Hypertension in Pregnancy最新文献_第2页

Maternal and neonatal outcome among women with early-onset preeclampsia and late-onset preeclampsia. 早发型子痫前期和晚发型子痫前期产妇和新生儿的预后。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1080/10641955.2024.2405991

Luthfi Rahman, Ruswana Anwar, Johanes Cornelius Mose

{"title":"Maternal and neonatal outcome among women with early-onset preeclampsia and late-onset preeclampsia.","authors":"Luthfi Rahman, Ruswana Anwar, Johanes Cornelius Mose","doi":"10.1080/10641955.2024.2405991","DOIUrl":"https://doi.org/10.1080/10641955.2024.2405991","url":null,"abstract":"Objective: This study aimed to determine the differences in characteristics and outcomes of early-onset and late-onset Preeclampsia.Methods: A retrospective cross-sectional study was conducted on female patients giving birth with preeclampsia admitted into the Department of Obstetrics and Gynecology of Dr. Hasan Sadikin Hospital Bandung from January 2020 to December 2022 who met the study criteria. A total of 435 subjects met the inclusion criteria were divided into two groups: early-onset preeclampsia and late-onset preeclampsia. Differences in outcomes were analyzed using the Chi-square or Fisher test for categorical data and the T-independent or Mann-Whitney test for numerical data.Results: There were differences in the incidence of HELLP syndrome (9.0 vs. 2.7%; p = 0.009), prematurity (77.7 vs. 21.4%; p = 0.000), early neonatal death (10.4 vs. 2.7%; p = 0.002), asphyxia (22.7 vs. 8.0%; p = 0.000), SGA (41.7 vs 21.9%; p = 0.000), and LBW (78.7 vs 40.2%; p = 0.000) in early-onset preeclampsia with late-onset. Length of stay was longer in early-onset preeclampsia cases (4.0 vs 3.0 days; p = 0.000). Increased ureum and liver enzymes results were significantly higher in early-onset preeclampsia.Conclusion: There is a difference in the outcome of pregnant women with early-onset and late-onset preeclampsia. Women with early-onset preeclampsia tend to have more adverse maternal and neonatal outcomes. In terms of maternal outcome, they tend to have higher liver enzymes level and HELLP syndrome, while in terms of neonatal outcome they tend to have prematurity, early neonatal death, asphyxia, SGA, and LBW.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2405991"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142285907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review. 子痫前期的抗高血压治疗：网络荟萃分析和系统综述。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-03-15 DOI: 10.1080/10641955.2024.2329068

Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li

{"title":"Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.","authors":"Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li","doi":"10.1080/10641955.2024.2329068","DOIUrl":"10.1080/10641955.2024.2329068","url":null,"abstract":"Background: Preeclampsia (PE) is a pregnancy disorder that represents a major cause of maternal and perinatal morbidity and mortality.Methods: This network meta-analysis was registered with PROSPERO. We searched the PubMed, ClinicalTrials.gov. and Embase databases for studies published from inception to the 31st of March 2023. RevMan5.3 software provided by the Cochrane Collaboration was used for direct meta-analysis (DMA) statistical analysis. Funnel maps, network meta-analysis (NMA), the surface under the cumulative ranking curve (SUCRA) to rank the different interventions and publication bias were generated by STATA 17.0 software.Results: We included eight randomized controlled trials (RCTs) involving a total of 1192 women with PE; two studies were of high quality and six were of moderate quality. Eight interventions were addressed in the NMA. In the DMA, we found that blood pressure in the Ketanserin group were significantly higher than those in the Nicardipine group. NMA showed that blood pressure in the Dihydralazine group was significantly higher than that in the Methyldopa, Labetalol, Nicardipine and Diltiazem groups. And the blood pressure in the Labetalol group was significantly lower than that in the Nicardipine group. SUCRA values showed that Diltiazem was more effective in lowering blood pressure than other drugs looked at in this study.Conclusion: According to the eight RCTs included in this study, Diltiazem was the most effective in reducing blood pressure in PE patients; Labetalol and Nicardipine also had good effects. Diltiazem is preferred for the treatment of patients with severe PE and high blood pressure.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2329068"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140131297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the USCOM® noninvasive cardiac output measurement system to predict the development of pre-eclampsia in hypertensive pregnancies. 使用 USCOM® 无创心排血量测量系统预测高血压孕妇先兆子痫的发展。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-02-14 DOI: 10.1080/10641955.2024.2310607

Jack George Mangos, Shyamalee Crocker, Macayla Flood, Jade Martyn, Lynne Roberts, Amanda Henry, Franziska Pettit

{"title":"Use of the USCOM® noninvasive cardiac output measurement system to predict the development of pre-eclampsia in hypertensive pregnancies.","authors":"Jack George Mangos, Shyamalee Crocker, Macayla Flood, Jade Martyn, Lynne Roberts, Amanda Henry, Franziska Pettit","doi":"10.1080/10641955.2024.2310607","DOIUrl":"10.1080/10641955.2024.2310607","url":null,"abstract":"Objectives: To assess the ability of the USCOM® (USCOM), using measurements of cardiac output (CO) and systemic vascular resistance (SVR), to predict the development of pre-eclampsia (PE) and severe PE in hypertensive pregnancies.Study design: Prospective cohort study of women in the second or third trimester recruited at a tertiary center in Sydney, Australia. Demographic data and hemodynamic measurements using the USCOM were taken for all study participants at recruitment. Pregnancy outcome, including development of PE and severe PE, was tracked. Data were analyzed using ANOVA testing, pair-wise comparison testing, and Student's t-testing.Results: Recruitment included 65 normotensive controls, 34 women with chronic hypertension (CH), 51 with gestational hypertension (GH), and 21 with PE. Significantly higher weight, body surface area, and blood pressure measurements were found in the hypertensive, compared with the normotensive control and pregnancies. There were no observed differences in USCOM-measured CO, cardiac index, SVR, or systemic vascular resistance index between hypertensive women who did versus did not develop PE or severe PE in later pregnancy. Analysis of the CH and GH subgroups, as well as only unmedicated hypertensive women (n = 24), also showed no significant difference in hemodynamic parameters between those who did or did not develop PE or severe PE.Conclusions: Our group was unable to successfully predict the onset of PE or severe PE based on hemodynamic parameters measured with the USCOM. It is possible this relates to the high proportion of women on antihypertensive medication at recruitment.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2310607"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of preeclampsia using metabolomic biomarkers. 利用代谢组生物标志物诊断子痫前期。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-07-22 DOI: 10.1080/10641955.2024.2379386

Yunfan Tian, Mingwei Liu, Jin-Yu Sun, Yifeng Wang, Lianmin Chen, Wei Sun, Ling Zhou

{"title":"Diagnosis of preeclampsia using metabolomic biomarkers.","authors":"Yunfan Tian, Mingwei Liu, Jin-Yu Sun, Yifeng Wang, Lianmin Chen, Wei Sun, Ling Zhou","doi":"10.1080/10641955.2024.2379386","DOIUrl":"https://doi.org/10.1080/10641955.2024.2379386","url":null,"abstract":"The diagnostic criteria for preeclampsia do not accurately reflect the pathophysiological characteristics of patients with preeclampsia. Conventional biomarkers and diagnostic approaches have proven insufficient to fully comprehend the intricacies of preeclampsia. This study aimed to screen differentially abundant metabolites as candidate biomarkers for preeclampsia. A propensity score matching method was used to perform a 1:1 match between preeclampsia patients (n = 70) and healthy control individuals (n = 70). Based on univariate and multivariate statistical analysis methods, the different characteristic metabolites were screened and identified. Least absolute shrinkage and selection operator (LASSO) regression analysis was subsequently used to further screen for differentially abundant metabolites. A receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of the metabolites. A total of 1,630 metabolites were identified and quantified in maternal serum samples. Fifty-three metabolites were significantly increased, and two were significantly decreased in preeclampsia patients. The area under the curve (AUC) of the model composed of isobutyryl-L-carnitine and acetyl-leucine was 0.878, and the sensitivity and specificity in detecting preeclampsia were 81.4% and 87.1%, respectively. There are significant differences in metabolism between preeclampsia patients and healthy pregnant women, and a range of novel biomarkers have been identified. These findings lay the foundation for the use of metabolomic biomarkers for the diagnosis of preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2379386"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants. 先兆子痫妇女患癌症的风险可能降低：一项对780万参与者的队列研究的荟萃分析。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2265482

Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong

{"title":"Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants.","authors":"Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong","doi":"10.1080/10641955.2023.2265482","DOIUrl":"10.1080/10641955.2023.2265482","url":null,"abstract":"This review pooled data from the literature to examine the association between preeclampsia (PE) and subsequent risk of breast cancer in women. Cohort studies published in the databases of PubMed, Embase, Scopus, and Web of Science up to 18 July 2023 were searched. Adjusted data were pooled to obtain the risk ratio (RR). Eleven studies with 15 cohorts and a cumulative sample size of 7,838,693 women were included. Meta-analysis of all studies demonstrated a reduced risk of breast cancer in women with PE as compared to those without PE (RR: 0.89 95% CI: 0.83, 0.95 p < 0.001 I2 = 50%). Follow-up ranged from 8 to 29.2 years. Results did not change during sensitivity analysis. Outcomes varied on subgroup analysis based on location, study type, data extraction method, incidence of breast cancer, and follow-up. To conclude, women with PE may have a reduced risk of breast cancer later in life. However, the risk reduction is minimal and may not have much clinical significance. The evidence is also limited by high inter-study heterogeneity and lack of adjustment of all possible confounders.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"42 1","pages":"2265482"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41234865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study. COVID-19与子痫前期/子痫之间的遗传倾向性:一项孟德尔随机研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-11-28 DOI: 10.1080/10641955.2023.2285757

Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu

{"title":"Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study.","authors":"Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu","doi":"10.1080/10641955.2023.2285757","DOIUrl":"10.1080/10641955.2023.2285757","url":null,"abstract":"Objective: The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.Methods: We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.Results: We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01-1.51), p = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02-1.30), p = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01-1.30), p = 0.040]. The results were robust under all sensitivity analyses.Conclusion: These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text].","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"42 1","pages":"2285757"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial. 退缩声明：甲基多巴与拉贝洛尔或不用药治疗妊娠期轻度和中度慢性高血压：一项随机临床试验。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2268991

引用次数: 0

Statement of Retraction: Maternal and fetal outcome in women with gestational hypertension in comparison to gestational proteinuria: A 3-year observational study. 收缩声明：妊娠期高血压妇女与妊娠期蛋白尿的母婴结局比较：一项为期3年的观察性研究。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2268984

引用次数: 0

Associations between extreme temperature exposure and hypertensive disorders in pregnancy: a systematic review and meta-analysis. 极端温度暴露与妊娠期高血压疾病之间的关系：系统回顾和荟萃分析。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-12-05 DOI: 10.1080/10641955.2023.2288586

Yanxia Mao, Qian Gao, Ying Zhang, Yan Yue, Tiechao Ruan, Yi Yang, Tao Xiong

{"title":"Associations between extreme temperature exposure and hypertensive disorders in pregnancy: a systematic review and meta-analysis.","authors":"Yanxia Mao, Qian Gao, Ying Zhang, Yan Yue, Tiechao Ruan, Yi Yang, Tao Xiong","doi":"10.1080/10641955.2023.2288586","DOIUrl":"10.1080/10641955.2023.2288586","url":null,"abstract":"Background: Hypertensive disorders in pregnancy (HDP) are a major cause of maternal mortality and morbidity. Recent studies indicated that pregnant women are the most vulnerable populations to ambient temperature influences, but it affected HDP with inconsistent conclusions. Our objective is to systematically review whether extreme temperature exposure is associated with a changed risk for HDP.Method: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases. We included cohort or case control studies examining the association between extreme temperature exposure before or during pregnancy and HDP. Heat sources such as saunas and hot baths were excluded. We pooled the odds ratio (OR) to assess the association between extreme temperature exposure and preeclampsia or eclampsia.Results: Fifteen studies involving 4,481,888 patients were included. Five studies were included in the meta-analysis. The overall result demonstrated that in the first half of pregnancy, heat exposure increases the risk of developing preeclampsia or eclampsia and gestational hypertension, and cold exposure decreases the risk. The meta-analysis revealed that during the first half of pregnancy, heat exposure increased the risk of preeclampsia or eclampsia (OR 1.54, 95% confidence interval (CI): 1.10, 2.15), whereas cold exposure decreased the risk (OR 0.90, 95% CI: 0.84, 0.97).Conclusion: The ambient temperature is an important determinant for the development of HDP, especially for preeclampsia or eclampsia. The effects of extreme temperatures may be bidirectional during the different trimesters of pregnancy, which should be evaluated by future studies. This review provided hints of temperature regulation in HDP administration.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"42 1","pages":"2288586"},"PeriodicalIF":1.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk. 收回声明：妊娠早期与中期的平均血小板体积和尿酸预测中、低风险女性先兆子痫。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2023-12-01 Epub Date: 2023-10-17 DOI: 10.1080/10641955.2023.2268988

引用次数: 0