Prognostic role of increased serum homocysteine concentration in preeclampsia.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-05-01 Epub Date: 2021-02-08 DOI:10.1080/10641955.2021.1884257

Andrey Gaiday, Akylbek Tussupkaliyev, Saule Bermagambetova, Svetlana Sakhanova, Andrii Dinets

引用次数: 3

Abstract

Objective: To assess homocysteine (Hcy) concentration in women with preeclampsia (PE).Methods: Hcy concentrations were detected by ELISA in 305 pregnancies.Results: Hcy concentration in patients with PE was 16.07 umol/L at 10-14 weeks as compared to 7.19 umol/L in normotensive pregnancies (p < 0.0001). Optimal cutoff level for Hcy in the first trimester of pregnancy was >9.55 umol/L with area under curve of 0.859, sensitivity of 91.67%, specificity of 72.24%.Conclusion: Assessment of serum Hcy concentration may be used as a predictor of PE, with the highest diagnostic utility in the first trimester of pregnancy.

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血清同型半胱氨酸浓度升高对子痫前期预后的影响。

目的:探讨同型半胱氨酸(Hcy)在子痫前期(PE)妇女中的含量。方法:采用ELISA法对305例孕妇进行Hcy浓度检测。结果:妊娠10 ~ 14周时，PE组Hcy浓度为16.07 umol/L，正常妊娠组为7.19 umol/L (p = 9.55 umol/L，曲线下面积为0.859，敏感性为91.67%，特异性为72.24%。结论:评估血清Hcy浓度可作为PE的预测指标，在妊娠前三个月具有最高的诊断效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.