Frontiers in Pediatrics最新文献_第8页

The development of national growth charts for Jordanian children aged 0-2 years. 约旦0-2岁儿童国家生长图表的制定。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1547581

Walid Al-Qerem, Lina Bataineh, Anan Jarab, Judith Eberhardt, Fawaz Alasmari, Alaa Hammad

{"title":"The development of national growth charts for Jordanian children aged 0-2 years.","authors":"Walid Al-Qerem, Lina Bataineh, Anan Jarab, Judith Eberhardt, Fawaz Alasmari, Alaa Hammad","doi":"10.3389/fped.2025.1547581","DOIUrl":"https://doi.org/10.3389/fped.2025.1547581","url":null,"abstract":"Purpose: This study aimed to determine the prevalence of underweight, overweight, and obesity among Jordanian infants aged 0-2 years, establish national growth reference charts, and compare the growth of Jordanian infants with the WHO growth standards.Methods: The present study analyzed 260,027 anthropometric measurements derived from 82,874 healthy Jordanian children (51% boys) aged 0-24 months. These measurements included both cross-sectional and repeated entries, with each child contributing between one visit and nine follow-up visits (10 measurements). Weight and height measurements were analyzed using the Generalized Additive Models for Location Scale and Shape (GAMLSS) statistical method to develop the growth charts.Results: Separate models for height-for-age, weight-for-age, and weight-for-height were constructed for each gender. Significant discrepancies were found between WHO growth references and the Jordanian references. Children in Jordan were shorter, particularly among girls, and had slightly higher weight-for-age from the age of 7 months onward.Conclusion: The availability of Jordanian-specific growth references will improve the accuracy of assessing children's growth and enhance the monitoring and evaluation of their health and development.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1547581"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Case Report: Diagnosis of Gaucher disease in a toddler with acute respiratory failure. 更正：病例报告：戈谢病的诊断在一个幼儿急性呼吸衰竭。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1651138

Sarah Householder, Ruchit Nagar, Nisarg Shah, Jodi Forward, Sean Bickerton, Pramod Mistry, E Vincent S Faustino

引用次数: 0

Critical conversations: a user-centric approach to chatbots for history taking in the pediatric intensive care unit. 关键对话：以用户为中心的聊天机器人方法，用于儿科重症监护病房的历史记录。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-12 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1646989

Candace Collins, James Fackler, Melissa Jerdonek Sacco, Maia Jacobs

{"title":"Critical conversations: a user-centric approach to chatbots for history taking in the pediatric intensive care unit.","authors":"Candace Collins, James Fackler, Melissa Jerdonek Sacco, Maia Jacobs","doi":"10.3389/fped.2025.1646989","DOIUrl":"https://doi.org/10.3389/fped.2025.1646989","url":null,"abstract":"In this article, we describe the potential utility and design of chatbots to improve history taking in the pediatric intensive care unit (PICU). The fast-paced, high-stakes environment of the PICU often forces clinicians to obtain only enough information to make immediate clinical decisions. Specific barriers to comprehensive history taking include insufficient time, frequent interruptions, caring for a wide range of conditions, need for timely interventions, and language differences. We propose that chatbots could play a critical role in improving history taking in the PICU by collecting information related to a patient's current presentation and exploring areas that are commonly neglected, such as social histories. To explore the use of chatbots in the PICU setting, we will first describe the current scope of chatbots as medical history taking aids. Next, we will outline specific considerations for the development of chatbots for the PICU, including methods for involving users, such as patients, caregivers, and clinicians directly in the design, mitigating false information, and establishing safeguards for chatbot behavior. Finally, we will review methods to evaluate chatbots. The overall purpose of this perspective article is to 1) propose the PICU as a novel environment where chatbots could improve history taking and diagnostic reasoning and 2) delineate specific user-centric design and evaluation methods.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1646989"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of overweight/obesity among Saudi adolescents relative to lifestyle behaviors using the IOTF or WHO reference standards. 使用IOTF或WHO参考标准对沙特青少年超重/肥胖与生活方式行为的分类

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1607811

Hazzaa M Al-Hazzaa, Amal Alhakami, Ahlam M Alotaibi

{"title":"Classification of overweight/obesity among Saudi adolescents relative to lifestyle behaviors using the IOTF or WHO reference standards.","authors":"Hazzaa M Al-Hazzaa, Amal Alhakami, Ahlam M Alotaibi","doi":"10.3389/fped.2025.1607811","DOIUrl":"10.3389/fped.2025.1607811","url":null,"abstract":"Purpose: To compare two BMI classifications (the IOTF and WHO references) in assessing overweight/obesity prevalence among Saudi adolescents and to evaluate the ability of the two standards to detect risks of unhealthy lifestyle behaviors.Methods: Healthy Saudi adolescents (15-19 years) were drawn from two data sets (n = 2,263) collected previously in 2009 and 2019, using a random multistage stratified cluster sampling technique. Measurements included weight, height, waist circumference (WC), wais to height ratio (WHtR), and selected lifestyle behaviors, including physical activity (PA), screen time, sleep duration, and dietary habits, using the Arab Teen Lifestyle Study (ATLS) questionnaire.Results: The proportions (%) of adolescents classified as underweight, normal weight, overweight, and with obesity varied according to the classification used. The IOTF system produces slightly lower overweight/obesity prevalence than the WHO standards (IOTF: 38.8%; WHO: 40.0%), with females exhibited lower overweight/obesity prevalence than males. The Kappa agreement between overweight/obesity in the two references was high (0.973), with high sensitivity (99.8%) and high specificity (98.0%). Kappa values between central obesity and both IOTF (0.691) and WHO (0.687) were moderate with moderate sensitivity and high specificity. In both classification system, intakes >4 days/week of French fries/potato chips, and chocolates/candy showed higher odds of overweight/obesity.Conclusion: Although overweight/obesity exhibited high Kappa agreement between the two classifications, variations were observed when estimating the prevalence of BMI classification using IOTF or WHO standards. Selected lifestyle behaviors showed significant associations with overweight/obesity in both classification standards.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1607811"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The expression pattern and role of circulating CXCR5⁺ γδ T cells in children with newly diagnosed immune thrombocytopenia. 循环CXCR5+ γδ T细胞在新诊断的免疫性血小板减少症患儿中的表达模式及其作用

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1646877

Jian-Yong Wang, Yi Xin, Xiao-Li Wang, Lin-Lin Li, Ai-Min Li, Xiao-Lu Zhang

{"title":"The expression pattern and role of circulating CXCR5+ γδ T cells in children with newly diagnosed immune thrombocytopenia.","authors":"Jian-Yong Wang, Yi Xin, Xiao-Li Wang, Lin-Lin Li, Ai-Min Li, Xiao-Lu Zhang","doi":"10.3389/fped.2025.1646877","DOIUrl":"10.3389/fped.2025.1646877","url":null,"abstract":"Introduction: Immune thrombocytopenia (ITP) is the most common bleeding disorder in children. Tfh cells play a crucial role in the pathogenesis of ITP by promoting the production of anti-platelet autoantibodies. Recent studies have shown that CXCR5+ γδ T cells not only possess \"Tfh-like\" cell functions but also can induce Tfh cell differentiation. However, it remains unknown whether CXCR5+ γδ T cells are involved in the pathogenesis of ITP. This study aims to investigate the role of CXCR5+ γδ T cells in children with newly diagnosed ITP (nITP).Methods: A total of 96 children with nITP and 48 healthy children were enrolled in this study. FCM was used to compare the frequencies of circulating CXCR5+ γδ T cells and circulating Tfh cells, as well as the levels of ICOS and CD40l on circulating CXCR5+ γδ T cells in both groups. The correlation between circulating CXCR5+ γδ T cells and platelets as well as circulating Tfh cells were further analyzed.Results: Compared with healthy controls, the frequency of circulating CXCR5+ γδ T cells was higher in children with nITP, and it was negatively correlated with platelet count. The levels of ICOS and CD40l on circulating CXCR5+ γδ T cells in children with nITP were also higher. Children with nITP had a higher frequency of circulating Tfh cells, which was positively correlated with circulating CXCR5+ γδ T cells.Conclusions: The excessive activation and proliferation of CXCR5+ γδ T cells may contribute to the pathogenesis of nITP in children. Therefore, it can be used as a target for the immunotherapy of pediatric ITP.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1646877"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Eltrombopag in mosaic and gene therapy-treated patients with Fanconi anemia. 病例报告：Eltrombopag在马赛克和基因治疗的范可尼贫血患者。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1625751

Josune Zubicaray, June Iriondo, Elena Sebastián, Alejandro Sanz, Paula Rio, Jean Soulier, Sonsoles San Román, José J Uriz, Susana Navarro, Eileen Nicoletti, Juan A Bueren, Jonathan D Schwartz, Julián Sevilla

{"title":"Case Report: Eltrombopag in mosaic and gene therapy-treated patients with Fanconi anemia.","authors":"Josune Zubicaray, June Iriondo, Elena Sebastián, Alejandro Sanz, Paula Rio, Jean Soulier, Sonsoles San Román, José J Uriz, Susana Navarro, Eileen Nicoletti, Juan A Bueren, Jonathan D Schwartz, Julián Sevilla","doi":"10.3389/fped.2025.1625751","DOIUrl":"10.3389/fped.2025.1625751","url":null,"abstract":"Fanconi anemia (FA) constitutes the most common of the inherited bone marrow failure syndromes, a group of rare heterogeneous disorders characterized by cytopenia, predisposition to hematologic and solid malignancies and diverse clinical features. Currently, the only available hematopoietic curative treatment for bone marrow failure is an allogeneic hematopoietic stem cell transplantation (HSCT), although gene therapy has demonstrated evidence of efficacy and substantially reduced toxicity. It has been demonstrated that eltrombopag stimulates trilineage hematopoiesis in aplastic anemia, and preclinical studies suggest it promotes DNA repair in FA hematopoietic stem cells (HSCs). Herein, we report the experience with eltrombopag in a patient misdiagnosed with aplastic anemia and subsequently determined to have FA mosaicism and in two FA patients who previously received gene therapy but who were infused with very low numbers of gene-corrected HSCs. Strikingly, the patient with somatic mosaicism achieved transfusion independence and averted HSCT, and the gene-therapy patients showed a marked increase of corrected cells during treatment.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1625751"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Incidental diagnosis of cystic fibrosis via whole genome sequencing alters HSCT planning in a child with cerebral X-linked adrenoleukodystrophy. 病例报告：通过全基因组测序对囊性纤维化的偶然诊断改变了脑x连锁肾上腺脑白质营养不良儿童的HSCT计划。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1650645

Jann Adriel Chua Sy, Poh Lin Tan, Jeremy Bingyuan Lin, Stacey Kiat-Hong Tay, Hui-Lin Chin

{"title":"Case Report: Incidental diagnosis of cystic fibrosis via whole genome sequencing alters HSCT planning in a child with cerebral X-linked adrenoleukodystrophy.","authors":"Jann Adriel Chua Sy, Poh Lin Tan, Jeremy Bingyuan Lin, Stacey Kiat-Hong Tay, Hui-Lin Chin","doi":"10.3389/fped.2025.1650645","DOIUrl":"10.3389/fped.2025.1650645","url":null,"abstract":"Cerebral X-linked adrenoleukodystrophy (cALD) is an X-linked peroxisomal disorder caused by pathogenic variation in the ABCD1 gene, characterized by progressive central nervous system demyelination leading to severe neurocognitive decline, as well as concomitant adrenal insufficiency resulting from fatty acid accumulation. When instituted early, haematopoietic stem cell transplantation (HSCT) can halt neurological disease progression. Whole genome sequencing can clarify the diagnosis of cALD but may also reveal conditions with significant clinical implications, as in our case. To our knowledge, this is the first published case where an incidental finding of cystic fibrosis influenced pre-HSCT workup and subsequent management in a child with cALD. A 6-year-old boy presented with subacute neuroregression, manifesting as deteriorating cognition and speech, hyperactivity, clumsiness, and swallowing dysfunction. Brain MRI confirmed symmetrical demyelinating lesions consistent with cALD, and whole genome sequencing (WGS) identified a maternally-inherited pathogenic ABCD1(NM_000033.4):c.521A>G (p.Tyr174Cys) variant. WGS also incidentally identified compound heterozygosity for two pathogenic variants in CFTR, supporting an incidental cystic fibrosis (CF) diagnosis, clinically verified by an abnormal sweat test and radiological findings of subclinical bronchiectasis, as the child was asymptomatic. This influenced the HSCT conditioning regimen prescription and reinforced the need for enhanced infectious prophylaxis and vigilant respiratory support. This case highlights the potential of comprehensive genomic approaches to reveal previously undetected comorbidities. Integrating CF management into a cALD-directed HSCT protocol mitigated peri-transplant risks, demonstrating the value of multidisciplinary care when incidental diagnoses emerge.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1650645"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young lungs cared enough? India's frontiers in diagnosing pediatric TB. 年轻的肺足够关心吗？印度儿科结核病诊断的前沿。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1638167

Silla Varghese Thomas, Priya Rajendran, Sivakumar Shanmugam

{"title":"Young lungs cared enough? India's frontiers in diagnosing pediatric TB.","authors":"Silla Varghese Thomas, Priya Rajendran, Sivakumar Shanmugam","doi":"10.3389/fped.2025.1638167","DOIUrl":"https://doi.org/10.3389/fped.2025.1638167","url":null,"abstract":"This review provides an insight into pediatric tuberculosis (TB) diagnosis in India. Significant challenges still exist in the accurate diagnosis of pediatric TB due to the paucibacillary status of the bacilli and the nonspecific clinical symptoms. Despite advancements in newer diagnostics that allow for rapid identification of TB and detection of drug resistance in children, their sensitivity is compromised due to these challenges. It is crucial to consider that children may not always expectorate sputum, further complicating the diagnostic process. Testing multiple samples, like aspirates, bronchoalveolar lavages, stool, urine, saliva, and swabs, may improve sensitivity. However, the efficacy of using these samples for pediatric TB diagnosis requires extensive research to validate their accuracy and reliability. This is crucial, especially in countries like India, which bears a high burden of TB cases, making the need for novel diagnostic approaches even more pressing. This need for innovative diagnostic approaches is particularly important in countries like India, which bears a high burden of TB cases. Collaborative efforts between researchers, healthcare providers, and policymakers are essential to drive innovation and progress toward achieving the END-TB goal. In this review, we have included studies and case reports published over a decade by utilizing scientific databases like PubMed, Scopus, and Google Scholar, and a set of key search terms including \"pediatric TB in India\", and \"pediatric TB diagnosis\".","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1638167"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and demographic predictors of the need for pharmacotherapy in neonatal abstinence syndrome. 新生儿戒断综合征需要药物治疗的临床和人口学预测因素。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1527276

Shawana Bibi, Rachana Singh, Janis L Breeze, Jason Nelson, Walter K Kraft, Jonathan M Davis

{"title":"Clinical and demographic predictors of the need for pharmacotherapy in neonatal abstinence syndrome.","authors":"Shawana Bibi, Rachana Singh, Janis L Breeze, Jason Nelson, Walter K Kraft, Jonathan M Davis","doi":"10.3389/fped.2025.1527276","DOIUrl":"10.3389/fped.2025.1527276","url":null,"abstract":"Objective: Development and validation of a clinical prediction model for receipt of pharmacotherapy for Neonatal Abstinence Syndrome (NAS).Study design: Data from three cohorts included in- utero opioid exposed neonates ≥37 weeks gestation. Primary outcome was the receipt of pharmacotherapy utilizing a modified Finnegan Neonatal Abstinence Scoring System (FNASS). A stepwise multivariable logistic regression model was built and internally validated.Results: Of 698 infants included, 430 received pharmacotherapy. The final model included seven predictors of receipt of pharmacotherapy: gestational age, exposure to maternal breast milk, type of maternal opioid medication, and exposure to heroin, cocaine, benzodiazepines, and/or antipsychotic medications. The model had an AUROC of 0.68 (95% CI: 0.64-0.72; optimism corrected 0.65).Conclusion: Our prediction model was parsimonious and identified seven predictors associated with the need for PT. Larger cohort studies are needed to more definitively establish risk of significant NAS requiring pharmacotherapy.","PeriodicalId":12637,"journal":{"name":"Frontiers in Pediatrics","volume":"13 ","pages":"1527276"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Diagnosis, treatment and follow-up of venous thrombosis in adolescent diabetic patients with SARS-CoV-2. 病例报告：青少年糖尿病患者合并SARS-CoV-2静脉血栓的诊断、治疗及随访。

IF 2 3区医学

Frontiers in Pediatrics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI: 10.3389/fped.2025.1562590

Fanshu Ma, Qiang Zhang, Li Pei, JinFeng Shuai, Jinying Li

引用次数: 0