{"title":"A systematic review and meta-analysis of salmonellosis in poultry farms in Ethiopia: prevalence, risk factors, and antimicrobial resistance.","authors":"Eyoel Basazinew, Haileyesus Dejene, Gashaw Getaneh Dagnaw, Asres Zegeye Lakew, Abebe Tesfaye Gessese","doi":"10.3389/fvets.2025.1538963","DOIUrl":"10.3389/fvets.2025.1538963","url":null,"abstract":"<p><p>Salmonellosis has a significant impact on the chicken production industry and is becoming a serious threat to public health. However, there is no systematic and inclusive report on the prevalence, associated risk factors, and antimicrobial resistance of chicken salmonellosis in Ethiopia. Therefore, the objective of this study was to estimate the pooled prevalence, identify possible risk factors, and assess antimicrobial resistance of <i>Salmonella</i> in poultry farms across Ethiopia. Studies were identified from databases such as Medline/PubMed, ScienceDirect/Scopus, Google Scholar, Web of Science, and Science Pub. The overall literature review and quantitative synthesis were conducted following the PRISMA guidelines. Overall, data extraction was conducted using Microsoft Excel, and statistical analysis was performed using R software. A total of 12 articles, published between August 2017 and October 2024, were included in the final quantitative synthesis. A random-effects meta-regression model was employed to estimate the pooled prevalence. The overall pooled prevalence of poultry salmonellosis was 12.46% (95% CI: 8.44, 16.48), with high heterogeneity (I<sup>2</sup> = 97%, <i>τ</i> <sup>2</sup> = 0.0041, <i>p</i> < 0.01). The subgroup meta-analysis of the study area showed that the prevalence proportion was higher in western Ethiopia, at 23.18% (95% CI: 8.96-37.39%). Based on the purpose of production, the highest pooled prevalence was observed in broilers at 28.23% (95% CI: 19.97-36.49%), while the highest prevalence based on age was in poultry under 6 months, at 14.45% (95% CI: 8.92-19.99%). Additionally, higher prevalence proportions were observed in local breeds and the Cobb 500 variety, with prevalence rates of 39.78% (95% CI: 19.50-60.06%) and 45.26% (95% CI: 23.44-67.08%), respectively. The highest pooled resistance levels for antimicrobials were observed against tetracycline (75%) (95% CI: 70-79%) and oxytetracycline (64%) (95% CI: 56-71%), while the lowest pooled resistance levels were against cefotaxime (3%) (95% CI: 0-7%) and gentamycin (6%) (95% CI: 4-9%). The results of the publication bias analysis showed the presence of asymmetry in the slope distribution, with no statistical difference. In conclusion, poultry salmonellosis is highly prevalent in Ethiopia. So, it is crucial to increase biosecurity and implement prevention and control methods to safeguard the health of poultry and humans in Ethiopia.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1538963"},"PeriodicalIF":2.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Report: Successful surgical intervention for portal hypertension caused by primary hypoplasia of the portal vein in a dog.","authors":"Joon-Ho Shin, Hyun-Jung Han","doi":"10.3389/fvets.2025.1582290","DOIUrl":"10.3389/fvets.2025.1582290","url":null,"abstract":"<p><p>An 11-year-old, 5-kg castrated male Miniature Poodle presented with persistent ascites lasting 3 weeks. A thorough physical examination, comprehensive blood tests, and diagnostic imaging (including radiography, ultrasonography, and computed tomography) revealed ascites, splenomegaly, hepatomegaly, and decreased portal vein velocity (5-6.6 cm/s), leading to a diagnosis of portal hypertension. Prehepatic and posthepatic causes were ruled out, and the patient was diagnosed with intrahepatic portal hypertension. Despite conservative management with diuretics and a sodium-restricted diet, severe ascites persisted. A surgical liver biopsy via exploratory laparotomy was performed to determine the specific cause of intrahepatic portal hypertension. Concurrently, splenectomy was carried out after identifying splenomegaly and congestion, which were likely associated with portal hypertension. Histological examination of the spleen revealed mild-to-moderate congestion and complex nodular hyperplasia, while liver examination confirmed a diagnosis of primary hypoplasia of the portal vein (PHPV). Postoperatively, the dog experienced a transient increase in ascites and complications such as anorexia, mild anemia, and hypoalbuminemia, all of which were managed with supportive care. From postoperative day 4, the ascites completely resolved, and the portal vein velocity normalized (17-18 cm/s). Four months post-surgery, the patient showed no further signs of ascites. This case report describes the diagnosis and successful management of PHPV-induced portal hypertension in a dog, highlighting the efficacy of splenectomy in resolving ascites and improving portal vein hemodynamics in cases of PHPV in dogs.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1582290"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isadora F Machado, Peng Li, Jinnan Xiao, Thomas Petznick, Ana Paula P Silva, Onyekachukwu H Osemeke, Lucina Galina Pantoja, Phillip Gauger, Giovani Trevisan, Gustavo S Silva, Daniel C L Linhares
{"title":"Evaluating stillborn and litter size as indicators of PRRSV detection in live piglets and the use of stillborn tongue fluids as risk-based samples for PRRSV monitoring.","authors":"Isadora F Machado, Peng Li, Jinnan Xiao, Thomas Petznick, Ana Paula P Silva, Onyekachukwu H Osemeke, Lucina Galina Pantoja, Phillip Gauger, Giovani Trevisan, Gustavo S Silva, Daniel C L Linhares","doi":"10.3389/fvets.2025.1600064","DOIUrl":"10.3389/fvets.2025.1600064","url":null,"abstract":"<p><strong>Introduction: </strong>A risk-based approach to animal selection for sampling enhances pathogen detection by increasing the probability of selecting an animal harboring the pathogen while requiring a smaller sample size. Postmortem tongue fluids (TF) have emerged as a promising risk-based approach, with a PRRSV RNA positivity rate similar to serum, processing fluids, and family oral fluids. Thus, this study assessed the effect of stillborn presence, litter size, and PRRSV RNA detection by RT-qPCR in stillborn TF on the probability of having viremic piglets within the litter.</p><p><strong>Methods: </strong>Samples from 130 litters were collected within 12 hours after farrowing from two breeding herds. TF and intracardiac blood were collected from stillborns, and tail blood swabs were collected from liveborn littermates within the selected litters. Samples were individually tested for PRRSV RNA detection by RT-qPCR. Litters with ≤ 11 liveborn piglets were defined as small. Generalized linear regression models were used to evaluate the litter size, presence of stillborns, and stillborn PRRSV results on the probability that a litter or at least one liveborn littermate would test PRRSV-positive.</p><p><strong>Results: </strong>The live piglets' mean positivity within the litter was 5.0%, while the total born was 4.6%. Litters with at least one stillborn had 12.5 times higher odds of having a PRRSV-positive result, and 4.8 times higher odds of having at least one viremic liveborn piglet. In small litters, the odds of having a PRRSV-positive result increased 12.2 times, whereas the odds of having a viremic liveborn littermate increased 10.8 times. When the stillborn TF was positive, the odds of having a viremic liveborn littermate increased 17.6 times.</p><p><strong>Discussion: </strong>In conclusion, stillborn TFs were a reliable indicator of PRRSV status among litters. Liveborn piglets from litters with PRRSV-positive stillborn TF or small litters had greater odds of testing PRRSV-positive. Therefore, stillborn TF collection and targeting small litters improve PRRSV detection and support farrowing room biocontainment strategies.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1600064"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rianna Anwar Sani, Jaap A Wagenaar, Tagrid E H A Dinar, Sunandar Sunandar, Nofita Nurbiyanti, Imron Suandy, Gian Pertela, Elvina J Jahja, Budi Purwanto, Ingeborg M van Geijlswijk, David C Speksnijder
{"title":"Corrigendum: The comparison and use of tools for quantification of antimicrobial use in Indonesian broiler farms.","authors":"Rianna Anwar Sani, Jaap A Wagenaar, Tagrid E H A Dinar, Sunandar Sunandar, Nofita Nurbiyanti, Imron Suandy, Gian Pertela, Elvina J Jahja, Budi Purwanto, Ingeborg M van Geijlswijk, David C Speksnijder","doi":"10.3389/fvets.2025.1613626","DOIUrl":"https://doi.org/10.3389/fvets.2025.1613626","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fvets.2023.1092302.].</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1613626"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case series and review of canine idiopathic osteonecrosis of the jaw.","authors":"Amy Rossi, Jamie G Anderson","doi":"10.3389/fvets.2025.1614645","DOIUrl":"10.3389/fvets.2025.1614645","url":null,"abstract":"<p><p>Idiopathic osteonecrosis of the jaw in dogs is a rare disease. Research into human osteonecrosis of the jaw has increased considerably in recent years revealing numerous underlying risk factors and comorbidities. The goal of this case series was to evaluate similar risk factors and comorbidities in dogs. The medical records from 10 cases were retrospectively reviewed for patient signalment, diagnostic results and treatment. Most cases had either cone beam or conventional computed tomography performed which allowed a detailed evaluation of maxillofacial structures. In this cohort, lesions had a predilection for the caudal maxilla and ipsilateral zygomatic arch and dental surgery did not always precede development of lesions. More cases and additional diagnostics will be needed to uncover the etiology of this disease.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1614645"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Heyndrickxia coagulans</i> SANK70258 supplementation improves growth performance, gut health, and liver function in growing pigs.","authors":"Masanori Aida, Ryouichi Yamada, Takahiro Kawase, Toshiki Matsuo, Takamitsu Tsukahara","doi":"10.3389/fvets.2025.1537913","DOIUrl":"10.3389/fvets.2025.1537913","url":null,"abstract":"<p><p><i>Heyndrickxia coagulans</i> is a Gram-positive, facultatively anaerobic, and spore forming bacterium. This species is often used as probiotics, therefore it is known for its health-conferring effects on livestock and humans. Previously, we showed that administering <i>H. coagulans</i> SANK70258 (SANK70258) to coccidiosis-infested broilers improved their growth performance by inducing anti-inflammation. Nonetheless, a few studies have observed the effects not only of <i>H. coagulans</i> spp. but also of SANK70258 in pigs. Here, we evaluated if SANK70258 could help improve the growth of pigs from weaning (days 0-42), growing (days 42-84) to fattening (days 84-126) periods. Twenty-four weaned crossbred (Duroc × Large White × Landrace) piglets were divided into control (CC; 4 replicants, <i>n</i> = 8) and 0.01% SANK70258 supplementation (P; 8 replicants, <i>n</i> = 16) groups. Diets and water were given <i>ad libitum</i>. After the weaning period (day 42), the pigs in group P were further sub-divided into pens with (PP; 4 replicants, <i>n</i> = 8) or without SANK70258 administration (PC; 4 replicants, <i>n</i> = 8). SANK70258 improved growth performance during the growing period [statistical differences were observed on days 42-56 (PP) and 70-84 (PP and PC)]. During weaning, a period well recognized as a frequent pathogen infection stage, due to the portal blood of pigs with leaky guts flows into the liver carrying gut microbes and their products such as endotoxin and bacterial DNA. P pigs experienced an improved liver function evidenced by the plasma alanine aminotransferase reduction and hence, a putative improved leaky gut condition evidenced by the plasma lactulose/mannitol ratio reduction. Nonetheless, during the fattening period, the positive effects became confounding with a pathogenic infection expressing a drastic increase in plasma aspartate aminotransferase on day 126. Nonetheless, stearate composition in meat of PP pigs were observed on day 126. Our results suggested that the SANK70258 administration may be a good natural product to improve the growth performance of pigs during production stages with a lower probability of infection like the growing period.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1537913"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rumen acidosis in ruminants: a review of the effects of high-concentrate diets and the potential modulatory role of rumen foam.","authors":"Jinju Mao, Lizhi Wang","doi":"10.3389/fvets.2025.1595615","DOIUrl":"10.3389/fvets.2025.1595615","url":null,"abstract":"<p><p>This review delves into the intricate processes by which high concentrate diets (HCD) in ruminants trigger rumen acidosis, with particular attention to the initiating factors of the condition and the pivotal role of rumen foams in its progression. High concentrate diets lead to an excessive accumulation of acids within the rumen, creating a favorable environment for the formation of rumen foam. This foam exacerbates the severity of rumen acidosis, making it a more challenging condition to manage. Additionally, HCD significantly diminishes salivary secretion, which not only increases the viscosity of rumen contents but also hampers the absorption of volatile fatty acids and the release of carbon dioxide (CO₂). Moreover, the review highlights a previously underexplored mechanism: the build-up of CO₂ may play a crucial role in the pathogenesis of rumen acidosis. This oversight could have significant implications for understanding the onset and advancement of the condition. In essence, this paper seeks to establish a robust scientific framework to optimize ruminant nutrition and production practices, ultimately ensuring the health and well-being of these animals.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1595615"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theofanis Liatis, Elizabeth Attree, Laura Ruiz De Alejos Blanco, Patrick Santens, Alberta De Stefani, Androniki Psifidi
{"title":"Case Report: Phenotypic and genetic characterization of a presumptive sporadic hypothalamic hamartoma in a standard Schnauzer dog.","authors":"Theofanis Liatis, Elizabeth Attree, Laura Ruiz De Alejos Blanco, Patrick Santens, Alberta De Stefani, Androniki Psifidi","doi":"10.3389/fvets.2025.1591863","DOIUrl":"10.3389/fvets.2025.1591863","url":null,"abstract":"<p><strong>Introduction: </strong>Hypothalamic hamartoma (HH) is a rare suprasellar developmental lesion that resembles ectopically located grey matter within the hypothalamus. Genetic mutations in genes involved in the sonic hedgehog intracellular pathway have been reported in humans with HH. Hypothalamic hamartoma has been reported in dogs; however, no genetic mutation has been associated with it. The aim of this study was to phenotypically and genetically characterize presumptive sporadic HH in a dog.</p><p><strong>Case presentation: </strong>A 7-month-old male Schnauzer was presented with chronic left head tilt, episodes of imbalance, circling to the left, and continuous repetitive movements of the head and neck to the left. These episodes could increase with stress or interaction, and the dog could not be distracted out of it. Clinical examination was normal. Neurological examination revealed a continuous repetitive involuntary movement of the head and neck to the left and left ocular torsion. Haematology and serum biochemistry were within normal limits. Magnetic resonance imaging of the head raised a suspicion of HH. Whole genome sequencing and genetic analysis identified germline variants with a high predicted impact on the encoding proteins in the candidate genes <i>SEPTIN8</i>, <i>UBXN10</i>, and <i>BLOC1S1</i>, which are involved in ciliogenesis and may be associated with the manifestation of HH in this dog.</p><p><strong>Conclusion: </strong>Sporadic HH should be considered in the differential diagnoses list for a young dog with chronic progressive intracranial neurologic signs and may be genetically associated with germline mutations in primary cilia-related genes.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1591863"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro
{"title":"Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study.","authors":"Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro","doi":"10.3389/fvets.2025.1585564","DOIUrl":"10.3389/fvets.2025.1585564","url":null,"abstract":"<p><p>Ovine footrot has <i>Dichelobacter nodosus</i> as the primary pathogen, and it is characterized by its infectious and multifactorial nature, such as environmental conditions, management practices, and host susceptibility, leading to variable prevalence and economic impacts across regions. The present study investigated factors associated with footrot scores in individual sheep from a non-probabilistic sample of 60 flocks enrolled by the Uruguayan Wool Secretariat, from which 6,139 sheep had their feet clinically evaluated from 2021 to 2024. PCR was employed to confirm <i>D. nodosus</i> at the farm level, and data on flock management were collected. The occurrence of footrot-related lesions at the animal level was 17.7%, mainly due to severe footrot. Ordinal multivariable mixed models with a random farm effect showed that the intraclass correlation coefficient for farms was 57.2%. Regarding fixed effects, breed stock size, sanitary protocol at sheep admission, formalin footbath, meat production purpose, hoof trimming, and veterinarian assistance for sheep had a protective effect. In contrast, the footrot vaccine and footrot control and eradication program had a risk effect. We conclude that specific management effects influencing <i>D. nodosus</i> infection in Uruguayan sheep flocks could guide context-specific, preventive interventions against footrot at the farm level.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1585564"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12148904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siyuan Zhan, Jing Luo, Ruiyang Li, Guangyao Li, Linxiang Li, Dandan Li, Tao Zhong, Linjie Wang, Jiazhong Guo, Jiaxue Cao, Hongping Zhang, Li Li
{"title":"Whole-genome resequencing reveals genetic diversity and selection signatures of Tongjiang and five goat breeds.","authors":"Siyuan Zhan, Jing Luo, Ruiyang Li, Guangyao Li, Linxiang Li, Dandan Li, Tao Zhong, Linjie Wang, Jiazhong Guo, Jiaxue Cao, Hongping Zhang, Li Li","doi":"10.3389/fvets.2025.1559764","DOIUrl":"10.3389/fvets.2025.1559764","url":null,"abstract":"<p><p>One of the first livestock that humans domesticated was the goat. They give people access to vital supplies. However, the exploration and conservation of the genetic resources of goats are not comprehensive enough. Here, we generated whole-genome sequencing data for 35 samples from three populations (Tongjiang, Banjiao, and Chuandong white) and downloaded the genome sequence data of 30 individuals from three breeds (Jintang black, Chengdu grey, and Tibetan cashmere) to characterize the genomic variations of Tongjiang and other goat breeds. Among the six goat populations studied, the Tongjiang goat exhibits the highest levels of observed heterozygosity and runs of homozygosity, alongside the lowest inbreeding coefficient. The nucleotide diversity and linkage disequilibrium in this population were observed to be at intermediate levels. The population genetic structure analysis showed that significant differentiation of Tongjiang goats from other goat breeds, as evidenced by their distinct clustering and considerable genetic distance from other groups. Furthermore, based on selective sweeps, we identified positive selection genes in Tongjiang goats, which were probably related to important traits such as development (<i>BMP4</i>), reproduction (<i>HTR1E</i>), meat quality (<i>HDAC9</i>, <i>PITX2</i>, and <i>PDGFD</i>), and immune response (<i>IKBKB</i> and <i>DLG1</i>). Our findings indicate that Tongjiang goats possess elevated genomic diversity and exhibit minimal inbreeding. The unique genetic structure of Tongjiang goats can be partly attributed to the specific geographic conditions of the region. We have identified several selection signatures within the genomic regions of Tongjiang goats, which may play a role in their meat quality and environmental adaptation. All of our findings have the potential to provide an invaluable genomic resource for future genetic research and conservation efforts.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1559764"},"PeriodicalIF":2.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}