Frontiers in Veterinary Science最新文献

{"title":"Arthroscopy and arthrotomy were equally effective for medial meniscal release but arthroscopy was minimally advantageous at preventing iatrogenic damage to the caudal cruciate ligament: a canine cadaveric study.","authors":"Dana N Gale, Steven W Frederick, Bianca F Hettlich, Jennifer J Au, Tatiana Motta","doi":"10.3389/fvets.2025.1452969","DOIUrl":"10.3389/fvets.2025.1452969","url":null,"abstract":"<p><strong>Objective: </strong>To compare efficacy of four techniques used for medial meniscal release by medial caudal meniscotibial ligament transection and evaluate associated iatrogenic damage to the medial meniscus, caudal cruciate ligament (CdCL), and articular cartilage of the canine stifle joint.</p><p><strong>Study design: </strong>Twenty-four pairs of canine cadaveric pelvic limbs were randomly assigned to groups by methods of approach, cranial tibial translation, and meniscal release. I: arthrotomy, Hohmann, #11 scalpel blade; II: arthrotomy, Hohmann, #64 Beaver blade; III: arthroscopy, Hohmann, meniscal hook knife; IV: arthroscopy, no joint translation, meniscal hook knife. Post-procedure stifle dissection and evaluation of meniscal release success rate and presence of iatrogenic damage were performed. Fisher's exact tests were performed for meniscal release and damage comparisons. Iatrogenic damage to the CdCL and articular cartilage were compared using generalized linear mixed effects model and linear mixed effects models (G/LMM) respectively.</p><p><strong>Results: </strong>Incomplete meniscal release was identified in 0/12 (0%) stifles in group I, 1/12 (8.3%) stifles in group II, 2/12 (16.7%) stifles in group III, and 1/12 (8.3%) stifles in group IV (<i>p</i> = 0.89, Fisher's exact test). There was no difference in iatrogenic meniscal damage rates between groups (<i>p</i> = 0.48, Fisher's exact test). There were no differences in total surface area of iatrogenic articular cartilage damage in any tested region between groups: femoral trochlea (<i>p</i> = 0.32, LMM), femoral condyles (<i>p</i> = 0.54, LMM), tibia (<i>p</i> = 0.28, LMM). Group I had more iatrogenic damage to the CdCL than group IV (<i>p</i> = 0.04, GLMM); no other differences were found.</p><p><strong>Conclusion: </strong>Arthroscopy and arthrotomy were equally effective for performing medial meniscal release by transection of the medial caudal meniscotibial ligament. Arthroscopic evaluation and medial meniscal release without joint translation was minimally advantageous in preventing iatrogenic damage to the CdCL.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1452969"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linkage of jockey falls and injuries with racehorse injuries and fatalities in Thoroughbred flat racing in Victoria, Australia.","authors":"Ashleigh V Morrice-West, Megan Thomas, Adelene S M Wong, Meredith Flash, R Chris Whitton, Peta L Hitchens","doi":"10.3389/fvets.2024.1481016","DOIUrl":"10.3389/fvets.2024.1481016","url":null,"abstract":"<p><strong>Introduction: </strong>Racehorse and jockey incidents on race-days frequently occur together, yet risk factors for their occurrence have historically been investigated separately. Consideration of both horses and humans in tandem is required for a One Health approach to risk reduction. Our objectives were to therefore identify modifiable risk factors for adverse outcomes that are common or conflicting to both horses and their jockeys in Thoroughbred racing.</p><p><strong>Methods: </strong>Australian Single National System records for the 2004/05 to 2018/19 flat racing season were merged with the corresponding Australian Racing Incident Database records. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated for the outcomes of racehorse musculoskeletal injury (MSI), racehorse fatality, jockey falls and jockey injury using Poisson regression. Horse-level, race-level, jockey-level and trainer-level factors associated with each adverse outcome during or post-race were identified using multivariable logistic regression.</p><p><strong>Results: </strong>The incidence of MSI was 21.21 (20.84, 21.59), racehorse fatalities 0.55 (0.50, 0.61), jockey falls was 3.01 (2.80, 3.24), and jockey injuries 1.79 (1.63, 1.97) per 1000 flat race starts. There was a decrease in racehorse MSI and jockey falls over the study period but no change in racehorse fatality or jockey injury incidence. In multivariable analysis, longer race distances and higher caliber races were associated with horse (<i>p</i> < 0.01), but not jockey, incidents. Firmer turf surfaces were associated with greater risk of both horse incidents and jockey falls (<i>p</i> < 0.05). Racehorses that were of older age at their first start, and/or had prior race-day injuries had a greater risk of injury and fatality (<i>p</i> < 0.001, <i>p</i> < 0.01, respectively). The most prominent risk factor for jockey fall or injury was a racehorse incident, although overall contributing to a relatively small proportion; 8.6% (<i>n</i> = 42/489) of jockey falls and 15.3% (<i>n</i> = 24/147) of injuries. Jockeys with fewer career starts were at greater risk of falling, and those with a higher percentage of last place finishing positions were at greater risk of injury (<i>p</i> < 0.001).</p><p><strong>Discussion: </strong>As there were no conflicting risk factors identified between racehorse and jockey injury, policies aimed at reducing horse injury risk are also expected to benefit their riders.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"11 ","pages":"1481016"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of <i>Brucella</i> in dogs in China: a systematic review and meta-analysis-Epidemiological analysis of canine brucellosis.","authors":"Mei-Mei Xiang, Hong-Yun Jiang, Qiu-Chi Jiang, Yi-Fan Zhang, Jia-Yu Yu, Lian-Min Li, Qi Wang, Ting Li, Wen-Tao Xiang, Chong-Bin Chen, Zheng-Yang Xie, Xue Leng, Qian-Zhen Zhang, Fei Liu, Jian-Ming Li","doi":"10.3389/fvets.2024.1515405","DOIUrl":"10.3389/fvets.2024.1515405","url":null,"abstract":"<p><strong>Introduction: </strong>Brucellosis is a zoonotic disease that affects both dogs and humans. With the increase in dog ownership, the risk of transmission has risen for both adults and children.</p><p><strong>Methods: </strong>This study used meta-analysis to comprehensively analyze the prevalence of canine brucellosis in China and to identify the relevant factors affecting its transmission.</p><p><strong>Result: </strong>We conducted a meta-analysis of 38 studies published between January 1983 and March 2024, sourced from six databases. The results showed a higher prevalence of canine brucellosis in northern and northwestern regions of China, with Xinjiang having the highest prevalence (19.77%) and Hunan the lowest (0.23%). Significant differences were found in positivity rates across different diagnostic methods (<i>P</i> < 0.05), with ELISA yielding the highest positivity rate (11.6%) and PCR and SAT the lowest (3.3%). The positivity rate of stray dogs (22.6%) was significantly higher than that of other dog sources (<i>P</i> < 0.05). Furthermore, environmental factors, such as temperature and altitude, were identified as influencing the incidence of brucellosis.</p><p><strong>Discussion: </strong>In conclusion, canine brucellosis is prevalent across China, with detection methods, dog sources, and environmental factors contributing to the varying incidence rates. We recommend regular brucellosis testing for pet dogs, improved kennel hygiene, and reduced contact with potentially infected animals.</p><p><strong>Systematic review registration: </strong>https://www.frontiersin.org/journals/veterinary-science.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"11 ","pages":"1515405"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of fecal microbiome to understand the impact of housing conditions on metabolic stress responses in farmed saltwater crocodiles (<i>Crocodylus porosus</i>).","authors":"David J Beale, Thao V Nguyen, Tim Dyall, Jodie van de Kamp, Andrew Bissett, Leisha Hewitt, Alison H Small","doi":"10.3389/fvets.2025.1496946","DOIUrl":"10.3389/fvets.2025.1496946","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the impact of housing conditions on the stress responses in farmed saltwater crocodiles (<i>Crocodylus porosus</i>) is crucial for optimizing welfare and management practices.</p><p><strong>Methods: </strong>This study employed a multi-omics methodology, combining targeted and untargeted LC-MS for metabolite, lipid, and hormone profiling with 16S rRNA gene sequencing for microbiome analysis, to compare stress responses and changes in fecal samples of crocodiles housed in single versus group pens. Metabolic responses to a startle test were evaluated through multivariate analysis, and changes post-stress were examined.</p><p><strong>Results: </strong>A total of 564 metabolic features were identified. Of these, 15 metabolites were linked to the cortisol biosynthesis pathway. Metabolite origin analysis showed that 128 metabolites originated from the host, 151 from the microbiota, and 400 remained unmatched. No significant differences in fecal corticosterone levels were observed between single and group pens. However, metabolic profiling revealed distinct differences in stress responses: single pen crocodiles exhibited downregulation of certain compounds and upregulation of others, affecting pyrimidine and purine metabolism pathways when compared to grouped pen crocodiles, linked to altering energy associated induced stress. Additionally, fecal microbiome analysis indicated increased Firmicutes:Bacteroides (F:B) ratio in group-housed animals, suggesting greater stress.</p><p><strong>Discussion: </strong>The study highlights that while traditional stress indicators like corticosterone levels may not differ significantly between housing conditions, metabolic and microbiome analyses provide deeper insights into stress responses. Single pens are associated with less metabolic disruption and potentially better health outcomes compared to group pens. These findings underscore the value of fecal microbiome and metabolomics in assessing animal welfare in farmed crocodiles.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1496946"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological investigation of goose circovirus based on a newly developed indirect ELISA method.","authors":"Jialong Chen, Wenchang Xue, Zhanxin Yao, Chao Wang, Wanjun Zhu, He Wang, Jipei Zhang, Yi Tang, Rongchang Liu, Jidang Chen","doi":"10.3389/fvets.2025.1521705","DOIUrl":"10.3389/fvets.2025.1521705","url":null,"abstract":"<p><p>Goose circovirus (GoCV) is a recently identified pathogen in geese that is known to cause slow growth, feather disorder syndrome, and immunosuppression. Infection with GoCV may increase the risk of coinfections with multiple pathogens, leading to significant economic losses in the goose industry. However, due to a lack of serological detection methods, analysis of viral nucleic acids has been widely used in GoCV epidemiological surveys, which has limited accurate monitoring of the prevalence of GoCV. In this study, we developed and optimized an indirect ELISA method based on the prokaryotic-expressed recombinant GoCV capsid protein (△Cap-iELISA). The △Cap-iELISA was then used to test 349 goose serum samples collected from Guangdong, Shandong, and Fujian provinces during 2023 and 2024. The results showed that the positive rate of GoCV antibodies in the sampled geese was 71.06%. Further analysis indicated that the positive rate of GoCV antibodies increased with the age of the geese. In conclusion, we have developed a novel iELISA method that is well-suited for large-scale clinical detection and early diagnosis of GoCV infection. Notably, a significant correlation between age and the positive rate of GoCV antibodies among geese was observed based on this newly established method.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1521705"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Resolution of lameness via compartmental resection of a malignant nerve sheath neoplasm of the median nerve in a dog.","authors":"Jeffery Smith, Marc Kent, Eric Glass, Garrett Davis","doi":"10.3389/fvets.2025.1551567","DOIUrl":"10.3389/fvets.2025.1551567","url":null,"abstract":"<p><p>A 7-year-old golden retriever was evaluated for a 6-month history of progressive right thoracic limb lameness. A lameness (grade 3 out of 5 on visual gait analysis) and pain with palpation of the medial aspect of the brachium proximal to the elbow were identified on exam. Magnetic resonance imaging of the right thoracic limb revealed a well-delineated, ovoid mass arising from the median nerve just proximal to the elbow. Compartmental resection of the mass with limb preservation was performed. Microscopically, the mass was a malignant nerve sheath neoplasm. One week postoperatively, the lameness was mild (grade 1). Three months postoperatively, the lameness had resolved (grade 0). One year postoperatively, the dog's gait remains normal. Malignant nerve sheath neoplasms commonly arise in the brachial plexus or cervical spinal nerves, often affecting the innervation provided by the radial nerve. Given its role in providing weight support, dysfunction of the radial nerve significantly impacts the gait. Conversely, dysfunction of the median nerve should not impair the gait. In the present case, compartmental resection of the neoplasm affecting the median nerve resolved the dog's lameness. The return of normal limb function supports the contention that the lameness was consequent to general somatic afferent dysfunction, neuropathic pain, rather than general somatic efferent function (paresis).</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1551567"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Insights in veterinary epidemiology and economics: 2023.","authors":"Ioannis Magouras, Salome Dürr, Beatriz Martínez-López, Victoria J Brookes","doi":"10.3389/fvets.2025.1564068","DOIUrl":"10.3389/fvets.2025.1564068","url":null,"abstract":"","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1564068"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation of a field condition to evaluate the risk of enrofloxacin-resistant <i>Pasteurella multocida</i> strain selection in food producing rabbits treated via drinking water.","authors":"Elena Circella, Lorena Lucatello, Ludovica Montanucci, Chiara Belloli, Francesca Capolongo","doi":"10.3389/fvets.2025.1474409","DOIUrl":"10.3389/fvets.2025.1474409","url":null,"abstract":"<p><strong>Introduction: </strong><i>Pasteurella multocida</i> is a key bacterial agent involved in most respiratory disorders in rabbits. The objective of this study was to evaluate the risk of selecting <i>Pasteurella multocida</i> strains resistant to enrofloxacin (ENRO) in food producing rabbits treated with ENRO via drinking water, according to the standard husbandry practices. Indeed, despite the EU community guidelines recommend a prudent use of antibiotics and promote new strategies to prevent bacterial diseases, antimicrobial therapy remains the primary approach for pasteurellosis management in rabbits. Therefore, the potential risk of selecting resistant bacteria in food-producing animals requires identifying optimized dosage regimens to minimize resistance emergence and to extend the useful lifetime of the drug.</p><p><strong>Methods: </strong>In this study, we isolated <i>Pasteurella multocida</i> strains from bacterial colonies sampled in nasal swabs collected from 6 healthy rabbits and 12 rabbits suffering respiratory disorders. Animals were sourced from industrial farms and were randomly selected to investigate the inter-individual variability in antimicrobial exposure associated with treatment via drinking water. Sick rabbits underwent an approved ENRO treatment (10 mg/kg for 5 days) administered via drinking water, following standard husbandry practices. We investigated the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC), and the mutant prevention concentration (MPC) of ENRO against bacterial strains in healthy rabbits and in sick rabbits before and after treatment. We recorded plasma drug concentrations of treated animals, and we applied the mutant selection window (MSW) approach to each subject. Finally, we calculated the PK/PD indices for concentration-dependent antimicrobials to assess ENRO's clinical efficacy and it's potential for promoting resistance using published pharmacokinetic (PK) parameters and maximum drug plasma concentrations recorded in this study.</p><p><strong>Results: </strong>Here we showed that treatment with ENRO improved clinical signs in rabbits with pasteurellosis but failed to completely eradicate the pathogen, consistent with previous studies. MPC-based analysis showed acquired resistance and potential ENRO-induced shift to a lesser sensitivity in the <i>P. multocida</i> population. Moreover, MSW analysis revealed that 45% of treated rabbits exhibited potential for drug resistance selection.</p><p><strong>Conclusion: </strong>These findings suggest that the current ENRO dosing regimen for pasteurellosis in rabbits is inadequate and may contribute to resistance development.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1474409"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exhaled propofol monitoring for plasma drug prediction in rats.","authors":"Xiaoxiao Li, Pan Chang, Xing Liu, Yi Kang, Zhongjun Zhao, Yixiang Duan, Wensheng Zhang","doi":"10.3389/fvets.2025.1540413","DOIUrl":"10.3389/fvets.2025.1540413","url":null,"abstract":"<p><p>While propofol can be detected in exhaled breath in rats, robust evidence supporting its correlation with plasma concentrations or its use in predicting plasma levels remains lacking. In this study, eighteen mechanically ventilated rats were divided into three groups and injected with low (Group BL, <i>n</i> = 6), medium (Group BM, <i>n</i> = 6), or high (Group BH, <i>n</i> = 6) doses of propofol. The propofol concentration in exhaled breath (Ce-pro) was determined online using vacuum ultraviolet time-of-flight mass spectrometry (VUV-TOF MS), while the propofol concentration in plasma (Cp-pro) were measured using high-performance liquid chromatograph. The results indicated that after propofol injection, the peak Ce-pro was 5.87 ± 1.67 ppbv, 16.54 ± 7.22 ppbv, and 25.40 ± 3.68 ppbv, respectively. Across the different dose groups, C_max of Ce-pro and Cp-pro were linearly correlated (<i>P</i> _BL = 0.032, <i>P</i> _BM = 0.031, <i>P</i> _BH = 0.049). T_max of Ce-pro was 1.22 ± 0.17 min, 1.28 ± 0.13 min, and 1.33 ± 0.01 min, respectively (<i>P</i> = 0.341), similar to the T_max of Cp-pro (1.00 ± 0.00 min). After natural logarithm transformation, the correlation between LN(Ce-pro) and LN(Cp-pro) was well fitted by a linear model, with <math> <mrow><msubsup><mi>R</mi> <mrow><mi>B</mi> <mi>L</mi></mrow> <mn>2</mn></msubsup> </mrow> </math> = 0.94, <math> <mrow><msubsup><mi>R</mi> <mrow><mi>B</mi> <mi>M</mi></mrow> <mn>2</mn></msubsup> </mrow> </math> = 0.95, <math> <mrow><msubsup><mi>R</mi> <mrow><mi>B</mi> <mi>H</mi></mrow> <mn>2</mn></msubsup> </mrow> </math> = 0.98, and <math> <mrow><msubsup><mi>R</mi> <mrow><mi>A</mi> <mi>L</mi> <mi>L</mi></mrow> <mn>2</mn></msubsup> </mrow> </math> = 0.96. Using the obtained regression equation LN(Cp-pro) = 1.42^*LN(Ce-pro)-1.70, the predicted Cp-pro values showed excellent agreement with the actual values within groups (ICC_BL = 0.92; ICC_BM = 0.97, ICC_BH = 0.99, all <i>P</i> < 0.001). This study demonstrates a strong correlation between exhaled and plasma propofol concentrations in rats, indicating that exhaled concentrations can be effectively used to estimate plasma levels.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1540413"},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative biomechanical analysis of monocortical and bicortical polyaxial screw rod fixation in canine lumbar vertebral stabilization.","authors":"Julien Guevar, Benjamin Voumard, Robert Bergman, Christina Precht, Franck Forterre","doi":"10.3389/fvets.2024.1434251","DOIUrl":"10.3389/fvets.2024.1434251","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the biomechanical properties of polyaxial screws-rod fixation (PSR) in stabilizing a single vertebral motion unit (VMU) fracture model and to compare the effectiveness of different stabilization techniques such as monocortical and bicortical.</p><p><strong>Methods: </strong>A total of 12 thoracolumbar vertebral column specimens were harvested from canine cadavers. These specimens were divided into two groups based on the stabilization technique applied: a monocortical group and a bicortical group. Each group underwent biomechanical testing to assess flexion/extension and lateral bending motions. The range of motion (ROM), neutral zone (NZ), and stiffness were measured for each lumbar VMU in three conditions: intact, fractured with unilateral stabilization, and fractured with bilateral stabilization.</p><p><strong>Results: </strong>In the 3-column fracture model, PSR was unable to restore the ROM of an intact spine in flexion/extension. In lateral bending, only bilateral PSR successfully approached the ROM of the intact spine. Notably, PSR failures were observed in four specimens when applied as monocortical and unilateral stabilization.</p><p><strong>Conclusion: </strong>The findings indicate that even bilateral PSR does not fully restore the intact spine's ROM in canine fracture models, highlighting the need for further research to optimize stabilization techniques. The current study demonstrates that a single 3-column lumbar fracture model VMU cannot be adequately stabilized using PSR in a canine model, suggesting potential limitations in both monocortical and bicortical approaches.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"11 ","pages":"1434251"},"PeriodicalIF":2.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}