Hypertension in Pregnancy最新文献_第2页

The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis. 高雄激素血症对多囊卵巢综合征患者妊娠并发症和妊娠结局的影响：系统综述和荟萃分析。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-07-14 DOI: 10.1080/10641955.2024.2379389

Xiaohan Guo, Yingsha Yao, Ting Wang, Juanhong Wu, Ruoan Jiang

{"title":"The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis.","authors":"Xiaohan Guo, Yingsha Yao, Ting Wang, Juanhong Wu, Ruoan Jiang","doi":"10.1080/10641955.2024.2379389","DOIUrl":"10.1080/10641955.2024.2379389","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder. Current research findings present conflicting views on the effects of different PCOS phenotypes on outcomes in pregnancy and for newborns.Methods: This research study followed the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). A thorough search of literature was carried out using the Cochrane Menstrual Disorders and Subfertility Group trials register, Web of Science, and EMBASE databases from their start to December 2023. The search focused on studies examining the links between hyperandrogenic and non-hyperandrogenic PCOS phenotypes and risks in pregnancy and neonatology. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using either a fixed-effects or random-effects model.Results: Our analysis incorporated 10 research studies. Expectant mothers with a hyperandrogenic PCOS subtype had increased ORs for gestational diabetes mellitus (GDM) and preeclampsia (PE) compared to those with a non-hyperandrogenic PCOS subtype, with respective values of 2.14 (95% CI, 1.18-3.88, I2 = 0%) and 2.04 (95% CI, 1.02-4.08, I2 = 53%). Nevertheless, no notable differences were detected in ORs for outcomes like preterm birth, live birth, miscarriage, cesarean delivery, pregnancy-induced hypertension, small for gestational age babies, large for gestational age newborns, and neonatal intensive care unit admissions between pregnant women with hyperandrogenic PCOS phenotype and those without.Conclusions: This meta-analysis highlights that the presence of hyperandrogenism heightens the risks of GDM and PE within the PCOS population. Healthcare providers ought to be aware of this connection for improved patient management.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2379389"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Would the utilization of sFlt-1/PlGF ratio in clinical practice prevent unnecessary hospital admissions of cases with preeclampsia? 在临床实践中使用sFlt-1/PlGF比值是否可以防止子痫前期患者不必要的住院？

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI: 10.1080/10641955.2024.2434477

Majed Alhudhud, Hina Yousuf, Hanan Aljohani, Salwa Ibrahem, Shazia Maqsood, Rifat Shahin

{"title":"Would the utilization of sFlt-1/PlGF ratio in clinical practice prevent unnecessary hospital admissions of cases with preeclampsia?","authors":"Majed Alhudhud, Hina Yousuf, Hanan Aljohani, Salwa Ibrahem, Shazia Maqsood, Rifat Shahin","doi":"10.1080/10641955.2024.2434477","DOIUrl":"https://doi.org/10.1080/10641955.2024.2434477","url":null,"abstract":"Objectives: Preeclampsia (PET) is a serious pregnancy complication with potential adverse maternal and fetal outcomes. Recent research has examined the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio for predicting PET. The study aimed to assess the efficacy of the sFlt-1/PlGF ratio in ruling out unnecessary hospital admission and PET.Methods: sFlt-1/PlGF ratio was performed in patients as clinically indicated.Results: The sFlt-1/PlGF ratio at a cutoff value of 51 predicted hospital admission with AUC, PPV, NPV, sensitivity, and specificity of 85%, 44%, 98%, 88%, and 85%, respectively. Additionally, at a cutoff value of 38, the sFlt-1/PlGF ratio predicted the short-term development of PET with PPV, NPV, sensitivity, and specificity of 42%, 100%, 100%, and 81%, respectively. The PlGF alone at a cutoff value of 193.36 predicted hospital admission with AUC, PPV, NPV, sensitivity, and specificity of 87%, 80%, 97%, 67%, and 98%, respectively. Moreover, at a cutoff value of 51.35, the PlGF alone predicted the development of PET with PPV, NPV, sensitivity, and specificity of 54%, 98%, 88%, and 90%, respectively. There was a significant association between a high sFlt-1/PlGF ratio and developing PET.Conclusion: The sFlt-1/PlGF ratio and PlGF are promising for ruling out PET and hospital admission in pregnant women.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2434477"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy. 孕期感染 SARS-CoV-2 的月份和严重程度与妊娠高血压疾病的风险。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-01-27 DOI: 10.1080/10641955.2024.2308922

Samantha E Parker, Bhavana Annapragada, Idalis A Chestnut, Jessica Fuchs, Annette Lee, Vishakha Sabharwal, Elisha M Wachman, Christina D Yarrington

{"title":"Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy.","authors":"Samantha E Parker, Bhavana Annapragada, Idalis A Chestnut, Jessica Fuchs, Annette Lee, Vishakha Sabharwal, Elisha M Wachman, Christina D Yarrington","doi":"10.1080/10641955.2024.2308922","DOIUrl":"10.1080/10641955.2024.2308922","url":null,"abstract":"Objective: SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SARS-CoV-2 infection impact HDP.Methods: We conducted a cohort study of SARS-CoV-2-infected individuals during pregnancy (n = 205) and examined the association between trimester and severity of infection with incidence of HDP using modified Poisson regression models to calculate risk ratios (RR) and 95% confidence intervals (CI). We stratified the analysis of trimester by severity to understand the role of timing of infection among those with similar symptomatology and also examined timing of infection as a continuous variable.Results: Compared to a reference cohort from 2018, SARS-CoV-2 infection did not largely increase the risk of HDP (RR: 1.17; CI:0.90, 1.51), but a non-statistically significant higher risk of preeclampsia was observed (RR: 1.33; CI:0.89, 1.98), in our small sample. Among the SARS-CoV-2 cohort, severity was linked with risk of HDP, with infections requiring hospitalization increasing the risk of HDP compared to asymptomatic/mild infections. Trimester of infection was not associated with risk of HDP, but a slight decline in the risk of HDP was observed with later gestational week of infection. Among patients with asymptomatic or mild symptoms, SARS-CoV-2 in the first trimester conferred a higher risk of HDP compared to the third trimester (RR: 1.70; CI:0.77, 3.77), although estimates were imprecise.Conclusion: SARS-CoV-2 infection in early pregnancy may increase the risk of HDP compared to infection later in pregnancy.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2308922"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal and neonatal outcome among women with early-onset preeclampsia and late-onset preeclampsia. 早发型子痫前期和晚发型子痫前期产妇和新生儿的预后。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1080/10641955.2024.2405991

Luthfi Rahman, Ruswana Anwar, Johanes Cornelius Mose

{"title":"Maternal and neonatal outcome among women with early-onset preeclampsia and late-onset preeclampsia.","authors":"Luthfi Rahman, Ruswana Anwar, Johanes Cornelius Mose","doi":"10.1080/10641955.2024.2405991","DOIUrl":"https://doi.org/10.1080/10641955.2024.2405991","url":null,"abstract":"Objective: This study aimed to determine the differences in characteristics and outcomes of early-onset and late-onset Preeclampsia.Methods: A retrospective cross-sectional study was conducted on female patients giving birth with preeclampsia admitted into the Department of Obstetrics and Gynecology of Dr. Hasan Sadikin Hospital Bandung from January 2020 to December 2022 who met the study criteria. A total of 435 subjects met the inclusion criteria were divided into two groups: early-onset preeclampsia and late-onset preeclampsia. Differences in outcomes were analyzed using the Chi-square or Fisher test for categorical data and the T-independent or Mann-Whitney test for numerical data.Results: There were differences in the incidence of HELLP syndrome (9.0 vs. 2.7%; p = 0.009), prematurity (77.7 vs. 21.4%; p = 0.000), early neonatal death (10.4 vs. 2.7%; p = 0.002), asphyxia (22.7 vs. 8.0%; p = 0.000), SGA (41.7 vs 21.9%; p = 0.000), and LBW (78.7 vs 40.2%; p = 0.000) in early-onset preeclampsia with late-onset. Length of stay was longer in early-onset preeclampsia cases (4.0 vs 3.0 days; p = 0.000). Increased ureum and liver enzymes results were significantly higher in early-onset preeclampsia.Conclusion: There is a difference in the outcome of pregnant women with early-onset and late-onset preeclampsia. Women with early-onset preeclampsia tend to have more adverse maternal and neonatal outcomes. In terms of maternal outcome, they tend to have higher liver enzymes level and HELLP syndrome, while in terms of neonatal outcome they tend to have prematurity, early neonatal death, asphyxia, SGA, and LBW.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2405991"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142285907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review. 子痫前期的抗高血压治疗：网络荟萃分析和系统综述。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-03-15 DOI: 10.1080/10641955.2024.2329068

Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li

{"title":"Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.","authors":"Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li","doi":"10.1080/10641955.2024.2329068","DOIUrl":"10.1080/10641955.2024.2329068","url":null,"abstract":"Background: Preeclampsia (PE) is a pregnancy disorder that represents a major cause of maternal and perinatal morbidity and mortality.Methods: This network meta-analysis was registered with PROSPERO. We searched the PubMed, ClinicalTrials.gov. and Embase databases for studies published from inception to the 31st of March 2023. RevMan5.3 software provided by the Cochrane Collaboration was used for direct meta-analysis (DMA) statistical analysis. Funnel maps, network meta-analysis (NMA), the surface under the cumulative ranking curve (SUCRA) to rank the different interventions and publication bias were generated by STATA 17.0 software.Results: We included eight randomized controlled trials (RCTs) involving a total of 1192 women with PE; two studies were of high quality and six were of moderate quality. Eight interventions were addressed in the NMA. In the DMA, we found that blood pressure in the Ketanserin group were significantly higher than those in the Nicardipine group. NMA showed that blood pressure in the Dihydralazine group was significantly higher than that in the Methyldopa, Labetalol, Nicardipine and Diltiazem groups. And the blood pressure in the Labetalol group was significantly lower than that in the Nicardipine group. SUCRA values showed that Diltiazem was more effective in lowering blood pressure than other drugs looked at in this study.Conclusion: According to the eight RCTs included in this study, Diltiazem was the most effective in reducing blood pressure in PE patients; Labetalol and Nicardipine also had good effects. Diltiazem is preferred for the treatment of patients with severe PE and high blood pressure.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2329068"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the USCOM® noninvasive cardiac output measurement system to predict the development of pre-eclampsia in hypertensive pregnancies. 使用 USCOM® 无创心排血量测量系统预测高血压孕妇先兆子痫的发展。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-02-14 DOI: 10.1080/10641955.2024.2310607

Jack George Mangos, Shyamalee Crocker, Macayla Flood, Jade Martyn, Lynne Roberts, Amanda Henry, Franziska Pettit

{"title":"Use of the USCOM® noninvasive cardiac output measurement system to predict the development of pre-eclampsia in hypertensive pregnancies.","authors":"Jack George Mangos, Shyamalee Crocker, Macayla Flood, Jade Martyn, Lynne Roberts, Amanda Henry, Franziska Pettit","doi":"10.1080/10641955.2024.2310607","DOIUrl":"10.1080/10641955.2024.2310607","url":null,"abstract":"Objectives: To assess the ability of the USCOM® (USCOM), using measurements of cardiac output (CO) and systemic vascular resistance (SVR), to predict the development of pre-eclampsia (PE) and severe PE in hypertensive pregnancies.Study design: Prospective cohort study of women in the second or third trimester recruited at a tertiary center in Sydney, Australia. Demographic data and hemodynamic measurements using the USCOM were taken for all study participants at recruitment. Pregnancy outcome, including development of PE and severe PE, was tracked. Data were analyzed using ANOVA testing, pair-wise comparison testing, and Student's t-testing.Results: Recruitment included 65 normotensive controls, 34 women with chronic hypertension (CH), 51 with gestational hypertension (GH), and 21 with PE. Significantly higher weight, body surface area, and blood pressure measurements were found in the hypertensive, compared with the normotensive control and pregnancies. There were no observed differences in USCOM-measured CO, cardiac index, SVR, or systemic vascular resistance index between hypertensive women who did versus did not develop PE or severe PE in later pregnancy. Analysis of the CH and GH subgroups, as well as only unmedicated hypertensive women (n = 24), also showed no significant difference in hemodynamic parameters between those who did or did not develop PE or severe PE.Conclusions: Our group was unable to successfully predict the onset of PE or severe PE based on hemodynamic parameters measured with the USCOM. It is possible this relates to the high proportion of women on antihypertensive medication at recruitment.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2310607"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of preeclampsia using metabolomic biomarkers. 利用代谢组生物标志物诊断子痫前期。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1080/10641955.2024.2379386

Yunfan Tian, Mingwei Liu, Jin-Yu Sun, Yifeng Wang, Lianmin Chen, Wei Sun, Ling Zhou

{"title":"Diagnosis of preeclampsia using metabolomic biomarkers.","authors":"Yunfan Tian, Mingwei Liu, Jin-Yu Sun, Yifeng Wang, Lianmin Chen, Wei Sun, Ling Zhou","doi":"10.1080/10641955.2024.2379386","DOIUrl":"https://doi.org/10.1080/10641955.2024.2379386","url":null,"abstract":"The diagnostic criteria for preeclampsia do not accurately reflect the pathophysiological characteristics of patients with preeclampsia. Conventional biomarkers and diagnostic approaches have proven insufficient to fully comprehend the intricacies of preeclampsia. This study aimed to screen differentially abundant metabolites as candidate biomarkers for preeclampsia. A propensity score matching method was used to perform a 1:1 match between preeclampsia patients (n = 70) and healthy control individuals (n = 70). Based on univariate and multivariate statistical analysis methods, the different characteristic metabolites were screened and identified. Least absolute shrinkage and selection operator (LASSO) regression analysis was subsequently used to further screen for differentially abundant metabolites. A receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of the metabolites. A total of 1,630 metabolites were identified and quantified in maternal serum samples. Fifty-three metabolites were significantly increased, and two were significantly decreased in preeclampsia patients. The area under the curve (AUC) of the model composed of isobutyryl-L-carnitine and acetyl-leucine was 0.878, and the sensitivity and specificity in detecting preeclampsia were 81.4% and 87.1%, respectively. There are significant differences in metabolism between preeclampsia patients and healthy pregnant women, and a range of novel biomarkers have been identified. These findings lay the foundation for the use of metabolomic biomarkers for the diagnosis of preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2379386"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants. 先兆子痫妇女患癌症的风险可能降低：一项对780万参与者的队列研究的荟萃分析。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2265482

Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong

{"title":"Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants.","authors":"Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong","doi":"10.1080/10641955.2023.2265482","DOIUrl":"10.1080/10641955.2023.2265482","url":null,"abstract":"This review pooled data from the literature to examine the association between preeclampsia (PE) and subsequent risk of breast cancer in women. Cohort studies published in the databases of PubMed, Embase, Scopus, and Web of Science up to 18 July 2023 were searched. Adjusted data were pooled to obtain the risk ratio (RR). Eleven studies with 15 cohorts and a cumulative sample size of 7,838,693 women were included. Meta-analysis of all studies demonstrated a reduced risk of breast cancer in women with PE as compared to those without PE (RR: 0.89 95% CI: 0.83, 0.95 p < 0.001 I2 = 50%). Follow-up ranged from 8 to 29.2 years. Results did not change during sensitivity analysis. Outcomes varied on subgroup analysis based on location, study type, data extraction method, incidence of breast cancer, and follow-up. To conclude, women with PE may have a reduced risk of breast cancer later in life. However, the risk reduction is minimal and may not have much clinical significance. The evidence is also limited by high inter-study heterogeneity and lack of adjustment of all possible confounders.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"42 1","pages":"2265482"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study. COVID-19与子痫前期/子痫之间的遗传倾向性:一项孟德尔随机研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI: 10.1080/10641955.2023.2285757

Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu

{"title":"Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study.","authors":"Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu","doi":"10.1080/10641955.2023.2285757","DOIUrl":"10.1080/10641955.2023.2285757","url":null,"abstract":"Objective: The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.Methods: We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.Results: We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01-1.51), p = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02-1.30), p = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01-1.30), p = 0.040]. The results were robust under all sensitivity analyses.Conclusion: These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text].","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"42 1","pages":"2285757"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial. 退缩声明：甲基多巴与拉贝洛尔或不用药治疗妊娠期轻度和中度慢性高血压：一项随机临床试验。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2268991

引用次数: 0