Hypertension in Pregnancy最新文献_第3页

WGCNA combined with machine learning for analysis of diagnostic markers of preeclampsia associated with the hedgehog signaling pathway. WGCNA结合机器学习分析与hedgehog信号通路相关的子痫前期诊断标志物。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.1080/10641955.2025.2542869

Xiaofeng Wang, Yichi Xu, Junpeng Dong, Jinwen Zhang, Wei Gu, Xiaoli Qin

{"title":"WGCNA combined with machine learning for analysis of diagnostic markers of preeclampsia associated with the hedgehog signaling pathway.","authors":"Xiaofeng Wang, Yichi Xu, Junpeng Dong, Jinwen Zhang, Wei Gu, Xiaoli Qin","doi":"10.1080/10641955.2025.2542869","DOIUrl":"https://doi.org/10.1080/10641955.2025.2542869","url":null,"abstract":"Background: Abnormal hedgehog (Hh) signaling is linked to preeclampsia (PE). This study aimed to identify Hh-related diagnostic biomarkers for PE and assess the role of immune infiltration.Methods: The PE dataset was obtained from GEO to screen DEGs. WGCNA was utilized to identify Hh pathway-related genes. Following the intersection of the two genes, key genes were screened by using LASSO, SVM-RFE, and RF. A model was constructed, with ROC applied for evaluating its performance. The ssGSEA was employed to analyze immune infiltration. Network Analyst was utilized to predict miRNA/TF targets.Results: Six Hh-related diagnostic genes were identified (SLC20A1, GPT2, PDK4, COASY, KRT81, CD163L1). The diagnostic model showed high accuracy (AUC > 0.8) in training and validation sets. PE patients exhibited immune dysfunction, including reduced dendritic cell, macrophage, and mast cell activity. Diagnostic genes strongly correlated with immune cells. Additionally, 25 miRNAs and 34 TFs potentially regulating these genes were predicted.Conclusions: Six potential PE diagnostic biomarkers were identified, and their immune interactions were explored. This study enhances understanding of PE pathogenesis and suggests therapeutic targets.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2542869"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal deaths due to hypertensive disorders of pregnancy in Brazil from 2012 until 2023: a cross-sectional populational-based study. 2012年至2023年巴西妊娠期高血压疾病导致的孕产妇死亡：一项基于人口的横断面研究。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-04-13 DOI: 10.1080/10641955.2025.2492094

Deltharma Frantzia Dorcély, Fernanda Garanhani Surita, Maria Laura Costa, José Paulo de Siqueira Guida

{"title":"Maternal deaths due to hypertensive disorders of pregnancy in Brazil from 2012 until 2023: a cross-sectional populational-based study.","authors":"Deltharma Frantzia Dorcély, Fernanda Garanhani Surita, Maria Laura Costa, José Paulo de Siqueira Guida","doi":"10.1080/10641955.2025.2492094","DOIUrl":"https://doi.org/10.1080/10641955.2025.2492094","url":null,"abstract":"Objective: This study evaluated the maternal deaths due to hypertensive disorders in Brazil from 2012 until 2023.Methods: We performed a cross-sectional study including public data from Brazilian Ministry of Health, including age group, self-reported skin color, and geographical region. The Maternal Mortality Ratio (MMR) was calculated for each year and for the entire period; we estimated the prevalence ratio (PR), confidence interval (CI) and trend (R2) of MMR according to the variables included.Results: We analyzed 3,721 deaths attributed to complications of hypertension (MMR = 11.01/100,000 live births; R2 = 0.03). Those deaths were most prevalent among women aged 30 and older (PR 1.73, CI 1.61-1.85), especially those over 40 (PR 3.77, CI 3.34-4.25). Black (PR 2.75, CI 2.46-3.06), mixed-race (Pardo) (PR 1.27, CI 1.18-1.37), and Indigenous (PR 2.28, CI 1.76-2.97) women had significantly higher MMRs compared to White women. Central-West (PR 1.30, CI 1.13-1.46), North (PR 1.92, CI 1.74-2.13), and Northeast (PR 1.82, CI 1.68-1.97) regions had the highest maternal mortality rates due to hypertension. MMR due to hypertensive disorders of pregnancy in Brazil remained stable.Conclusion: Women at higher risk of dying were older, Black, Indigenous, Pardo, and lived in the Central-West, North, and Northeast regions of the country.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2492094"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated bioinformatics analysis identifies neutrophils and villous cytotrophoblasts infiltration characterized by BLC6 upregulation as associated with the co-occurrence of gestational diabetes mellitus and pre-eclampsia. 综合生物信息学分析发现，以BLC6上调为特征的中性粒细胞和绒毛细胞滋养细胞浸润与妊娠糖尿病和先兆子痫的共同发生有关。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-03-23 DOI: 10.1080/10641955.2025.2475814

Jingjing Xie, Le He, Shuang Qin

{"title":"Integrated bioinformatics analysis identifies neutrophils and villous cytotrophoblasts infiltration characterized by BLC6 upregulation as associated with the co-occurrence of gestational diabetes mellitus and pre-eclampsia.","authors":"Jingjing Xie, Le He, Shuang Qin","doi":"10.1080/10641955.2025.2475814","DOIUrl":"10.1080/10641955.2025.2475814","url":null,"abstract":"Background: Gestational diabetes mellitus (GDM) patients are one of the important high-risk groups for the development of pre-eclampsia (PE). The pathogenesis of PE in GDM patients is not fully understood. This study aims to identify hub genes and pathways associated with the co-occurrence of GDM and PE.Methods: The matrix files of GDM and PE datasets were downloaded from GEO to identify differentially expressed genes (DEGs). The common DEGs were predicted for functional analysis through GO and KEGG analysis. A protein-protein interaction (PPI) network was constructed to determine the common hub genes for GDM and PE. Diagnostic hub genes were obtained through regression modeling and ROC analysis, and validated in publicly available datasets. The differences in immune infiltration between GDM and PE were analyzed. The expression and role of common hub genes in the co-occurrence of GDM and PE were explored through analysis of single-cell sequencing data.Results: A total of 104 DEGs were identified between GDM and PE. These common DEGs were found to be involved in mucosal immune response and the JAK-STAT signaling pathway. A total of 27 common hub genes were identified for both GDM and PE. BCL6, DNAH9, and SCG2 were identified as potential diagnostic biomarkers for PE. BCL6 showed high expression in neutrophils and villous cytotrophoblasts (VCTs) in both PE and GDM.Conclusion: This study identified BCL6, DNAH9, and SCG2 as common hub genes in GDM and PE. BCL6 is expected to be a new target for the diagnosis and treatment of GDM concurrent with PE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2475814"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the timing and type of inflammatory markers for potential prediction of preeclampsia in women with obesity. 确定肥胖女性子痫前期潜在预测的炎症标志物的时间和类型。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-04-17 DOI: 10.1080/10641955.2025.2492084

McKenzie K Jancsura, Nathan P Helsabeck, Cindy M Anderson, Yvette P Conley, Carl A Hubel, James M Roberts

{"title":"Identifying the timing and type of inflammatory markers for potential prediction of preeclampsia in women with obesity.","authors":"McKenzie K Jancsura, Nathan P Helsabeck, Cindy M Anderson, Yvette P Conley, Carl A Hubel, James M Roberts","doi":"10.1080/10641955.2025.2492084","DOIUrl":"10.1080/10641955.2025.2492084","url":null,"abstract":"Background: Preeclampsia is a leading contributor to maternal and infant mortality, and early risk identification is a high priority. Inflammatory markers have shown potential as biomarkers for preeclampsia prediction, though optimal timing and marker selection remain unclear.Methods: We measured 20 inflammatory markers using the Luminex platform across all three trimesters in 37 participants who developed preeclampsia and 74 normotensive controls, matched for pre-pregnancy body mass index (>25), smoking status, and race. We examined individual markers by trimester, changes in marker levels between trimesters, and ratios of pro- to anti-inflammatory markers, adjusting analyses for maternal age, gestational age, and fetal sex.Results: First-trimester levels of proinflammatory cytokines (GM-CSF, IFN-α, IFN-γ, IL-1α, IL-1β, IL-8, IL-12p70, IL-17a, TNF-α) and anti-inflammatory cytokines (IL-4, IL-10, and IL-13) were strongly associated with preeclampsia (standardized odds ratios > 2). First-trimester pro-anti-inflammatory ratios (e.g. TNF-α:IL-10 and IFN-γ:IL-10) also correlated with preeclampsia. Changes in inflammatory markers across trimesters and interactions with fetal sex were not significant.Conclusion: Our results suggest that the first trimester inflammatory markers and ratios may offer utility for preeclampsia prediction. Future research should explore these associations in diverse populations and validate their clinical utility. Early risk identification can inform interventions to prevent preeclampsia and improve perinatal outcomes.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2492084"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel molecular strategies for preeclampsia management: a pathophysiological and therapeutic perspective. 子痫前期管理的新分子策略：病理生理和治疗角度。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-08-11 DOI: 10.1080/10641955.2025.2540285

Yunxia Lou, Yan Chen, Lanying Chen, Tianshuo Yang, Leilei He

{"title":"Novel molecular strategies for preeclampsia management: a pathophysiological and therapeutic perspective.","authors":"Yunxia Lou, Yan Chen, Lanying Chen, Tianshuo Yang, Leilei He","doi":"10.1080/10641955.2025.2540285","DOIUrl":"https://doi.org/10.1080/10641955.2025.2540285","url":null,"abstract":"Aim: The objective of this study was to explore emerging pharmacological approaches for the prevention and treatment of PE, with a focus on novel molecular targets.Methods: A review of current literature on oxidative stress, inflammation, and endothelial dysfunction in PE, along with investigational therapies undergoing preclinical and clinical evaluation.Results: PE is strongly associated with oxidative stress and inflammation, leading to impaired placentation and maternal endothelial dysfunction. However, the key regulatory factors driving these processes remain unidentified. Many investigational therapies, though not yet endorsed by obstetric and gynecological societies, are being evaluated for potential clinical application.Conclusion: Currently, the only definitive intervention is preterm delivery, often via cesarean section, highlighting the limitations of existing preventive and therapeutic strategies. Ongoing research into novel pharmacological targets holds promise for improved management of PE in the future.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2540285"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review. 先兆子痫筛查与母体危险因素和眼多普勒动脉：一个系统的回顾。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-06-05 DOI: 10.1080/10641955.2025.2506451

Meta Amelia, Winnee Hana Siahaan, Nicholas Wijaya, Arif Maulana Harahap, Mouza Abiyyu Rivany, Sarma Nursani Lumbanraja

{"title":"Pre-eclampsia screening with maternal risk factors and ophthalmic Doppler artery: a systematic review.","authors":"Meta Amelia, Winnee Hana Siahaan, Nicholas Wijaya, Arif Maulana Harahap, Mouza Abiyyu Rivany, Sarma Nursani Lumbanraja","doi":"10.1080/10641955.2025.2506451","DOIUrl":"10.1080/10641955.2025.2506451","url":null,"abstract":"Background: Pre-eclampsia (PE) affects 2-8% of pregnant women and is a major cause of maternal and perinatal complications. Early risk identification is critical to reducing maternal and neonatal mortality and morbidity.Objective: This systematic review evaluates the role of ophthalmic Doppler arteries parameters, combined with maternal risk factors, physical examination results, and laboratory results for PE screening.Methods: Relevant articles were identified from PubMed, Wiley Online Library, and ScienceDirect using predefined inclusion and exclusion criteria. Articles were screened in two stages - primary extraction by title and abstract, followed by full-text evaluation. The final analysis included observational studies and randomized trials assessing PE prediction using ophthalmic Doppler artery indices.Results: Of the 103 records screened, 24 articles were retrieved, and 7 met the eligibility criteria. All studies examined ophthalmic artery Doppler parameters - especially the peak systolic velocity (PSV) ratio - for PE screening across different gestational ages. The PSV ratio showed moderate-to-high predictive value when combined with established clinical biomarkers.Conclusion: The ophthalmic Doppler artery is regarded as a viable alternative or combination for early detection of PE that is simple to implement and effective, particularly in healthcare facilities in developing countries. However, further large-scale, externally validated studies are needed to establish its clinical utility across different gestational stages.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2506451"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in vitro study of coagulation evaluation in obstetric hemorrhage for pregnancy-induced hypertension with coagulation and platelet function analyzer. 使用凝血和血小板功能分析仪对妊娠高血压产科出血进行凝血评估的体外研究。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-06-12 DOI: 10.1080/10641955.2024.2366824

Caihong Cao, Yusupu Maimaitijiang, Yaoqi Wang, Yonghao Yu

{"title":"An in vitro study of coagulation evaluation in obstetric hemorrhage for pregnancy-induced hypertension with coagulation and platelet function analyzer.","authors":"Caihong Cao, Yusupu Maimaitijiang, Yaoqi Wang, Yonghao Yu","doi":"10.1080/10641955.2024.2366824","DOIUrl":"https://doi.org/10.1080/10641955.2024.2366824","url":null,"abstract":"This study aimed to establish in vitro hemodilution and resupplementation assays for obstetric hemorrhage in pregnancy-induced hypertension (PIH) and to monitor the coagulation function dynamically using a coagulation and platelet function analyzer. Forty-seven singleton pregnant women were divided into normal (n = 24) and PIH (n = 23) groups. Peripheral blood samples were used to construct the assays, and the activated clotting time (ACT), clotting rate (CR), and platelet function index (PF) were measured. The results showed that the baseline ACT was higher in the PIH group (p < 0.01). Hemodilution assays showed decreased ACT and increased CR and PF, with ACT changes significantly lower in the PIH group (p < 0.05). CR changed most in both groups at lower dilution ratios (35% to 50%), while ACT changed most at a higher dilution ratio (75%). In the resupplementation assay, ACT exhibited the most significant response. The analyzer effectively detected differences between pregnant women with and without PIH. Thus, we need to pay more attention to the changes of ACT in the actual clinical application to assess the coagulation status of parturients.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2366824"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hypertensive disorders of pregnancy on the complications in very low birth weight neonates. 妊娠高血压对极低出生体重新生儿并发症的影响。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/10641955.2024.2314576

Baoquan Zhang, Xiujuan Chen, Changyi Yang, Huiying Shi, Wenlong Xiu

{"title":"Effects of hypertensive disorders of pregnancy on the complications in very low birth weight neonates.","authors":"Baoquan Zhang, Xiujuan Chen, Changyi Yang, Huiying Shi, Wenlong Xiu","doi":"10.1080/10641955.2024.2314576","DOIUrl":"10.1080/10641955.2024.2314576","url":null,"abstract":"Objective: This study was designed to investigate the effects of hypertensive disorders of pregnancy (HDP) on the complications in very low birth weight (VLBW) neonates.Methods: We retrospectively included VLBW neonates (<37 weeks) who were delivered by HDP pregnant women with a body weight of < 1,500 g (HDP group) hospitalized in our hospital between January 2016 and July 2021. Gestational age matched VLBW neonates delivered by pregnant women with a normal blood pressure, with a proportion of 1:1 to the HDP group in number, served as normal control.Results: Then we compared the peripartum data and major complications between HDP group and control. The body weight, prelabor rupture of membrane (PROM), maternal age, cesarean section rate, fetal distress, small for gestational age (SGA), mechanical ventilation, RDS, necrotizing enterocolitis (NEC) (≥2 stage), Apgar score at 1 min, and mortality in HDP group showed statistical differences compared with those of the control (all p < 0.05). To compare the major complications among HDP subgroups, we classified the VLBW neonates of the HDP group into three subgroups including gestational hypertension group (n = 72), pre-eclampsia (PE) group (n = 222), and eclampsia group (n = 14), which showed significant differences in the fetal distress, Apgar score at 1 min, SGA, ventilation, RDS and NEC (≥2 stage) among these subgroups (all p < 0.05). Multivariate regression analysis showed that eclampsia and PE were the independent risk factors for SGA and NEC, respectively.Conclusion: HDP was associated with increased incidence of neonatal asphyxia, fatal distress, SGA, mechanical ventilation, RDS, NEC and mortality. Besides, eclampsia and PE were independent risk factors for SGA and NEC.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2314576"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury. CircYTHDF1/miR-19b-3p/YTHDF1轴通过增强血管内皮细胞损伤促进妊娠诱发高血压的发展。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1080/10641955.2024.2414976

Fangyun Wang, Qinping Yang, Xiaolan Wang, Yuyan Guo, Shunhe Lin

{"title":"CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.","authors":"Fangyun Wang, Qinping Yang, Xiaolan Wang, Yuyan Guo, Shunhe Lin","doi":"10.1080/10641955.2024.2414976","DOIUrl":"10.1080/10641955.2024.2414976","url":null,"abstract":"Objective: The biological role of circ_0004858 (circYTHDF1) in pregnancy-induced hypertension (PIH) and the underlying mechanisms were unknown, and which were explored in this study.Methods: ELISA was employed to detect the level of inflammatory cytokines and biochemical parameters; flow cytometry was employed to detect cell apoptosis; western blot and qRT-PCR were employed to examine expression level.Results: The level of IL-1β, TNF-α, IL-6, TGF-β1, ET-1, and Ang-II were significantly elevated in the peripheral blood of PIH patients. The co-culture of HUVEC and CD4+ T cells isolated from the peripheral blood of PIH patients significantly elevated the apoptosis and expression level of NRF2/HO-1 but reduced the protein level of ferroptosis-related markers (GPX4, FSP, and CoQ10B) in HUVEC. Also, the expression of circYTHDF1 and YTHDF1 were markedly up-regulated in HUVEC co-cultured with CD4+ T cells isolated from PIH patients, but miR-19b-3p expression was markedly down-regulated, and the similar results were observed in Ang-II-treated HUVEC. Based on the predicted binding sites, the luciferase reporter assay confirmed the interaction between miR-19b-3p and circYTHDF1 or YTHDF1. The results of qRT-PCR and western blot further demonstrated that circYTHDF1 competitively bound to miR-19b-3p to up-regulate YTHDF1 in HUVEC. Functionally, deleting circYTHDF1markedly reduced ferroptosis and apoptosis in Ang-II-treated HUVEC, but both which were reversed by miR-19b-3p inhibitor, suggesting the involvement of circYTHDF1/miR-19b-3p/YTHDF1 axis in vascular endothelial cell injury in PIH.Conclusions: This study may provide a novel insight into the pathogenesis of PIH as well as a new treatment strategy.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2414976"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium sulfate improves blood flow of uterine, umbilical, and fetal middle cerebral arteries in women with severe preeclampsia at 30-34 gestational weeks. 硫酸镁可改善 30-34 孕周重度子痫前期妇女子宫、脐带和胎儿大脑中动脉的血流量。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2024-12-01 Epub Date: 2024-09-21 DOI: 10.1080/10641955.2024.2404459

Baoxiang Xing, Xie Dai, Guoqiang Gao, Ling Liu, Yan Zhang

{"title":"Magnesium sulfate improves blood flow of uterine, umbilical, and fetal middle cerebral arteries in women with severe preeclampsia at 30-34 gestational weeks.","authors":"Baoxiang Xing, Xie Dai, Guoqiang Gao, Ling Liu, Yan Zhang","doi":"10.1080/10641955.2024.2404459","DOIUrl":"https://doi.org/10.1080/10641955.2024.2404459","url":null,"abstract":"Objectives: Magnesium sulfate (MgSO4) is one of the most commonly used agents for the treatment and prophylaxis of eclampsia in patients with severe preeclampsia. However, there is no international consensus regarding the optimal gestational age for MgSO4 treatment. The aim of this study was to assess the effect of MgSO4 on uterine (UtA), umbilical, and fetal middle cerebral arteries (MCA) by calculating the SD ratio (S/D), resistance index (RI), and pulsatility index (PI) at different gestational weeks.Methods: In total, 66 pregnant women as participants with severe preeclampsia were divided into two groups based on gestational age: Group 1 (n = 28, 26-30 weeks) and Group 2 (n = 38, 30-34 weeks). Color Doppler (Philip HD11) measurements were taken and compared before and after the MgSO4 loading dose.Results: Within-group analysis revealed significant differences in RI-UtA, PI-UtA, and S/D in UtA before and after MgSO4 administration in Group 1. Furthermore, the RI-UA and RI-MCA decreased statistically significantly after MgSO4 treatment, whereas the pulsatility index and S/D did not change in either the umbilical or middle cerebral arteries. After MgSO4 treatment, all Doppler parameters in the uterine and umbilical arteries in Group 2 showed significant changes when compared to before MgSO4 administration.Conclusion: MgSO4 can effectively improve umbilical and MCA blood flow at 30-34 gestational weeks but not at 26-30w. Meanwhile, using MgSO4 can improve uterine blood flow in severe preeclampsia, which may contribute to the management of reducing adverse events in pregnant women who have preeclampsia and fetal growth restriction.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"43 1","pages":"2404459"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142285906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0