Novel molecular strategies for preeclampsia management: a pathophysiological and therapeutic perspective.

Abstract

Aim: The objective of this study was to explore emerging pharmacological approaches for the prevention and treatment of PE, with a focus on novel molecular targets.

Methods: A review of current literature on oxidative stress, inflammation, and endothelial dysfunction in PE, along with investigational therapies undergoing preclinical and clinical evaluation.

Results: PE is strongly associated with oxidative stress and inflammation, leading to impaired placentation and maternal endothelial dysfunction. However, the key regulatory factors driving these processes remain unidentified. Many investigational therapies, though not yet endorsed by obstetric and gynecological societies, are being evaluated for potential clinical application.

Conclusion: Currently, the only definitive intervention is preterm delivery, often via cesarean section, highlighting the limitations of existing preventive and therapeutic strategies. Ongoing research into novel pharmacological targets holds promise for improved management of PE in the future.