Hypertension in Pregnancy最新文献_第9页

Evaluation of obstetric outcomes and prognostic factors in pregnancies with chronic kidney disease. 妊娠合并慢性肾脏疾病的产科结局和预后因素评估

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-03 DOI: 10.1080/10641955.2020.1869249

Riza Madazlı, Didem Kaymak, Verda Alpay, Aytac Mahmudova, Nurhan Seyahi

{"title":"Evaluation of obstetric outcomes and prognostic factors in pregnancies with chronic kidney disease.","authors":"Riza Madazlı, Didem Kaymak, Verda Alpay, Aytac Mahmudova, Nurhan Seyahi","doi":"10.1080/10641955.2020.1869249","DOIUrl":"https://doi.org/10.1080/10641955.2020.1869249","url":null,"abstract":"Objective: To evaluate the obstetric outcomes of pregnancies with chronic kidney disease (CKD) and to assess the prognostic factors on adverse obstetric outcomes. Methods: We retrospectively reviewed 101 singleton pregnancies with CKD. Obstetric outcomes were explored according to CKD stages. The composite adverse obstetric outcome was defined as at least one of stillbirth, neonatal death and delivery <34 weeks due to preeclampsia or fetal distress. Results: The incidences of preeclampsia, fetal growth restriction, perinatal mortality and composite adverse obstetric outcome were 40.5%, 26.7%, 14.8% and 37.6% respectively in pregnancies with CKD. Composite obstetric adverse outcome was significantly higher in pregnancies with CKD stage 4-5 than the other stages (p < 0.01). CKD stage 4-5 and baseline proteinuria >3 g/24 h were associated with composite obstetric adverse outcome (OR 43.2, p = 0.005 and OR 6.08, p = 0.01 respectively) comparing to stage 1 and proteinuria <0.5 g/24 h. Conclusion: Incidences of adverse obstetric outcomes are high even in early stages of CKD. CKD stage 4-5 and baseline proteinuria >3 g/24 h are poor prognostic factors.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"75-80"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1869249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38776894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertensive disorders of pregnancy by oocyte donation pregnancy in Japanese women aged 40 years or older: a single-center retrospective cohort study. 日本40岁及以上女性捐赠卵母细胞妊娠高血压疾病:一项单中心回顾性队列研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-11 DOI: 10.1080/10641955.2020.1861461

Yoko Gekka, Tomoko Adachi, Rie Oi, Setsuko Nakayama, Yukiko Kawana, Yoshiharu Takeda, Shuhei Nomura, Akihiko Ozaki, Tetsuya Tanimoto, Hideki Sakamoto, Takahiro Yamashita

引用次数: 0

Pathological investigation of placentas in preeclampsia (the PEARL study). 子痫前期胎盘的病理研究(PEARL研究)。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-29 DOI: 10.1080/10641955.2020.1866008

Alexandre Fillion, Paul Guerby, Didier Menzies, Caroline Lachance, Marie-Pier Comeau, Marie-Claude Bussières, Félicia-Allysson Doucet-Gingras, Sophie Zérounian, Emmanuel Bujold

{"title":"Pathological investigation of placentas in preeclampsia (the PEARL study).","authors":"Alexandre Fillion, Paul Guerby, Didier Menzies, Caroline Lachance, Marie-Pier Comeau, Marie-Claude Bussières, Félicia-Allysson Doucet-Gingras, Sophie Zérounian, Emmanuel Bujold","doi":"10.1080/10641955.2020.1866008","DOIUrl":"https://doi.org/10.1080/10641955.2020.1866008","url":null,"abstract":"INTRODUCTION: Preeclampsia (PE), but mainly preterm PE, is associated with deep placentation disorders. We aimed to compare placental pathologies in pregnancies affected by term and preterm PE compared to normal pregnancies. METHODS: We performed a prospective case-cohort study. Low-risk nulliparous women were recruited in the first trimester and women who developed PE were recruited at diagnosis. Placental pathologies were reported according to the Amsterdam Placental Workshop Group Consensus Statement and were compared between cases and controls. PE cases stratified as term (≥37 weeks) and preterm PE (<37 weeks). Our primary outcome was maternal vascular malperfusion (MVM). RESULTS: Twenty-four women who developed preterm PE were compared to 10 women who developed term PE and 41 women without PE. Preterm PE (92%) was associated with more MVM than term PE (10%, p < 0.01) and controls (4%, p < 0.01), but the rate of MVM was similar between term PE and controls (p = 0.56). Preterm PE was also associated with more placental infarcts (65% vs. 20% vs. 15%); advanced villous maturation (91% vs. 30% vs. 1%); and hypoplastic villous maturation (70% vs. 10% vs. 3%); and moderate to severe decidual vasculopathy (56% vs. 10% vs. 3%) than term PE and controls (all p < 0.05). CONCLUSION: Most cases of preterm PE are associated with MVM, placental infarcts, advanced and/or hypoplastic villous maturation, and moderate to severe decidual vasculopathy, while it is infrequent in term PE and pregnancies without PE. Preterm and term preeclampsia have a different pathologic process that should be considered for their prevention and clinical management.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"56-62"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1866008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38759308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia. 血浆核因子κB细胞(NF-κB)和抑制亚单位κB α (i -κB -α)在hiv相关性子痫前期的表达

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-05 DOI: 10.1080/10641955.2020.1854299

Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker

{"title":"Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia.","authors":"Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker","doi":"10.1080/10641955.2020.1854299","DOIUrl":"https://doi.org/10.1080/10641955.2020.1854299","url":null,"abstract":"Objective:To investigate the expression of plasma NF-κB and the inhibitory subunit IκB-α in HIV-associated pre-eclampsia. Method: This retrospective study examined plasma NF-κB and IκB-α expression expressed as Mean Fluorescence Intensity (MFI) in normotensive (n = 32) and pre-eclamptic (n = 34) pregnant women stratified by HIV status. Results: A significant decrease in the level of plasma NF-κB expression between pre-eclamptic and normotensive pregnant women was observed, irrespective of HIV status (MFI = 82.8 vs 134.3; p = 0.03). Similarly, a significant decline in the level of plasma IκB-α expression was noted in the pre-eclamptic compared to normotensive pregnant women, irrespective of HIV status (MFI = 91.2 vs 120.1; p = 0.04). Plasma NF-κB (p = 0.7) and IκB-α (p = 0.8) expression was similar between HIV positive and HIV negative pregnant women, irrespective of pregnancy type. Conclusion: This study demonstrates decreased plasma NF-κB and IκB-α expression in preeclampsia compared to normotensive pregnant women irrespective of HIV status.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"15-20"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1854299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38781547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of three definitions of metabolic syndrome and relation to risk of recurrent preeclampsia. 代谢综合征三种定义的比较及其与子痫前期复发风险的关系。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-18 DOI: 10.1080/10641955.2021.1872614

Eva Stekkinger, Ralph R Scholten, Wieteke M Heidema, Marc E A Spaanderman

{"title":"Comparison of three definitions of metabolic syndrome and relation to risk of recurrent preeclampsia.","authors":"Eva Stekkinger, Ralph R Scholten, Wieteke M Heidema, Marc E A Spaanderman","doi":"10.1080/10641955.2021.1872614","DOIUrl":"https://doi.org/10.1080/10641955.2021.1872614","url":null,"abstract":"Objective. To determine the prevalence of metabolic syndrome in formerly preeclamptic women according to three definitions of metabolic syndrome (World Health Organization [WHO], International Diabetes Federation [IDF], and Third Adult Treatment Panel updated [ATPIII]), to evaluate agreement amongst definitions and to compare the risk of recurrent preeclampsia. Methods. In 197 women with a history of preeclampsia, we determined presence of metabolic syndrome using WHO, IDF, and ATPIII criteria. We evaluated agreement amongst definitions by using Kappa statistics. The prevalence of recurrent preeclampsia was compared between women with and without inter-pregnancy metabolic syndrome, according to the three definitions. Results. A total of 40 (20%), 46 (23%), and 31 (16%) of women with previous preeclampsia were classified as having metabolic syndrome postpartum according to WHO, IDF, and ATPIII criteria, respectively. Agreement among criteria was considered substantial between WHO and IDF (κ = 0.64, 95% CI 0.53-0.79), WHO and ATPIII (κ = 0.74, 95% CI 0.62-0.86), and IDF and ATPIII (κ = 0.66, 95% CI 0.51-0.77). The prevalence of recurrent preeclampsia was 45% versus 17% in women with and without inter-pregnancy metabolic syndrome according to the WHO definition (P < 0.001), 26% versus 21% according to the IDF criteria (P = 0.16), and 39% versus 20% according to the ATPIII definition (P = 0.02). Conclusions. Agreement among WHO, IDF, and ATPIII criteria of metabolic syndrome in women after preeclampsia is considered substantial. The risk of recurrent preeclampsia is almost one out of two in women with inter-pregnancy metabolic syndrome according to the WHO criteria.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"97-108"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1872614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38834186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring. 产前暴露于子痫前期是子代长期内分泌疾病的危险因素。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-02 DOI: 10.1080/10641955.2020.1854300

Sharon Davidesko, Kira Nahum Sacks, Michael Friger, Alon Haim, Eyal Sheiner

引用次数: 5

Prehypertension in early pregnancy is a risk factor for hypertensive disorders during pregnancy: A historical cohort study in Japan. 妊娠早期高血压前期是妊娠期高血压疾病的危险因素:日本的一项历史队列研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-26 DOI: 10.1080/10641955.2020.1864637

Takeshi Nagao, Keisuke Saito, Michiko Yamanaka

引用次数: 3

Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia. 可溶性Flt1水平与有或无严重子痫前期黑人妇女的心功能障碍有关。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-20 DOI: 10.1080/10641955.2020.1861462

Lisa Levine, Zolt Arany, Adina Kern-Goldberger, Nathanael Koelper, Jennifer Lewey, Mary D Sammel, Michal A Elovitz, Bonnie Ky

引用次数: 2

Role of maternal nutrition and oxidative stress in placental telomere attrition in women with preeclampsia. 母体营养和氧化应激在子痫前期妇女胎盘端粒磨损中的作用。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-07 DOI: 10.1080/10641955.2020.1869248

Aditi A Godhamgaonkar, Deepali P Sundrani, Sadhana R Joshi

引用次数: 4

Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy. 基于单倍型的肌球蛋白磷酸酶靶亚基1 (PPP1R12A)基因与妊娠高血压疾病的病例对照研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2021-01-18 DOI: 10.1080/10641955.2021.1872613

Ai Kono, Kaori Shinya, Tomohiro Nakayama, Elisa Shikata, Tatsuo Yamamoto, Kei Kawana

{"title":"Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy.","authors":"Ai Kono, Kaori Shinya, Tomohiro Nakayama, Elisa Shikata, Tatsuo Yamamoto, Kei Kawana","doi":"10.1080/10641955.2021.1872613","DOIUrl":"https://doi.org/10.1080/10641955.2021.1872613","url":null,"abstract":"Objective: Hypertensive disorders of pregnancy (HDP) are thought to be a multifactorial genetic disease. Myosin light chain phosphorylation, which is involved in the regulation of vascular smooth muscle contraction and relaxation and thus contributes to the maintenance of blood pressure, is related to HDP. The official symbol of the gene for the production of MYPT1 protein is PPP1R12A gene. Thus, we investigated the possibility that the PPP1R12A gene is related to HDP. Methods: Subjects were 194 pregnant women with HDP and a control group of 262 pregnant women from those women examined. Four SNVs (rs7296839, rs11114256, rs2596793, and rs2694657) were selected from the PPP1R12A gene region. The HDP group was divided according to disease type, and each group was analyzed in comparison with the control group. Results: In the association analysis using the PPP1R12A gene, there were significant differences between the control group and the superimposed preeclampsia (SPE) group for rs11114256 in allele frequency distribution (P = 0.017) and genome frequency distribution in the dominant model (P = 0.014), and for rs2694657 genotype distribution frequency in the recessive model (P = 0.018). In the association analysis using haplotypes, there was a significant difference for G-A-A-G (rs7296839-rs11114256-rs2596793-rs2694657). In an analysis of haplotype-based case-control study, there was a significant difference for G-A-A-G between the control group (0.00%) and the HDP group (2.46%) (P = 0.038). Furthermore, the G-T-A-G haplotype was significantly higher in SPE group than in control group (P = 0.011). Conclusions: The implication is that the PPP1R12A gene may be a disease-susceptibility gene for SPE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"88-96"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1872613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38834188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3