长链非编码RNA paxiip - as1通过miR-210-3p/BDNF轴促进HTR-8/SVneo细胞的活力、侵袭和迁移。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-05-01 Epub Date: 2022-03-22 DOI:10.1080/10641955.2022.2056194

Xuejuan Chen, Xiang Kong, Gang Niu, Fengjin Qin, Yan Duan, Fengjiao Ren

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引用次数: 2

摘要

目的:探讨长链非编码RNA PAXIP-AS1在子痫前期的作用及其潜在机制。方法:观察PAXIP-AS1对细胞活力、迁移和侵袭的影响。验证了mir -210-3p与lncRNA PAXIP-AS1或BDNF的靶向关系。结果:PAXIP-AS1与miR-210-3p呈负相关，miR-210-3p靶向BDNF。子痫前期患者血清中BDNF与PAXIP-AS1呈正相关。滋养细胞中miR-210-3p上调或BDNF敲低可逆转PAXIP-AS1对细胞活力、迁移和侵袭的促进作用。结论:PAXIP-AS1通过调节miR-210-3p/BDNF轴促进滋养细胞的活力、迁移和侵袭。

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Long non-coding RNA PAXIP-AS1 promotes viability, invasion, and migration of HTR-8/SVneo cells through miR-210-3p/BDNF axis.

Objective: The aim of this research was to explore the role and potential mechanism of long non-coding RNA PAXIP-AS1 in preeclampsia.

Methods: To investigate the effects of PAXIP-AS1 on cell viability, migration, and invasion. The miR-210-3p-targeted relationship with lncRNA PAXIP-AS1 or BDNF was verified.

Results: PAXIP-AS1 was inversely correlated with miR-210-3p and BDNF was targeted by miR-210-3p. BDNF was positively correlated with PAXIP-AS1 in the serum of preeclampsia patients. The promotion effects of PAXIP-AS1 on cell viability, migration, and invasion were reversed by miR-210-3p up-regulation or BDNF knockdown in trophoblast cells.

Conclusion: PAXIP-AS1 promoted the viability, migration, and invasion of trophoblast cells by regulating the miR-210-3p/BDNF axis.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.