{"title":"Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs.","authors":"Wenchen Sun, Linglan Deng, Wanjie Zou, Panting Wei, Shaobin Hao, Huadong Wu, Wei Lu, Yuyong He","doi":"10.3389/fvets.2025.1620128","DOIUrl":null,"url":null,"abstract":"<p><p>The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher (<i>p</i> < 0.05) TNF-<i>α</i> concentration, partially hepatic steatosis, higher (<i>p</i> < 0.05) relative abundances of <i>Escherichia_shigella</i>, <i>Prevotellaceae_UCG_003</i>, <i>Lachnospiraceae_XPB1014_group</i>, <i>Coprococcus</i>, <i>Lactococcus</i> and <i>Megamonas</i>, lower (<i>p</i> < 0.05) solute carrier family 7 member 11 (<i>SLC7A11</i>) expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher (<i>p</i> < 0.05) relative abundance of <i>Faecalibaculum</i> and expression of <i>SLC7A11</i>, lower (<i>p</i> < 0.05) relative abundances of <i>Staphylococcus</i> and <i>Clostridium_sensu_stricto_1</i> in liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased (<i>p</i> < 0.05) the ferrous ion level, the relative abundances of <i>Escherichia_Shigella</i>, <i>Lactococcus</i> and <i>Desulfobacterota</i>, the expressions of gene Cryptochrome-1(<i>CRY1</i>) and <i>SLC7A11</i>, but decreased (<i>p</i> < 0.05) the expressions of gene C-reactive protein (<i>CRP</i>) and galactokinase 1 (<i>GALK1</i>) in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1620128"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213335/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1620128","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher (p < 0.05) TNF-α concentration, partially hepatic steatosis, higher (p < 0.05) relative abundances of Escherichia_shigella, Prevotellaceae_UCG_003, Lachnospiraceae_XPB1014_group, Coprococcus, Lactococcus and Megamonas, lower (p < 0.05) solute carrier family 7 member 11 (SLC7A11) expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher (p < 0.05) relative abundance of Faecalibaculum and expression of SLC7A11, lower (p < 0.05) relative abundances of Staphylococcus and Clostridium_sensu_stricto_1 in liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased (p < 0.05) the ferrous ion level, the relative abundances of Escherichia_Shigella, Lactococcus and Desulfobacterota, the expressions of gene Cryptochrome-1(CRY1) and SLC7A11, but decreased (p < 0.05) the expressions of gene C-reactive protein (CRP) and galactokinase 1 (GALK1) in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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