Hypertension in Pregnancy最新文献_第2页

Comparison of the burden of maternal hypertensive disorders between China and the globe from 1990 to 2023: epidemiological trends and age-period-cohort analysis. 1990 - 2023年中国与全球孕产妇高血压疾病负担比较：流行病学趋势和年龄期队列分析

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2026-12-31 Epub Date: 2026-02-26 DOI: 10.1080/10641955.2026.2634182

Bairong Liu, Dandan Yan

{"title":"Comparison of the burden of maternal hypertensive disorders between China and the globe from 1990 to 2023: epidemiological trends and age-period-cohort analysis.","authors":"Bairong Liu, Dandan Yan","doi":"10.1080/10641955.2026.2634182","DOIUrl":"10.1080/10641955.2026.2634182","url":null,"abstract":"Objective: To compare epidemiological trends and burden of maternal hypertensive disorders (MHD) between China and the globe from 1990 to 2023 and project future trends through 2035.Methods: Based on Global Burden of Disease (GBD) 2023 data, temporal trends and age-period-cohort effects were analyzed using Joinpoint regression, Age-Period-Cohort (APC) models, and Nordpred forecasting.Results: From 1990 to 2023, China's MHD incident cases and disability-adjusted life years (DALYs) decreased by 79.73% and 95.33%, respectively. China's age-standardized incidence rate (ASIR) and age-standardized DALY rate (ASDR) remained consistently lower than global averages with a greater magnitude of decline. Joinpoint analysis showed China's ASIR fluctuated, while ASDR declined steadily. APC models revealed an incidence increase among Chinese females aged 35-54, particularly in the 45-49 group (local drift: 3.28%/year), while global incidence declined across all ages. In China, incidence risk was lowest in 2009-2013, with birth cohort risk peaking in 1972-1976. Overall MHD burden is projected to continue declining by 2035.Conclusion: Despite overall progress, the rising risk among older pregnant women in China remains a key challenge, necessitating enhanced age-based screening and specialized perinatal care.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2634182"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147305239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of early second trimester maternal serum cadherin-11 levels in the prediction of preeclampsia. 孕中期早期孕妇血清钙粘蛋白-11水平在子痫前期预测中的作用。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2026-12-31 Epub Date: 2026-02-19 DOI: 10.1080/10641955.2026.2633230

Naziye Gurkan, Samettin Celik, Neset Gumusburun, Sebati Sinan Urkmez, Yesim Civil Urkmez, Ozge Deniz Unyeli

{"title":"The role of early second trimester maternal serum cadherin-11 levels in the prediction of preeclampsia.","authors":"Naziye Gurkan, Samettin Celik, Neset Gumusburun, Sebati Sinan Urkmez, Yesim Civil Urkmez, Ozge Deniz Unyeli","doi":"10.1080/10641955.2026.2633230","DOIUrl":"https://doi.org/10.1080/10641955.2026.2633230","url":null,"abstract":"Objective: Preeclampsia is a significant pregnancy complication associated with abnormal placental formation. Cadherin-11, a cell adhesion molecule, plays a role in trophoblast differentiation and placental development. The aim of this study was to evaluate the relationship between cadherin-11 levels in maternal serum in early second trimester and subsequent development of preeclampsia.Methods: In this retrospective nested case-control study, 160 pregnant women (80 preeclampsia, 80 control) who were evaluated and followed up between 15-20 weeks of gestation between 1 March and 1 June 2024 were included. Serum cadherin-11 levels were measured by enzyme-linked immunosorbent assay method. Clinical, biochemical and obstetric data were compared. Diagnostic values were determined by receiver operating characteristic curve and logistic regression analyses.Results: Cadherin-11 levels were significantly higher in the preeclampsia group compared to the control group (p < 0.001). This increase was more pronounced in early-onset preeclampsia. According to receiver operating characteristic analysis, area under the curve was 0.880 in the diagnosis of preeclampsia and 0.903 in early-onset preeclampsia. In addition, the mean age of pregnant women in the early-onset preeclampsia group was significantly higher than both the control and late-onset preeclampsia groups.Conclusion: Maternal serum cadherin-11 levels may be a significant biomarker for predicting preeclampsia, especially early-onset forms. This finding may provide a new insight for early intervention and prophylactic strategies.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2633230"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced maternal age is a risk factor for both early-onset and late-onset hypertensive disorders of pregnancy: the Japan environment and children's study. 高龄产妇是早发性和晚发性妊娠高血压疾病的危险因素：日本环境与儿童研究

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2026-12-31 Epub Date: 2026-03-10 DOI: 10.1080/10641955.2026.2634181

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

{"title":"Advanced maternal age is a risk factor for both early-onset and late-onset hypertensive disorders of pregnancy: the Japan environment and children's study.","authors":"Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito","doi":"10.1080/10641955.2026.2634181","DOIUrl":"10.1080/10641955.2026.2634181","url":null,"abstract":"Objective: Advanced maternal age (AMA, ≥35 years), particularly prevalent in Japan, is associated with adverse perinatal outcomes, including hypertensive disorders of pregnancy (HDP), which vary in severity based on the timing of onset (early-onset and late-onset). This study aimed to investigate the association between maternal age and early-onset and late-onset HDP.Methods: A total of 80,872 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early-onset, preterm late-onset, and term late-onset HDP were evaluated using a multinomial logistic regression model adjusted for potential confounding factors. Maternal age was categorized into five: <25, 25‒29.9, 30‒34.9, 35‒39.9, and ≥40 years, with the reference category set as 30‒34.9 years.Results: Higher maternal age was significantly associated with increased odds of developing early-onset, preterm late-onset, and term late-onset HDP. The adjusted odds ratios (aORs) for early-onset HDP in women aged 35‒39.9 and ≥40 years were 2.724 (95% confidence interval [CI]: 2.095-3.542) and 3.493 (95% CI: 2.349-5.196), respectively. Regarding preterm late-onset HDP, the aORs were 1.346 (95% CI: 1.057-1.714) and 3.011 (95% CI: 2.171-4.176) for these age groups, respectively. Similarly, the aORs for term late-onset HDP were 1.417 (95% CI: 1.206-1.664) and 1.762 (95% CI: 1.341-2.316), respectively.Conclusion: Higher maternal age was associated with an increased HDP risk, irrespective of diagnosis timing. Associations between maternal age and early-onset and preterm late-onset HDP were stronger than that with t erm late-onset HDP.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2634181"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study. 内质网应激相关基因通过调节代谢重编程驱动子痫前期M1巨噬细胞极化：一项生物信息学研究。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2026-12-31 Epub Date: 2026-03-26 DOI: 10.1080/10641955.2026.2649740

Chunzi Xu, Ruikun Hu, Yun Lu, Ling Gu, Hui Xu, Xu Huang

{"title":"Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study.","authors":"Chunzi Xu, Ruikun Hu, Yun Lu, Ling Gu, Hui Xu, Xu Huang","doi":"10.1080/10641955.2026.2649740","DOIUrl":"https://doi.org/10.1080/10641955.2026.2649740","url":null,"abstract":"Background: Preeclampsia (PE), a serious obstetric complication impacting maternal and fetal health, still lacks reliable biomarkers owing to limited sensitivity, specificity, and disease heterogeneity.Methods: Differentially expressed genes (DEGs) were identified from placental samples in GSE114691 (20 PE, 21 controls), and module genes were determined via weighted gene co-expression network analysis (WGCNA). These genes were intersected with ERS genes. Feature genes were selected using LASSO, RF, and SVM-RFE, and a diagnostic model was constructed. Single-gene gene set enrichment analysis (GSEA), interaction network analysis (including PPI, miRNA/TF-target gene, chemical-gene interaction), immune infiltration, and molecular docking were performed.Results: Using analyses performed in R, along with WGCNA and ML algorithms, four ERS-related feature genes (HTRA1, GBA1, KL, PC) were identified, which showed high discriminatory power (AUC = 0.846). GSEA linked these genes to metabolic reprogramming, involving central energy metabolism, amino acid metabolism, short-chain fatty acid metabolism, and redox homeostasis. Immune infiltration analysis showed KL and PC negatively correlated with M1 but positively with M2 macrophages, opposite to HTRA1 and GBA1. Molecular docking showed stable binding between aspirin and the signature gene-encoded proteins.Conclusions: HTRA1, GBA1, KL, and PC may serve as diagnostic biomarkers for PE, potentially influencing M1 polarization of placental macrophages via metabolic reprogramming.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"45 1","pages":"2649740"},"PeriodicalIF":2.1,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the dynamic patterns of sFlt-1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management. 评估母体血浆中sFlt-1、PlGF及其比值从诊断到产后的动态变化规律，作为子痫前期治疗的新工具。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-31 Epub Date: 2025-11-26 DOI: 10.1080/10641955.2025.2579976

Despoina Lykou, Mille Kirk, Sevasti Koulouraki, Line Rode, Maria Andersson, Eva Hansson, Lena Erlandsson, Grigorios Karampas, Stefan R Hansson

{"title":"Evaluation of the dynamic patterns of sFlt-1, PlGF and their ratio in maternal plasma from diagnosis to postpartum as a new tool for preeclampsia management.","authors":"Despoina Lykou, Mille Kirk, Sevasti Koulouraki, Line Rode, Maria Andersson, Eva Hansson, Lena Erlandsson, Grigorios Karampas, Stefan R Hansson","doi":"10.1080/10641955.2025.2579976","DOIUrl":"https://doi.org/10.1080/10641955.2025.2579976","url":null,"abstract":"Objective: To investigate the dynamic changes of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and their ratio in maternal plasma, from preeclampsia diagnosis to postpartum, evaluating its clinical utility.Methods: Single-center prospective longitudinal cohort study with repeated sample collection in women with established preeclampsia (PE). Seventy-five (n = 75) women with PE were included, from which 19, 21 and 35 developed early-onset (EPE), late-onset (LPE) and severe-LPE (SLPE) preeclampsia, respectively. Thirty-five (n = 35) women with normotensive pregnancy (NP) served as the reference group.Results: In all subgroups of PE, PlGF decreased from diagnosis to peripartum. In contrast, sFlt-1 and the ratio rose in LPE and SLPE subgroups, whereas they remained continuously higher and stable in the EPE subgroup. In all subgroups, postpartum concentrations decreased compared to pregnancy levels. Post-term NP had higher sFlt-1 and ratio, and lower PlGF in comparison to term and late-term NP. Preeclamptic pregnancies complicated with fetal growth restriction (FGR) had continuously higher and stable sFlt-1 concentrations and ratio, and lower PlGF concentrations compared to PE without FGR. Different patterns of the three biomarker trajectories were observed in a case-by-case analysis.Conclusion: Further research is warranted to refine pattern analysis and to integrate trajectories of these biomarkers into clinical practice towards personalized care in preeclampsia management.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2579976"},"PeriodicalIF":2.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145632759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of potential circadian rhythm-related hub genes and immune infiltration in preeclampsia through bioinformatics analysis. 通过生物信息学分析鉴定子痫前期潜在的昼夜节律相关中枢基因和免疫浸润。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-31 Epub Date: 2025-09-19 DOI: 10.1080/10641955.2025.2559734

Juan Tang, Qiuping Dong, Xiaowen Chen

{"title":"Identification of potential circadian rhythm-related hub genes and immune infiltration in preeclampsia through bioinformatics analysis.","authors":"Juan Tang, Qiuping Dong, Xiaowen Chen","doi":"10.1080/10641955.2025.2559734","DOIUrl":"https://doi.org/10.1080/10641955.2025.2559734","url":null,"abstract":"Objective: Preeclampsia (PE) is a severe pregnancy complication with unclear molecular mechanisms. Emerging evidence suggests that circadian rhythm disruption contributes to PE pathogenesis. The study aims to identify circadian rhythm-related genes in PE and explore their diagnostic value and immune characteristics.Methods: Four gene expression datasets (GSE75010, GSE60438, GSE186257, GSE14722) were downloaded from the GEO database. Modules correlated with PE were identified via weighted gene co-expression network analysis (WGCNA). Differential expression was assessed with the limma package in R, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were carried out using clusterProfiler. Diagnostic accuracy was evaluated using Receiver operating characteristic curves in training and validation sets. Immune infiltration was analyzed using CIBERSORT and Single Sample Gene Set Enrichment Analysis algorithms. PE patients were clustered into subtypes with ConsensusClusterPlus. ceRNA and Transcription Factor regulatory networks were constructed using miRTarBase, ENCODE, and NetworkAnalyst.Results: CRH and LEP were identified as circadian rhythm-related hub genes with strong diagnostic value. Molecular subtyping based on their expression revealed two PE subtypes with distinct immune infiltration patterns and biological functions. Regulatory network construction highlighted potential upstream mechanisms.Conclusion: This bioinformatics analysis provides preliminary evidence for CRH and LEP as potential circadian rhythm-related diagnostic biomarkers in PE. However, as the findings are derived from limited GEO datasets, they should be interpreted with caution, and large‑scale, multi‑center prospective studies measuring their expression in serum or placental tissues across diverse populations are required to confirm their clinical utility.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2559734"},"PeriodicalIF":2.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum sFlt-1 at 18-20 weeks in advanced maternal age: a key difference from younger pregnancies. 高龄产妇18-20周血清sFlt-1升高：与年轻妊娠的关键区别

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-31 Epub Date: 2025-10-25 DOI: 10.1080/10641955.2025.2565501

Kazunari Nemoto, Keiichi Kumasawa, Motoaki Kinugawa, Keisuke Nakajima, Kei Inaba, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takayuki Iriyama, Yutaka Osuga, Yasushi Hirota

{"title":"Elevated serum sFlt-1 at 18-20 weeks in advanced maternal age: a key difference from younger pregnancies.","authors":"Kazunari Nemoto, Keiichi Kumasawa, Motoaki Kinugawa, Keisuke Nakajima, Kei Inaba, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takayuki Iriyama, Yutaka Osuga, Yasushi Hirota","doi":"10.1080/10641955.2025.2565501","DOIUrl":"https://doi.org/10.1080/10641955.2025.2565501","url":null,"abstract":"Advanced maternal age (AMA) is associated with preeclampsia (PE). Although serum sFlt-1 levels at term are lower in PE cases among AMA women compared to those in PE cases among non-AMA women, evidence from mid-pregnancy remain limited. Since the clinical phenotype of PE has not yet emerged at 18-20 weeks of gestation, assessing angiogenic markers during this period may lead to a better understanding of the pathophysiology of PE. We retrospectively analyzed singleton pregnancies delivered at The University of Tokyo Hospital between January 2022 and March 2024. Serum sFlt-1 and PlGF levels were measured at 18-20 weeks of gestation, and their associations with PE were assessed based on maternal age (<35 years: non-AMA; 35-44 years: AMA). In non-AMA pregnancies, serum sFlt-1 levels tended to be lower in PE cases compared to normotensive (NT) cases. Conversely, in AMA pregnancies, PE cases showed significantly higher serum sFlt-1 levels and sFlt-1/PlGF ratios than NT cases. Serum PlGF levels did not differ significantly between any of the groups. These findings highlight differences in PE-associated markers between AMA and non-AMA pregnancies at mid-pregnancy. Clarifying these differences is essential for optimizing early risk stratification and management strategies in AMA populations.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2565501"},"PeriodicalIF":2.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145367906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umbilical cord-derived exosomal miR-548 is involved in driving preeclampsia pathogenesis by Inhibiting trophoblast cells invasion. 脐带源性外泌体miR-548通过抑制滋养细胞侵袭参与子痫前期发病。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-31 Epub Date: 2025-11-11 DOI: 10.1080/10641955.2025.2579984

Yali Deng, Ling Yu, Songyuan Xiao, Mei Peng, Yang Zhou, Weisi Lai, Yanting Nie, Wen Zhang

{"title":"Umbilical cord-derived exosomal miR-548 is involved in driving preeclampsia pathogenesis by Inhibiting trophoblast cells invasion.","authors":"Yali Deng, Ling Yu, Songyuan Xiao, Mei Peng, Yang Zhou, Weisi Lai, Yanting Nie, Wen Zhang","doi":"10.1080/10641955.2025.2579984","DOIUrl":"10.1080/10641955.2025.2579984","url":null,"abstract":"Background: Preeclampsia (PE) is a severe pregnancy-related disorder characterized by hypertension and end-organ manifestation, and remains a leading cause of perinatal maternal and fetal mortality and morbidity in developing countries. The pathogenesis of PE involves reduced uteroplacental blood flow and impaired trophoblast invasion; however, the role of exosomes in these processes is not fully understood.Methods: This study employed Transwell assay, wound healing assay, and CCK-8 assays to evaluate the effects of umbilical cord exosomes derived from women with PE (PE-exosomes) on trophoblast function. Additionally, miRNA sequencing, in vitro transfection, western blotting, RT-PCR amd FISH assays were used to investigate the involvement of the microRNA-548 (miR-548)/Ras homolog family member A (RhoA) axis. Statistical analysis was performed using t-tests, with a significance threshold of P < 0.01.Results: Expression levels of miR-548 were significantly elevated in PE-exosomes. Both treatment with PE-exosomes and the overexpression of miR-548 inhibited trophoblast invasion and proliferation. These effects were reversed by RhoA overexpression. Together, these findings suggest that PE-exosomes suppress trophoblast invasion via the miR-548/RhoA axis. In pregnant women with PE, high miR-548 expression levels were observed, and were positively correlated with blood pressure and proteinuria.Conclusions: Elevated miR-548 levels may contribute to the development of PE, suggesting that miR-548 could serve as a novel diagnostic or therapeutic target for this condition.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2579984"},"PeriodicalIF":2.1,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas. 法属圭亚那子痫前期危险因素：人口和地理区域之间的巨大异质性。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/10641955.2025.2484019

Malika Leneuve-Dorilas, Fabrice Quet, Stéphanie Bernard, Lindsay Osei, Alphonse Louis, Marie-Noella Capé, Dominique Dotou, Anne-Christèle Dzierzek, Narcisse Elenga, Mathieu Nacher

{"title":"Preeclampsia risk factors in French Guiana: a great heterogeneity among populations and geographic areas.","authors":"Malika Leneuve-Dorilas, Fabrice Quet, Stéphanie Bernard, Lindsay Osei, Alphonse Louis, Marie-Noella Capé, Dominique Dotou, Anne-Christèle Dzierzek, Narcisse Elenga, Mathieu Nacher","doi":"10.1080/10641955.2025.2484019","DOIUrl":"10.1080/10641955.2025.2484019","url":null,"abstract":"Background: French Guiana is France's largest overseas territory, accounting for 1/6th of mainland France. French Guiana has the highest fertility rate in France and Latin America. However, infant mortality, especially neonatal mortality, remains 2.6 times higher than in mainland France. Preeclampsia was found to be the most important pregnancy-related condition contributing to preterm birth in the primary analysis of risk factors for preterm birth in French Guiana.Methods: Therefore, by analyzing the Registre des Issues de Grossesse de Guyane (RIGI), we sought to better describe this condition and understand its risk factors in our area. A retrospective and comparative study was conducted using 2014-2020 data from the RIGI, which describes 53,522 viable births (≥22 weeks of amenorrhea) in all four perinatal facilities in French Guiana. The RIGI is performed by midwives after patients' delivery. It records data up to two hours postpartum.Results: During the study 12.9% of children were born preterm at less than 37 WA (weeks of amenorrhea). 4.5% of the study population had preeclampsia, of which almost half, 49.5%, were expected to deliver prematurely. The Afro-Caribbean population has a higher risk of preeclampsia than the white population, more than double that of the caucasians. Despite adjustment for place of birth, there are spatial heterogeneities in preeclampsia, with an increased risk for residents of towns in western French Guiana.Conclusion: In conclusion, preeclampsia is a major cause of preterm birth and morbidity in French Guiana. The great heterogeneity between populations and geographical areas requires specific blood tests such as angiogenic balance or still heavy metal assays.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2484019"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting oxidative stress in preeclampsia. 靶向氧化应激在子痫前期。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2024-12-27 DOI: 10.1080/10641955.2024.2445556

Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements

{"title":"Targeting oxidative stress in preeclampsia.","authors":"Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements","doi":"10.1080/10641955.2024.2445556","DOIUrl":"10.1080/10641955.2024.2445556","url":null,"abstract":"Preeclampsia is a complex condition characterized by elevated blood pressure and organ damage involving kidneys or liver, resulting in significant morbidity and mortality for both the mother and the fetus. Increasing evidence suggests that oxidative stress, often caused by mitochondrial dysfunction within fetal trophoblast cells may play a major role in the development and progression of preeclampsia. Oxidative stress occurs as a result of an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidant defenses, which can lead to placental cellular damage and endothelial cell dysfunction. Targeting oxidative stress appears to be a promising therapeutic approach that has the potential to improve both short- and long-term maternal and fetal outcomes, thus reducing the global burden of preeclampsia. The purpose of this review is to provide a comprehensive account of the mechanisms of oxidative stress in preeclampsia. Furthermore, it also examines potential interventions for reducing oxidative stress in preeclampsia, including natural antioxidant supplements, lifestyle modifications, mitochondrial targeting antioxidants, and pharmacological agents.A better understanding of the mechanism of action of proposed therapeutic strategies targeting oxidative stress is essential for the identification of companion biomarkers and personalized medicine approaches for the development of effective treatments of preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2445556"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0