Hypertension in Pregnancy最新文献

{"title":"MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway","authors":"Ji-Yun Li, Yan Jin, Yan Cao, Gui-Mei Wu","doi":"10.1080/10641955.2022.2056195","DOIUrl":"https://doi.org/10.1080/10641955.2022.2056195","url":null,"abstract":"ABSTRACT Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abilities and decreased the activity of TGF-β/Smad pathway, while TGFBR1 can reverse the role of miR-140-5p mimic in trophoblasts.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"116 - 125"},"PeriodicalIF":1.5,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41760164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs","authors":"Adelene Y Tan, Ken Kearney, Courtney J. Jenkins, S. A. Karumanchi, W. Bee, P. Kussie","doi":"10.1080/10641955.2022.2048390","DOIUrl":"https://doi.org/10.1080/10641955.2022.2048390","url":null,"abstract":"ABSTRACT Placental growth factor (PlGF), a member of the vascular endothelial growth factor family of proteins regulating angiogenesis, has been shown to have acute vasodilatory effects on human resistance arteries. However, the acute hemodynamic effects of PlGF in vivo are not known. The aim of this study was to report acute cardiovascular changes induced by recombinant human PlGF administered intravenously in male Guinea Pigs with implanted telemeters. PlGF decreased mean arterial blood pressure by 10–20% within minutes. The magnitude of reduction was similar at three dose levels; however, the duration of relative hypotension was dose-dependent. Blood pressure reduction resulted in a compensatory increase in heart rate, or reflex tachycardia. To rule out any direct effect on the heart, PlGF was tested in the ex vivo Langendorff heart preparation, and no cardiac changes were found. Together these results suggest that the PlGF-related changes in blood pressure are largely mediated by its actions in the vasculature.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"99 - 106"},"PeriodicalIF":1.5,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46492299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical myocardial dysfunction in patients with complete recovery from peripartum cardiomyopathy: a long-term clinical strain-echocardiographic study","authors":"Haldun Akgoz, U. Gurkan","doi":"10.1080/10641955.2022.2046049","DOIUrl":"https://doi.org/10.1080/10641955.2022.2046049","url":null,"abstract":"ABSTRACT Purpose The aim of this study was to assess long-term left ventricular (LV) systolic function using 3D speckle tracking echocardiography in patients with complete LV recovery following peripartum cardiomyopathy (PPCM). Methods A total of 20 PPCM patients who exhibited LV recovery (ejection fraction ≥50%) in the follow-up period and 20 age-matched, healthy women were included in the study. Standard 2D echocardiographic examinations were performed. Global longitudinal strain and global circumferential strain were analyzed. Results Age, weight, body surface area, smoking, heart rate, and systolic and diastolic blood pressure were similar in both groups. Echocardiographic examination showed no significant difference between both groups. Only the global longitudinal strain (18.1 ± 2.7 vs 20.16 ± 1.7, p = 0.02) and global circumferential strain (22.1 ± 2.9 vs 24.4 ± 1.19, p = 0.01) were significantly lower in PPCM patients. The lowest values for longitudinal strain belonged to the basal and mid regions of anterior, anteroseptal and lateral walls in the PPCM patients. Conclusion Subclinical myocardial damage may persist in PPCM patients with full LV systolic recovery. 3D Speckle Tracking strain analysis is a useful method for detecting subtle myocardial dysfunction.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"89 - 96"},"PeriodicalIF":1.5,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43140319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of gestational hypertension and preeclampsia in pregnant women with new onset blood pressure of 120-129/≤89 mmHg: a meta-analysis of prospective studies.","authors":"Yun Liu,&nbsp;Qingfang Meng","doi":"10.1080/10641955.2021.1994588","DOIUrl":"https://doi.org/10.1080/10641955.2021.1994588","url":null,"abstract":"<p><strong>Background: </strong>To explore whether elevated blood pressure and stage 1 hypertension were risks to GH and PE occurrence by a meta-analysis.</p><p><strong>Methods: </strong>Electronic databases were searched systematically up to Dec 2020. Combined risk ratio (RR) and 95%CI were used to evaluate the relationship between two blood pressure groups and GH and PE.</p><p><strong>Results: </strong>Seven studies were included in this study. In elevated blood pressure group, the overall RR of GH group is 1.93 and the combined RR is 1.98 in PE group.</p><p><strong>Conclusion: </strong>Elevated BP and stage 1 hypertension were risk factors of GH and PE occurrence in pregnant women.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats.","authors":"Ying Li,&nbsp;Yuanyuan Liu,&nbsp;Jinfeng Chen,&nbsp;Jian Hu","doi":"10.1080/10641955.2021.2013874","DOIUrl":"https://doi.org/10.1080/10641955.2021.2013874","url":null,"abstract":"<p><strong>Objective: </strong>This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats.</p><p><strong>Methods: </strong>LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo.</p><p><strong>Results: </strong>Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats. Moreover, Fisetin suppressed TLR4/NF-κB pathway, as well as promoting Nrf2/HO-1 pathway in placental tissues of PE rats.</p><p><strong>Conclusions: </strong>Fisetin exerted protective role and modulated the activation of TLR4/NF-κB and Nrf2/HO-1 pathways in PE-like rat models.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"23-30"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39622391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGFBP1 inhibits the invasion, migration, and apoptosis of HTR-8/SVneo trophoblast cells in preeclampsia.","authors":"Xiujuan Li,&nbsp;Chenxi Li,&nbsp;Ye Wang,&nbsp;Jianxing Cai,&nbsp;Li Zhao,&nbsp;Zhiying Su,&nbsp;Huiming Ye","doi":"10.1080/10641955.2022.2033259","DOIUrl":"https://doi.org/10.1080/10641955.2022.2033259","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects and underlying mechanisms of IGFBP1 on the biological functions of trophoblasts in simulated preeclampsia.</p><p><strong>Methods: </strong>IGFBP1 expression in placenta was determined by immunohistochemistry. HTR-8/SVneo cells were stimulated with/without IGFBP1-overexpression and hypoxia-reoxygenation, and the proliferation, invasion, migration, and apoptosis were detected by CCK8, transwell, and flow cytometry, respectively.</p><p><strong>Results: </strong>IGFBP1 expression was increased in placenta of preeclampsia. IGFBP1 overexpression inhibited proliferation, invasion, migration, and apoptosis of HTR-8/SVneo cells and induced MMP-26 expression with/without hypoxia-reoxygenation challenge.</p><p><strong>Conclusion: </strong>IGFBP1 affects biological functions of trophoblasts, and it may play a role in pathophysiology of preeclampsia by inducing MMP-26.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"53-63"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39788396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between food groups and preeclampsia: a case-control study.","authors":"Akram Kooshki,&nbsp;Behnaz Sovizi,&nbsp;Rahil Mahmoudi,&nbsp;Saiedeh Ghezi,&nbsp;Elaheh Foroumandi","doi":"10.1080/10641955.2022.2033260","DOIUrl":"https://doi.org/10.1080/10641955.2022.2033260","url":null,"abstract":"ABSTRACT Purpose The aim of current study was to investigate the correlation between preeclampsia and food groups among pregnant women. Methods This case-control study was done on pregnant women with a diagnosis of preeclampsia in Sabzevar. The control group was included non-infected postpartum women. Results Intake of vegetables (OR = 0.952, CI: 0.724–0.985, p < 0.001), fruits (OR = 0.901, CI: 0.852–0.990, p = 0.012), nuts and legumes (OR = 0.712, CI: 0.531–0.848, p = 0.009), and sugars and sweets (OR = 1.254, CI: 1.112–1.497, p < 0.001) were related to the odds of preeclampsia. Conclusions Women with preeclampsia had lower intake of vegetables, fruits, milk and products, and also fluids. Intake of sugars and sweets compared with the intake of vegetables, fruits, nuts, and legumes was associated with increasing odds of preeclampsia.","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"64-69"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39903330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preconceptual leptin levels in gestational diabetes and hypertensive pregnancy.","authors":"Antti Peltokorpi,&nbsp;Lisinen Irina,&nbsp;Viikari Liisa,&nbsp;Kaaja Risto","doi":"10.1080/10641955.2022.2033763","DOIUrl":"https://doi.org/10.1080/10641955.2022.2033763","url":null,"abstract":"<p><p>Pregnancy - induced hypertension (PIH), preeclampsia (PE), and gestational diabetes (GDM) are common adverse outcomes in pregnancy.</p><p><strong>Objective: </strong>To find out whether preconceptual leptin levels differ in subsequent pregnancy between control vs. GDM and hypertensive pregnancy groups.</p><p><strong>Materials and methods: </strong>Data was from The Cardiovascular Risk in Young Finns Study and The Medical Birth Register of Finland. Of 293 subjects 71 developed GDM, 27 PIH/PE and 201 were controls.</p><p><strong>Results: </strong>Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).</p><p><strong>Conclusion: </strong>Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"70-77"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant status in hypertensive disorders of pregnancy.","authors":"Jasmina Ivanišević,&nbsp;Daniela Ardalić,&nbsp;Gorica Banjac,&nbsp;Jelena Janać,&nbsp;Petar Cabunac,&nbsp;Jelena Vekić,&nbsp;Aleksandra Zeljković,&nbsp;Vesna Spasojević-Kalimanovska,&nbsp;Nataša Karadžov Orlić,&nbsp;Vesna Mandić Marković,&nbsp;Željko Miković,&nbsp;Aleksandra Stefanović","doi":"10.1080/10641955.2021.2013875","DOIUrl":"https://doi.org/10.1080/10641955.2021.2013875","url":null,"abstract":"<p><strong>Objective: </strong>Pregnancy can be associated with maternal hypertension leading to possible complications in pregnancy outcome. Antioxidant status may be proned to changes during pregnancy with hypertension. The aim of our study was to estimate antioxidant status through high-risk pregnancies.</p><p><strong>Methods: </strong>Seventy-nine pregnant women with high-risk for preeclampsia development were included and 46 of them developed some hypertensive disorder in pregnancy. Superoxide-dismutase (SOD) and paraoxonase 1 (PON1) activities and relative proportion of PON1 activiity on different HDL subclasses were determined in 1^st, 2^nd, and 3^rd trimester and prior to delivery.</p><p><strong>Results: </strong>SOD activity was significantly lower in 2^nd and 3^rd trimesters when compared to 1^st trimester (P˂0.001) whereas PON1 activity was significantly higher in 3^rd than in 1^st trimester (P˂0.05) in group of hypertensive women. This group had significantly higher SOD and PON1 activities and relative proportion of PON1 on HDL_3c subclasses in the 1^st trimester, significantly increased PON1 in the 3^rd trimester and prior to delivery and significantly higher PON1 activity on HDL_3c subclasses (P˂0.05) than nonhypertensive group. In 1^st trimester and prior to delivery, total PON1 activity and relative proportion of PON1 on HDL_3c subclasses exhibited significant ability to mark out hypertension in pregnancy (P˂0.05).</p><p><strong>Conclusions: </strong>SOD activity decreased whereas total PON1 activity increased during pregnancy with hypertension. Pregnant women with hypertension had higher activities of PON1 and SOD and relative proportion of PON1 on HDL_3c subclasses than nonhypertensive ones. PON1 activity and relative proportion of PON1 on HDL_3c subclasses exhibited significant association with hypertension in pregnancy.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"31-38"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39723415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined apocyanin and aspirin treatment activates the PI3K/Nrf2/HO-1 signaling pathway and ameliorates preeclampsia symptoms in rats.","authors":"Yaru Ju,&nbsp;Yan Feng,&nbsp;Xiaolin Hou,&nbsp;Lixia Wu,&nbsp;Huixia Yang,&nbsp;Hongjuan Zhang,&nbsp;Yan'Na Ma","doi":"10.1080/10641955.2021.2014518","DOIUrl":"https://doi.org/10.1080/10641955.2021.2014518","url":null,"abstract":"<p><strong>Objective: </strong>Pre-eclampsia (PE) is a pregnancy-associated disease characterized by placental dysfunction and increased oxidative stress. Apocyanin is a potent antioxidant and anti-inflammatory which has shown beneficial effects on PE pathogenesis. Aspirin is recognized as the recommendable drug in PE prevention and therapy. Therefore, we aimed to investigate the effects of combining apocyanin and aspirin to treat PE on rat models induced by N-nitro-L-arginine methyl ester (L-NAME) from gestational day (GD) 6 to 16 and elucidate the potential mechanisms.</p><p><strong>Methods: </strong>First, female pregnant rats were divided into five different groups: pregnant control, PE, PE + apocyanin, PE + aspirin, and PE + apocyanin + aspirin. Animals received apocyanin (16 mg/kg/day) orally or aspirin by gavage (1.5 mg/kg BM/day) from GD 4 to 16. Blood pressure and urine protein content were monitored every 4 days.</p><p><strong>Results: </strong>In the PE rat model, elevated systolic blood pressure and proteinuria were ameliorated by the combination of apocyanin and aspirin. Meanwhile, compared with single-dose apocyanin or aspirin, the combined treatment significantly corrected abnormal pregnancy outcomes, decreased sFlt-1 and PlGF, and alleviated oxidative stress both in blood and placental tissues. Moreover, the combined treatment upregulated PI3K, Akt, Nrf2, and HO-1 protein levels in the placental tissues from PE rats.</p><p><strong>Conclusion: </strong>Overall, our results suggested that combined treatment of apocyanin and aspirin ameliorates the PE symptoms compared with single-dose apocyanin or aspirin in a PE rat model. Also, we demonstrated that activating the PI3K/Nrf2/HO-1 pathway can be a valuable therapeutic target to improve the pregnancy outcomes of PE.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"41 1","pages":"39-50"},"PeriodicalIF":1.5,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39700158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}