Hypertension in Pregnancy最新文献

{"title":"Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome.","authors":"Iara Dos Santos Fagundes,&nbsp;Eduardo Pletsch Brendler,&nbsp;Isadora Nunes Erthal,&nbsp;Raquel Jaqueline Eder Ribeiro,&nbsp;Rafaela Siviero Caron-Lienert,&nbsp;Denise Cantarelli Machado,&nbsp;Bartira Ercília Pinheiro da Costa,&nbsp;Carlos Eduardo Poli-de-Figueiredo","doi":"10.1080/10641955.2021.2008424","DOIUrl":"https://doi.org/10.1080/10641955.2021.2008424","url":null,"abstract":"<p><p>To evaluate total Th1/Th2 cytokines in CD3⁺ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3⁺, INF-g⁺/CD3⁺, IL-4⁺/CD3⁺, and IL-10⁺/CD3⁺, CD4⁺/CD8⁺ were determined by flow-cytometry. Preeclampsia (<i>n</i>= 26) and normal pregnancy (<i>n</i>= 25) participants were age and gestational age matched. CD4⁺ lymphocytes count was higher in preeclampsia, compared with normal pregnancy (43.6 ± 5.8 vs 37.6 ± 5.6%; <i>P</i>< 0.001). CD3⁺ cells Th1/Th2 shift was not detected in preeclampsia, yet may be present in other cell types, such as CD4⁺ and CD3 - lymphocytes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"15-22"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39917586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA.","authors":"Phumelele Kikine,&nbsp;Yazira Pillay,&nbsp;Thajasvarie Naicker","doi":"10.1080/10641955.2021.2001819","DOIUrl":"https://doi.org/10.1080/10641955.2021.2001819","url":null,"abstract":"<p><strong>Objectives: </strong>This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.</p><p><strong>Methods: </strong>This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.</p><p><strong>Results: </strong>A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.</p><p><strong>Conclusion: </strong>Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"9-14"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39715670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Lu et al. regarding article, \"Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia\".","authors":"Zhuo Deng,&nbsp;Dan Lu","doi":"10.1080/10641955.2021.2024224","DOIUrl":"https://doi.org/10.1080/10641955.2021.2024224","url":null,"abstract":"We read with the great interest the article by Brownfoot et al., titled “Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia” (1). The authors deciphered the potential therapeutic value of combined someprazole and sulfasalazine additively in reducing the secretion of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) for the pathogenesis of preeclampsia (PE), which was identified as new candidate medication to treat or prevent PE. Previously, we have noticed that the impacts of PE on women are not limited to the pregnancy itself but rather extended to the long-term life (2). Studies have demonstrated consistently that post-PE women were at higher risk of developing cardiovascular disease later in life, such as ischemic heart disease, stroke and heart failure, and so on (3,4). Brown and Wu et al. have found that women with a history of PE had the increased incidence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) (5,6). In addition, it became more apparent that there was significant relation between insulin resistance and formerly PE (7). Notably, emerging evidence proving EGFR and sFlt-1 signaling pathways was associated with the long-term complications in PE became available (8). In light of the exciting clues, we wondered whether the available follow-up about long-term complication among women with PE and consequently the survival quality analysis would be included in evaluating the effectiveness of combining esomeprazole and sulfasalazine in extended studies for broadening our understanding of its effect. Hence, it was worth elucidating the long-term survival quality analysis, which might shed some light on the clinical value of combining esomeprazole and sulfasalazine and contribute to improve the prognosis of PE. Finally, we congratulate that the authors identified the combination of esomeprazole and sulfasalazine as the novel therapeutic strategies in PE and look forward to that our interest will stimulate intriguing findings carried out on the clinical use of esomeprazole and sulfasalazine.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"51-52"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39869971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictability of adverse outcomes in hypertensive disorders of pregnancy: a multicenter prospective cohort study.","authors":"Daniela N Vasquez,&nbsp;Andrea V Das Neves,&nbsp;Vanina M Aphalo,&nbsp;Laura Vidal,&nbsp;Miriam Moseinco,&nbsp;Jorge Lapadula,&nbsp;Analía Santa-Maria,&nbsp;Graciela Zakalik,&nbsp;Raúl A Gomez,&nbsp;Mónica Capalbo,&nbsp;Claudia Fernandez,&nbsp;Enrique Agüero-Villareal,&nbsp;Santiago Vommaro,&nbsp;Marcelo Moretti,&nbsp;Silvana B Soli,&nbsp;Florencia Ballestero,&nbsp;Juan P Sottile,&nbsp;Viviana Chapier,&nbsp;Carlos Lovesio,&nbsp;José Santos,&nbsp;Fernando Bertoletti,&nbsp;Fernando A Mos,&nbsp;Alejandro Risso-Vazquez,&nbsp;Mercedes Esteban-Chacon,&nbsp;Santiago Illutovich,&nbsp;Sebastián Chapela,&nbsp;Cecilia I Loudet,&nbsp;José L Scapellato,&nbsp;Alfredo D Intile,&nbsp;Elisa Estenssoro","doi":"10.1080/10641955.2021.1981373","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981373","url":null,"abstract":"<p><strong>Objectives: </strong>To explore variables associated with adverse maternal/fetal/neonatal outcomes among pregnant/postpartum patients admitted to ICU for hypertensive disorders of pregnancy (HDP).</p><p><strong>Methods: </strong>Multicenter, prospective, national cohort study.</p><p><strong>Results: </strong>Variables independently associated with maternal/fetal/neonatal mortality among 172 patients were as follows: Acute Physiology and Chronic Health Evaluation-II (APACHE-II)(OR1.20[1.06-1.35]), gestational age (OR0.698[0.59-0.82]) and aspartate aminotransferase (AST)(OR1.004[1.001-1.006]). Positive likelihood ratio for headache, epigastric pain, and visual disturbances to predict composite adverse outcomes were 1.23(1.16-1.30), 0.76(0.59-1.02), and 1.1(0.98-1.2), respectively.</p><p><strong>Conclusions: </strong>Maternal/fetal mortality due to HDP was independently associated with severity of illness on admission, gestational age, and elevated AST. Accuracy of clinical symptoms to predict composite adverse outcomes was low.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"279-287"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39470830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity.","authors":"Mitali Ray,&nbsp;Lacey W Heinsberg,&nbsp;Yvette P Conley,&nbsp;James M Roberts,&nbsp;Arun Jeyabalan,&nbsp;Carl A Hubel,&nbsp;Daniel E Weeks,&nbsp;Mandy J Schmella","doi":"10.1080/10641955.2021.1987453","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987453","url":null,"abstract":"<p><p><b>Objective:</b> Examine white blood cell (WBC) proportions across preeclamptic (n = 28 cases) and normotensive (n = 28 controls) pregnancy in individuals with overweight/obesity.<b>Methods:</b> WBC proportions were inferred from genome-wide DNA methylation data and compared by case/control status and self-identified race.<b>Results:</b> In Trimester 1, ean B cell proportions were suggestively lower in cases in the overall sample and significantly lower in White participants but not in Black participants. More significant WBC proportion changes were observed across normotensive than preeclamptic pregnancy.<b>Conclusions:</b> These findings in a small sample demonstrate need for additional studies investigating the relationship between self-identified race and WBCs in pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"312-321"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740522/pdf/nihms-1751747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study.","authors":"Michael S Tanner,&nbsp;Deborah De Guingand,&nbsp;Maya Reddy,&nbsp;Saskia Rowson,&nbsp;Daniel L Rolnik,&nbsp;Fabricio Da Silva Costa,&nbsp;Mary-Ann Davey,&nbsp;Ben W Mol,&nbsp;Euan M Wallace,&nbsp;Kirsten R Palmer","doi":"10.1080/10641955.2021.1991371","DOIUrl":"https://doi.org/10.1080/10641955.2021.1991371","url":null,"abstract":"<p><p><b>Objective:</b>To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia.<b>Methods:</b> A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes.<b>Results:</b>We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications.<b>Conclusion:</b> Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"336-345"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of complement system in HELLP syndrome.","authors":"Shi Chen,&nbsp;Zheng Li,&nbsp;Yingdong He,&nbsp;Qian Chen","doi":"10.1080/10641955.2021.1983593","DOIUrl":"https://doi.org/10.1080/10641955.2021.1983593","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the expression of complement system's activation factors in patients with HELLP syndrome.</p><p><strong>Methods: </strong>A case-control study was performed. Sixteen HELLP syndrome patients, 32 severe preeclampsia patients, and 48 normal pregnancy women were involved in this studyELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, sC5b-9, s-Endoglin, and sflt-1 in the plasma.</p><p><strong>Results: </strong>The levels of C5a (P < 0.01) and sC5b-9 (P = 0.014) in HELLP syndrome were higher than those in severe preeclampsia patients.</p><p><strong>Conclusions: </strong>The abnormal activation of the complement system is more significant in the pathogenesis of HELLP syndrome than in severe preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"303-311"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39560845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of preeclampsia in women with diabetic kidney disease.","authors":"Jakub Kornacki,&nbsp;Daniel Boroń,&nbsp;Paweł Gutaj,&nbsp;Urszula Mantaj,&nbsp;Przemysław Wirstlein,&nbsp;Ewa Wender-Ozegowska","doi":"10.1080/10641955.2021.1987454","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987454","url":null,"abstract":"<p><p><b>Objective:</b> assessing the incidence of preeclampisa (PE) in women with diabetic kidney disease (DKD) and analyzing the significance of clinical characteristics and changes in laboratory findings throughout the pregnancy on the onset of PE.<b>Methods:</b> the study included 79 patients with DKD. All patients had elevated urinary protein loss (30-299 mg/24 h) or proteinuria (≥300 mg/24 h) in the first trimester of pregnancy. PE was diagnosed in 22,8% patients with DKD.<b>Results:</b> women with proteinuria and/or proliferative retinopathy at the admission developed preeclampsia significantly more frequently than those without these findings. The degree of proteinuria was significantly associated with the risk of PE development in each trimester of pregnancy. Patients with chronic hypertension developed PE significantly more frequently than those who had no chronic hypertension.<b>Conclusion:</b> chronic hypertension and the degree of primary kidney injury and dysfunction are crucial determinants of PE development in women with DKD. Proteinuria seems to be the best renal predictive factors of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"322-329"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39557813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality improvement: patient education for management of hypertension in pregnancy.","authors":"Kriti M Goel,&nbsp;Rose A Maxwell,&nbsp;Morgan E Cooley,&nbsp;Traci M Rackett,&nbsp;Jerome L Yaklic","doi":"10.1080/10641955.2021.1981371","DOIUrl":"https://doi.org/10.1080/10641955.2021.1981371","url":null,"abstract":"<p><p><b><i>Objective</i>:</b> To assess the effectiveness of interactive education tools for hypertension in pregnancy.Two interactive education tools were introduced.<b><i>Methods</i>:</b> Pregnant women with hypertension completed questionnaires before (Pre-I) and after)Post-I) the intervention.Providers rated satisfaction and effectiveness of the education methods.<b><i>Results</i>:</b> The Post-I group (N=45) showed slight improvement on both Perceived (4.5±0.7) and Actual knowledge (2.2 ± 1.0) compared to the Pre-I group (N=45; Perceived: 4.2±1.0; Actual: 1.7±1.3; p<.05) .Providers reported higher satisfaction after the intervention (2.6±1.1 vs 4.1±0.7; p <.001).<b><i>iscussion</i>:</b> The intervention increased patients' knowledge and providers rating of patient knowledge, and decreased the time needed for patient education.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"271-278"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study.","authors":"Satoshi Shinohara,&nbsp;Rei Sunami,&nbsp;Mayuko Kasai,&nbsp;Genki Yasuda,&nbsp;Yuzo Uchida","doi":"10.1080/10641955.2021.1987455","DOIUrl":"https://doi.org/10.1080/10641955.2021.1987455","url":null,"abstract":"<p><p><b>Objective</b>: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies.<b>Methods</b>: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + 6 weeks of gestation were enrolled. A receiver-operating characteristic curve was used to determine the sFlt-1/PlGF ratio threshold to predict PE.<b>Results</b>: A cutoff value for the sFlt-1/PlGF ratio of 22.2 predicted PE presence within 4 weeks.<b>Conclusion</b>: An sFlt-1/PlGF ratio of ≤22.2 is potentially indicative of PE absence within 4 weeks in twin pregnancies.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"40 4","pages":"330-335"},"PeriodicalIF":1.5,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}