Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-03-07 DOI:10.1080/10641955.2022.2048390

Adelene Y Tan, Ken Kearney, Courtney J. Jenkins, S. A. Karumanchi, W. Bee, P. Kussie

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Abstract

ABSTRACT Placental growth factor (PlGF), a member of the vascular endothelial growth factor family of proteins regulating angiogenesis, has been shown to have acute vasodilatory effects on human resistance arteries. However, the acute hemodynamic effects of PlGF in vivo are not known. The aim of this study was to report acute cardiovascular changes induced by recombinant human PlGF administered intravenously in male Guinea Pigs with implanted telemeters. PlGF decreased mean arterial blood pressure by 10–20% within minutes. The magnitude of reduction was similar at three dose levels; however, the duration of relative hypotension was dose-dependent. Blood pressure reduction resulted in a compensatory increase in heart rate, or reflex tachycardia. To rule out any direct effect on the heart, PlGF was tested in the ex vivo Langendorff heart preparation, and no cardiac changes were found. Together these results suggest that the PlGF-related changes in blood pressure are largely mediated by its actions in the vasculature.

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重组胎盘生长因子给药对豚鼠心血管和血液动力学的影响

摘要胎盘生长因子（PlGF）是调节血管生成的血管内皮生长因子家族蛋白的一员，已被证明对人类阻力动脉具有急性血管舒张作用。然而，PlGF在体内的急性血液动力学影响尚不清楚。本研究的目的是报告通过植入遥测仪在雄性豚鼠体内静脉注射重组人PlGF引起的急性心血管变化。PlGF在几分钟内将平均动脉血压降低了10-20%。三个剂量水平的减少幅度相似；然而，相对低血压的持续时间是剂量依赖性的。血压降低导致心率代偿性增加，或反射性心动过速。为了排除对心脏的任何直接影响，在离体Langendorff心脏制剂中测试了PlGF，没有发现心脏变化。总之，这些结果表明，PlGF相关的血压变化在很大程度上是由其在血管系统中的作用介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.