Hypertension in Pregnancy最新文献_第9页

Transcriptome analysis of placentae reveals HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia. 胎盘转录组分析显示，HELLP综合征比先兆子痫表现出更大程度的胎盘代谢功能障碍。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-04-05 DOI: 10.1080/10641955.2021.1908348

Lili Gong, Huanqiang Zhao, Yutong Cui, Xiaotian Li

引用次数: 3

Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia. 子痫前期维生素D生物合成、运输和功能的基因变异和单倍型

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-11 DOI: 10.1080/10641955.2020.1849274

Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba

{"title":"Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia.","authors":"Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba","doi":"10.1080/10641955.2020.1849274","DOIUrl":"https://doi.org/10.1080/10641955.2020.1849274","url":null,"abstract":"Objective: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and retinoid-X receptor (RXR) affect the risk of preeclampsia. Methods: In a case-control study 100 women with preeclampsia and 100 healthy pregnant women were investigated for gene variants and haplotypes of vitamin D biosynthesis, transport, and function using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The frequency of gene variants of PPARγ Pro12Ala and RXR -α (A/G, rs749759) were not significantly different comparing patients and controls. The TT genotype of CYP 27B1 (G > T) was associated with 2.2-fold (95% CI 1.04-4.7, p = 0.039) increased risk of early-onset preeclampsia. Also, the TT genotype of GC rs7041 (T > G) increased the risk of preeclampsia [OR = 2.13 (95% CI 1.09-4.17, p = 0.027)]. The VDR ApaI GT genotype elevated susceptibility to preeclampsia (OR = 2.55, p = 0.04). Further, the presence of VDR ApaI GT+TT genotype was associated with higher levels of body mass index, and systolic blood pressure, and lower level of 25 (OH)-D3. In the presence of haplotype CYP T, VDR T, and RXR A (TTA) compared to haplotype GTG the risk of preeclampsia was 6.71-fold (p = 0.044). Conclusions: The present study indicated an association between the CYP 27B1, GC, and VDR ApaI variants with the risk of preeclampsia. Also, the variants of the latter polymorphism influenced BMI, blood pressure, and vitamin D levels.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1849274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38361952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia. 重度子痫前期患者脑生物标志物与视神经鞘直径的相关性

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-11-18 DOI: 10.1080/10641955.2020.1849275

Gabrijela Brzan Simenc, Jana Ambrozic, Josko Osredkar, Ksenija Gersak, Miha Lucovnik

引用次数: 4

Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women. 长链非编码RNA HOTAIR变异对伊朗妇女子痫前期易感性的贡献

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-02 DOI: 10.1080/10641955.2020.1855192

Sahra Esmkhani, Hossein Sadeghi, Majid Ghasemian, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Fakhrolmolouk Yassaee, Reza Mirfakhraie

引用次数: 3

Evaluation of obstetric outcomes and prognostic factors in pregnancies with chronic kidney disease. 妊娠合并慢性肾脏疾病的产科结局和预后因素评估

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-03 DOI: 10.1080/10641955.2020.1869249

Riza Madazlı, Didem Kaymak, Verda Alpay, Aytac Mahmudova, Nurhan Seyahi

{"title":"Evaluation of obstetric outcomes and prognostic factors in pregnancies with chronic kidney disease.","authors":"Riza Madazlı, Didem Kaymak, Verda Alpay, Aytac Mahmudova, Nurhan Seyahi","doi":"10.1080/10641955.2020.1869249","DOIUrl":"https://doi.org/10.1080/10641955.2020.1869249","url":null,"abstract":"Objective: To evaluate the obstetric outcomes of pregnancies with chronic kidney disease (CKD) and to assess the prognostic factors on adverse obstetric outcomes. Methods: We retrospectively reviewed 101 singleton pregnancies with CKD. Obstetric outcomes were explored according to CKD stages. The composite adverse obstetric outcome was defined as at least one of stillbirth, neonatal death and delivery <34 weeks due to preeclampsia or fetal distress. Results: The incidences of preeclampsia, fetal growth restriction, perinatal mortality and composite adverse obstetric outcome were 40.5%, 26.7%, 14.8% and 37.6% respectively in pregnancies with CKD. Composite obstetric adverse outcome was significantly higher in pregnancies with CKD stage 4-5 than the other stages (p < 0.01). CKD stage 4-5 and baseline proteinuria >3 g/24 h were associated with composite obstetric adverse outcome (OR 43.2, p = 0.005 and OR 6.08, p = 0.01 respectively) comparing to stage 1 and proteinuria <0.5 g/24 h. Conclusion: Incidences of adverse obstetric outcomes are high even in early stages of CKD. CKD stage 4-5 and baseline proteinuria >3 g/24 h are poor prognostic factors.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"75-80"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1869249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38776894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive disorders of pregnancy by oocyte donation pregnancy in Japanese women aged 40 years or older: a single-center retrospective cohort study. 日本40岁及以上女性捐赠卵母细胞妊娠高血压疾病:一项单中心回顾性队列研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-11 DOI: 10.1080/10641955.2020.1861461

Yoko Gekka, Tomoko Adachi, Rie Oi, Setsuko Nakayama, Yukiko Kawana, Yoshiharu Takeda, Shuhei Nomura, Akihiko Ozaki, Tetsuya Tanimoto, Hideki Sakamoto, Takahiro Yamashita

引用次数: 0

Pathological investigation of placentas in preeclampsia (the PEARL study). 子痫前期胎盘的病理研究(PEARL研究)。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-29 DOI: 10.1080/10641955.2020.1866008

Alexandre Fillion, Paul Guerby, Didier Menzies, Caroline Lachance, Marie-Pier Comeau, Marie-Claude Bussières, Félicia-Allysson Doucet-Gingras, Sophie Zérounian, Emmanuel Bujold

{"title":"Pathological investigation of placentas in preeclampsia (the PEARL study).","authors":"Alexandre Fillion, Paul Guerby, Didier Menzies, Caroline Lachance, Marie-Pier Comeau, Marie-Claude Bussières, Félicia-Allysson Doucet-Gingras, Sophie Zérounian, Emmanuel Bujold","doi":"10.1080/10641955.2020.1866008","DOIUrl":"https://doi.org/10.1080/10641955.2020.1866008","url":null,"abstract":"INTRODUCTION: Preeclampsia (PE), but mainly preterm PE, is associated with deep placentation disorders. We aimed to compare placental pathologies in pregnancies affected by term and preterm PE compared to normal pregnancies. METHODS: We performed a prospective case-cohort study. Low-risk nulliparous women were recruited in the first trimester and women who developed PE were recruited at diagnosis. Placental pathologies were reported according to the Amsterdam Placental Workshop Group Consensus Statement and were compared between cases and controls. PE cases stratified as term (≥37 weeks) and preterm PE (<37 weeks). Our primary outcome was maternal vascular malperfusion (MVM). RESULTS: Twenty-four women who developed preterm PE were compared to 10 women who developed term PE and 41 women without PE. Preterm PE (92%) was associated with more MVM than term PE (10%, p < 0.01) and controls (4%, p < 0.01), but the rate of MVM was similar between term PE and controls (p = 0.56). Preterm PE was also associated with more placental infarcts (65% vs. 20% vs. 15%); advanced villous maturation (91% vs. 30% vs. 1%); and hypoplastic villous maturation (70% vs. 10% vs. 3%); and moderate to severe decidual vasculopathy (56% vs. 10% vs. 3%) than term PE and controls (all p < 0.05). CONCLUSION: Most cases of preterm PE are associated with MVM, placental infarcts, advanced and/or hypoplastic villous maturation, and moderate to severe decidual vasculopathy, while it is infrequent in term PE and pregnancies without PE. Preterm and term preeclampsia have a different pathologic process that should be considered for their prevention and clinical management.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"56-62"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1866008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38759308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia. 血浆核因子κB细胞(NF-κB)和抑制亚单位κB α (i -κB -α)在hiv相关性子痫前期的表达

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-05 DOI: 10.1080/10641955.2020.1854299

Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker

{"title":"Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia.","authors":"Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker","doi":"10.1080/10641955.2020.1854299","DOIUrl":"https://doi.org/10.1080/10641955.2020.1854299","url":null,"abstract":"Objective:To investigate the expression of plasma NF-κB and the inhibitory subunit IκB-α in HIV-associated pre-eclampsia. Method: This retrospective study examined plasma NF-κB and IκB-α expression expressed as Mean Fluorescence Intensity (MFI) in normotensive (n = 32) and pre-eclamptic (n = 34) pregnant women stratified by HIV status. Results: A significant decrease in the level of plasma NF-κB expression between pre-eclamptic and normotensive pregnant women was observed, irrespective of HIV status (MFI = 82.8 vs 134.3; p = 0.03). Similarly, a significant decline in the level of plasma IκB-α expression was noted in the pre-eclamptic compared to normotensive pregnant women, irrespective of HIV status (MFI = 91.2 vs 120.1; p = 0.04). Plasma NF-κB (p = 0.7) and IκB-α (p = 0.8) expression was similar between HIV positive and HIV negative pregnant women, irrespective of pregnancy type. Conclusion: This study demonstrates decreased plasma NF-κB and IκB-α expression in preeclampsia compared to normotensive pregnant women irrespective of HIV status.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"15-20"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1854299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38781547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of three definitions of metabolic syndrome and relation to risk of recurrent preeclampsia. 代谢综合征三种定义的比较及其与子痫前期复发风险的关系。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-18 DOI: 10.1080/10641955.2021.1872614

Eva Stekkinger, Ralph R Scholten, Wieteke M Heidema, Marc E A Spaanderman

{"title":"Comparison of three definitions of metabolic syndrome and relation to risk of recurrent preeclampsia.","authors":"Eva Stekkinger, Ralph R Scholten, Wieteke M Heidema, Marc E A Spaanderman","doi":"10.1080/10641955.2021.1872614","DOIUrl":"https://doi.org/10.1080/10641955.2021.1872614","url":null,"abstract":"Objective. To determine the prevalence of metabolic syndrome in formerly preeclamptic women according to three definitions of metabolic syndrome (World Health Organization [WHO], International Diabetes Federation [IDF], and Third Adult Treatment Panel updated [ATPIII]), to evaluate agreement amongst definitions and to compare the risk of recurrent preeclampsia. Methods. In 197 women with a history of preeclampsia, we determined presence of metabolic syndrome using WHO, IDF, and ATPIII criteria. We evaluated agreement amongst definitions by using Kappa statistics. The prevalence of recurrent preeclampsia was compared between women with and without inter-pregnancy metabolic syndrome, according to the three definitions. Results. A total of 40 (20%), 46 (23%), and 31 (16%) of women with previous preeclampsia were classified as having metabolic syndrome postpartum according to WHO, IDF, and ATPIII criteria, respectively. Agreement among criteria was considered substantial between WHO and IDF (κ = 0.64, 95% CI 0.53-0.79), WHO and ATPIII (κ = 0.74, 95% CI 0.62-0.86), and IDF and ATPIII (κ = 0.66, 95% CI 0.51-0.77). The prevalence of recurrent preeclampsia was 45% versus 17% in women with and without inter-pregnancy metabolic syndrome according to the WHO definition (P < 0.001), 26% versus 21% according to the IDF criteria (P = 0.16), and 39% versus 20% according to the ATPIII definition (P = 0.02). Conclusions. Agreement among WHO, IDF, and ATPIII criteria of metabolic syndrome in women after preeclampsia is considered substantial. The risk of recurrent preeclampsia is almost one out of two in women with inter-pregnancy metabolic syndrome according to the WHO criteria.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"97-108"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1872614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38834186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring. 产前暴露于子痫前期是子代长期内分泌疾病的危险因素。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-02 DOI: 10.1080/10641955.2020.1854300

Sharon Davidesko, Kira Nahum Sacks, Michael Friger, Alon Haim, Eyal Sheiner

引用次数: 5