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Hypertension in Pregnancy最新文献

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An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity. 一项探索性研究白细胞比例在子痫前期和正常妊娠体重超重或肥胖个体的自我认同种族。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1987453
Mitali Ray, Lacey W Heinsberg, Yvette P Conley, James M Roberts, Arun Jeyabalan, Carl A Hubel, Daniel E Weeks, Mandy J Schmella
{"title":"An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity.","authors":"Mitali Ray,&nbsp;Lacey W Heinsberg,&nbsp;Yvette P Conley,&nbsp;James M Roberts,&nbsp;Arun Jeyabalan,&nbsp;Carl A Hubel,&nbsp;Daniel E Weeks,&nbsp;Mandy J Schmella","doi":"10.1080/10641955.2021.1987453","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987453","url":null,"abstract":"<p><p><b>Objective:</b> Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity.<b>Methods:</b> WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race.<b>Results:</b> In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.<b>Conclusions:</b> These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"312-321"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740522/pdf/nihms-1751747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study. 既往医学合并症对子痫前期表型的影响:一项回顾性队列研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1991371
Michael S Tanner, Deborah De Guingand, Maya Reddy, Saskia Rowson, Daniel L Rolnik, Fabricio Da Silva Costa, Mary-Ann Davey, Ben W Mol, Euan M Wallace, Kirsten R Palmer
{"title":"The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study.","authors":"Michael S Tanner,&nbsp;Deborah De Guingand,&nbsp;Maya Reddy,&nbsp;Saskia Rowson,&nbsp;Daniel L Rolnik,&nbsp;Fabricio Da Silva Costa,&nbsp;Mary-Ann Davey,&nbsp;Ben W Mol,&nbsp;Euan M Wallace,&nbsp;Kirsten R Palmer","doi":"10.1080/10641955.2021.1991371","DOIUrl":"https://doi.org/10.1080/10641955.2021.1991371","url":null,"abstract":"<p><p><b>Objective:</b>To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia.<b>Methods:</b> A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes.<b>Results:</b>We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications.<b>Conclusion:</b> Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"336-345"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of complement system in HELLP syndrome. HELLP综合征补体系统失调。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1983593
Shi Chen, Zheng Li, Yingdong He, Qian Chen
{"title":"Dysregulation of complement system in HELLP syndrome.","authors":"Shi Chen,&nbsp;Zheng Li,&nbsp;Yingdong He,&nbsp;Qian Chen","doi":"10.1080/10641955.2021.1983593","DOIUrl":"https://doi.org/10.1080/10641955.2021.1983593","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression of complement system's activation factors in patients with HELLP syndrome.</p><p><strong>Methods: </strong>A case-control study was performed. Sixteen HELLP syndrome patients, 32 severe preeclampsia patients, and 48 normal pregnancy women were involved in this studyELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, sC5b-9, s-Endoglin, and sflt-1 in the plasma.</p><p><strong>Results: </strong>The levels of C5a (P < 0.01) and sC5b-9 (P = 0.014) in HELLP syndrome were higher than those in severe preeclampsia patients.</p><p><strong>Conclusions: </strong>The abnormal activation of the complement system is more significant in the pathogenesis of HELLP syndrome than in severe preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"303-311"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39560845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Diagnosis of preeclampsia in women with diabetic kidney disease. 糖尿病肾病妇女先兆子痫的诊断
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1987454
Jakub Kornacki, Daniel Boroń, Paweł Gutaj, Urszula Mantaj, Przemysław Wirstlein, Ewa Wender-Ozegowska
{"title":"Diagnosis of preeclampsia in women with diabetic kidney disease.","authors":"Jakub Kornacki,&nbsp;Daniel Boroń,&nbsp;Paweł Gutaj,&nbsp;Urszula Mantaj,&nbsp;Przemysław Wirstlein,&nbsp;Ewa Wender-Ozegowska","doi":"10.1080/10641955.2021.1987454","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987454","url":null,"abstract":"<p><p><b>Objective:</b> assessing the incidence of preeclampisa (PE) in women with diabetic kidney disease (DKD) and analyzing the significance of clinical characteristics and changes in laboratory findings throughout the pregnancy on the onset of PE.<b>Methods:</b> the study included 79 patients with DKD. All patients had elevated urinary protein loss (30-299 mg/24 h) or proteinuria (≥300 mg/24 h) in the first trimester of pregnancy. PE was diagnosed in 22,8% patients with DKD.<b>Results:</b> women with proteinuria and/or proliferative retinopathy at the admission developed preeclampsia significantly more frequently than those without these findings. The degree of proteinuria was significantly associated with the risk of PE development in each trimester of pregnancy. Patients with chronic hypertension developed PE significantly more frequently than those who had no chronic hypertension.<b>Conclusion:</b> chronic hypertension and the degree of primary kidney injury and dysfunction are crucial determinants of PE development in women with DKD. Proteinuria seems to be the best renal predictive factors of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"322-329"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Quality improvement: patient education for management of hypertension in pregnancy. 质量改进:对妊娠期高血压管理的患者教育。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1981371
Kriti M Goel, Rose A Maxwell, Morgan E Cooley, Traci M Rackett, Jerome L Yaklic
{"title":"Quality improvement: patient education for management of hypertension in pregnancy.","authors":"Kriti M Goel,&nbsp;Rose A Maxwell,&nbsp;Morgan E Cooley,&nbsp;Traci M Rackett,&nbsp;Jerome L Yaklic","doi":"10.1080/10641955.2021.1981371","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981371","url":null,"abstract":"<p><p><b><i>Objective</i>:</b> To assess the effectiveness of interactive education tools for hypertension in pregnancy.Two interactive education tools were introduced.<b><i>Methods</i>:</b> Pregnant women with hypertension completed questionnaires before (Pre-I) and after)Post-I) the intervention.Providers rated satisfaction and effectiveness of the education methods.<b><i>Results</i>:</b> The Post-I group (N=45) showed slight improvement on both Perceived (4.5±0.7) and Actual knowledge (2.2 ± 1.0) compared to the Pre-I group (N=45; Perceived: 4.2±1.0; Actual: 1.7±1.3; p<.05) .Providers reported higher satisfaction after the intervention (2.6±1.1 vs 4.1±0.7; p <.001).<b><i>iscussion</i>:</b> The intervention increased patients' knowledge and providers rating of patient knowledge, and decreased the time needed for patient education.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"271-278"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study. sFlt-1/PlGF比值对双胎先兆子痫的预测价值:一项回顾性研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI: 10.1080/10641955.2021.1987455
Satoshi Shinohara, Rei Sunami, Mayuko Kasai, Genki Yasuda, Yuzo Uchida
{"title":"Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study.","authors":"Satoshi Shinohara,&nbsp;Rei Sunami,&nbsp;Mayuko Kasai,&nbsp;Genki Yasuda,&nbsp;Yuzo Uchida","doi":"10.1080/10641955.2021.1987455","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987455","url":null,"abstract":"<p><p><b>Objective</b>: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies.<b>Methods</b>: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + 6 weeks of gestation were enrolled. A receiver-operating characteristic curve was used to determine the sFlt-1/PlGF ratio threshold to predict PE.<b>Results</b>: A cutoff value for the sFlt-1/PlGF ratio of 22.2 predicted PE presence within 4 weeks.<b>Conclusion</b>: An sFlt-1/PlGF ratio of ≤22.2 is potentially indicative of PE absence within 4 weeks in twin pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"330-335"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia. 一项临床和计算机研究探讨了CASP-3、NF-kB、miR-187和miR-146在先兆子痫中的相关性。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-11-02 DOI: 10.1080/10641955.2021.1983592
Charu Sharma, Purvi Purohit, Manoj Khokhar, Anupama Modi, Pratibha Singh, Shashank Shekhar, Shailja Sharma, Meenakshi Gothwal, Praveen Sharma
{"title":"A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia.","authors":"Charu Sharma,&nbsp;Purvi Purohit,&nbsp;Manoj Khokhar,&nbsp;Anupama Modi,&nbsp;Pratibha Singh,&nbsp;Shashank Shekhar,&nbsp;Shailja Sharma,&nbsp;Meenakshi Gothwal,&nbsp;Praveen Sharma","doi":"10.1080/10641955.2021.1983592","DOIUrl":"https://doi.org/10.1080/10641955.2021.1983592","url":null,"abstract":"<p><strong>Introduction: </strong>Apoptosis is involved in pathogenesis of Pre-eclampsia (PE), further research is needed to determine its molecular mechanism.</p><p><strong>Methods: </strong>The study recruited two groups (controls; 09, PE; 11). Biochemical tests, RT-PCR and ELISA were employed for analysis of genes and MicroRNAs (miRNA). Bioinformatics tools were employed for interactomics analysis.</p><p><strong>Results: </strong>There was increased apoptosis in maternal placental tissue (MPT) and Maternal Blood Cells (MBC) as demonstrated by expression of CASP3 and NF-κB1. miR-146-5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT)..</p><p><strong>Discussion: </strong>An increased apoptosis in MBC and MPT is a significant contributory factor for PE in pregnancy, while FPT is immune to the aforementioned effects.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"288-302"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE. IL-25通过与IL-17RB结合并与PE相关，促进滋养细胞增殖和侵袭。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-07-15 DOI: 10.1080/10641955.2021.1950177
Siyu Liu, Yi Sun, Yao Tang, Rong Hu, Qiongjie Zhou, Xiaotian Li
{"title":"IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE.","authors":"Siyu Liu,&nbsp;Yi Sun,&nbsp;Yao Tang,&nbsp;Rong Hu,&nbsp;Qiongjie Zhou,&nbsp;Xiaotian Li","doi":"10.1080/10641955.2021.1950177","DOIUrl":"https://doi.org/10.1080/10641955.2021.1950177","url":null,"abstract":"<p><p><b>Introduction:</b> Interleukin-25 is a Th2 interleukin and has been shown to influence cell behavior. This study aims to illustrate its affection on extravillous trophoblasts function and association with PE. Methods qPCR and immunohistochemistry demonstrate IL-25 and IL-17RB expression. CCK-8 test and transwell were to access the behavior of HTR8 in the presence or absence of IL-25, IL-25 neutralization antibody. Results EVTs and HTR8 express IL-25 and IL-17RB. IL-25 promotes proliferation and invasion (p< 0.05),which was abolished in the presence of IL-25Ab (p< 0.05). Conclusion: IL-25 may contribute to promote trophoblast invasion and proliferation and abnormal decline of IL-25 might be associated with PE.<b>Methods:</b> qPCR and immunohistochemistry (IHC) were used to demonstrate IL-25 and its receptor IL-17RB expression in primary human trophoblasts of normal first- and third- trimester, as well as third-trimester of PE. CCK-8 test and transwell invasion system in vitro were applied separately to access the behavior of trophoblast cell line (HTR8) in the presence or absence of IL-25, IL-25 neutralization antibody (IL-25 Ab).<b>Results:</b> EVTs and HTR8 express IL-25 and IL-17RB. The expressions increase in third-trimester during normal pregnancy. In PE, both of IL-25 and IL-17RB expressions decrease (<i>p</i>< 0.05). IL-25 for 24 h promoted HTR8 proliferation and invasion (<i>p</i>< 0.05). The effect was abolished in the presence of IL-25Ab (<i>p</i>< 0.05).<b>Conclusion:</b> This study demonstrates that IL-25 may contribute to promote trophoblast invasion and proliferation and abnormal decline of IL-25 might be associated with PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"209-217"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1950177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39186885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia. 子痫前期母体微血管内皮细胞中肿瘤坏死因子α表达升高。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-12 DOI: 10.1080/10641955.2021.1921794
Dennis K Lee, Ori Nevo
{"title":"Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia.","authors":"Dennis K Lee,&nbsp;Ori Nevo","doi":"10.1080/10641955.2021.1921794","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921794","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study was to explore the expression and effects of tumor necrosis factor alpha (TNFα) in maternal endothelial cells in preeclampsia (PE).<b>Methods:</b> Expression levels in primary microvascular endothelial cells (MVEC) isolated from patients with severe preeclampsia (PE) and normal pregnancies were determined by RT-qPCR with or without treatment of TNFα and inhibitors for downstream signaling.<b>Results:</b> PE MVEC exhibited increased basal TNFα expression. TNFα treatment increased TNFα, VCAM, and endocan expression in MVEC.<b>Conclusion:</b> TNFα expression is increased in PE MVEC and the treatment of these cells with exogenous TNFα modifies their gene expression.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"193-201"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis. 多发性硬化症会增加子痫前期的风险吗?系统回顾和荟萃分析。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-17 DOI: 10.1080/10641955.2021.1921792
Ahmed Arafa, Xiaowen Wang, Jia-Yi Dong, Ehab S Eshak
{"title":"Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis.","authors":"Ahmed Arafa,&nbsp;Xiaowen Wang,&nbsp;Jia-Yi Dong,&nbsp;Ehab S Eshak","doi":"10.1080/10641955.2021.1921792","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921792","url":null,"abstract":"<p><p><b>Objective</b>: We investigated, via systematic review and meta-analysis, whether multiple sclerosis (MS) is associated with the risk of preeclampsia (PE).<b>Methods</b>: From the eligible studies, we pooled odds ratios (ORs) and confidence intervals (CIs) of PE for pregnant women with MS compared with pregnant women without it using the fixed-effects model. The <i>I</i><sup>2</sup> measured heterogeneity between studies.<b>Results</b>: Eight eligible studies (9 cohorts) were included. Pregnant women with MS had no excess risk of PE compared with pregnant women without MS (pooled OR = 0.99, 95% CI: 0.89, 1.09; <i>I</i><sup>2</sup> = 0.00%).<b>Conclusion</b>: MS is not associated with PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"180-185"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38991119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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