人补体蛋白因子b和因子/正常蛋白在hiv相关先兆子痫中的作用

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-02-01 Epub Date: 2021-11-16 DOI:10.1080/10641955.2021.2001819

Phumelele Kikine, Yazira Pillay, Thajasvarie Naicker

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引用次数: 0

摘要

目的:本研究旨在发现hiv相关PE中补体蛋白、因子B和P的浓度是如何受到影响的。方法:本研究纳入72例孕妇:36例先兆子痫，36例血压正常。采用Bioplex免疫分析法测定血清因子B和P的浓度。结果:与HIV-组相比，HIV+组的B因子明显降低。两种分析物在所有组间无显著差异。结论:我们的研究结果表明，替代途径(AP)被HIV逃避免疫检测所抑制。在妊娠晚期，AP在PE中不会过度激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

THE ROLE OF HUMAN COMPLEMENT PROTEIN FACTOR B AND FACTORP/PROPERDIN IN HIV-ASSOCIATED PRE-ECLAMPSIA.

Objectives: This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.

Methods: This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.

Results: A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.

Conclusion: Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.