MiR-140-5p通过介导TGF-β/Smad信号通路在妊娠高血压中发挥保护作用

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-03-30 DOI:10.1080/10641955.2022.2056195

Ji-Yun Li, Yan Jin, Yan Cao, Gui-Mei Wu

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引用次数: 3

摘要

摘要动物实验表明，妊高征大鼠平均动脉压（MAP）、收缩压（SBP）和舒张压（DBP）升高，但产仔数、活胎数、胎儿体重和胎盘重量降低。在TNF-α和IL-6水平升高、IL-10水平降低的PIH大鼠中观察到较高的Flt-1和较低的VEGF。agomiR-140-5p治疗改善了上述指标。细胞实验表明，miR-140-5p模拟物增加了细胞的侵袭和迁移能力，降低了TGF-β/Smad通路的活性，而TGFBR1可以逆转miR-140-5p模拟物在滋养层中的作用。

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MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway

ABSTRACT Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abilities and decreased the activity of TGF-β/Smad pathway, while TGFBR1 can reverse the role of miR-140-5p mimic in trophoblasts.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.