非瑟酮对脂多糖诱导的子痫前期样大鼠的保护作用。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-02-01 Epub Date: 2021-12-22 DOI:10.1080/10641955.2021.2013874

Ying Li, Yuanyuan Liu, Jinfeng Chen, Jian Hu

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引用次数: 4

摘要

目的:探讨非瑟酮在lps诱导的PE大鼠中的作用及其作用机制。方法:建立lps诱导的PE样大鼠模型，探讨非塞汀对PE的体内影响。结果:非西汀降低PE大鼠高血压、蛋白尿、TNF-α、IL-6、IL-1β、MDA和sFlt-1/PlGF比值，但升高胎盘、胎儿体重、GSH和SOD。非西汀抑制PE大鼠胎盘组织TLR4/NF-κB通路，促进Nrf2/HO-1通路。结论:非塞汀可调节pe样大鼠TLR4/NF-κB和Nrf2/HO-1通路的激活，发挥保护作用。

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Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats.

Objective: This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats.

Methods: LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo.

Results: Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats.

Conclusions: Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.