在临床实践中使用sFlt-1/PlGF比值是否可以防止子痫前期患者不必要的住院？

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI:10.1080/10641955.2024.2434477

Majed Alhudhud, Hina Yousuf, Hanan Aljohani, Salwa Ibrahem, Shazia Maqsood, Rifat Shahin

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引用次数: 0

摘要

目的：子痫前期（PET）是一种严重的妊娠并发症，具有潜在的不良母婴结局。最近的研究检测了可溶性类膜酪氨酸激酶1 (sFlt-1)/胎盘生长因子（PlGF）比值用于预测PET。本研究旨在评估sFlt-1/PlGF比值在排除不必要住院和PET方面的功效。方法：根据临床指示对患者进行sFlt-1/PlGF比值测定。结果：sFlt-1/PlGF比值在临界值为51时，预测AUC、PPV、NPV、敏感性和特异性分别为85%、44%、98%、88%和85%。此外，在截断值为38时，sFlt-1/PlGF比值预测PET的短期发展，PPV、NPV、敏感性和特异性分别为42%、100%、100%和81%。截止值为193.36的PlGF单独预测AUC、PPV、NPV的住院率，敏感性和特异性分别为87%、80%、97%、67%和98%。此外，在51.35的临界值下，仅PlGF预测PET的PPV、NPV、敏感性和特异性分别为54%、98%、88%和90%。高sFlt-1/PlGF比值与PET的发生有显著相关性。结论：sFlt-1/PlGF比值和PlGF有希望用于排除PET和孕妇住院。

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Would the utilization of sFlt-1/PlGF ratio in clinical practice prevent unnecessary hospital admissions of cases with preeclampsia?

Objectives: Preeclampsia (PET) is a serious pregnancy complication with potential adverse maternal and fetal outcomes. Recent research has examined the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio for predicting PET. The study aimed to assess the efficacy of the sFlt-1/PlGF ratio in ruling out unnecessary hospital admission and PET.

Methods: sFlt-1/PlGF ratio was performed in patients as clinically indicated.

Results: The sFlt-1/PlGF ratio at a cutoff value of 51 predicted hospital admission with AUC, PPV, NPV, sensitivity, and specificity of 85%, 44%, 98%, 88%, and 85%, respectively. Additionally, at a cutoff value of 38, the sFlt-1/PlGF ratio predicted the short-term development of PET with PPV, NPV, sensitivity, and specificity of 42%, 100%, 100%, and 81%, respectively. The PlGF alone at a cutoff value of 193.36 predicted hospital admission with AUC, PPV, NPV, sensitivity, and specificity of 87%, 80%, 97%, 67%, and 98%, respectively. Moreover, at a cutoff value of 51.35, the PlGF alone predicted the development of PET with PPV, NPV, sensitivity, and specificity of 54%, 98%, 88%, and 90%, respectively. There was a significant association between a high sFlt-1/PlGF ratio and developing PET.

Conclusion: The sFlt-1/PlGF ratio and PlGF are promising for ruling out PET and hospital admission in pregnant women.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.