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Hypertension in Pregnancy最新文献

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A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia. 一项临床和计算机研究探讨了CASP-3、NF-kB、miR-187和miR-146在先兆子痫中的相关性。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-11-02 DOI: 10.1080/10641955.2021.1983592
Charu Sharma, Purvi Purohit, Manoj Khokhar, Anupama Modi, Pratibha Singh, Shashank Shekhar, Shailja Sharma, Meenakshi Gothwal, Praveen Sharma
{"title":"A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia.","authors":"Charu Sharma,&nbsp;Purvi Purohit,&nbsp;Manoj Khokhar,&nbsp;Anupama Modi,&nbsp;Pratibha Singh,&nbsp;Shashank Shekhar,&nbsp;Shailja Sharma,&nbsp;Meenakshi Gothwal,&nbsp;Praveen Sharma","doi":"10.1080/10641955.2021.1983592","DOIUrl":"https://doi.org/10.1080/10641955.2021.1983592","url":null,"abstract":"<p><strong>Introduction: </strong>Apoptosis is involved in pathogenesis of Pre-eclampsia (PE), further research is needed to determine its molecular mechanism.</p><p><strong>Methods: </strong>The study recruited two groups (controls; 09, PE; 11). Biochemical tests, RT-PCR and ELISA were employed for analysis of genes and MicroRNAs (miRNA). Bioinformatics tools were employed for interactomics analysis.</p><p><strong>Results: </strong>There was increased apoptosis in maternal placental tissue (MPT) and Maternal Blood Cells (MBC) as demonstrated by expression of CASP3 and NF-κB1. miR-146-5p and 187-5p were downregulated in MBC and MPT but upregulated in fetal placental tissue (FPT)..</p><p><strong>Discussion: </strong>An increased apoptosis in MBC and MPT is a significant contributory factor for PE in pregnancy, while FPT is immune to the aforementioned effects.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"288-302"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39837225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE. IL-25通过与IL-17RB结合并与PE相关，促进滋养细胞增殖和侵袭。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-07-15 DOI: 10.1080/10641955.2021.1950177
Siyu Liu, Yi Sun, Yao Tang, Rong Hu, Qiongjie Zhou, Xiaotian Li
{"title":"IL-25 promotes trophoblast proliferation and invasion via binding with IL-17RB and associated with PE.","authors":"Siyu Liu,&nbsp;Yi Sun,&nbsp;Yao Tang,&nbsp;Rong Hu,&nbsp;Qiongjie Zhou,&nbsp;Xiaotian Li","doi":"10.1080/10641955.2021.1950177","DOIUrl":"https://doi.org/10.1080/10641955.2021.1950177","url":null,"abstract":"<p><p><b>Introduction:</b> Interleukin-25 is a Th2 interleukin and has been shown to influence cell behavior. This study aims to illustrate its affection on extravillous trophoblasts function and association with PE. Methods qPCR and immunohistochemistry demonstrate IL-25 and IL-17RB expression. CCK-8 test and transwell were to access the behavior of HTR8 in the presence or absence of IL-25, IL-25 neutralization antibody. Results EVTs and HTR8 express IL-25 and IL-17RB. IL-25 promotes proliferation and invasion (p< 0.05),which was abolished in the presence of IL-25Ab (p< 0.05). Conclusion: IL-25 may contribute to promote trophoblast invasion and proliferation and abnormal decline of IL-25 might be associated with PE.<b>Methods:</b> qPCR and immunohistochemistry (IHC) were used to demonstrate IL-25 and its receptor IL-17RB expression in primary human trophoblasts of normal first- and third- trimester, as well as third-trimester of PE. CCK-8 test and transwell invasion system in vitro were applied separately to access the behavior of trophoblast cell line (HTR8) in the presence or absence of IL-25, IL-25 neutralization antibody (IL-25 Ab).<b>Results:</b> EVTs and HTR8 express IL-25 and IL-17RB. The expressions increase in third-trimester during normal pregnancy. In PE, both of IL-25 and IL-17RB expressions decrease (<i>p</i>< 0.05). IL-25 for 24 h promoted HTR8 proliferation and invasion (<i>p</i>< 0.05). The effect was abolished in the presence of IL-25Ab (<i>p</i>< 0.05).<b>Conclusion:</b> This study demonstrates that IL-25 may contribute to promote trophoblast invasion and proliferation and abnormal decline of IL-25 might be associated with PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"209-217"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1950177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39186885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia. 子痫前期母体微血管内皮细胞中肿瘤坏死因子α表达升高。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-12 DOI: 10.1080/10641955.2021.1921794
Dennis K Lee, Ori Nevo
{"title":"Tumor necrosis factor alpha expression is increased in maternal microvascular endothelial cells in preeclampsia.","authors":"Dennis K Lee,&nbsp;Ori Nevo","doi":"10.1080/10641955.2021.1921794","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921794","url":null,"abstract":"<p><p><b>Objective:</b> The aim of this study was to explore the expression and effects of tumor necrosis factor alpha (TNFα) in maternal endothelial cells in preeclampsia (PE).<b>Methods:</b> Expression levels in primary microvascular endothelial cells (MVEC) isolated from patients with severe preeclampsia (PE) and normal pregnancies were determined by RT-qPCR with or without treatment of TNFα and inhibitors for downstream signaling.<b>Results:</b> PE MVEC exhibited increased basal TNFα expression. TNFα treatment increased TNFα, VCAM, and endocan expression in MVEC.<b>Conclusion:</b> TNFα expression is increased in PE MVEC and the treatment of these cells with exogenous TNFα modifies their gene expression.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"193-201"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis. 多发性硬化症会增加子痫前期的风险吗?系统回顾和荟萃分析。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-17 DOI: 10.1080/10641955.2021.1921792
Ahmed Arafa, Xiaowen Wang, Jia-Yi Dong, Ehab S Eshak
{"title":"Does multiple sclerosis increase the risk of preeclampsia? A systematic review and meta-analysis.","authors":"Ahmed Arafa,&nbsp;Xiaowen Wang,&nbsp;Jia-Yi Dong,&nbsp;Ehab S Eshak","doi":"10.1080/10641955.2021.1921792","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921792","url":null,"abstract":"<p><p><b>Objective</b>: We investigated, via systematic review and meta-analysis, whether multiple sclerosis (MS) is associated with the risk of preeclampsia (PE).<b>Methods</b>: From the eligible studies, we pooled odds ratios (ORs) and confidence intervals (CIs) of PE for pregnant women with MS compared with pregnant women without it using the fixed-effects model. The <i>I</i><sup>2</sup> measured heterogeneity between studies.<b>Results</b>: Eight eligible studies (9 cohorts) were included. Pregnant women with MS had no excess risk of PE compared with pregnant women without MS (pooled OR = 0.99, 95% CI: 0.89, 1.09; <i>I</i><sup>2</sup> = 0.00%).<b>Conclusion</b>: MS is not associated with PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"180-185"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38991119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Coronavirus disease 2019 (COVID-19) and the risk of hypertensive disorders of pregnancy: a retrospective cohort study. 冠状病毒病2019 (COVID-19)与妊娠高血压疾病的风险:一项回顾性队列研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-08-24 DOI: 10.1080/10641955.2021.1965621
Michael Baracy, Fareeza Afzal, Susanna M Szpunar, Makenzie Tremp, Karlee Grace, Marina Liovas, Muhammad Faisal Aslam
{"title":"Coronavirus disease 2019 (COVID-19) and the risk of hypertensive disorders of pregnancy: a retrospective cohort study.","authors":"Michael Baracy,&nbsp;Fareeza Afzal,&nbsp;Susanna M Szpunar,&nbsp;Makenzie Tremp,&nbsp;Karlee Grace,&nbsp;Marina Liovas,&nbsp;Muhammad Faisal Aslam","doi":"10.1080/10641955.2021.1965621","DOIUrl":"https://doi.org/10.1080/10641955.2021.1965621","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate of COVID-19 disease in pregnant women and its association with hypertensive disorders of pregnancy.<b>Design:</b> Retrospective Cohort Study<b>Setting:</b> Multicenter study from a large metropolitan hospital system<b>Methods:</b> Patients who tested positive for COVID-19 during their pregnancy and delivered were compared to the three subsequent deliveries of patients who tested negative (controls). We evaluated the impact of COVID-19 on the development of hypertensive disorders of pregnancy.<b>Results:</b> Compared with pregnancies negative for SARs-CoV-2 infection, maternal SARs-CoV-2 infection was associated with an increased risk for hypertensive disorders of pregnancy (OR 3.68, 95% CI 1.67 - 8.10).<b>Tweetable Abstract</b>Patients who test positive for COVID-19 during their pregnancy are at increased risk of developing a hypertensive disorder of pregnancy. Earlier SARs-CoV-2 infection results in an increased risk of developing a hypertensive disorder.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"226-235"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39341634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital. 前bnp水平及其在慢性高血压妊娠中的预后作用:一项来自三级医院的前瞻性病例对照研究
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-06-18 DOI: 10.1080/10641955.2021.1939712
Mehmet Akif Erdol, Atakan Tanacan, Hasan Eroglu, Nazan Vanli Tonyali, Mehmet Erdogan, Aykan Yucel, Nuray Yazihan, Dilek Sahin
{"title":"Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital.","authors":"Mehmet Akif Erdol,&nbsp;Atakan Tanacan,&nbsp;Hasan Eroglu,&nbsp;Nazan Vanli Tonyali,&nbsp;Mehmet Erdogan,&nbsp;Aykan Yucel,&nbsp;Nuray Yazihan,&nbsp;Dilek Sahin","doi":"10.1080/10641955.2021.1939712","DOIUrl":"https://doi.org/10.1080/10641955.2021.1939712","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT).<b>Method:</b> 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated.<b>Results:</b> NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04).<b>Conclusion:</b> NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"202-208"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1939712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39250913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia. 白介素-32基因多态性与子痫前期易感性的关系
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-08-04 DOI: 10.1080/10641955.2021.1958836
Fatemeh Mazlum, Behrouz Gharesi-Fard, Hossein Hadinedoushan, Yousef Bakhshizadeh Ghashti
{"title":"Association between interleukin-32 gene polymorphism and susceptibility to preeclampsia.","authors":"Fatemeh Mazlum,&nbsp;Behrouz Gharesi-Fard,&nbsp;Hossein Hadinedoushan,&nbsp;Yousef Bakhshizadeh Ghashti","doi":"10.1080/10641955.2021.1958836","DOIUrl":"https://doi.org/10.1080/10641955.2021.1958836","url":null,"abstract":"<p><strong>Objective: </strong>To determine association between IL-32 gene polymorphism, and serum levels of IL-32 and susceptibility to preeclampsia (PE).</p><p><strong>Methods: </strong>The frequency of IL-32 rs9927163 and rs4786370 polymorphisms was determined by PCR-RFLP. Also ELISA was used to determine the levels of serum IL-32.</p><p><strong>Results: </strong>Regarding rs4786370 C/T SNPs, the frequencies of CT, TT genotypes, and T allele were shown to be higher in the PE patients. IL-32 serum level significantly increased in the PE patients.</p><p><strong>Conclusion: </strong>Variety of allele and genotype IL32 rs4786370 as well as a rise in serum level of IL-32 can be regarded as a risk factor for PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"218-225"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1958836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39274408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Association between time of delivery and composite adverse outcomes in pregnancies complicated by hypertensive disorders. 妊娠合并高血压疾病的分娩时间与综合不良结局的关系。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-09-06 DOI: 10.1080/10641955.2021.1974879
Stephen M Wagner, Han-Yang Chen, Megha Gupta, Matthew J Bicocca, Hector Mendez-Figueroa, Suneet P Chauhan
{"title":"Association between time of delivery and composite adverse outcomes in pregnancies complicated by hypertensive disorders.","authors":"Stephen M Wagner,&nbsp;Han-Yang Chen,&nbsp;Megha Gupta,&nbsp;Matthew J Bicocca,&nbsp;Hector Mendez-Figueroa,&nbsp;Suneet P Chauhan","doi":"10.1080/10641955.2021.1974879","DOIUrl":"https://doi.org/10.1080/10641955.2021.1974879","url":null,"abstract":"<p><strong>Introduction: </strong>A potential manner to lower the morbidity with the hypertensive disoreders of pregancy is to explore the time of day of delivery.</p><p><strong>Objective: </strong>To compare composite neonatal adverse outcomes among term women with hypertensive disorders.</p><p><strong>Methods: </strong>This population-based cohort study used the U.S. vital statistics dataset from 2013 to 2017. Time of delivery was categorized into three shifts. The primary outcome was composite neonatal adverse outcome..</p><p><strong>Results: </strong>Compared to neonates delivered at the first shift, the risk of composite neonatal adverse outcome was higher at the third shift (aRR = 1.19, 95% CI = 1.13-1.25).</p><p><strong>Conclusion: </strong>the risk of composite neonatal adverse outcome is higher if the delivery occurs at the third (23:00-7:00) shift.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"246-253"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Predictors of readmission for postpartum preeclampsia. 产后子痫前期再入院的预测因素。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-09-11 DOI: 10.1080/10641955.2021.1975737
Rodney A McLaren, Melissa Magenta, Laura Gilroy, Maria Gabriela Duarte, Sujatha Narayanamoorthy, Jeremy Weedon, Howard Minkoff
{"title":"Predictors of readmission for postpartum preeclampsia.","authors":"Rodney A McLaren,&nbsp;Melissa Magenta,&nbsp;Laura Gilroy,&nbsp;Maria Gabriela Duarte,&nbsp;Sujatha Narayanamoorthy,&nbsp;Jeremy Weedon,&nbsp;Howard Minkoff","doi":"10.1080/10641955.2021.1975737","DOIUrl":"https://doi.org/10.1080/10641955.2021.1975737","url":null,"abstract":"<p><p><b>Objective</b>: To develop a predictive model for re-admission for postpartum preeclampsia (PPEC).<b>Methods</b>: A case-control study; cases were patients re-admitted for PPEC; controls were not re-admitted. Mixed linear modelling was used to develop a predictive model on the training set, then validated on the validation set.<b>Results</b>: Two-hundred-sixty-nine patients were readmitted, and matched to 538 controls. A risk calculator was developed and yielded a sensitivity and specificity for readmission of 80.9% and 53.5%, respectively.<b>Conclusion</b>: A predictive model using age, race, discharge blood pressures, and preeclampsia was able to predict re-admission for PPEC with a high level of sensitivity.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"254-260"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39408373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia. 白细胞介素-1β和尿酸作为子痫前期妊娠中期潜在的预测性生物标志物
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2021-08-01 Epub Date: 2021-05-06 DOI: 10.1080/10641955.2021.1921793
Keziban Dogan, Alev Kural, Yasin Oztoprak, Murat Dogan
{"title":"Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia.","authors":"Keziban Dogan,&nbsp;Alev Kural,&nbsp;Yasin Oztoprak,&nbsp;Murat Dogan","doi":"10.1080/10641955.2021.1921793","DOIUrl":"https://doi.org/10.1080/10641955.2021.1921793","url":null,"abstract":"ABSTRACT Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups. Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not. Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 3","pages":"186-192"},"PeriodicalIF":1.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10641955.2021.1921793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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