{"title":"厚朴提高了龙胆石斑鱼的免疫应答和对哈维弧菌感染的抗性。","authors":"Yilin Zhang, Yuhao Li, Xinlan Xu, Luxi Xu, Weifu Li, Zhen Gan, Yishan Lu","doi":"10.3389/fvets.2025.1603997","DOIUrl":null,"url":null,"abstract":"<p><p><i>Magnolia officinalis</i> (MO) is a kind of traditional Chinese herbs, which has been studied for thousands of years in Chinese pharmacopoeia. In recent years, MO has been reported as an antibacterial agent in aquaculture, but the antibacterial properties of MO against <i>Vibrio harveyi</i> infection in fish remains unexplored. In this study, the effects of MO treatment on immune responses and the resistance to <i>V. harveyi</i> infection were detected in pearl gentian groupers. The results revealed that the expression levels of immune-related genes (<i>IL-12, TLR2, TLR5S, CD4, MHC-Iα</i>, and <i>IFN-</i> <i>γ</i>) in spleen, head kidney, liver and thymus, and the enzyme activities of CAT, SOD, LZM, and total serum protein in serum were significantly up-regulated at most of time points in MO -treated groupers. After being challenged with <i>V. harveyi</i> ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to <i>V. harveyi</i> infection in groupers. The present study revealed that MO can be considered as a promising immunostimulant to induce the immune responses against <i>V. harveyi</i> infection in marine fishes.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1603997"},"PeriodicalIF":2.9000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213365/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Magnolia officinalis</i> enhanced immune responses and the resistance to <i>Vibrio harveyi</i> infection in pearl gentian groupers.\",\"authors\":\"Yilin Zhang, Yuhao Li, Xinlan Xu, Luxi Xu, Weifu Li, Zhen Gan, Yishan Lu\",\"doi\":\"10.3389/fvets.2025.1603997\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Magnolia officinalis</i> (MO) is a kind of traditional Chinese herbs, which has been studied for thousands of years in Chinese pharmacopoeia. In recent years, MO has been reported as an antibacterial agent in aquaculture, but the antibacterial properties of MO against <i>Vibrio harveyi</i> infection in fish remains unexplored. In this study, the effects of MO treatment on immune responses and the resistance to <i>V. harveyi</i> infection were detected in pearl gentian groupers. The results revealed that the expression levels of immune-related genes (<i>IL-12, TLR2, TLR5S, CD4, MHC-Iα</i>, and <i>IFN-</i> <i>γ</i>) in spleen, head kidney, liver and thymus, and the enzyme activities of CAT, SOD, LZM, and total serum protein in serum were significantly up-regulated at most of time points in MO -treated groupers. After being challenged with <i>V. harveyi</i> ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to <i>V. harveyi</i> infection in groupers. The present study revealed that MO can be considered as a promising immunostimulant to induce the immune responses against <i>V. harveyi</i> infection in marine fishes.</p>\",\"PeriodicalId\":12772,\"journal\":{\"name\":\"Frontiers in Veterinary Science\",\"volume\":\"12 \",\"pages\":\"1603997\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12213365/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Veterinary Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fvets.2025.1603997\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1603997","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Magnolia officinalis enhanced immune responses and the resistance to Vibrio harveyi infection in pearl gentian groupers.
Magnolia officinalis (MO) is a kind of traditional Chinese herbs, which has been studied for thousands of years in Chinese pharmacopoeia. In recent years, MO has been reported as an antibacterial agent in aquaculture, but the antibacterial properties of MO against Vibrio harveyi infection in fish remains unexplored. In this study, the effects of MO treatment on immune responses and the resistance to V. harveyi infection were detected in pearl gentian groupers. The results revealed that the expression levels of immune-related genes (IL-12, TLR2, TLR5S, CD4, MHC-Iα, and IFN-γ) in spleen, head kidney, liver and thymus, and the enzyme activities of CAT, SOD, LZM, and total serum protein in serum were significantly up-regulated at most of time points in MO -treated groupers. After being challenged with V. harveyi ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to V. harveyi infection in groupers. The present study revealed that MO can be considered as a promising immunostimulant to induce the immune responses against V. harveyi infection in marine fishes.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
