, whereas placental growth factor (PLGF) was negatively correlated. The area under the curve (AUC) for the combined diagnostic value was 0.97 (95% CI: 0.96-0.99), suggesting satisfactory discrimination. DCA demonstrated that the predictive model provided high net benefits and significant clinical utility.</p><p><strong>Conclusions: </strong>The nomogram developed in this study, which includes pre-pregnancy BMI, PLGF, MAP, and UA for the prediction of PE risk, can assist clinicians in identifying high-risk individuals during the first trimester.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2616548"},"PeriodicalIF":3.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}