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Hypertension in Pregnancy最新文献

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Household food insecurity associations with pregnancy hypertension, diabetes mellitus and infant birth anthropometric measures: a cross-sectional study of Iranian mothers. 家庭粮食不安全与妊娠高血压、糖尿病和婴儿出生人体测量测量的关系:对伊朗母亲的横断面研究。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-01-21 DOI: 10.1080/10641955.2021.1874010
Elham Hojaji, Mobina Aghajani, Rosa Zavoshy, Mostafa Noroozi, Hassan Jahanihashemi, Neda Ezzeddin
{"title":"Household food insecurity associations with pregnancy hypertension, diabetes mellitus and infant birth anthropometric measures: a cross-sectional study of Iranian mothers.","authors":"Elham Hojaji,&nbsp;Mobina Aghajani,&nbsp;Rosa Zavoshy,&nbsp;Mostafa Noroozi,&nbsp;Hassan Jahanihashemi,&nbsp;Neda Ezzeddin","doi":"10.1080/10641955.2021.1874010","DOIUrl":"https://doi.org/10.1080/10641955.2021.1874010","url":null,"abstract":"<p><p><b>Objective</b>: The purpose of this study was to determine the associations between food insecurity on pregnancy and its outcomes.<b>Materials and methods</b>: This cross-sectional study was carried out on 700 Iranian mothers. Household socioeconomic status, prenatal information and household food security status <b>were assessed using questionnaires. Data analysis was applied by SPSS version 22.</b><b>Results</b>: The results of the study showed a significant association between food insecurity with gestational diabetes mellitus. The results also showed a significant association between birth weight, and height with pregnancy-induced hypertension.<b>Conclusion</b>: food insecure women should be recognized, and receive appropriate training and assistance.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"109-117"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1874010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38764948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells. 先前用水飞蓟宾治疗的子痫前期妇女的单核细胞减弱了人内皮细胞的氧化应激。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-02-14 DOI: 10.1080/10641955.2021.1884258
Virgínia Juliani Gomes, Priscila Rezeck Nunes, Sarah McCann Haworth, Valéria Cristina Sandrim, José Carlos Peraçoli, Maria Terezinha S Peraçoli, Mattias Carlström
{"title":"Monocytes from preeclamptic women previously treated with silibinin attenuate oxidative stress in human endothelial cells.","authors":"Virgínia Juliani Gomes,&nbsp;Priscila Rezeck Nunes,&nbsp;Sarah McCann Haworth,&nbsp;Valéria Cristina Sandrim,&nbsp;José Carlos Peraçoli,&nbsp;Maria Terezinha S Peraçoli,&nbsp;Mattias Carlström","doi":"10.1080/10641955.2021.1884258","DOIUrl":"https://doi.org/10.1080/10641955.2021.1884258","url":null,"abstract":"<p><p><b>Objective:</b> To investigate whether the supernatant from monocytes of preeclamptic and normotensive pregnant women, cultured in vitro with silibinin, can modulate oxidative stress in HUVEC.<b>Methods</b>: Concentrations of IL-1β, IL-10, and TNF-α in monocyte culture supernatants were determined by ELISA. HUVEC and their supernatant cultures were employed for determination of NO, nitrite and nitrate, lipid peroxidation, and hemeoxygenase-1 (HO-1).<b>Results</b>: HUVEC treatment with supernatant of preeclamptic monocytes cultured with silibinin produced increased levels of nitrite, reduced lipid peroxidation, and increased HO-1.<b>Conclusion</b>: Supernatant of monocytes from preeclamptic women induce oxidative stress in HUVEC which can be reduced by silibinin treatment.<b>Abbreviations:</b> DAF-FM<sup>TM</sup>, Diaminofluorescein-FM; EDTA, Ethylenediaminetetraacetic acid; HO-1, heme oxygenase-1; HPLC, high-performance liquid chromatography; HUVEC, human umbilical vein endothelial cell; MDA, malondialdehyde; NO, nitric oxide; NT, normotensive; PE, preeclampsia; ROS, reactive oxygen species; Sb, silibinin.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"124-132"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1884258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25368548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prognostic role of increased serum homocysteine concentration in preeclampsia. 血清同型半胱氨酸浓度升高对子痫前期预后的影响。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-02-08 DOI: 10.1080/10641955.2021.1884257
Andrey Gaiday, Akylbek Tussupkaliyev, Saule Bermagambetova, Svetlana Sakhanova, Andrii Dinets
{"title":"Prognostic role of increased serum homocysteine concentration in preeclampsia.","authors":"Andrey Gaiday,&nbsp;Akylbek Tussupkaliyev,&nbsp;Saule Bermagambetova,&nbsp;Svetlana Sakhanova,&nbsp;Andrii Dinets","doi":"10.1080/10641955.2021.1884257","DOIUrl":"https://doi.org/10.1080/10641955.2021.1884257","url":null,"abstract":"<p><p><b>Objective:</b> To assess homocysteine (Hcy) concentration in women with preeclampsia (PE).<b>Methods:</b> Hcy concentrations were detected by ELISA in 305 pregnancies.<b>Results:</b> Hcy concentration in patients with PE was 16.07 umol/L at 10-14 weeks as compared to 7.19 umol/L in normotensive pregnancies (p < 0.0001). Optimal cutoff level for Hcy in the first trimester of pregnancy was >9.55 umol/L with area under curve of 0.859, sensitivity of 91.67%, specificity of 72.24%.<b>Conclusion:</b> Assessment of serum Hcy concentration may be used as a predictor of PE, with the highest diagnostic utility in the first trimester of pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"118-123"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1884257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25342152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Letter to the Editor regarding Cunningham et al. 2020. 关于Cunningham et al. 2020的致编辑信。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-04-09 DOI: 10.1080/10641955.2021.1899201
{"title":"Letter to the Editor regarding Cunningham et al. 2020.","authors":"","doi":"10.1080/10641955.2021.1899201","DOIUrl":"https://doi.org/10.1080/10641955.2021.1899201","url":null,"abstract":"","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"133"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1899201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25574315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells. LINC01128 - miR-16相互作用调节人绒毛膜滋养细胞的迁移和侵袭。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-04-21 DOI: 10.1080/10641955.2021.1917602
Xinyuan Zhao, Fei Liu, Jin Zhang, Jianhua Zhang, Ludan Zhang, Lin Chen
{"title":"LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells.","authors":"Xinyuan Zhao,&nbsp;Fei Liu,&nbsp;Jin Zhang,&nbsp;Jianhua Zhang,&nbsp;Ludan Zhang,&nbsp;Lin Chen","doi":"10.1080/10641955.2021.1917602","DOIUrl":"https://doi.org/10.1080/10641955.2021.1917602","url":null,"abstract":"<p><p><b>Objective</b>: Pre-eclampsia (PE) is a major complication of pregnancy, but its pathogenesis is unclear. This study explored the role of LINC01128 in the progression of PE, and its interaction with miR-16 on the behaviors of trophoblasts.<b>Methods</b>: The mRNA levels of LINC01128 and miR-16 in placental tissues and HTR-8/SVneo cells were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Cell Counting Kit (CCK)-8, wound healing assay and transwell assay were used to detect proliferation, migration and invasion. E-Cadherin, Vimentin, Matrix metalloproteinase 2 (MMP2) and MMP9 protein expressions were detected by Western blot. The correlation between LINC01128 and miR-16 was determined and verified by starBase and dual-luciferase assay.<b>Results</b>: The expression of LINC01128 was downregulated in PE. Overexpression of LINC01128 promoted LINC01128 expression, cell proliferation, migration, invasion and the expressions of Vimentin, MMP2 and MMP9, but inhibited the expression of E-Cadherin. SiLINC01128 showed opposite effects. MiR-16 interacted with LINC01128, and miR-16 was high-expressed in PE placentae. MiR-16 inhibitor promoted cell proliferation, migration, invasion and related protein expressions, but inhibited the expression of E-Cadherin. However, siLINC01128 inhibited the regulatory effect of miR-16 inhibitor on HTR-8/Svneo cells.<b>Conclusion</b>: LINC01128/miR-16 is involved in HTR-8/SVneo cells by regulating the migration and invasion of human chorionic trophoblast cells.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"152-161"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1917602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38901579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia. 揭示氧化应激和脂质状态参数在子痫前期发病中的作用。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-05-03 DOI: 10.1080/10641955.2021.1921790
Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Gorica Banjac, Jasmina Ivanišević, Jelena Janać, Jelena Vekić, Aleksandra Zeljković, Marija Mihajlović, Nina Rajović, Nataša Milić, Željko Miković
{"title":"Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia.","authors":"Petar Cabunac,&nbsp;Nataša Karadžov Orlić,&nbsp;Daniela Ardalić,&nbsp;Gorica Banjac,&nbsp;Jasmina Ivanišević,&nbsp;Jelena Janać,&nbsp;Jelena Vekić,&nbsp;Aleksandra Zeljković,&nbsp;Marija Mihajlović,&nbsp;Nina Rajović,&nbsp;Nataša Milić,&nbsp;Željko Miković","doi":"10.1080/10641955.2021.1921790","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921790","url":null,"abstract":"<p><p><b>OBJECTIVE</b>: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia.<b>METHODS</b>: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy.<b>RESULTS</b>: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05).<b>CONCLUSION</b>: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"162-170"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38944023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Transcriptome analysis of placentae reveals HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia. 胎盘转录组分析显示，HELLP综合征比先兆子痫表现出更大程度的胎盘代谢功能障碍。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-04-05 DOI: 10.1080/10641955.2021.1908348
Lili Gong, Huanqiang Zhao, Yutong Cui, Xiaotian Li
{"title":"Transcriptome analysis of placentae reveals HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia.","authors":"Lili Gong,&nbsp;Huanqiang Zhao,&nbsp;Yutong Cui,&nbsp;Xiaotian Li","doi":"10.1080/10641955.2021.1908348","DOIUrl":"https://doi.org/10.1080/10641955.2021.1908348","url":null,"abstract":"<p><p><b>Objective:</b> The association between HELLP syndrome and preeclampsia has been investigated with conflicting conclusions. This study is to investigate the pathogenesis underlying these two diseases by analyzing placental transcriptome.<b>Methods:</b> The gene expression profile downloaded from Gene Expression Omnibus database was analyzed by R language.<b>Results:</b> A total of 573 differentially expressed genes in HELLP syndrome and 358 in preeclampsia were identified, among which 295 were unique to HELLP syndrome. Some metabolism-associated pathways were uniquely enriched in HELLP syndrome.<b>Conclusions:</b> HELLP syndrome exhibits a greater extent of placental metabolic dysfunction than preeclampsia, although these two diseases might share partial pathogenesis.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 2","pages":"134-143"},"PeriodicalIF":1.5,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1908348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25562954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia. 子痫前期维生素D生物合成、运输和功能的基因变异和单倍型
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-11 DOI: 10.1080/10641955.2020.1849274
Zahra Ghorbani, Mohammad Shakiba, Negin Rezavand, Ziba Rahimi, Asad Vaisi-Raygani, Zohreh Rahimi, Ebrahim Shakiba
{"title":"Gene variants and haplotypes of Vitamin D biosynthesis, transport, and function in preeclampsia.","authors":"Zahra Ghorbani,&nbsp;Mohammad Shakiba,&nbsp;Negin Rezavand,&nbsp;Ziba Rahimi,&nbsp;Asad Vaisi-Raygani,&nbsp;Zohreh Rahimi,&nbsp;Ebrahim Shakiba","doi":"10.1080/10641955.2020.1849274","DOIUrl":"https://doi.org/10.1080/10641955.2020.1849274","url":null,"abstract":"<p><p><b>Objective</b>: To find whether the gene variants and haplotypes of cytochrome (CYP) 27B1 (1α-hydroxylase), group-specific component (GC) that is a vitamin D binding protein, vitamin D receptor (VDR), peroxisome proliferator-activated receptor γ (PPARγ) and retinoid-X receptor (RXR) affect the risk of preeclampsia. <b>Methods</b>: In a case-control study 100 women with preeclampsia and 100 healthy pregnant women were investigated for gene variants and haplotypes of vitamin D biosynthesis, transport, and function using the polymerase chain reaction-restriction fragment length polymorphism method. <b>Results</b>: The frequency of gene variants of PPARγ Pro12Ala and RXR -α (A/G, rs749759) were not significantly different comparing patients and controls. The TT genotype of CYP 27B1 (G > T) was associated with 2.2-fold (95% CI 1.04-4.7, p = 0.039) increased risk of early-onset preeclampsia. Also, the TT genotype of GC rs7041 (T > G) increased the risk of preeclampsia [OR = 2.13 (95% CI 1.09-4.17, p = 0.027)]. The VDR ApaI GT genotype elevated susceptibility to preeclampsia (OR = 2.55, p = 0.04). Further, the presence of VDR ApaI GT+TT genotype was associated with higher levels of body mass index, and systolic blood pressure, and lower level of 25 (OH)-D3. In the presence of haplotype CYP T, VDR T, and RXR A (TTA) compared to haplotype GTG the risk of preeclampsia was 6.71-fold (p = 0.044). <b>Conclusions</b>: The present study indicated an association between the CYP 27B1, GC, and VDR ApaI variants with the risk of preeclampsia. Also, the variants of the latter polymorphism influenced BMI, blood pressure, and vitamin D levels.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1849274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38361952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia. 重度子痫前期患者脑生物标志物与视神经鞘直径的相关性
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-11-18 DOI: 10.1080/10641955.2020.1849275
Gabrijela Brzan Simenc, Jana Ambrozic, Josko Osredkar, Ksenija Gersak, Miha Lucovnik
{"title":"Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia.","authors":"Gabrijela Brzan Simenc,&nbsp;Jana Ambrozic,&nbsp;Josko Osredkar,&nbsp;Ksenija Gersak,&nbsp;Miha Lucovnik","doi":"10.1080/10641955.2020.1849275","DOIUrl":"https://doi.org/10.1080/10641955.2020.1849275","url":null,"abstract":"<p><p><b>Objective</b>: To examine the correlation between plasma cerebral biomarkers (S100B and neuron-specific enolase (NSE)) and ultrasonographic optic-nerve-sheath-diameter (ONSD) in preeclampsia. <b>Methods</b>: Thirty preeclampsia patients and 27 controls were included. Mann-Whitney-U test was used for comparison of S100B, NSE, and ONSD in preeclampsia vs. controls. Kendall's tau was used to assess the correlation between biomarkers and ONSD (p < 0.05 significant). <b>Results</b>: ONSD, S100B and NSE were significantly higher in preeclampsia (p < 0.001, p = 0.004, and p < 0.001, respectively). There was significant correlation between NSE levels and ONSD: Kendall's tau = 0.26; p = 0.01. <b>Conclusions</b>: S100B and NSE are elevated in severe preeclampsia. NSE correlates with increased ONSD suggesting cerebral edema.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"9-14"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1849275","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38615744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women. 长链非编码RNA HOTAIR变异对伊朗妇女子痫前期易感性的贡献
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-02-01 Epub Date: 2020-12-02 DOI: 10.1080/10641955.2020.1855192
Sahra Esmkhani, Hossein Sadeghi, Majid Ghasemian, Reihaneh Pirjani, Mona Amin-Beidokhti, Milad Gholami, Fakhrolmolouk Yassaee, Reza Mirfakhraie
{"title":"Contribution of long noncoding RNA <i>HOTAIR</i> variants to preeclampsia susceptibility in Iranian women.","authors":"Sahra Esmkhani,&nbsp;Hossein Sadeghi,&nbsp;Majid Ghasemian,&nbsp;Reihaneh Pirjani,&nbsp;Mona Amin-Beidokhti,&nbsp;Milad Gholami,&nbsp;Fakhrolmolouk Yassaee,&nbsp;Reza Mirfakhraie","doi":"10.1080/10641955.2020.1855192","DOIUrl":"https://doi.org/10.1080/10641955.2020.1855192","url":null,"abstract":"<p><p><b>Objective</b>: To investigate the possible association of lncRNA <i>HOTAIR</i> rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. <b>Method</b>: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. <b>Results</b>: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, <i>P</i> < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, <i>P</i> < 0.0001; respectively). <b>Conclusion</b>: This study confirmed the association of <i>HOTAIR</i> rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 1","pages":"29-35"},"PeriodicalIF":1.5,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2020.1855192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38667017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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