An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI:10.1080/10641955.2021.1987453

Mitali Ray, Lacey W Heinsberg, Yvette P Conley, James M Roberts, Arun Jeyabalan, Carl A Hubel, Daniel E Weeks, Mandy J Schmella

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引用次数: 1

Abstract

Objective: Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity.Methods: WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race.Results: In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.Conclusions: These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.

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一项探索性研究白细胞比例在子痫前期和正常妊娠体重超重或肥胖个体的自我认同种族。

目的:检查白细胞(WBC)的比例在前期子痫(n = 28例)和正常妊娠(n = 28对照)个体超重/肥胖。方法:从全基因组DNA甲基化数据推断WBC比例，并与病例/对照状态和自我识别的种族进行比较。结果:在妊娠第一阶段，整个样本中B细胞的比例明显降低，白人参与者明显降低，而黑人参与者则没有。与子痫前期相比，正常妊娠期间WBC比例的变化更为显著。结论:这些小样本的发现表明需要进一步研究自我识别种族与妊娠白细胞之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.