Hypertension in Pregnancy最新文献_第5页

Elevated central blood pressure, NT-proBNP and hs-cTnI in women with maternal complications of hypertensive disorders of pregnancy. 妊娠期高血压疾病孕妇并发症的中心血压升高、NT-proBNP和hs-cTnI

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-01 DOI: 10.1080/10641955.2025.2524324

Xolani B Mbongozi, Stuart D R Galloway, Angus Hunter, Mirabel Nanjoh, Charles B Businge

{"title":"Elevated central blood pressure, NT-proBNP and hs-cTnI in women with maternal complications of hypertensive disorders of pregnancy.","authors":"Xolani B Mbongozi, Stuart D R Galloway, Angus Hunter, Mirabel Nanjoh, Charles B Businge","doi":"10.1080/10641955.2025.2524324","DOIUrl":"https://doi.org/10.1080/10641955.2025.2524324","url":null,"abstract":"Objective: The main objective of the study was to compare the levels of CBP and these cardiac biomarkers in women with maternal complications of hypertensive disorders of pregnancy (HDP).Methods: This was a cross-sectional study that enrolled 270 women with HDP and 270 normotensive pregnant controls. Data on basic characteristics and incidence of maternal complications were collected among the two groups. Additionally, information on cardiac biomarkers and CBP was gathered from the women with HDP, to compare the levels of these biomarkers with maternal complications experience by this group.Results: Non-hypertensive controls were significantly older than hypertensive cases and had a higher median gestational age at recruitment compared to hypertensive cases The median levels of CBP and cardiac biomarkers were significantly higher among hypertensive participants with maternal complications (n = 107/270) than those without complications (n = 163/270). Specifically, central systolic blood pressure (CSBP) was 133 (120-142) mmHg vs 128 (109-129) mmHg (p = 0.033) and central diastolic blood pressure (CDBP) was 75 (62-86) mmHg vs 69 (56-73) mmHg (p < 0.01), while NT-proBNP was 446 (145-1126) vs. 57 (21-167)) pg.ml-1; p < 0.0001, and hs-cTnI was 12 (7-35) ng.L-1 compared to 8 (3-8) ng.L-1; p < 0.0001, in cases v. controls, respectively.Conclusion: In conclusion, the study found that pregnant hypertensive women with maternal complications had significantly higher median values of CSBP and CDBP, NT-proBNP, and hs-cTnI in compared to those without complications. These findings suggest that measuring these vital signs and cardiac biomarkers in hypertensive pregnancies might be helpful for screening and monitoring maternal complications.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2524324"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction. 子痫前期尿和血清l型脂肪酸结合蛋白水平：一项预测母体恶化的前瞻性队列研究

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1080/10641955.2025.2534508

Daisuke Katsura, Shunichiro Tsuji, Shinsuke Tokoro, Ayako Inatomi, Nobuyuki Kita, Takashi Murakami

{"title":"Urine and serum L-type fatty acid-binding protein levels in preeclampsia: a prospective cohort study on maternal deterioration prediction.","authors":"Daisuke Katsura, Shunichiro Tsuji, Shinsuke Tokoro, Ayako Inatomi, Nobuyuki Kita, Takashi Murakami","doi":"10.1080/10641955.2025.2534508","DOIUrl":"https://doi.org/10.1080/10641955.2025.2534508","url":null,"abstract":"Background: We aimed to examine the association between maternal urine and serum L-type fatty acid-binding protein (L-FABP) levels and preeclampsia (PE) severity and their potential as predictors of maternal and fetal deterioration following PE diagnosis.Method: A prospective cohort of women with singleton pregnancies diagnosed with PE was analyzed. Participants were classified into two groups based on the timing of delivery: PE-delivery (delivery within 1 week of sample collection) and PE-non-delivery (no delivery within 1 week). Urine and serum samples were collected at the time of PE diagnosis, and cases were classified based on the presence of maternal or fetal complications.Results: In total, 53 singleton pregnancies were analyzed and classified into the PE-delivery (n = 32) and PE-non-delivery groups (n = 21). No significant differences in L-FABP levels were observed between severe and non-severe PE cases. However, L-FABP levels were significantly higher in cases of severe PE due to maternal factors. In the PE-delivery group, urine and serum L-FABP levels were significantly elevated in cases requiring delivery within 1 week due to maternal indications compared to the PE-non-delivery group, whereas no such differences were found in cases with fetal indications. Receiver operating characteristic analysis showed strong predictive performance of L-FABP levels for delivery within 1 week due to maternal deterioration, with areas under the curve of 0.892 (urine, cutoff: 12.3 μg/gCr) and 0.795 (serum, cutoff: 1.64 ng/mL).Conclusion: Maternal urine and serum L-FABP levels are closely associated with PE severity due to maternal complications and may serve as reliable biomarkers for imminent maternal deterioration.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2534508"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of parity and pre-pregnancy BMI on second-trimester sFlt-1 and PlGF levels in normotensive pregnancies. 胎次和孕前BMI对正常妊娠中期sFlt-1和PlGF水平的影响

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-20 DOI: 10.1080/10641955.2025.2534022

Motoaki Kinugawa, Keiichi Kumasawa, Kazunari Nemoto, Keisuke Nakajima, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Yasushi Hirota, Yutaka Osuga

{"title":"Impact of parity and pre-pregnancy BMI on second-trimester sFlt-1 and PlGF levels in normotensive pregnancies.","authors":"Motoaki Kinugawa, Keiichi Kumasawa, Kazunari Nemoto, Keisuke Nakajima, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Yasushi Hirota, Yutaka Osuga","doi":"10.1080/10641955.2025.2534022","DOIUrl":"https://doi.org/10.1080/10641955.2025.2534022","url":null,"abstract":"Background: Advanced maternal age, obesity, and primiparity are established risk factors for preeclampsia (PE). While soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) are key biomarkers for predicting PE, their variation based on maternal background factors remains unclear. This study aimed to identify maternal factors associated with sFlt-1 and PlGF levels.Methods: We analyzed blood concentrations of sFlt-1 and PlGF in 830 pregnant women during the second trimester. Multivariate analysis was performed to examine their associations with maternal background factors. Based on the results, pregnant women who did not develop PE or superimposed PE were categorized by parity (0, 1, and ≥2) and pre-pregnancy BMI (<18.5, 18.5-25, and ≥25), and comparisons were conducted within each category.Results: Multivariate analysis revealed that sFlt-1 was affected by parity and pre-pregnancy BMI, while PlGF was influenced by pre-pregnancy BMI. Multiparous women exhibited lower sFlt-1 and sFlt-1/PlGF ratios than primiparous women. Additionally, women with a BMI ≥ 25 showed lower sFlt-1 and PlGF levels, but higher sFlt-1/PlGF ratios than those with a BMI < 25.Conclusion: These findings suggest differences in placental development based on maternal background factors and raise the possibility that parity and BMI could influence the interpretation of cutoff values for PE prediction.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2534022"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction. 撤回声明。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI: 10.1080/10641955.2025.2477933

引用次数: 0

Statement of Retraction: Fetal gender, serum human chorionic gonadotropin, and testosterone in women with preeclampsia. 撤回声明：胎儿性别，血清人绒毛膜促性腺激素，和睾酮与先兆子痫妇女。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-04-29 DOI: 10.1080/10641955.2025.2496571

引用次数: 0

Pregnancy urine biomarkers for effectively preeclampsia prediction: a systematic review and meta-analysis. 妊娠尿液生物标志物有效预测子痫前期：一项系统回顾和荟萃分析。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-04-08 DOI: 10.1080/10641955.2025.2487794

Juanhong Wu, Yingsha Yao, Ting Wang, Ting Xu, Ruoan Jiang

{"title":"Pregnancy urine biomarkers for effectively preeclampsia prediction: a systematic review and meta-analysis.","authors":"Juanhong Wu, Yingsha Yao, Ting Wang, Ting Xu, Ruoan Jiang","doi":"10.1080/10641955.2025.2487794","DOIUrl":"10.1080/10641955.2025.2487794","url":null,"abstract":"Preeclampsia (PE) is a common multi-organ disorder in pregnancy. Urine as a source for test samples is noninvasive and easy to obtain. This study followed the Priority Reporting Project for Systematic Evaluation and Meta-Analysis protocol. We searched PubMed and Web of Science databases for studies relating to urine biomarker analysis for PE from inception to the 28th of February 2023. The Chi-squared test was utilized to evaluate the statistical heterogeneity of the results. The combined sensitivity, combined specificity, combined positive likelihood ratio, combined negative likelihood ratio, combined diagnostic odds ratio for urine analysis in the context of PE were calculated. Sixty-five studies were eventually included in the final analysis. In only hypertensive disorders of pregnancy (HDP) pregnant women, the the area under the summary receiver operating characteristic curve (AUC) of urine analysis to predict PE was 0.93 (0.91-0.95). The results show that spot random urine analysis or shortened-hour urinary analysis for the diagnosis of PE is a credible alternative method when 24-h urine collection is difficult to complete. The protein/creatinine ratio from spot random urine analysis may be an effective biomarker of the further progression of HDP into PE.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2487794"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia pathogenesis and prediction - where are we now: the focus on the role of galectins and miRNAs. 子痫前期的发病机制和预测-我们现在在哪里：集中于凝集素和mirna的作用。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI: 10.1080/10641955.2025.2470626

Natasa Karadzov Orlic, Ivana Joksić

{"title":"Preeclampsia pathogenesis and prediction - where are we now: the focus on the role of galectins and miRNAs.","authors":"Natasa Karadzov Orlic, Ivana Joksić","doi":"10.1080/10641955.2025.2470626","DOIUrl":"10.1080/10641955.2025.2470626","url":null,"abstract":"Preeclampsia is a complex, progressive multisystem hypertensive disorder during pregnancy that significantly contributes to increased maternal and perinatal morbidity and mortality. Two screening algorithms are in clinical use for detecting preeclampsia: first-trimester screening, which has been developed and validated for predicting early-onset preeclampsia but is less effective for late-onset disease; and the sFlt-1:PlGF biomarker ratio (soluble tyrosine kinase and placental growth factor) used in suspected cases of preeclampsia. This ratio has a high negative predictive value, allowing for the reliable exclusion of the disease. Both of these screening tests have not met expectations. This review attempts to summarize the current knowledge on the pathogenesis and prediction of preeclampsia and to draw attention to novel biomarkers with a focus on microRNAs and galectins. Although these molecules belong to two distinct biological classes, they functionally converge in regulating placental and immune pathways. Ample evidence supports their involvement in the molecular mechanisms underlying preeclampsia. Based on current knowledge, galectin-13, C19MC members, and miRNA-210 are associated with the trophoblast/placenta and conditions of placental ischemia or hypoxia. Their levels differ significantly in pregnant women at risk of preeclampsia as early as the late first and early second trimester, making them potential markers for predicting preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2470626"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LifeAPP: self-monitoring of blood pressure after preterm preeclampsia: a randomized controlled feasibility trial. LifeAPP：早产子痫前期血压自我监测：一项随机对照可行性试验。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI: 10.1080/10641955.2024.2439312

Wilson Koike, Maria Laura Costa, José Paulo Guida, James M Roberts, Ana Paula Martins, Larissa Martinez Soldá, Vitor Lira Vilela Dos Reis, Tábata Regina Zumpano Dos Santos, Richard J McManus, Leandro De Oliveira

{"title":"LifeAPP: self-monitoring of blood pressure after preterm preeclampsia: a randomized controlled feasibility trial.","authors":"Wilson Koike, Maria Laura Costa, José Paulo Guida, James M Roberts, Ana Paula Martins, Larissa Martinez Soldá, Vitor Lira Vilela Dos Reis, Tábata Regina Zumpano Dos Santos, Richard J McManus, Leandro De Oliveira","doi":"10.1080/10641955.2024.2439312","DOIUrl":"10.1080/10641955.2024.2439312","url":null,"abstract":"Objective: This was a pilot study to investigate the feasibility of developing a low-cost mobile technology-based intervention to encourage blood pressure (BP) monitoring and adoption of healthy lifestyle habits.Methods: This was a prospective, controlled, randomized, non-blinding feasibility study that involved the use of electronic BP monitor and smartphone. Eligible participants in the intervention group were instructed to send the BP measurements to members of the LifeAPP team digitally from an application for smartphones linked to the BP device by Bluetooth and also via WhatsApp. The LifeAPP team sent feedback containing information as follows: a) safety of the BP levels; b) motivational messages aiming at maintaining self-monitoring; c) motivational messages aiming at the importance of developing healthy lifestyle habits. The primary outcome was feasibility: recruitment capacity, retention, and compliance with follow-up rates.Results: Between 1 June 2020 and 24 January 2021, 48 participants were randomized to the intervention group, and 48 participants were randomized to the control group. The recruitment capacity of the participating centers proved to be adequate. Among the participants recruited for intervention group, 21 (43.7%) attended predefined visits at 3 months and only 12 (25%) attended predefined visits at 6 months. Similar loss to follow-up was observed in the control group.Conclusion: Despite successful recruitment of a cohort of women following preterm preeclampsia, there was no sufficient retention of participants. Therefore, new strategies for long-term follow-up of women who developed preeclampsia are needed before a further study in this group of patients can be contemplated.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2439312"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the relationship between maternal preeclampsia and autism spectrum disorder in childhood. 探讨母体子痫前期与儿童自闭症谱系障碍的关系。

IF 1.5 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-07-02 DOI: 10.1080/10641955.2025.2527137

Noam Shema, Omri Zamstein, Tamar Wainstock, Gali Pariente, Eyal Sheiner

{"title":"Examining the relationship between maternal preeclampsia and autism spectrum disorder in childhood.","authors":"Noam Shema, Omri Zamstein, Tamar Wainstock, Gali Pariente, Eyal Sheiner","doi":"10.1080/10641955.2025.2527137","DOIUrl":"https://doi.org/10.1080/10641955.2025.2527137","url":null,"abstract":"Objective: Autism spectrum disorder (ASD) has multifactorial origins, some related to the prenatal period. Preeclampsia, a serious pregnancy complication, is also multifactorial. This study aimed to explore the potential association between preeclampsia and ASD in a diverse population.Study design: A retrospective cohort study including all deliveries of Clalit Health Services-insured women at Soroka University Medical Center from 2005 to 2017. The study compared ASD incidence in offspring of mothers with varying severities of preeclampsia. Kaplan-Meier survival curves assessed cumulative ASD incidence, and Cox proportional hazards models adjusted for confounding factors.Results: Of 115,081 parturients, 2,856 (2.5%) had preeclampsia, 956 (0.8%) with severe features. Preeclampsia, especially severe, was linked to adverse outcomes (e.g. fetal growth restriction, earlier delivery, cesarean delivery; p < 0.001). Among 767 (0.7%) offspring diagnosed with ASD, prevalence was higher in the preeclampsia group compared to those without preeclampsia (1.1% mild, 0.9% severe, no preeclampsia 0.7%; p = 0.02). However, Kaplan-Meier analysis showed no significant difference in cumulative ASD morbidity (log-rank p = 0.928). Cox regression models, conducted both with and without adjustment for gestational age, showed no significant association between preeclampsia and ASD after adjustment for relevant confounders.Conclusion: To gain a deeper understanding of the obstetrical aspects related to the development of autism spectrum disorder, our findings indicate that preeclampsia does not play a contributory role.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2527137"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WGCNA combined with machine learning for analysis of diagnostic markers of preeclampsia associated with the hedgehog signaling pathway. WGCNA结合机器学习分析与hedgehog信号通路相关的子痫前期诊断标志物。

IF 2.1 4区医学

Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.1080/10641955.2025.2542869

Xiaofeng Wang, Yichi Xu, Junpeng Dong, Jinwen Zhang, Wei Gu, Xiaoli Qin

{"title":"WGCNA combined with machine learning for analysis of diagnostic markers of preeclampsia associated with the hedgehog signaling pathway.","authors":"Xiaofeng Wang, Yichi Xu, Junpeng Dong, Jinwen Zhang, Wei Gu, Xiaoli Qin","doi":"10.1080/10641955.2025.2542869","DOIUrl":"https://doi.org/10.1080/10641955.2025.2542869","url":null,"abstract":"Background: Abnormal hedgehog (Hh) signaling is linked to preeclampsia (PE). This study aimed to identify Hh-related diagnostic biomarkers for PE and assess the role of immune infiltration.Methods: The PE dataset was obtained from GEO to screen DEGs. WGCNA was utilized to identify Hh pathway-related genes. Following the intersection of the two genes, key genes were screened by using LASSO, SVM-RFE, and RF. A model was constructed, with ROC applied for evaluating its performance. The ssGSEA was employed to analyze immune infiltration. Network Analyst was utilized to predict miRNA/TF targets.Results: Six Hh-related diagnostic genes were identified (SLC20A1, GPT2, PDK4, COASY, KRT81, CD163L1). The diagnostic model showed high accuracy (AUC > 0.8) in training and validation sets. PE patients exhibited immune dysfunction, including reduced dendritic cell, macrophage, and mast cell activity. Diagnostic genes strongly correlated with immune cells. Additionally, 25 miRNAs and 34 TFs potentially regulating these genes were predicted.Conclusions: Six potential PE diagnostic biomarkers were identified, and their immune interactions were explored. This study enhances understanding of PE pathogenesis and suggests therapeutic targets.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2542869"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0